Astrazeneca

This study tested an experimental daily pill called atuliflapon in 670 adults with moderate to severe asthma that is not well controlled by current treatments. The goal was to see if the drug could reduce asthma worsening episodes compared to a placebo over 12 weeks. Participants…

This study tracked 712 people with lung or biliary tract cancer who received durvalumab (Imfinzi) as part of their normal treatment in Korea. The goal was to see how safe and effective the drug is outside of strict clinical trial settings. Researchers monitored side effects, trea…

This study looked at how well the drug tezepelumab works for people with severe uncontrolled asthma in real-world settings, outside of a controlled trial. Over 500 participants aged 12 and older were followed after starting tezepelumab. The main goal was to measure changes in ast…

This study tested a drug called anifrolumab in 277 Asian adults with active lupus. The goal was to see if it works better than a placebo at controlling disease activity. Participants received the drug or placebo through an IV, and researchers measured how many had less lupus acti…

This study looked at the safety of two drugs (IMJUDO and IMFINZI) given together or alone to 1,200 people with advanced liver cancer that cannot be removed by surgery. The goal was to track side effects in real-world use, not to cure the disease. Participants received these treat…

This study tested a new medicine called AZD6234, given as a weekly shot, to help people with obesity or overweight lose weight. 262 adults took part for 36 weeks. The main goal was to see if the drug helped people lose more weight than a placebo. The study is now complete, and re…

This study tested a new drug called AZD9291 in 603 people with advanced non-small cell lung cancer whose tumors had started growing again after previous targeted therapy. The main goals were to find the best dose, check for side effects, and see if the drug could shrink tumors. R…

This study tracked side effects in 236 people with advanced bile duct cancer that cannot be removed by surgery. Participants received the drug IMFINZI together with two standard chemotherapy drugs. The goal was to see how often unwanted reactions occur in real-world use, not to t…

This study tested a new medicine called CIN-107 in 15 adults with primary aldosteronism, a condition where a hormone imbalance causes high blood pressure. The goal was to see if the drug could safely lower blood pressure over 12 weeks, with long-term follow-up for up to 74 weeks.…

This study tested two experimental drug combinations (durvalumab plus either danvatirsen or AZD5069) in 340 adults with advanced solid tumors or head and neck cancer that had returned or spread. The goal was to find safe doses and see if the treatments could shrink tumors. While …

This study looked at the safety of the drug LYNPARZA when used as a long-term treatment after chemotherapy in 130 people with a type of pancreatic cancer linked to BRCA gene changes. The goal was to track side effects like bone marrow problems, lung issues, new cancers, and risks…

This early-stage study tested a new drug called AZD4144 in 29 adults who have both heart disease and chronic kidney disease. The main goal was to check if the drug is safe and to see how it affects inflammation markers in the blood. Participants took either the drug or a placebo …

This study looked at 291 adults with severe eosinophilic asthma who were starting benralizumab (Fasenra). Researchers tracked how well the drug controlled asthma symptoms over time using patient questionnaires. The goal was to see real-world benefits and improve doctor-patient co…

This early-stage study tested a new drug called AZD6234 in 104 healthy adults with overweight or obesity. The main goal was to check if the drug is safe and tolerable when given as repeated injections under the skin. Researchers also looked at how the drug moves through the body.…

This study tested two doses of a drug called tozorakimab in over 1,100 adults with COPD who had frequent or severe flare-ups. Participants continued their usual inhaled treatments. The goal was to see if the drug could safely reduce the number of moderate to severe COPD attacks o…

This early-phase study tested the safety of an experimental drug (AZD2014) combined with a standard hormone therapy (fulvestrant) in 99 people with advanced, estrogen receptor-positive breast cancer. The main goal was to see if the combination is safe and tolerable, not to cure t…

This early-phase study tested the safety of combining two experimental drugs (AZD1775 and durvalumab) in 56 adults with advanced solid tumors that had stopped responding to standard treatments. The main goal was to identify side effects and determine safe dosing. This trial did n…

