New combo therapy targets hard-to-treat lung cancer in early trial

NCT ID NCT04686305

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 25, 2026 · Updated 32 times

Summary

This early-phase study tests a targeted drug (trastuzumab deruxtecan) combined with immunotherapy, with or without chemotherapy, in people with advanced non-small cell lung cancer that has high levels of a protein called HER2. The main goal is to see if the combinations are safe and tolerable. About 304 adults whose cancer has spread or cannot be removed by surgery will take part. The study also looks at whether the tumors shrink or stop growing.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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Locations

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Duarte, California, 91010, United States
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Newport Beach, California, 92663, United States
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RECRUITING

Orange, California, 92868, United States
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Santa Rosa, California, 95403, United States
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Westwood, Kansas, 66205, United States
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Baltimore, Maryland, 21287, United States
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Detroit, Michigan, 48201, United States
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Buffalo, New York, 14263, United States
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New York, New York, 10029, United States
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The Bronx, New York, 10461, United States
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Houston, Texas, 77030, United States
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Fairfax, Virginia, 22031, United States
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Tacoma, Washington, 98405, United States
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TERMINATED

Adelaide, 5000, Australia
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Heidelberg, 3084, Australia
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Nedlands, 6009, Australia
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COMPLETED

Edegem, 2650, Belgium
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Barretos, 14784-400, Brazil
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Porto Alegre, 90035-903, Brazil
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São Paulo, 05652-900, Brazil
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Winnipeg, Manitoba, R3E 0V9, Canada
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London, Ontario, N6A 5W9, Canada
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Montreal, Quebec, H3T 1E2, Canada
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NOT_YET_RECRUITING

Changchun, 130000, China
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NOT_YET_RECRUITING

Chengdu, 610041, China
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NOT_YET_RECRUITING

Fuzhou, 350011, China
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NOT_YET_RECRUITING

Shandong, China
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Shanghai, 200433, China
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NOT_YET_RECRUITING

Zhengzhou, 450000, China
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Bordeaux, 33075, France
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Dijon, 21079, France
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Pierre-Bénite, 69495, France
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Saint-Herblain, 44800, France
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Villejuif, 94805, France
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Kfar Saba, 4428164, Israel
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Tel Litwinsky, 52620, Israel
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COMPLETED

Milan, 20133, Italy
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Milan, 20162, Italy
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Monza, 20052, Italy
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Naples, 80131, Italy
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Padova, 35128, Italy
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George Town, 10450, Malaysia
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Kuala Lumpur, 59100, Malaysia
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Kuala Selangor, 62250, Malaysia
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Kuching, 93586, Malaysia
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COMPLETED

Amsterdam, 1066 CX, Netherlands
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Bacolod, 6100, Philippines
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Cebu City, 6000, Philippines
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City of Taguig, 1634, Philippines
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TERMINATED

Davao City, PH-8000, Philippines
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TERMINATED

Manila, 1000, Philippines
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Manila, 1015, Philippines
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Quezon City, 1100, Philippines
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Quezon City, 1112, Philippines
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TERMINATED

San Juan City, 1500, Philippines
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Gdansk, 80-214, Poland
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SUSPENDED

Krakow, 30-727, Poland
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Olsztyn, 10-357, Poland
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TERMINATED

Tomaszów Mazowiecki, 97-200, Poland
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Warsaw, 02-781, Poland
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COMPLETED

Singapore, 119228, Singapore
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COMPLETED

Singapore, 168583, Singapore
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COMPLETED

Singapore, 308433, Singapore
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Cheongju-si, 28644, South Korea
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Goyang-si, 10408, South Korea
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Jinju, 52727, South Korea
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Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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Seoul, 06351, South Korea
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Badalona, 08013, Spain
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Madrid, 28041, Spain
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Seville, 41013, Spain
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Valencia, 46010, Spain
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Kaohsiung City, 833, Taiwan
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Taichung, 402, Taiwan
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Taichung, 40705, Taiwan
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Tainan, 70403, Taiwan
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Taipei, 100, Taiwan
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Taipei, 11217, Taiwan
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Taipei, 235, Taiwan
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Taoyuan, 333, Taiwan
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RECRUITING

Bangkok, 10300, Thailand
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COMPLETED

Bangkok, 10330, Thailand
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COMPLETED

Hat Yai, 90110, Thailand
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COMPLETED

Khon Kaen, 40002, Thailand
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NOT_YET_RECRUITING

Muang, 22000, Thailand
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Muang, 50200, Thailand
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Ankara, 06800, Turkey (Türkiye)
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Ankara, 6200, Turkey (Türkiye)
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ACTIVE_NOT_RECRUITING

Bornova-Izmir, 35100, Turkey (Türkiye)
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RECRUITING

Istanbul, 31755, Turkey (Türkiye)

Conditions

Explore the condition pages connected to this study.

LOCALLY ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER