Astrazeneca

This study tests an investigational drug called tezepelumab in adults with moderate to very severe COPD. The goal is to see if it can reduce the number of moderate or severe flare-ups (exacerbations) compared to a placebo. About 990 participants will receive either tezepelumab or…

This study follows 50 adults with generalized myasthenia gravis (gMG) who are starting ravulizumab, a drug that controls the immune system. Researchers will measure changes in daily activities like breathing, swallowing, and moving over time. The goal is to see how well the treat…

This study follows 1,000 people aged 12 and older in China who have severe eosinophilic asthma and are prescribed benralizumab. Researchers will track how well the drug controls asthma symptoms over 56 weeks using patient questionnaires. The goal is to understand real-world treat…

This study tests two drugs, saruparib and darolutamide, given alone or together before prostate removal surgery in men with newly diagnosed, localized prostate cancer. The goal is to see how these drugs affect cancer cells and to check their safety. About 120 men will take part.

This study tests an experimental drug called AZD9793 in people with advanced solid tumors, especially liver cancer, that have a specific marker called GPC3. The drug is designed to help the body's immune T cells find and attack cancer cells. The main goals are to check safety and…

This study follows 200 adults with systemic lupus erythematosus (SLE) who are starting anifrolumab for the first time as part of their regular treatment. Researchers will track disease activity, skin symptoms, fatigue, and quality of life over time using standard medical assessme…

This study looks at whether people with severe asthma who are taking the drug tezepelumab can safely cut back on their other asthma medicines without losing control of their symptoms. About 400 participants aged 12 to 80 will try to reduce or stop certain controller medications o…

This study tests an experimental drug called AZD8359 for men with metastatic prostate cancer that has spread and is no longer responding to standard treatments. The drug is an antibody designed to guide the body's immune cells to attack cancer cells. The trial has two parts: firs…

This study tests a new drug, AZD0901, against standard treatments for people with advanced stomach or gastroesophageal junction cancer that has not responded to prior therapy. The trial includes 572 adults whose tumors have a specific marker called CLDN18.2. The main goals are to…

This study tests an experimental drug called AZD5492 in people with B-cell blood cancers (like lymphoma or leukemia) that have come back or not responded to at least two prior treatments. The drug works by helping the body's immune T-cells find and attack cancer cells. The main g…

This study is testing whether adding an extra medication called glycopyrronium to standard asthma treatment can improve lung function in children aged 4 to under 12. About 69 children with asthma will receive two different doses of glycopyrronium and a placebo in random order to …

This study tests whether a new drug combination (trastuzumab deruxtecan plus rilvegostomig or pembrolizumab) works better than standard chemotherapy plus pembrolizumab for people with a specific type of advanced or recurrent endometrial cancer. The cancer must have high levels of…

This study is checking the long-term safety of a drug called tozorakimab in people with COPD who have had flare-ups in the past. About 82 adults who finished a previous tozorakimab study will take the drug and be monitored for side effects. The goal is to see if the drug remains …

This study follows 300 adults with severe eosinophilic asthma who are prescribed benralizumab as part of their normal care. Researchers will track asthma control, quality of life, and medication use over 52 weeks to see how well the drug works in real-life settings. The goal is t…

This study looks at how well the drug anifrolumab works in real life for people with lupus. The goal is to see if it helps patients achieve low disease activity while taking a low dose of steroids (5 mg or less per day). About 218 adults in Italy will be followed for a year. This…

This study tests an experimental oral drug, AZD3632, in about 84 adults with advanced blood cancers (acute leukemias or high-risk MDS) that have certain genetic markers. The main goals are to check safety, find the right dose, and see if the drug shrinks the cancer. Participants …

This study tests whether a new drug called rilvegostomig, given with bevacizumab (with or without another drug, tremelimumab), helps people with advanced liver cancer live longer. About 1220 adults whose cancer cannot be removed or treated with local therapies will take part. The…

This study tests an experimental drug called AZD4956, alone or with other cancer treatments, in people with advanced or spreading solid tumors that have a specific DNA repair flaw. About 180 adults will take part to see if the drug is safe and works. The goal is to control the di…

This early-stage study tests a new treatment using a patient's own immune cells, modified in a lab to recognize and attack cancer cells with a specific KRAS mutation (G12D). It is for adults with advanced solid tumors (like lung, colon, or pancreatic cancer) that have not respond…

This early-stage study tests a new treatment called NT-175 for people with advanced solid tumors (like lung, colon, or breast cancer) that have a specific mutation (TP53 R175H) and a certain immune marker (HLA-A*02:01). NT-175 uses the patient's own T cells, which are modified in…

This study tests a new drug combination for people with advanced HER2-positive stomach or gastroesophageal junction cancer whose tumors also have a protein called PD-L1. About 840 participants will receive either the experimental treatment (rilvegostomig plus chemotherapy and tra…

This study is checking how safe and tolerable the drug Breztri Aerosphere is for people with moderate to severe COPD. It involves 150 Indian patients who will take the medication as a maintenance treatment. The main goal is to track any side effects and see how well patients hand…

This large Phase 3 study tests a daily oral medication, AZD0780, to see if it reduces the risk of major heart problems like heart attacks, strokes, and urgent procedures in people with existing heart disease or those at high risk. About 15,100 participants will receive either AZD…

This study is testing a new drug called AZD9550, alone or combined with another drug (AZD6234), to help people with obesity or overweight lose weight. The study includes people with or without type 2 diabetes. Researchers want to see if the drugs are safe, how the body processes …

This study tracks 100 adults with lupus who are taking anifrolumab as part of their normal treatment in Poland. Researchers will measure changes in disease activity and overall health over time. The goal is to see how well the drug works outside of controlled trials, in real-life…

This study tests a new treatment called AZD0120 for people with multiple myeloma that has returned or stopped responding to at least three prior therapies. AZD0120 is a personalized cell therapy that uses a patient's own immune cells, modified to target two proteins (CD19 and BCM…

This study tests whether a new drug combination (trastuzumab deruxtecan plus rilvegostomig) works better than standard chemotherapy for people with advanced bile duct cancer that has a specific protein called HER2. About 620 adults who have not had prior treatment for advanced di…

This study monitors the safety and effectiveness of Danicopan when used alongside standard PNH treatments (ravulizumab or eculizumab) in routine Korean medical practice. It involves 8 participants and aims to confirm known side effects or detect new ones, as well as measure chang…

This early-phase study tests a new drug called AZD6750, which is designed to guide the immune system to attack cancer cells. It is for adults with advanced solid tumors like melanoma, lung cancer, or breast cancer that have not responded to other treatments. The study will check …

This study tests whether a new drug (AZD0486) plus rituximab works better than standard chemotherapy plus rituximab for people with untreated follicular lymphoma. About 1,018 adults will take part. The goal is to see if the new combination can control the disease longer and with …

