Engineered immune cells take aim at lupus in new trial

NCT ID NCT06897930

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 21, 2026 · Updated 26 times

Summary

This study tests a new treatment called AZD0120 for adults with severe lupus that hasn't improved with standard therapies. AZD0120 uses a patient's own immune cells, modified to target and destroy faulty immune cells that drive lupus. The trial has two phases: first to find a safe dose, then to see if it can reduce lupus disease activity. About 150 participants will be enrolled.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Research Site
NOT_YET_RECRUITING

San Francisco, California, 94143, United States
Research Site
NOT_YET_RECRUITING

Stanford, California, 94304-2201, United States
Research Site
SUSPENDED

Tampa, Florida, 33612, United States
Research Site
NOT_YET_RECRUITING

Atlanta, Georgia, 30322, United States
Research Site
NOT_YET_RECRUITING

Chicago, Illinois, 60611, United States
Research Site
WITHDRAWN

Bethesda, Maryland, 20892, United States
Research Site
RECRUITING

Boston, Massachusetts, 02115, United States
Research Site
NOT_YET_RECRUITING

St Louis, Missouri, 63110, United States
Research Site
RECRUITING

New York, New York, 10032, United States
Research Site
RECRUITING

Syracuse, New York, 13202-2240, United States
Research Site
NOT_YET_RECRUITING

Chapel Hill, North Carolina, 27599-7280, United States
Research Site
RECRUITING

Charlotte, North Carolina, 28204, United States
Research Site
NOT_YET_RECRUITING

Richmond, Virginia, 23298, United States
Research Site
RECRUITING

Seattle, Washington, 98104, United States
Research Site
RECRUITING

Seattle, Washington, 98195, United States
Research Site
NOT_YET_RECRUITING

Darlinghurst, 2010, Australia
Research Site
NOT_YET_RECRUITING

Melbourne, 3000, Australia
Research Site
NOT_YET_RECRUITING

Toronto, M5T 2S8, Canada

Conditions

Explore the condition pages connected to this study.

LUPUS ERYTHEMATOSUS, SYSTEMIC