New drug AZD1163 aims to ease rheumatoid arthritis pain
NCT ID NCT07276581
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests an experimental drug called AZD1163 in 320 people with moderate-to-severe rheumatoid arthritis who haven't gotten enough relief from standard treatments. Participants receive either AZD1163 or a placebo as an injection, along with their usual care. The main goal is to see if AZD1163 reduces joint swelling and tenderness after 12 weeks.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- AZD1163 (an experimental drug given as an injection under the skin)
- What this could lead to
- If it works, this could lead to a new treatment option for people with rheumatoid arthritis who haven't responded well to standard therapies.
- What could go wrong
- This is an early Phase 2 trial with only 320 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects are still being studied.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 320 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Dec 2025
- Expected to finish
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Aug 2028
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
* Inclusion * Diagnosed with adult-onset RA as defined by the 2010 ACR/EULAR classification criteria for at least 12 weeks prior to screening. * Moderately-to-severely active RA as defined by: a. \>= 6 swollen joints on 66SJC and \>= 6 tender joints on 68TJC; b. CRP \> upper limit of normal. * Have a positive ACPA at screening. * A history of inadequate response, or loss of response, or intolerance to: a. at least one csDMARD treatment, AND/OR b. At least one and at most 2 TNFi. * A history of at least 12 weeks treatment and \>= 4 weeks stable on a csDMARD and/or SC TNFi prior to the day of randomisation. * Exclusion * History or evidence of an alternate autoimmune or other condition that could confound the diagnosis of RA. Participants with RA and secondary Sjogren's disease are eligible. * Have received or planning to receive any biologic DMARDs (except for TNFi) or targeted synthetic DMARDs.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Rheumatoid arthritis are added.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
134 sites in 17 countries. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Research Site
NOT_YET_RECRUITINGGlendale, Arizona, 85306, United States
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WITHDRAWNPrescott Valley, Arizona, 86314, United States
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NOT_YET_RECRUITINGTucson, Arizona, 85748, United States
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NOT_YET_RECRUITINGLa Jolla, California, 92037, United States
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WITHDRAWNSan Dimas, California, 91773, United States
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NOT_YET_RECRUITINGSan Leandro, California, 94578, United States
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NOT_YET_RECRUITINGAurora, Colorado, 80045, United States
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WITHDRAWNBoynton Beach, Florida, 33435, United States
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WITHDRAWNJacksonville, Florida, 32216, United States
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SUSPENDEDSouth Miami, Florida, 33143, United States
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WITHDRAWNTampa, Florida, 33607, United States
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NOT_YET_RECRUITINGWinter Haven, Florida, 33880, United States
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NOT_YET_RECRUITINGMarietta, Georgia, 30060, United States
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NOT_YET_RECRUITINGSkokie, Illinois, 60076, United States
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RECRUITINGWillowbrook, Illinois, 60527, United States
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RECRUITINGLake Charles, Louisiana, 70605, United States
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NOT_YET_RECRUITINGBaltimore, Maryland, 21224, United States
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RECRUITINGNew Bedford, Massachusetts, 02740, United States
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NOT_YET_RECRUITINGKansas City, Missouri, 64151, United States
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RECRUITINGSt Louis, Missouri, 63131, United States
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RECRUITINGHenderson, Nevada, 89052, United States
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NOT_YET_RECRUITINGMyrtle Beach, South Carolina, 29572, United States
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RECRUITINGAustin, Texas, 78745, United States
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RECRUITINGBaytown, Texas, 77521, United States
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RECRUITINGHouston, Texas, 77027, United States
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RECRUITINGHouston, Texas, 77089, United States
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NOT_YET_RECRUITINGMesquite, Texas, 75150, United States
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RECRUITINGTomball, Texas, 77375, United States
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RECRUITINGCaba, C1128AAF, Argentina
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RECRUITINGCiudad de Buenos Aires, C1015ABO, Argentina