This early-phase study tests a new drug called AZD4360 in adults with advanced stomach, bile duct, or pancreatic cancers that have not responded to prior treatments. The main goals are to check safety, find the best dose, and see if the drug can shrink tumors. About 117 participa…

This study tests a drug called Dato-DXd in people with a common type of advanced breast cancer (HR-positive, HER2-negative) that has stopped responding to hormone therapy. The goal is to see if Dato-DXd can slow or stop the cancer from growing. About 100 participants will receive…

This study follows 1,400 adults with moderate to severe COPD who are starting the triple-combination inhaler Breztri/Trixeo. Researchers will track changes in symptoms and quality of life over 12 months in routine clinics across Latin America, Asia, and the Middle East & Africa. …

This study tests a drug called tozorakimab in about 2,870 adults hospitalized with a viral lung infection who need extra oxygen. The goal is to see if adding this drug to standard care can prevent death or the need for a breathing machine or life support. Participants will receiv…

This study tests a new drug called volrustomig combined with other cancer treatments in people with advanced non-small cell lung cancer. The main goals are to check safety and see if tumors shrink. About 180 adults with specific types of lung cancer will take part.

This study tests a new drug called AZD4512, alone or with other cancer medicines, in adults with relapsed or treatment-resistant B-cell non-Hodgkin lymphoma. The goal is to find safe doses and see if the drug can shrink tumors. About 91 participants will take part across multiple…

This study tests whether adding the experimental drug saruparib to standard hormone therapy can delay cancer growth in men with metastatic castration-sensitive prostate cancer. About 1,800 men will receive either saruparib or a placebo alongside their hormone treatment. The main …

This study monitors the safety and effectiveness of Ondexxya, a drug used to reverse the effects of certain blood thinners (apixaban, rivaroxaban, or edoxaban) during life-threatening or uncontrollable bleeding. Researchers will track side effects and how well the drug works in 3…

This study tests a drug called trastuzumab deruxtecan (T-DXd), alone or with other treatments, in people with advanced HER2-positive stomach cancer. About 450 adults with cancer that has spread will take part. The goal is to see if the drug shrinks tumors and is safe, but it is n…

This study tests a new medicine called anifrolumab, given as a shot under the skin, for adults with polymyositis or dermatomyositis—rare diseases that cause muscle weakness and inflammation. About 240 people will receive either the drug or a placebo, added to their usual treatmen…

This study tests an experimental drug called AZD4144 in adults with sepsis who develop acute kidney injury. About 124 participants will receive either the drug or a placebo daily while in the hospital. The main goal is to see if the drug helps improve kidney function compared to …

This study is testing a new drug called AZD0486, either alone or with other cancer drugs, in people with certain types of blood cancers like leukemia and lymphoma. The goal is to see if the drug is safe and works against the cancer. About 408 adults will take part in this early-p…

This study tests an experimental drug called AZD0292 in people aged 12 and older who have bronchiectasis and a long-term lung infection with Pseudomonas aeruginosa. The goal is to see if the drug can reduce the number of moderate-to-severe lung flare-ups compared to a placebo. Ab…

This study follows 40 children aged 6 to 14 with severe asthma that doesn't improve with standard treatments. They receive Fasenra injections to see how safe the drug is and how well it controls asthma symptoms. The goal is to manage the disease, not cure it.

This study tests whether a new combination drug (balcinrenone/dapagliflozin) works better than dapagliflozin alone to prevent heart failure events and heart-related death. About 4,800 adults with heart failure and moderate-to-severe kidney problems who recently had a heart failur…

This study tests a new drug called AZD0901, alone or with other cancer drugs, in people with advanced solid tumors that have a specific marker (CLDN18.2). The goal is to see if it is safe and shrinks tumors. About 224 adults with stomach, bile duct, or pancreatic cancer will take…

This study tests a new drug called AZD3470 in people with advanced solid tumors that lack a gene called MTAP. The drug is designed to block a protein these cancer cells need to grow. The trial will first find the safest dose, then see if it shrinks tumors or slows cancer growth, …

This study is tracking 150 women with advanced or recurrent endometrial cancer to see how well a treatment plan works in everyday medical practice. The plan starts with chemotherapy plus the drug durvalumab, followed by long-term maintenance with durvalumab alone or with another …

This study tests new combinations of drugs for people with advanced stomach cancer that cannot be removed by surgery or has spread. About 163 adults will receive these treatments to see if they can shrink tumors or slow the cancer's growth. The goal is to find better ways to cont…

This early-stage trial tests a new treatment called AZD0120, which uses a patient's own immune cells modified to target and calm overactive immune responses. It is for adults with systemic sclerosis, inflammatory myopathies, or difficult-to-treat rheumatoid arthritis. The main go…

This study tests a new drug called saruparib added to standard radiation and hormone therapy for men with high-risk prostate cancer that has a BRCA gene mutation. The goal is to see if it can delay the cancer from spreading to other parts of the body. About 700 men will participa…

This study tests new combinations of cancer drugs in people with advanced or metastatic non-small cell lung cancer. The goal is to find safer and more effective treatments. About 152 adults will take part, and the study is currently recruiting.

This study tests a drug called acalabrutinib combined with standard chemotherapy (R-CHOP) in people with untreated mantle cell lymphoma, a rare blood cancer. About 55 adults in Spain who cannot have a stem cell transplant will receive the combination for 6 cycles, then continue a…

This study tests whether a new drug called rilvegostomig, combined with chemotherapy, works better than the current standard treatment (pembrolizumab plus chemo) for people with advanced squamous non-small cell lung cancer that has spread. About 880 adults whose tumors show a spe…

This early-stage study tests a new medicine called surovatamig in 48 adults with rheumatoid arthritis or lupus. The main goal is to check if the drug is safe and tolerable, and how the body processes it. Participants receive increasing doses to find the best and safest level.

This phase 3 study tests whether adding baxdrostat to standard dapagliflozin treatment can better prevent kidney failure, heart failure, or heart-related death in 5,000 adults with chronic kidney disease and high blood pressure. Participants will receive either the combination or…

This study tests a new drug called AZD7798 in 30 adults with active Crohn's disease who have an ileostomy. The goal is to see if the drug is safe and helps heal the lining of the small intestine compared to a placebo. Participants will be randomly assigned to receive either the d…

This study tests a drug called osimertinib, which targets a specific genetic change in lung cancer cells. It is given before and after radiation therapy to people with stage III lung cancer who cannot have or refuse chemotherapy. The goal is to see if this approach helps control …

This study tests whether a triple-combination inhaler (budesonide, glycopyrronium, and formoterol) is better than a dual inhaler at preventing serious heart and lung events in people with COPD. About 5,000 adults aged 40–80 who smoke or used to smoke will take part. The goal is t…

This study is tracking 125 adults with lupus who are starting a new drug called anifrolumab. The goal is to see how well the drug controls disease activity and helps patients achieve remission over two years. Researchers are collecting data from regular doctor visits and patient …

This study tests two experimental drugs, AZD6234 and AZD9550, alone or together, in Chinese adults who are overweight or have obesity. The goal is to see if they are safe and help with weight loss. About 871 participants aged 18 to 55 with a BMI of 27 or higher will take part.

