New hope for tough leukemia: experimental drug AZD0486 enters human trials

NCT ID NCT06137118

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated Apr 28, 2026 · Updated 31 times

Summary

This study tests an experimental drug called AZD0486 in teenagers and adults with B-cell acute lymphoblastic leukemia (B-ALL) that has returned or not responded to at least two prior treatments. The goal is to see if the drug is safe and can shrink or eliminate cancer cells. Participants receive the drug alone, and the study will find the best dose. This is not a cure; patients may need ongoing treatment.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

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WITHDRAWN

Birmingham, Alabama, 35233, United States
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Duarte, California, 91010, United States
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Los Angeles, California, 90048, United States
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Palo Alto, California, 94304, United States
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Tampa, Florida, 33612, United States
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Atlanta, Georgia, 30322, United States
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Chicago, Illinois, 60637, United States
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New York, New York, 10016, United States
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Houston, Texas, 77030, United States
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Richmond, Virginia, 23298, United States
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Seattle, Washington, 98109, United States
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Milwaukee, Wisconsin, 53226, United States
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Melbourne, 3000, Australia
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NOT_YET_RECRUITING

Porto Alegre, 90035903, Brazil
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NOT_YET_RECRUITING

São Paulo, 01401-002, Brazil
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São Paulo, 05652-900, Brazil
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Toronto, Ontario, M5G 2M9, Canada
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Montreal, Quebec, H3T1C5, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Changsha, 410008, China
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Chengdu, 610041, China
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Guangzhou, 510060, China
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Guangzhou, 510280, China
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Hangzhou, 310003, China
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Nanjing, 210008, China
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Nanjing, 210009, China
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Suzhou, 215006, China
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NOT_YET_RECRUITING

Tianjin, 300020, China
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Zhengzhou, 450008, China
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Caen, 14033, France
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Marseille, 13009, France
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Nantes, 44000, France
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Paris, 75019, France
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Pierre-Bénite, 69495, France
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Toulouse, 31059, France
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Cologne, 50924, Germany
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Düsseldorf, 40225, Germany
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Essen, 45147, Germany
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Frankfurt, 60590, Germany
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Freiburg im Breisgau, 79106, Germany
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Halle, 06120, Germany
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Hamburg, 20246, Germany
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München, D-81337, Germany
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Münster, 48149, Germany
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Würzburg, 97080, Germany
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Bergamo, 24127, Italy
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Bologna, 40138, Italy
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Monza, 20900, Italy
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Naples, 80123, Italy
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Roma, 00165, Italy
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Bunkyō City, 113-8677, Japan
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Chiba, 260-8677, Japan
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Chūōku, 104-0045, Japan
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Fukuoka, 810-8563, Japan
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Kashiwa, 277-8577, Japan
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Kyoto, 606-8507, Japan
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Okayama, 701-1192, Japan
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Osaka, 545-8586, Japan
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Sapporo, 003-0006, Japan
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Toyohashi, 441-8570, Japan
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Yamagata, 990-9585, Japan
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 06351, South Korea
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Seoul, 6591, South Korea
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Barcelona, 08035, Spain
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NOT_YET_RECRUITING

Barcelona, 08036, Spain
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Madrid, 28025, Spain
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Madrid, 28046, Spain
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NOT_YET_RECRUITING

Salamanca, 37007, Spain
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Valencia, 46026, Spain
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Kaohsiung City, 833401, Taiwan
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Taichung, 40705, Taiwan
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Tainan, 70403, Taiwan
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Taipei, 10002, Taiwan
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Taoyuan District, 333, Taiwan
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London, EC1A 7BE, United Kingdom
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Manchester, M20 4BX, United Kingdom
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Surrey, SM1 2DL, United Kingdom

Conditions

Explore the condition pages connected to this study.

B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (B-ALL) B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (B-ALL)