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NOT_YET_RECRUITINGCiudad de Buenos Aires, C1428DUQ, Argentina
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RECRUITINGCórdoba, X5000EDC, Argentina
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RECRUITINGSan Isidro, 1643, Argentina
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RECRUITINGSan Miguel de Tucumán, T4000AXL, Argentina
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NOT_YET_RECRUITINGJuiz de Fora, 36010 570, Brazil
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NOT_YET_RECRUITINGPelotas, 96040-010, Brazil
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NOT_YET_RECRUITINGPorto Alegre, 90035-903, Brazil
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NOT_YET_RECRUITINGPorto Alegre, 9061-000, Brazil
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NOT_YET_RECRUITINGSalvador, 41820-020, Brazil
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WITHDRAWNSão Paulo, 04266-010, Brazil
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NOT_YET_RECRUITINGSão Paulo, 05403-9000, Brazil
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NOT_YET_RECRUITINGHaskovo, 6304, Bulgaria
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NOT_YET_RECRUITINGPleven, 5800, Bulgaria
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NOT_YET_RECRUITINGSofia, 1113, Bulgaria
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NOT_YET_RECRUITINGSofia, 1336, Bulgaria
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NOT_YET_RECRUITINGSofia, 1606, Bulgaria
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NOT_YET_RECRUITINGSofia, 1612, Bulgaria
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RECRUITINGWindsor, Ontario, N8X 5A7, Canada
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RECRUITINGTrois-Rivières, Quebec, G9A 3Y2, Canada
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NOT_YET_RECRUITINGProvidencia, 7510186, Chile
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NOT_YET_RECRUITINGSantiago, 7500571, Chile
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NOT_YET_RECRUITINGSantiago, 7500587, Chile
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NOT_YET_RECRUITINGTemuco, 4810345, Chile
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NOT_YET_RECRUITINGValdivia, 5110683, Chile
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NOT_YET_RECRUITINGVictoria, 4720097, Chile
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NOT_YET_RECRUITINGViña del Mar, 2531172, Chile
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NOT_YET_RECRUITINGBeijing, 100144, China
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RECRUITINGBeijing, 100730, China
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NOT_YET_RECRUITINGChangchun, 130021, China
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NOT_YET_RECRUITINGChangsha, 410008, China
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NOT_YET_RECRUITINGGuangzhou, 510515, China
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NOT_YET_RECRUITINGJiujiang, 332000, China
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NOT_YET_RECRUITINGKunming, 650032, China
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RECRUITINGLinyi, CN-276003, China
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RECRUITINGNanchong, 637000, China
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RECRUITINGPanjin, 124000, China
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RECRUITINGPingxiang, 337055, China
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NOT_YET_RECRUITINGShantou, 515041, China
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NOT_YET_RECRUITINGXuzhou, 221009, China
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NOT_YET_RECRUITINGYangzhou, 225001, China
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NOT_YET_RECRUITINGZhengzhou, 450000, China
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NOT_YET_RECRUITINGBad Doberan, 18209, Germany
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NOT_YET_RECRUITINGBerlin, 10777, Germany
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NOT_YET_RECRUITINGHamburg, 20095, Germany
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NOT_YET_RECRUITINGSendenhorst, 48324, Germany
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NOT_YET_RECRUITINGBudapest, 1023, Hungary
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NOT_YET_RECRUITINGBudapest, 1027, Hungary
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NOT_YET_RECRUITINGBudapest, 1036, Hungary
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NOT_YET_RECRUITINGDebrecen, 4032, Hungary
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NOT_YET_RECRUITINGGyula, 5700, Hungary
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NOT_YET_RECRUITINGSzeged, 6725, Hungary
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NOT_YET_RECRUITINGSzékesfehérvár, 8000, Hungary
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NOT_YET_RECRUITINGVeszprém, 8200, Hungary
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NOT_YET_RECRUITINGAomori, 030-8553, Japan
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NOT_YET_RECRUITINGBunkyō City, 113-8655, Japan
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RECRUITINGFukuoka, 815-8555, Japan
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RECRUITINGHamamatsu, 430-0906, Japan