This study tests the drug durvalumab as a follow-up treatment for people with limited-stage small cell lung cancer whose cancer has not grown after initial chemotherapy and radiation. About 70 adults in Spain will receive durvalumab to see how safe it is and how well it controls …

This study tests a new drug called AZD8421, alone or with other cancer drugs, in people with advanced ER+ HER2- breast cancer or high-grade serous ovarian cancer. The main goals are to check safety and find the right dose. About 564 women aged 18 and older will take part.

This early-stage study tests the safety of a new drug called AZD1613 in 40 adults with autosomal dominant polycystic kidney disease (ADPKD), a condition where cysts grow in the kidneys. Participants receive either the drug or a placebo to see how the body handles it and if any si…

This study tests a new drug called volrustomig in 800 women with high-risk locally advanced cervical cancer who finished standard chemoradiation without the cancer getting worse. The goal is to see if volrustomig can delay the cancer from coming back or improve survival compared …

This study tests a new drug called volrustomig combined with standard chemotherapy for people with advanced pleural mesothelioma that cannot be removed by surgery. The goal is to see if this combination helps people live longer compared to current treatments. About 825 adults wil…

This study tests a new drug called AZD1163 in 320 people with moderate-to-severe rheumatoid arthritis who haven't responded well to other treatments. The goal is to see if the drug reduces joint swelling and pain over 12 weeks. Participants will receive either AZD1163 or a placeb…

This study tests an experimental drug called tezepelumab in 990 adults with moderate to very severe COPD. The goal is to see if it can reduce the number of serious flare-ups (exacerbations) compared to a placebo over 76 weeks. Participants must be 40-80 years old, have had at lea…

This study tests whether adding an experimental drug (Dato-DXd) to the standard pill osimertinib helps people with advanced EGFR-mutant lung cancer live longer without their cancer growing. About 582 adults with stage IIIB/IV non-small cell lung cancer will receive either osimert…

This study tests several new drug combinations given before and after surgery for people with early-stage non-small cell lung cancer. The goal is to see if these combinations are safe and help destroy more cancer cells. About 630 adults with stage II to IIIB lung cancer will take…

This study tests new immune-boosting drugs, alone or with other cancer treatments, in people with advanced liver or bile duct cancer. The goal is to see if these drugs can shrink tumors or slow the disease. About 294 adults whose cancer has spread or cannot be removed by surgery …

This study tests a medicine called benralizumab in children aged 6 to 17 with two rare diseases that cause too many eosinophils (a type of white blood cell). The goal is to see if the drug is safe and helps control the disease. About 14 children will take part, and the study is c…

This study looks at whether training doctors to quickly start and adjust four types of heart failure medications while patients are still in the hospital leads to better long-term treatment. About 438 adults with heart failure and reduced pumping ability will take part. The goal …

This study tests whether a new drug combination (datopotamab deruxtecan plus rilvegostomig) or rilvegostomig alone works better than the current standard treatment (pembrolizumab) for people with advanced non-squamous lung cancer that has high PD-L1 levels. About 675 adults with …

This study tests whether adding a drug called capivasertib to standard hormone therapy and CDK4/6 inhibitors can help people with a certain type of advanced breast cancer (HR+/HER2-). About 895 adults whose cancer has spread or cannot be removed will take part. The goal is to see…

This study tests a new drug called volrustomig in people with advanced head and neck cancer that hasn't spread. Participants have already completed standard chemoradiation and their cancer hasn't grown. The trial compares receiving volrustomig versus just being watched to see if …

This study tests a new drug called baxdrostat in about 250 adults with primary aldosteronism, a condition where the adrenal glands make too much of a hormone, causing high blood pressure. Participants take either baxdrostat or a placebo daily for up to a year. The goal is to see …

This early-phase study tests a targeted drug (trastuzumab deruxtecan) combined with immunotherapy, with or without chemotherapy, in people with advanced non-small cell lung cancer that has high levels of a protein called HER2. The main goal is to see if the combinations are safe …

This study tests whether a combination inhaler (budesonide/albuterol) works better than a standard albuterol inhaler for teens aged 12 to 18 with asthma. The goal is to see if it reduces the number of severe asthma attacks over one year. Participants must have had at least one se…

This early-stage study tests a new treatment called AZD0120 for adults with multiple myeloma, a type of blood cancer. The therapy uses a patient's own immune cells, modified to target two cancer markers (BCMA and CD19). The main goal is to check safety and find the right dose, wh…

This study tests a new drug called AZD9750, alone or with another drug (saruparib), in people whose prostate cancer has spread to other parts of the body and is no longer controlled by standard treatments. The goal is to find the safest dose and see if it can shrink tumors or low…

This study tests new drug combinations given before and after surgery for people with a type of stomach or esophagus cancer that can be removed. The goal is to see if these treatments are safe and help shrink or eliminate the tumor before surgery. About 100 adults who have not ha…

This study tests a new drug, datopotamab deruxtecan (Dato-DXd), alone or with durvalumab, against standard chemotherapy for people with a type of advanced breast cancer called PD-L1 positive triple-negative breast cancer that cannot be removed by surgery or has spread. About 625 …

This study looks at whether the drug benralizumab can help adults with severe eosinophilic asthma achieve clinical remission—meaning fewer symptoms, no need for steroid pills, and better quality of life. Researchers will follow 335 participants in Italy for up to 24 months to see…

This early-stage study is testing a new under-the-skin injection of the cancer drug durvalumab for adults with solid tumours. The goal is to find a dose that works as well as the standard IV version. About 40 participants will be enrolled to check safety and how the drug moves th…

This study compares two immunotherapy drugs (rilvegostomig and durvalumab) combined with standard chemotherapy as a first treatment for people with advanced biliary tract cancer that cannot be removed by surgery. About 1,100 participants worldwide will be randomly assigned to one…

This study tests whether adding dapagliflozin to baxdrostat better reduces protein in urine (a sign of kidney damage) than baxdrostat alone in 218 adults with chronic kidney disease and high blood pressure. Participants must already be on stable blood pressure medication. The goa…

This study looks at how well the drug T-DXd works for people with advanced HER2-positive solid tumors who have already tried other treatments and have no good options left. About 100 adults in the US will be followed to see if their tumors shrink or stop growing. The goal is to u…

