New drug duo aims to slow advanced lung cancer in patients with EGFR mutation

NCT ID NCT06350097

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Nov 17, 2025 · Last updated May 22, 2026 · Updated 26 times

Summary

This study tests whether adding an experimental drug (Dato-DXd) to the standard pill osimertinib helps people with advanced EGFR-mutant lung cancer live longer without their cancer growing. About 582 adults with stage IIIB/IV non-small cell lung cancer will receive either osimertinib alone or osimertinib plus Dato-DXd infusions every 3 weeks. The main goal is to see if the combination delays cancer progression better than osimertinib alone.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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Locations

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SUSPENDED

Fountain Valley, California, 92708, United States
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Los Alamitos, California, 90720, United States
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Los Angeles, California, 90017, United States
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Los Angeles, California, 90033, United States
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NOT_YET_RECRUITING

Orange, California, 92868, United States
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San Diego, California, 92123, United States
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Santa Monica, California, 90404, United States
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Walnut Creek, California, 94598, United States
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New Haven, Connecticut, 06510, United States
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WITHDRAWN

Washington D.C., District of Columbia, 20037, United States
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Jacksonville, Florida, 32256, United States
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Ocala, Florida, 34474, United States
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Orange City, Florida, 32763, United States
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Honolulu, Hawaii, 96819, United States
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Chicago, Illinois, 60611, United States
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Hinsdale, Illinois, 60521, United States
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North Chicago, Illinois, 60064, United States
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Fort Wayne, Indiana, 46845, United States
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Bethesda, Maryland, 20817, United States
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Detroit, Michigan, 48201, United States
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Saint Paul, Minnesota, 55102, United States
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Bridgeton, Missouri, 63044, United States
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St Louis, Missouri, 63110, United States
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Las Vegas, Nevada, 89169, United States
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NOT_YET_RECRUITING

Brooklyn, New York, 11212, United States
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New York, New York, 10065, United States
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Dallas, Texas, 75390, United States
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Houston, Texas, 77030, United States
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Houston, Texas, 77090, United States
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Webster, Texas, 77598, United States
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Woodway, Texas, 76712, United States
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Fairfax, Virginia, 22031, United States
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Fort Belvoir, Virginia, 22060, United States
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Midlothian, Virginia, 23114, United States
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Seattle, Washington, 98104, United States
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Milwaukee, Wisconsin, 53226, United States
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Camperdown, 2050, Australia
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Clayton, 3168, Australia
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Kogarah, 2217, Australia
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South Brisbane, 4101, Australia
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Westmead, 2145, Australia
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Barretos, 14784-400, Brazil
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Natal, 59075-740, Brazil
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Porto Alegre, 91350-200, Brazil
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Salvador, 41253-190, Brazil
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São Paulo, 01246-000, Brazil
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Edmonton, Alberta, T6G 1Z2, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Beijing, 100029, China
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Beijing, 100034, China
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Beijing, 100142, China
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Changchun, 130000, China
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Changsha, 410013, China
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Chengdu, 610000, China
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Chengdu, 610042, China
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Chengdu, 610072, China
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Chongqing, 400030, China
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Chongqing, 402260, China
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Guangzhou, 510100, China
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Hangzhou, 310006, China
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Hangzhou, 31000, China
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Hangzhou, 310022, China
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Harbin, 150049, China
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Hefei, 230031, China
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Hefei, 230601, China
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Jinan, 250021, China
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Jinan, 250117, China
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Kunming, 650118, China
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Linhai, 317000, China
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Ningbo, 315010, China
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Shanghai, 200030, China
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Shanghai, 200433, China
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Shenyang, 110004, China
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Wenzhou, 325000, China
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Wuhan, 430022, China
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Wuhan, 430030, China
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Xi'an, 710061, China
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Xuzhou, 221000, China
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Yangzhou, 225001, China
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Zhengzhou, 450000, China
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Zhengzhou, 450008, China
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Angers, 49055, France
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Marseille, 13915, France
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Paris, 75005, France
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Strasbourg, 67091, Cedex, France
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Berlin, 13125, Germany
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Cologne, 51109, Germany
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Erfurt, 99089, Germany
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Frankfurt, 60488, Germany
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Göttingen, 37075, Germany
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Immenhausen, 34376, Germany
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Kiel, 24105, Germany
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Mainz, 55131, Germany
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München, 81925, Germany
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Hong Kong, 999077, Hong Kong
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NOT_YET_RECRUITING

