New hope for lymphoma patients: drug duo may replace harsh chemo

NCT ID NCT06549595

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 23, 2026 · Updated 30 times

Summary

This study tests whether a new drug (AZD0486) plus rituximab works better than standard chemotherapy plus rituximab for people with untreated follicular lymphoma. About 1,018 adults will take part. The goal is to see if the new combination can control the disease longer and with fewer side effects.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

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Darlinghurst, 2010, Australia
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Garran, 2605, Australia
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Heidelberg, 3084, Australia
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Macquarie University, 2109, Australia
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Nedlands, 6009, Australia
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Brussels, 1070, Belgium
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Brussels, 1090, Belgium
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Ghent, 9000, Belgium
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Mechelen, 2800, Belgium
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Porto Alegre, 90035-003, Brazil
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São Paulo, 04501-000, Brazil
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São Paulo, 05652-900, Brazil
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Winnipeg, Manitoba, R3E 0V9, Canada
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Halifax, Nova Scotia, B3H 2Y9, Canada
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Barrie, Ontario, L4M 6M2, Canada
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Hamilton, Ontario, L8V 5C2, Canada
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Oshawa, Ontario, L1G 2B9, Canada
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Toronto, Ontario, M5G 1X6, Canada
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Chicoutimi, Quebec, G7H 5H6, Canada
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Montreal, Quebec, H4J 1C5, Canada
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Québec, Quebec, G1J 1Z4, Canada
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Saint-Jérôme, Quebec, J7Z 2V4, Canada
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Beijing, 100044, China
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Beijing, 100142, China
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Beijing, 100730, China
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Changchun, 130021, China
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Changsha, 410013, China
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Chengdu, 610078, China
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Chongqing, 400030, China
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Fuzhou, 350001, China
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Guangzhou, 510000, China
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Guangzhou, 510060, China
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Guangzhou, 510100, China
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Hangzhou, 310003, China
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Hangzhou, 310022, China
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Harbin, 150081, China
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Hefei, 230031, China
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Lanzhou, 730000, China
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Nanchang, 330006, China
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Nanchang, 330029, China
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Nanjing, 210029, China
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Nanning, 530021, China
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Shandong, 250117, China
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Shanghai, 200065, China
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Shanghai, 20032, China
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Shenyang, 110001, China
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Shenyang, 110004, China
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Shijiazhuang, 054001, China
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Suzhou, 215006, China
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Tianjin, 300020, China
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Wenzhou, 325000, China
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Wuhan, 430079, China
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Xi'an, 710061, China
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Xiamen, 361003, China
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Zhengzhou, 450000, China
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Zhengzhou, 450008, China
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Brno, 625 00, Czechia
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Hradec Králové, 500 05, Czechia
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Prague, 12808, Czechia
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Aalborg, 9100, Denmark
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Copenhagen, 2100, Denmark
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Odense C, 5000, Denmark
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Roskilde, 4000, Denmark
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Helsinki, 00029, Finland
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Kuopio, 70029, Finland
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Tampere, 33520, Finland
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Hong Kong, 999077, Hong Kong
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Shatin, 00000, Hong Kong
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Budapest, 1088, Hungary
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Budapest, 1122, Hungary
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Debrecen, 4032, Hungary
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Győr, 9024, Hungary
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Kaposvár, 7400, Hungary
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Nyíregyháza, 4400, Hungary
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Pécs, 7624, Hungary
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Szeged, 6725, Hungary
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Delhi, 110029, India
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Delhi, 110085, India
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Fort Wayne, Indiana, 46804, United States
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Des Moines, Iowa, 50309, United States
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Iowa City, Iowa, 52242, United States
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Lexington, Kentucky, 40536, United States
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Louisville, Kentucky, 40207, United States
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Baton Rouge, Louisiana, 70808, United States
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Baltimore, Maryland, 21201, United States
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Bethesda, Maryland, 20817, United States
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Columbia, Maryland, 21044, United States
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Boston, Massachusetts, 02114, United States
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Boston, Massachusetts, 02215, United States
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Ann Arbor, Michigan, 48109, United States
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Detroit, Michigan, 48201, United States
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Ypsilanti, Michigan, 48197, United States
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Saint Paul, Minnesota, 55102, United States
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Springfield, Missouri, 65807, United States
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Hackensack, New Jersey, 07601, United States