This study looks at how well Airsupra works compared to albuterol for preventing serious asthma attacks in everyday life. Researchers will study about 4,000 people with asthma who use rescue inhalers. The goal is to see which medicine helps people have fewer severe asthma episode…

This study is testing an experimental drug called AZD9574, given alone or with other cancer treatments, in people with advanced solid tumors that have come back or gotten worse. The main goals are to check the drug's safety and find the right dose. About 695 participants will tak…

This study tests three different doses of an experimental tablet called AZD6793 against a placebo in 1160 adults with moderate to very severe COPD. The main goal is to see if the drug can reduce the number of moderate or severe COPD flare-ups over 24 weeks. Participants must be a…

This study tests a new drug, sonesitatug vedotin, combined with chemotherapy (capecitabine) and possibly another drug (rilvegostomig) for people with advanced stomach, gastroesophageal junction, or esophageal cancer that has a specific marker (CLDN18.2) and is HER2-negative. Abou…

This study tests a weekly injection of anifrolumab in 245 adults with lupus who have not used strong immune-suppressing drugs before. The goal is to see if this treatment can help patients achieve remission and safely reduce or stop steroid use over 52 weeks. Participants must ha…

This study compares a new drug, puxitatug samrotecan, to standard chemotherapy for people with advanced or metastatic endometrial cancer that has worsened after platinum-based chemo and immunotherapy. About 700 participants will be randomly assigned to receive either the new drug…

This early-phase study tests a new drug called AZD0486 in about 227 people with B-cell non-Hodgkin lymphoma, including types like diffuse large B-cell and follicular lymphoma. The drug is a special antibody that helps the immune system attack cancer cells. The main goals are to c…

This study tests an experimental drug called AZD5335, alone or with other cancer treatments, in people with advanced ovarian, lung, or endometrial cancer. The goal is to see if it is safe and can shrink tumors. About 506 participants will take part in this early-phase trial.

This study tests a new drug called AZD1390 given together with radiation therapy for people with glioblastoma (a fast-growing brain cancer) or brain tumors that have spread from other cancers. It is the first time this drug is used in humans, so the main goals are to find safe do…

This study tests whether adding benralizumab (an injectable drug) to standard medium-dose inhalers can better control eosinophilic asthma than switching to high-dose inhalers. About 400 people aged 12–75 with uncontrolled asthma will take part. The goal is to reduce asthma attack…

This study tests a drug called benralizumab in 200 children aged 6 to 17 with severe eosinophilic asthma that is not well controlled by current treatments. The goal is to see if the drug can reduce asthma attacks and improve daily symptoms. Participants will receive injections an…

This study tests a new inhaler (PT027) against a standard one (PT007) for Chinese adults with asthma. About 790 people who have had at least one severe asthma attack in the past year will use the inhaler as needed. The goal is to see if PT027 can delay or reduce severe asthma att…

This study tests a new drug called surovatamig in 240 adults with B-cell non-Hodgkin lymphoma that has come back or not responded to at least two prior treatments. The goal is to see if the drug can shrink or eliminate tumors. Participants receive the drug alone, and researchers …

This study tests a combination of two drugs, acalabrutinib and rituximab, in patients aged 80 and older or those 65-79 who are too frail for standard chemotherapy. The goal is to see if this treatment is safe and effective for controlling diffuse large B-cell lymphoma. About 80 p…

This study tests an experimental drug called AZD0486 in teenagers and adults with B-cell acute lymphoblastic leukemia (B-ALL) that has returned or not responded to at least two prior treatments. The goal is to see if the drug is safe and can shrink or eliminate cancer cells. Part…

This early-stage study tests whether a new drug called AZD5492 is safe and tolerable in 72 adults with lupus, myositis, or rheumatoid arthritis. Participants receive either one or two doses under the skin and are monitored for side effects and drug levels over 6 months. The goal …

This study tests whether adding an experimental drug (AZD0780) to a common statin (rosuvastatin) can lower 'bad' LDL cholesterol more than the statin alone. About 76 adults with high cholesterol and heart disease risk will take the combo or a placebo for 12 weeks. The goal is to …

This study tests a new drug, datopotamab deruxtecan (Dato-DXd), against a standard chemotherapy (docetaxel) in 400 people with advanced or metastatic non-squamous non-small cell lung cancer that has already been treated. The cancer must have a specific marker called TROP2 and no …

This study tests whether adding the immunotherapy drug durvalumab to standard chemotherapy before and after bladder removal surgery is safe and tolerable for people with muscle-invasive bladder cancer. About 150 participants will receive durvalumab alongside either of two chemoth…

This early-stage trial tests a new radioactive drug, [225Ac]-FPI-2068, in adults with advanced solid tumors that have not responded to standard treatments. The study aims to find a safe dose and see how the drug spreads in the body. About 70 people with cancers like lung, colon, …

This study is checking the safety of a drug called trastuzumab deruxtecan in 100 Indian adults with advanced HER2-positive breast cancer that cannot be removed by surgery or has spread. Participants have already tried another anti-HER2 treatment. The study will track side effects…

This study tests whether a shorter course of chemotherapy (2 cycles instead of 6) followed by a new targeted drug called AZD0486 works better and is safer than the standard 6-cycle chemo for elderly or frail patients newly diagnosed with large B-cell lymphoma. About 420 participa…

This study tests a new drug called Dato-DXd, given alone or with osimertinib, against standard chemotherapy in people with a specific type of advanced lung cancer (EGFR-mutated) that has worsened after osimertinib treatment. About 744 participants will be randomly assigned to one…

This study tests a new drug, AZD0305, alone or with other cancer drugs, in about 226 adults with multiple myeloma. The goal is to check safety, find the right dose, and see if it helps control the cancer. Participants must have confirmed multiple myeloma and be in good enough hea…

This study tests an experimental drug called AZD5863 in adults with advanced stomach, esophageal, or pancreatic cancers that have spread. The drug is designed to help the body's immune cells attack cancer cells. The main goals are to check safety and see if the drug can shrink tu…

This study tests a powder called sodium zirconium cyclosilicate (SZC) to lower high potassium levels in children under 18. About 140 kids will receive the medicine for up to 3 days to correct potassium levels, then continue for 28 days to keep levels normal. The goal is to see if…

This study tests a new drug called AZD0516, alone or with other cancer treatments, in people whose prostate cancer has spread to other parts of the body. The main goals are to check safety and find the best dose. About 177 adults with metastatic prostate cancer will take part. Th…

This study tests an investigational drug called anifrolumab in children aged 5 to 17 with moderate to severe systemic lupus erythematosus (SLE), an autoimmune disease. The goal is to see if the drug can help control lupus activity when added to standard treatments. About 100 part…

This early-phase study tests a new experimental drug called AZD9592, alone or with other cancer treatments, in people with advanced solid tumors (lung, head & neck, or colorectal cancers) that have not responded to standard therapy. The main goals are to check safety, find the ri…

