New Dual-Targeting CAR t therapy takes on Tough-to-Treat myeloma

NCT ID NCT05850234

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Apr 07, 2026 · Last updated May 23, 2026 · Updated 8 times

Summary

This study tests a new treatment called AZD0120 for people with multiple myeloma that has returned or stopped responding to at least three prior therapies. AZD0120 is a personalized cell therapy that uses a patient's own immune cells, modified to target two proteins (CD19 and BCMA) on myeloma cells. The goal is to see if it is safe and effective, with about 182 adults expected to take part.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

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Birmingham, Alabama, 35233, United States
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Phoenix, Arizona, 85054, United States
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La Jolla, California, 92037, United States
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Los Angeles, California, 90095, United States
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San Francisco, California, 94143, United States
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Aurora, Colorado, 80045, United States
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Denver, Colorado, 80218, United States
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Jacksonville, Florida, 32224, United States
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Miami, Florida, 33136, United States
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Tampa, Florida, 33612, United States
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Atlanta, Georgia, 30322, United States
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Chicago, Illinois, 60637, United States
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Iowa City, Iowa, 52242, United States
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Boston, Massachusetts, 02114, United States
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Boston, Massachusetts, 02215, United States
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Ann Arbor, Michigan, 48109, United States
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Detroit, Michigan, 48202, United States
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NOT_YET_RECRUITING

Minneapolis, Minnesota, 55455, United States
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Rochester, Minnesota, 55905, United States
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WITHDRAWN

Omaha, Nebraska, 68198, United States
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WITHDRAWN

Hackensack, New Jersey, 07601, United States
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NOT_YET_RECRUITING

Buffalo, New York, 14203, United States
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New York, New York, 10065, United States
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Stony Brook, New York, 11794, United States
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Charlotte, North Carolina, 28204, United States
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Durham, North Carolina, 27705, United States
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Nashville, Tennessee, 37203, United States
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Nashville, Tennessee, 37232, United States
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Austin, Texas, 78704, United States
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Dallas, Texas, 75390, United States
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Houston, Texas, 77030, United States
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NOT_YET_RECRUITING

Salt Lake City, Utah, 84112, United States
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Charlottesville, Virginia, 22908, United States
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Edmonds, Washington, 98026, United States
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Seattle, Washington, 98109, United States
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Milwaukee, Wisconsin, 53226, United States

Conditions

Explore the condition pages connected to this study.

RELAPSED/REFRACTORY MULTIPLE MYELOMA