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New Brunswick, New Jersey, 08901, United States
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New Hyde Park, New York, 11042, United States
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New York, New York, 10016, United States
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New York, New York, 10032, United States
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New York, New York, 10065, United States
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Charlotte, North Carolina, 28204, United States
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Winston-Salem, North Carolina, 27103, United States
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Blue Ash, Ohio, 45242, United States
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Columbus, Ohio, 43210, United States
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Eugene, Oregon, 97401, United States
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Pittsburgh, Pennsylvania, 15232, United States
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Nashville, Tennessee, 37203, United States
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Shenandoah, Texas, 77380, United States
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Tyler, Texas, 75702, United States
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Salt Lake City, Utah, 84112, United States
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Fairfax, Virginia, 22031, United States
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Richmond, Virginia, 23219, United States
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Tacoma, Washington, 98405, United States
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Madison, Wisconsin, 53792, United States
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Gurugram, 122002, India
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Kolkata, 700160, India
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Nashik, 422002, India
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Surat, 396007, India
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Thiruvananthapuram, 695011, India
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Bunkyō City, 113-8677, Japan
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Chiba, 260-8717, Japan
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Chuo-shi, 409-3898, Japan
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Fukuoka, 812-8582, Japan
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Hirakata-shi, 573-1191, Japan
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Kobe, 650-0047, Japan
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Kōtoku, 135-8550, Japan
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Kumamoto, 860-8556, Japan
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Kurashiki-shi, 710-8602, Japan
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Kyoto, 602-8566, Japan
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Minatoku, 105-8470, Japan
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Okayama, 700-8558, Japan
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Osaka, 541-8567, Japan
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Sapporo, 003-0006, Japan
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Sapporo, 060-8638, Japan
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Sunto-gun, 411-8777, Japan
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Toyoake-shi, 470-1192, Japan
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Yamagata, 990-9585, Japan
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Yokohama, 241-8515, Japan
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Gliwice, 44-102, Poland
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San Juan, 00918, Puerto Rico
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Busan, 49201, South Korea
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Busan, 49241, South Korea
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Goyang-si, 10408, South Korea
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Jeonnam, 519-763, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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Seoul, 06351, South Korea
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Seoul, 06591, South Korea
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Barcelona, 08035, Spain
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Barcelona, 8036, Spain
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El Palmar, 30120, Spain
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Girona, 17007, Spain
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Las Palmas de Gran Canaria, 35020, Spain
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Madrid, 28040, Spain
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Madrid, 28041, Spain
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Oviedo, 33011, Spain
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Pamplona, 31008, Spain
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Santander, 39008, Spain
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Falun, 79182, Sweden
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Uppsala, 75185, Sweden
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Changhua, 50006, Taiwan
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Kaohsiung City, 80756, Taiwan
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Kaohsiung City, 833, Taiwan
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Lukang Township, 505029, Taiwan
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Tainan, 704, Taiwan
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Taipei, 106, Taiwan
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Bangkok, 10330, Thailand
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Bangkok, 10700, Thailand
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Chiang Mai, 50200, Thailand
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Khon Kaen, 40002, Thailand
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London, EC1M6BQ, United Kingdom
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London, SE5 9RS, United Kingdom
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Newcastle upon Tyne, NE7 7DN, United Kingdom
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Norwich, NR4 7UY, United Kingdom
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Nottingham, NG5 1PB, United Kingdom
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Plymouth, PL6 8DH, United Kingdom
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Southampton, SO16 6YD, United Kingdom
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Huntsville, Alabama, 35805, United States
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Anchorage, Alaska, 99508, United States
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Phoenix, Arizona, 85054, United States
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Clovis, California, 93611, United States
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Los Alamitos, California, 90720, United States
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San Diego, California, 92121, United States
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Santa Monica, California, 90404, United States
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Aurora, Colorado, 80045, United States
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New Haven, Connecticut, 06510, United States
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Newark, Delaware, 19713, United States
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Jacksonville, Florida, 32224, United States
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Atlanta, Georgia, 30322, United States
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Macon, Georgia, 31201, United States
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Evanston, Illinois, 60201, United States
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Peoria, Illinois, 61615, United States

Conditions

Explore the condition pages connected to this study.

UNTREATED FOLLICULAR LYMPHOMA