This study tests an investigational drug called tezepelumab in children aged 5 to 11 with severe asthma that is not well controlled by their current medicines. The goal is to see if adding tezepelumab can reduce serious asthma attacks and improve lung function. About 231 children…

This study tests a new treatment called AZD0120 for adults with severe lupus that hasn't improved with standard therapies. AZD0120 uses a patient's own immune cells, modified to target and destroy faulty immune cells that drive lupus. The trial has two phases: first to find a saf…

This study looks at whether the drug durvalumab, given after standard chemoradiation, can help people with limited-stage small-cell lung cancer live longer without their cancer getting worse. About 200 adults in China will take part. The goal is to see how well the drug works in …

This study tests a new medicine called tozorakimab for adults whose asthma is not well controlled even with medium-to-high dose inhaled steroids. About 540 participants will receive either the drug or a placebo as a shot under the skin. The main goal is to see if tozorakimab can …

This study tests a new drug called AZD8205, alone or with other cancer drugs, for people with advanced solid tumors like breast, ovarian, or lung cancer that have stopped responding to standard treatments. The main goals are to check safety and find the right dose. About 460 adul…

This study tests whether a combination of two drugs (zibotentan and dapagliflozin) works better than dapagliflozin alone in adults with chronic kidney disease and high levels of protein in their urine. About 224 participants will take either the combo pill or the single drug for …

This early-stage study tests a new medicine called AZD4063 in 31 adults with a specific genetic heart condition (PLN R14del dilated cardiomyopathy). The main goal is to check if the drug is safe and how the body processes it. Participants must have a reduced heart pumping functio…

This study is testing a new drug called Dato-DXd, either alone or with other cancer drugs, in people with advanced solid tumors that have spread. The goal is to see if the drug can shrink tumors or slow cancer growth. About 454 adults with cancers like endometrial, gastric, prost…

This study tests a new drug called volrustomig, either alone or with chemotherapy, in people with advanced or spreading solid tumors (cervical, head and neck, esophageal, or mesothelioma). The goal is to see if the drug can shrink tumors and control the disease. About 257 adults …

This early-stage study tests a new drug called AZD2284 (and related compounds) in people with metastatic castration-resistant prostate cancer that has spread and stopped responding to hormone therapy. The main goal is to check safety and find the right dose. About 136 participant…

This study tests whether adding a second immunotherapy drug (domvanalimab) to the standard drug durvalumab can better control stage III lung cancer that hasn't grown after chemoradiation. About 860 adults with a specific type of lung cancer will receive either the combo or durval…

This study tests a new treatment called AZD0120, which uses a patient's own immune cells engineered to attack myeloma cells. It is for people with relapsed refractory multiple myeloma, meaning their cancer has returned or not responded to prior treatments. About 508 participants …

This study tests whether a new drug called AZD5335 works better than current treatments for women with a hard-to-treat type of ovarian cancer. About 1,100 women whose cancer has stopped responding to platinum chemotherapy will be randomly assigned to get AZD5335 or standard thera…

This early-stage study tests a new injection form of the cancer drug rilvegostomig in about 40 adults with advanced solid tumors that have already been treated. The goal is to find a dose that works as well as the current IV version and to check for side effects. Participants mus…

This early-stage trial tests a new treatment called AZD0120 for adults with hard-to-treat multiple sclerosis (MS). The therapy uses a patient's own immune cells, modified to target and potentially calm the immune attack on the brain and spinal cord. The main goal is to check if t…

This study tests a triple-combination inhaler (BGF MDI) in 56 adults with COPD and hyperinflation (trapped air in the lungs). The goal is to see if the inhaler improves both lung function and heart function compared to a placebo. Participants will use the inhaler or placebo for a…

This study compares a new drug, rilvegostomig, against the standard immunotherapy pembrolizumab, both given with chemotherapy, as a first treatment for people with advanced non-squamous non-small cell lung cancer that has spread and has a protein called PD-L1. About 878 participa…

This phase 3 study tests whether a new drug combination (saruparib plus camizestrant) works better than current standard treatments for advanced breast cancer that is hormone receptor positive and HER2-negative. The study is for people with BRCA1, BRCA2, or PALB2 gene mutations. …

This study compares a targeted drug called acalabrutinib to other standard treatments for adults with chronic lymphocytic leukemia (CLL) who also have moderate to severe heart failure. The main goal is to see if acalabrutinib causes fewer heart-related side effects. About 60 part…

This study tests a new oral drug called AZD3470 in people with certain blood cancers, including Hodgkin and non-Hodgkin lymphoma. The goal is to see if the drug is safe and works, either alone or with other cancer treatments. About 161 adults and adolescents will take part in thi…

This study tests new drug combinations in people with metastatic colorectal cancer that has spread. The goal is to see if these treatments can shrink tumors or slow cancer growth. About 120 adults with measurable disease and good performance status will participate. The trial foc…

This study looks at how well tezepelumab works for adults with chronic sinusitis and nasal polyps (with or without asthma). About 110 people will be followed for up to a year to see if their nasal polyps shrink and congestion improves. The drug is already approved, and this resea…

This study tests an experimental drug called AZD6621 for men with metastatic prostate cancer that has spread. The drug is designed to help the immune system attack cancer cells. The trial has two parts: first, finding the safest dose, then testing that dose in more people to see …

This study tests whether adding baxdrostat to the standard drug dapagliflozin can lower the risk of heart failure or heart-related death in people with type 2 diabetes, heart disease, and high blood pressure. About 11,300 adults aged 40 and older will take either the combo or a p…

This study tests a new drug called AZD2962, which blocks a protein (IRAK4) involved in cancer growth. It is for people with certain blood cancers (MDS or CMML) that have not responded to standard treatments. The main goals are to check safety, find the right dose, and see if the …

This study tests a new treatment called AZD0754, which uses a patient's own immune cells (CAR T-cells) to fight metastatic prostate cancer. About 60 adults with castration-resistant prostate cancer will receive this therapy to see if it is safe and can shrink tumors or lower PSA …

This study tests several new drug combinations in people with advanced non-small cell lung cancer that has spread. About 278 adults will receive different treatment mixes to see if they shrink tumors and are safe. The goal is to find better ways to control the disease and improve…

This study compares a new drug, rilvegostomig, to the current standard treatment, pembrolizumab, for people with advanced non-small cell lung cancer that has high levels of PD-L1. The goal is to see if the new drug works better at helping people live longer or stopping the cancer…

This study monitors the safety and effectiveness of two drugs, Imjudo and Imfinzi, in 246 liver cancer patients in Korea. It observes patients already receiving these drugs as part of their normal care, without adding new treatments. The goal is to see how well the drugs work and…

This study looks at how safe and effective durvalumab (with or without olaparib) is for people with endometrial cancer in everyday medical practice in Korea. About 50 patients will be followed for up to a year. The goal is to see how well the treatment works outside of a strict r…