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RECRUITINGHitachi-Naka, 312-0057, Japan
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RECRUITINGIizuka-shi, 820-8505, Japan
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RECRUITINGKawachinagano-shi, 586-8521, Japan
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NOT_YET_RECRUITINGMatsuyama, 790-8524, Japan
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RECRUITINGMeguro-ku, 152-8902, Japan
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RECRUITINGMiyazaki, 880-0834, Japan
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RECRUITINGNagoya, 457-8511, Japan
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WITHDRAWNOkayama, 700-8557, Japan
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RECRUITINGSagamihara-shi, 252-0315, Japan
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WITHDRAWNSapporo, 060-0001, Japan
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RECRUITINGSasebo-shi, 857-1195, Japan
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RECRUITINGSayama-shi, 350-1305, Japan
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NOT_YET_RECRUITINGYokohama, 236-0037, Japan
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NOT_YET_RECRUITINGChihuahua City, 31000, Mexico
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NOT_YET_RECRUITINGEstado de México, 50090, Mexico
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NOT_YET_RECRUITINGGuadalajara, 44160, Mexico
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NOT_YET_RECRUITINGGuadalajara, 44650, Mexico
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NOT_YET_RECRUITINGGuadalajara, 44690, Mexico
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NOT_YET_RECRUITINGGustavo A. Madero, 07300, Mexico
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NOT_YET_RECRUITINGMexicali, 021100, Mexico
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NOT_YET_RECRUITINGMexico City, 06700, Mexico
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NOT_YET_RECRUITINGMérida, 97070, Mexico
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NOT_YET_RECRUITINGMonterrey, 64460, Mexico
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WITHDRAWNSan Luis Potosí City, 78213, Mexico
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NOT_YET_RECRUITINGKrakow, 30-002, Poland
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NOT_YET_RECRUITINGKrakow, 30-727, Poland
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NOT_YET_RECRUITINGTorun, 87-100, Poland
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NOT_YET_RECRUITINGWarsaw, 00-874, Poland
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NOT_YET_RECRUITINGWroclaw, 50-244, Poland
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NOT_YET_RECRUITINGCaguas, 00725, Puerto Rico
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WITHDRAWNBrackenfell, 7560, South Africa
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NOT_YET_RECRUITINGCape Town, 7500, South Africa
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NOT_YET_RECRUITINGDurban, 4319, South Africa
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NOT_YET_RECRUITINGPinelands, 7405, South Africa
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NOT_YET_RECRUITINGPretoria, 0002, South Africa
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NOT_YET_RECRUITINGPretoria, South Africa
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NOT_YET_RECRUITINGSomerset West, 7130, South Africa
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NOT_YET_RECRUITINGBarcelona, 08003, Spain
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NOT_YET_RECRUITINGBarcelona, 08035, Spain
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NOT_YET_RECRUITINGBarcelona, 08041, Spain
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NOT_YET_RECRUITINGMálaga, 29009, Spain
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NOT_YET_RECRUITINGSabadell, 08208, Spain
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NOT_YET_RECRUITINGSantiago de Compostela, 15706, Spain
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NOT_YET_RECRUITINGValencia, 46026, Spain
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RECRUITINGIvano-Frankivsk, 76018, Ukraine
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RECRUITINGKyiv, 02002, Ukraine
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RECRUITINGKyiv, 03037, Ukraine
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RECRUITINGKyiv, 03049, Ukraine
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RECRUITINGKyiv, 04050, Ukraine
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RECRUITINGKyiv, 04210, Ukraine
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RECRUITINGUzhhorod, 88000, Ukraine
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RECRUITINGVinnytsia, 21018, Ukraine
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Research Site
RECRUITINGVinnytsia, 21029, Ukraine
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RECRUITINGGlasgow, G31 2ER, United Kingdom
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RECRUITINGLeeds, LS7 4SA, United Kingdom
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Research Site
RECRUITINGLuton, LU4 0DZ, United Kingdom
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Research Site
NOT_YET_RECRUITINGStaffordshire, WS11 5XY, United Kingdom
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