This study looked at how often bone marrow suppression (a serious side effect) happens in people with BRCA-mutated, HER2-negative breast cancer who are at high risk of the cancer coming back. Participants took LYNPARZA tablets after surgery to help keep the cancer away. The main …

This study followed 200 adults with moderate to severe COPD who started taking the triple-combination inhaler BREZTRI as part of their normal care. Researchers measured changes in symptoms and breathing over 24 weeks using standard questionnaires and lung function tests. The goal…

This study tested a drug called durvalumab in 446 people with advanced non-small cell lung cancer who had already tried at least two other treatments, including chemotherapy. The goal was to see if the drug could shrink tumors and how safe it was. Participants received the drug e…

This study tracked 296 people with advanced or recurrent non-small cell lung cancer who received a combination of IMJUDO, IMFINZI, and platinum-based chemotherapy. The goal was to see how safe the treatment is when used in everyday medical practice. Researchers recorded any side …

This study looked at whether the drug anifrolumab, when added to usual lupus treatments, can help prevent long-term organ damage in adults with active systemic lupus erythematosus (SLE). Researchers compared data from 561 patients who took anifrolumab in earlier trials to similar…

This study looked at 653 people with severe asthma that was not controlled by other treatments. They received FASENRA injections over a long period to see if it was safe and helped control their asthma. The main goal was to track side effects and check if symptoms improved.

This study tracked side effects of the drug Calquence (acalabrutinib) in 67 people with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The goal was to see how often certain side effects happen when the drug is used in everyday medical…

This study followed 152 adults with severe eosinophilic asthma in Greece who were starting benralizumab, a medication that helps control severe asthma. Over 48 weeks, researchers tracked not only standard asthma measures but also quality of life, sleep, mood, and physical activit…

This study looked at how well the drug Tagrisso works for people with a certain type of advanced lung cancer in everyday medical practice, not just in strict research settings. Over 900 patients in Korea took part, and researchers tracked side effects and how long the drug kept t…

This study looked at 186 adults with chronic kidney disease who had high potassium levels while in the hospital. Researchers compared continuing a drug called SZC after discharge versus standard care. The goal was to see if SZC helps maintain normal potassium levels and reduces h…

This study tested a new medicine called baxdrostat in 218 adults whose high blood pressure remained high despite taking three or more different blood pressure drugs. The goal was to see if baxdrostat could lower blood pressure more than a placebo over 12 weeks. Participants took …

This study looked at side effects of the drug Calquence (acalabrutinib) in 104 people with relapsed or refractory chronic lymphocytic leukemia (a type of blood cancer that has come back or not responded to treatment). Researchers tracked real-world use to see how often problems l…

This study tested how well tezepelumab works for adults with severe asthma that is not controlled by other treatments. Researchers measured asthma control and cough-related quality of life over 52 weeks. The goal was to see if the drug improves daily symptoms in real-world settin…

This study looked at the safety and effectiveness of the drug FASENRA in 51 Korean adults with severe eosinophilic asthma or a related condition called EGPA. Researchers tracked side effects and how well the drug controlled the diseases during normal doctor visits. The goal was t…

This study tested whether a combination inhaler (budesonide and formoterol) works better than a steroid-only inhaler (budesonide) for people whose asthma is not well controlled. Over 12 weeks, 374 adults and teens aged 12 to 80 took part. The main goal was to see if the combinati…

This study tested a new drug called AZD9291 (osimertinib) against standard targeted therapies for people with advanced lung cancer that has specific EGFR mutations. Over 670 participants received either the new drug or standard treatment. The goal was to see if the new drug could…

This study tested a new version of a triple-combination inhaler (budesonide, glycopyrronium, and formoterol) for people with moderate to very severe COPD. The goal was to see if the new inhaler design is as safe as the current one. 559 adults aged 40 to 80 took part, using the in…