This study tests an experimental drug called AZD2373 in 96 adults with a genetic form of kidney disease linked to the APOL1 gene. The goal is to see if the drug can lower protein levels in urine, a sign of kidney damage, compared to a placebo. Participants will take the drug or p…

This study tests a new daily pill, camizestrant, against standard hormone therapies to see if it better prevents breast cancer from returning in people with ER+/HER2- early breast cancer who have already completed initial treatments. About 4,300 participants at intermediate or hi…

This study tests a new drug called AZD4512 in people with a hard-to-treat blood cancer called B-cell acute lymphoblastic leukemia (B-ALL) that has come back or not responded to other treatments. The goal is to see if the drug is safe and how well it works, either alone or with ot…

This study tests a new drug called AZD7760 to see if it is safe and how it works in the body. First, healthy volunteers will receive a single dose. Then, people with end-stage kidney disease who get dialysis through a central line will receive one or two doses. The goal is to pre…

This study looks at whether an AI tool that collects family cancer history through WhatsApp can accurately predict a woman's genetic risk for breast cancer. Researchers will compare the AI's results with standard genetic tests in 800 women already identified as high-risk. If succ…

This early-stage study tests a new imaging drug called [111In]-FPI-2107 in 12 Chinese adults with a specific type of lung cancer (EGFR mutation-positive NSCLC). The goal is to see if it is safe and how it spreads in the body to help detect tumors. Participants receive the drug an…

This study is testing a lung cancer screening program for current and former smokers aged 45 to 74. It uses low-dose CT scans and metabolomics to find suspicious lung nodules early. The goal is to see how well the program works in a public health setting and to help smokers quit.…

This study looks at whether two easy breathing tests—oscillometry and FeNO—can help family doctors accurately diagnose asthma and COPD without needing complex spirometry. About 600 adults with symptoms like wheezing or shortness of breath will take these tests at their primary ca…

This study tests an experimental drug called AZD5148 to see if it can prevent Clostridioides difficile (C. diff) infections from returning in adults aged 18 and older. About 230 participants will receive either the drug or a placebo. The goal is to reduce the number of repeat inf…

This study is checking how safe palivizumab is for preventing severe RSV in infants and young children who are at high risk. About 138 children under 24 months old will receive a monthly injection for up to 5 months. The goal is to track any side effects and ensure the medicine i…

This study pools data from multiple countries to see how a triple-combination inhaler (BGF) affects COPD symptoms and quality of life in routine care. About 2,000 adults with moderate-to-severe COPD who are starting BGF will be followed for up to a year. The main goal is to measu…

This early-stage study tests an experimental drug called AZD1043 in healthy adults who are overweight or have obesity. The main goal is to check if the drug is safe and how the body processes it. About 104 participants, including people of Japanese and Chinese descent, will recei…

This study tests a drug called tezepelumab in 180 adults with chronic sinusitis and nasal polyps who are eligible for surgery. The goal is to see if the drug can reduce nasal congestion and other sinus symptoms over 24 weeks. Participants receive the drug every 4 weeks and report…

This study follows 300 men with metastatic castration-resistant prostate cancer who are taking olaparib as part of their normal treatment. Researchers want to see how long patients stay on the drug, how well it controls the cancer, and what side effects occur. The goal is to lear…

This study looks at how two experimental drugs, laroprovstat and AZD4954, affect each other in the body. It involves 32 healthy adults who will take both drugs and have their blood levels measured. The goal is to understand drug interactions, not to treat any disease.

This study will collect information from medical records of 2000 people with locally advanced lung cancer (non-small cell and small cell) who are receiving chemoradiotherapy in 50 cancer centers across Russia. The goal is to understand real-world treatment approaches and short-te…

This early-stage study tests a single dose of an experimental drug (AZD2389) in 12 adults with advanced liver scarring (cirrhosis). The main goal is to see how well the drug attaches to its target in the liver using a special PET scan. This is not a treatment study; it is designe…

This study watches over 16,000 teens and adults with severe asthma to see if the drug tezepelumab increases the risk of serious heart problems like heart attack or stroke. It compares those taking tezepelumab to those on standard treatment. The goal is to better understand the dr…

This study tests different versions of a drug called AZD6234 in 21 healthy adults aged 18-55 who are overweight or obese. The goal is to see how well each version is absorbed by the body and check for side effects. Participants receive a single dose of each formulation in a rando…

This study follows 693 adults in Brazil with severe or very severe COPD to track how often they are hospitalized, have flare-ups, or die. Researchers want to understand the real-world impact of the disease because there is no national data on this group. Participants will be obse…

This study will check 3,000 adults with heart disease (coronary artery disease, atrial fibrillation, or heart failure) to see how many also have COPD. It will then test whether managing both heart and lung conditions together can lower hospital readmission rates. The goal is to i…

This study is a registry that will follow 3,000 Chinese adults with chronic kidney disease (CKD) to see how they are treated in real life and what happens to their health over time. It does not test a new drug or treatment, but simply collects information to better understand the…

This study watches 250 men with metastatic castration-resistant prostate cancer who are already taking olaparib plus abiraterone as part of their normal care. Researchers will track how long patients stay on the treatment and what treatments they need next. The goal is to underst…

This early-stage study tests the safety and how the body handles a new drug, AZD1613, in healthy adults, including those of Japanese and Chinese descent. About 136 participants will receive either the drug or a placebo. The goal is to gather information on side effects and drug l…

This study looks at how the liver affects two experimental drugs, AZD9550 and AZD6234. Researchers will give a single dose to 28 adults with different levels of liver function (normal, moderate, or severe impairment) to see how the drugs move through the body and if they are safe…

This study looks at how ovarian cancer is currently treated in Brazil. Researchers will collect information from 250 patients to find what works well and what could be improved. The goal is to help set new quality standards for ovarian cancer care across the country.