Hong Kong, Hong Kong
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Jordan, 999077, Hong Kong
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NOT_YET_RECRUITING

Lai Chi Kok, Hong Kong
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Bangalore, 560027, India
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Delhi, 110085, India
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Hyderabad, 500032, India
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Kolkata, 700054, India
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Mysuru, 570017, India
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Nagpur, 440001, India
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Nashik, 422011, India
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New Delhi, 100049, India
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New Delhi, 11029, India
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Vadodara, 391760, India
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Varanasi, 221005, India
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Milan, 20141, Italy
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Monza, 20900, Italy
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Orbassano, 10043, Italy
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Padova, 35128, Italy
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Parma, 43100, Italy
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Chūōku, 104-0045, Japan
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Fukuoka, 812-8582, Japan
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Kashiwa, 277-8577, Japan
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Kōtoku, 135-8550, Japan
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Niigata, 951-8566, Japan
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Osaka, 541-8567, Japan
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Sakai, 590-0197, Japan
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Sapporo, 003-0804, Japan
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Sendai, 981-0914, Japan
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Wakayama, 641-8510, Japan
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Yokohama, 241-8515, Japan
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Bystra, 43-360, Poland
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Olsztyn, 10-357, Poland
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Poznan, 60-569, Poland
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Warsaw, 02-781, Poland
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Rio Piedras, 00935, Puerto Rico
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San Juan, 00918, Puerto Rico
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Goyang-si, 410-769, South Korea
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Namdong-gu, 21565, South Korea
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Seoul, 03080, South Korea
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Seoul, 06351, South Korea
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Seoul, 120-752, South Korea
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Suwon, 16247, South Korea
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A Coruña, 15006, Spain
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Barcelona, 8036, Spain
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Granada, 18007, Spain
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Madrid, 28040, Spain
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Majadahonda, 28222, Spain
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Valencia, 46009, Spain
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Taichung, 40705, Taiwan
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Tainan, 704, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 106, Taiwan
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Taipei, TAIWAN, Taiwan
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Taoyuan, 333, Taiwan
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ACTIVE_NOT_RECRUITING

Bangkok, 10400, Thailand
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ACTIVE_NOT_RECRUITING

Bangkok, 10700, Thailand
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ACTIVE_NOT_RECRUITING

Dusit, 10300, Thailand
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Hat Yai, 90110, Thailand
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ACTIVE_NOT_RECRUITING

Udon Thani, 41000, Thailand
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Adapazarı, 54100, Turkey (Türkiye)
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Ankara, 06530, Turkey (Türkiye)
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WITHDRAWN

Goztepe Istanbul, Turkey (Türkiye)
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Izmir, 35100, Turkey (Türkiye)
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Küçükçekmece, 34295, Turkey (Türkiye)
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Seyhan, 1060, Turkey (Türkiye)
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ACTIVE_NOT_RECRUITING

Hanoi, 100000, Vietnam
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ACTIVE_NOT_RECRUITING

Hà Nội, 100000, Vietnam
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ACTIVE_NOT_RECRUITING

Ho Chi Minh City, 700000, Vietnam
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ACTIVE_NOT_RECRUITING

Ho Chi Minh City, 70000, Vietnam
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ACTIVE_NOT_RECRUITING

Ho Chi Minh City, Vietnam
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ACTIVE_NOT_RECRUITING

Vinh, 460000, Vietnam

Conditions

Explore the condition pages connected to this study.

NON-SMALL CELL LUNG CANCER NON-SMALL CELL LUNG CANCER