This early-stage study tests a new drug called AZD4248 in healthy volunteers and people with chronic kidney disease and type 2 diabetes. The main goal is to check if the drug is safe and how the body processes it. The study also looks at whether people can reliably measure their …

This study is not testing a new treatment. Instead, it will observe 400 men in Russia with a specific type of advanced prostate cancer to see what treatments they actually receive in routine care. Researchers will also look at tumor samples to study biomarkers. The goal is to und…

This study is not testing a new treatment. Instead, researchers will observe 400 men in Russia with aggressive, high-volume metastatic hormone-sensitive prostate cancer. They will track which treatments doctors choose and analyze blood samples for genetic mutations. The goal is t…

This study reviews medical records from 150 Chinese adults with advanced papillary kidney cancer who were treated with sunitinib or sorafenib as their first therapy. Researchers want to see how long the drugs keep the cancer from growing in everyday practice. The study does not t…

This study looks back at medical records of 3,000 people in China with early-stage non-small cell lung cancer (stages I to III). Researchers want to see what treatments patients received and how they did over time. The goal is to learn about current care patterns to help improve …

This study observes how hospitals currently process and diagnose tissue samples from people with suspected lung or breast cancer. Researchers will also test artificial intelligence (AI) programs to see if they can help pathologists read slides faster and more accurately. About 60…

This study looks at how the antifungal drug itraconazole changes the way the body processes a cancer drug called AZ14170132, which is part of a targeted therapy for ovarian, peritoneal, and fallopian tube cancers. About 24 people with these cancers will take both drugs in a fixed…

This study is not testing a new treatment. Instead, it will collect information from 9,000 adults with uncontrolled asthma across 70 clinics in Russia. Researchers want to learn about patients' backgrounds, symptoms, and current treatments to better understand the disease in real…

This study is observing 600 adults with bladder cancer in Russia to see what treatments they receive and how common certain markers (HER2 and PD-L1) are. It does not test a new drug but collects information to understand current care patterns. The goal is to improve future treatm…

This study looks at how a new medicine called elecoglipron changes the way the body processes two common cholesterol drugs (atorvastatin and rosuvastatin) in 40 healthy adults. Participants will take the statins alone and then with elecoglipron to compare drug levels and safety. …

This study is observing over 52,000 people with ATTR amyloidosis to learn about their disease from diagnosis through treatment. Researchers will collect information from medical records to see how the disease progresses, what treatments are used, and how it affects quality of lif…

This study looks at how a drug called capivasertib changes the way the body processes another drug, dextromethorphan. About 42 healthy adults will take both drugs in a fixed order. The goal is to measure drug levels in the blood, not to treat any disease.

This study watches about 3,200 adults with moderate-to-severe lupus to see if those taking the drug anifrolumab have more serious infections or cancers than those on standard treatments. Researchers will look at medical records over time, but no new treatments or tests are given.…

This study follows about 442 pregnant women with moderate-to-severe lupus to see if taking the drug anifrolumab during pregnancy affects the health of mothers or their babies. Some women took the drug while pregnant, and others did not. The goal is to gather safety information, n…

This study is checking if people with type 2 diabetes who take the drug exenatide have a higher chance of getting pancreatic cancer compared to those taking other diabetes medicines. Researchers will look at health records from over 24,000 adults in seven European countries. The …

This study looks at 500 women with advanced or aggressive endometrial cancer in Russia. Researchers will test tumor samples for specific genetic changes to learn more about the disease and how it is treated. The goal is to gather information, not to test a new treatment.

This study is observing about 4,490 adults with liver or bile duct cancers who are receiving durvalumab-based treatments as part of their routine care. Researchers are collecting data on survival, treatment duration, and side effects to understand how well these drugs work in rea…

This study follows 300 people with non-small cell lung cancer who are already taking approved AstraZeneca drugs. Researchers will track how long the drugs keep the cancer from growing or coming back. No new treatments are given—this is just observation to see how the drugs perfor…

This study looks at a chronic lung condition called non-cystic fibrosis bronchiectasis, where airways are damaged and cause coughing and infections. Researchers will study 320 patients and healthy volunteers in China to find biological markers and disease patterns. The goal is to…

This study observes 200 adults with advanced non-small cell lung cancer starting their first treatment in Brazil between 2025 and 2026. Researchers will review medical records and survey doctors to understand which therapies are chosen and if they follow national guidelines. The …

This study is observing 600 adults in Germany with a type of advanced lung cancer that has spread and has certain genetic changes. Participants are already receiving a combination of three drugs (tremelimumab, durvalumab, and platinum chemo) as their first treatment. The goal is …

This study will follow about 1,850 people with ATTR amyloidosis, a rare disease that affects the heart and nerves. Researchers will collect information on symptoms, treatments, and outcomes over time to better understand the disease and how current treatments work in everyday pra…

This study tracks the safety and effectiveness of the drug capivasertib in 130 breast cancer patients in South Korea. It is a post-marketing surveillance study, meaning the drug is already approved and this research monitors how it performs in everyday medical practice. The goal …

This study is gathering information about 200 adults in Russia who have neurofibromatosis type 1 (NF1) with plexiform neurofibromas. Researchers will collect data on patients' age, symptoms, medical history, and other health conditions. The goal is to better understand the diseas…

This study looks at whether two experimental drugs (AZD6234 and AZD9550) change how the body processes a common birth control pill. About 50 healthy overweight women will take the birth control pill alone and then again after receiving the study drugs. The goal is to see if the d…

This study will review health records of up to 60,000 people with lung cancer in Alberta and Ontario to understand how the disease is treated, what it costs, and what outcomes patients experience. It aims to describe current treatment patterns, survival rates, and healthcare use.…

This study uses a survey to understand what factors influence treatment choices for Chinese patients with advanced non-small cell lung cancer and their doctors. About 590 participants (patients and physicians) will share their preferences for different aspects of first-line EGFR-…

This study looks back at medical records of 250 adults in Brazil with advanced non-squamous non-small cell lung cancer. Researchers want to see what treatments patients receive after platinum-based chemotherapy stops working. The goal is to describe real-world patient characteris…

This study is a disease registry that collects information from medical records of 200 people in Egypt diagnosed with neurofibromatosis type 1 (NF1), a genetic condition that causes tumors on nerves. Researchers aim to understand how common NF1 is, how it progresses, and how it i…

This study looks at how the drug osimertinib is used in everyday practice for people with a specific type of lung cancer (EGFR-mutated NSCLC) in Spain. Researchers will track about 500 patients to see how long they live, how well the drug controls the cancer, and their quality of…

This study looks at how the drug opemalirsen behaves in people with different levels of kidney function. About 50 adults aged 18 to 80 will receive a single dose, and researchers will measure drug levels in the blood. The goal is to understand safety and dosing, not to treat any …

This study looks at how often a protein called HER2 is found at high levels in gynecological cancers (like endometrial, ovarian, and cervical cancer). Researchers will test tumor samples from 350 adults in Brazil using special lab methods. The goal is to learn which patients migh…

This study looks at health records from over 14,000 people with chronic kidney disease in Spain to see how the drug dapagliflozin is used and how well it works in real life. Researchers will track changes in kidney function, hospital visits, and costs over about three years. No n…

This early-stage study tests the safety and tolerability of a new drug called AZD4954 in healthy volunteers and people with high Lp(a) or dyslipidemia (abnormal cholesterol levels). About 136 participants will receive either the drug or a placebo to see how the body processes it …

This study watches for health problems in pregnant or breastfeeding women who have taken eplontersen for transthyretin amyloidosis, and in their babies up to one year old. It does not give any treatment—it only collects information from real-world cases. The goal is to better und…

This study looks at how much of the lupus drug anifrolumab passes into breast milk and into the baby's blood. Researchers will collect milk and blood samples from 16 breastfeeding mothers with lupus who are already taking anifrolumab. The goal is to better understand the safety o…

This study follows 126 people with early HER2-negative breast cancer who are taking the drug olaparib after surgery. Researchers want to see how many patients complete the full 12-month treatment course in everyday medical practice. The study does not test a new drug or treatment…

This study will collect information from about 500 adults in Moscow who have moderate to very severe COPD and have had frequent flare-ups. Researchers will look at their medical records and ask them questions to understand their age, lifestyle, treatments, and other health proble…

This study measures how chronic lymphocytic leukemia (CLL) patients feel and function while taking acalabrutinib in everyday life, not just in a controlled trial. Researchers will look at quality-of-life scores from treatment start up to 12 months later, using data from 120 Frenc…

This study is not testing a new treatment—it simply observes patients with chronic lymphocytic leukemia (CLL) who already received acalabrutinib through a UK early access program. Researchers will review medical records to see how long patients went without their cancer worsening…

This study aims to find out how many smokers visiting heart clinics have undiagnosed chronic lung disease (COPD). Researchers will test lung function in 1,000 adults aged 40 and older who have smoked for at least 10 pack-years. The goal is to better understand the link between he…

This study looks at how certain gene mutations (ESR1 and others) appear in the blood of people with metastatic breast cancer. Researchers will compare patients who have had prior treatments with those who haven't. The goal is to understand how these mutations develop, which may h…

This early-stage study tests the safety of a new drug, AZD3974, in 176 healthy adults, including people of Japanese and Chinese descent. Participants receive either the drug or a placebo, and researchers monitor for side effects and measure drug levels in the blood. The goal is t…

This study watches 50 adults with chronic lymphocytic leukemia (CLL) who are starting acalabrutinib alone (no other cancer drugs) to see how long they stay on treatment and why they might stop. It aims to fill a knowledge gap by collecting real-world data on effectiveness and saf…

This early-stage study in 64 healthy adults aims to see how different pill versions of AZD5004 are absorbed by the body and whether eating changes that. Participants receive a single dose of each formulation on separate days. The goal is to gather safety and absorption data, not …

This study looks at people with high blood pressure in Kazakhstan to find out how many also have early signs of chronic kidney disease (CKD). Researchers will track about 1,282 adults over time, checking urine and blood tests. The goal is to understand how often CKD goes undiagno…

This study follows 800 adults with advanced HER2-positive, low, or ultralow breast cancer who are receiving the drug trastuzumab deruxtecan as part of their normal care. Researchers will track how long patients stay on the drug before switching treatments and how their quality of…

This early-phase study looks at how the drug saruparib is absorbed, distributed, broken down, and removed from the body in 8 people with advanced solid tumors. Participants receive a single oral dose and a single intravenous dose with a radioactive tracer to track the drug. The g…

This study aims to observe the natural course of hypophosphatasia (HPP) in 55 children and adults in Russia who have not received enzyme-replacement therapy. Researchers will track symptoms, lab results, and quality of life to better understand how the disease unfolds over time. …

This study looks at tumor samples from 2,100 Chinese patients with lung, gynecological, bile duct, or bladder cancers. Researchers will compare several HER2 testing methods to see if they give the same results. The goal is to improve accuracy and consistency in diagnosing HER2-po…

This study is observing 355 adults with asthma in China to learn about their symptoms, treatments, and biological markers. The goal is to identify different types of asthma to help develop more personalized treatment strategies in the future. Participants will undergo lung functi…

This study is a large registry that collects information from 35,000 adults with type 2 diabetes, high blood pressure, heart failure, and/or chronic kidney disease. Researchers will observe how these conditions are managed in everyday medical practice, including treatments, hospi…

This study looks at how doctors in Russia currently treat a rare muscle-weakening disease called generalized myasthenia gravis (gMG). Researchers will collect medical records and follow about 450 adults with the AChR-antibody form of the disease to see which treatments are used a…

This study is for healthy adults to see how well andexanet reverses the effects of common blood thinners (rivaroxaban or apixaban) and how it interacts with another blood thinner, enoxaparin. Participants will receive andexanet or a placebo, and researchers will measure blood clo…

This study observes 200 Chinese patients with chronic sinusitis and nasal polyps after surgery to understand their symptoms, quality of life, and disease control over one year. Researchers will track how patients feel and whether their condition returns. The goal is to gather rea…

This study looks back at medical records of 200 people diagnosed with atypical hemolytic uremic syndrome (aHUS) in Egyptian hospitals between 2010 and 2023. aHUS is a rare, life-threatening disease that damages kidneys and other organs. The goal is to describe patient characteris…

This study is observing 750 women with advanced ovarian cancer in Germany to gather real-world information about their treatment journey, including chemotherapy and maintenance therapy. Researchers want to understand how BRCA testing affects treatment choices and what patients ex…

This study looks at how two different inhalers deliver asthma medicine into the bodies of children aged 4 to 12. The goal is to compare the amount of drug absorbed and check for safety. About 12 children with stable asthma will take part. The results will help doctors understand …

This study looks at how a single dose of capivasertib is processed by the body in people with moderate liver impairment compared to those with normal liver function. About 20 participants will take part. The goal is to understand safety and drug levels, not to treat a disease.

This study tracks 240 pregnant women with lupus who have taken the drug anifrolumab during pregnancy or shortly before conception. Researchers will monitor for birth defects and other pregnancy complications to better understand the drug's safety. The goal is to gather informatio…

This study is observing 850 people with COPD in China to understand how the disease progresses and what factors affect it. Researchers will collect medical history, lung function tests, and blood samples over 1 to 3 years. The goal is to identify different types of COPD and find …

This study looks at medical records from over 6,000 Brazilian adults with heart or kidney problems to understand how common high potassium levels are and what factors increase the risk. The goal is to learn more about patient profiles and current treatments to help doctors better…

This study will look at health records from 15,000 adults with high blood pressure in Brazil's public health system. The goal is to understand how doctors treat the condition and whether they adjust medications when blood pressure stays high. No new treatments are being tested; i…

This study aims to find out how many children and teens in Russia have a rare genetic condition called lysosomal acid lipase deficiency (LAL-D). Researchers will check kids with certain warning signs, like an enlarged liver or abnormal cholesterol levels, to see if they have the …

This study will look at 5,000 adults in Russia who have severe asthma that is not well controlled. Researchers will collect information on the medicines patients are already taking and their health details. The goal is to better understand current treatment patterns and patient c…

This study is observing 200 people in South Korea who are already prescribed Koselugo for neurofibromatosis type 1 (NF1) with plexiform neurofibromas. Researchers will track side effects and how well the drug works in everyday medical practice. The goal is to confirm the drug's s…