This study tested whether a triple-combination inhaler (BGF MDI) helps people with moderate to severe COPD breathe easier and exercise longer compared to a placebo or a dual-combination inhaler. 171 adults aged 40-80 participated. The main goal was to measure lung capacity and en…

This study tested a new drug called baxdrostat in 326 adults whose high blood pressure remains uncontrolled despite taking two or more medications, including some with resistant hypertension. The goal was to see if adding baxdrostat lowers blood pressure more than a placebo after…

This study tested a new medicine called AZD2693 in 220 adults with a type of fatty liver disease (NASH) that includes liver scarring. Only people with a specific gene variant (PNPLA3 148M) that raises their risk were included. The goal was to see if the drug could reverse the liv…

This study tested an experimental oral tablet called AZD5004 to see if it helps people with obesity or overweight lose weight. About 310 adults took the pill or a placebo once daily for 36 weeks. The goal was to measure weight loss and safety. This is a phase 2 trial, meaning it'…

This study tested whether a single pill containing two diabetes drugs (dapagliflozin and metformin) works as well as taking them separately in Chinese adults with type 2 diabetes. Over 600 participants took either the combo pill or the two separate pills for 24 weeks. The main go…

This study tested a new medicine called AZD5004 in 406 adults with type 2 diabetes to see if it helps control blood sugar better than a placebo or another diabetes drug. Participants had diabetes for at least 6 months and were either on diet/exercise alone or stable doses of metf…

This study tested a medicine called D961H in 50 Japanese children. The goal was to see if it could prevent reflux esophagitis (heartburn damage) from coming back and stop stomach or duodenal ulcers from returning in kids taking NSAIDs or low-dose aspirin. Children took the medici…

This study looked at how well and how safely the drug tezepelumab works for people aged 12 and older with severe asthma, including groups often left out of research. Over 52 weeks, researchers tracked asthma attacks, hospital visits, and medication use. The goal was to see if tez…

This study tested an investigational drug called AZD3427 in 260 adults with heart failure and a related lung condition called pulmonary hypertension (Group 2). The goal was to see if the drug could lower blood pressure in the lungs after 24 weeks of treatment. Participants receiv…

This study tested a targeted drug called olaparib against standard chemotherapy in 302 people with advanced breast cancer who have inherited BRCA1 or BRCA2 gene mutations. The goal was to see if olaparib could slow cancer growth better than chemo. Participants received either ola…

This study tested whether a combination inhaler (AIRSUPRA) works better than the usual rescue inhaler (albuterol) for adults with mild asthma. Over 12 weeks, researchers measured airway inflammation, symptoms, and how often rescue medication was needed. The goal was to see if the…

This early-stage study tested a new drug called AZD0780 in 81 healthy adults with high LDL (bad) cholesterol. Participants took AZD0780 or a placebo on top of standard cholesterol medicines like ezetimibe, rosuvastatin, or bempedoic acid. The main goals were to see how well the c…

This study looked at the long-term safety of the drug roflumilast in adults with asthma. Participants had already finished a 24-week study and took the drug once daily for another 28 weeks. The goal was to see if the drug remained safe over a longer period.

This study tested a drug called AZD9291 in 171 adults from Asia Pacific with advanced non-small cell lung cancer that had a specific gene mutation (T790M). All participants had already tried other treatments that stopped working. The goal was to see if the drug could shrink tumor…

This study tested a new daily medication called AZD0780 in 428 adults with high cholesterol. Participants took one of several doses of the drug or a placebo for 12 weeks to see how well it lowered their bad (LDL) cholesterol. The goal was to find out if AZD0780 is safe and effect…

This study tested a new drug called AZD7789 in 45 people with classical Hodgkin lymphoma that had returned or stopped responding to at least two prior treatments. The main goals were to check the drug's safety and find the right dose, while also looking for early signs that it mi…

This study tested a daily medication called acalabrutinib in 552 adults with chronic lymphocytic leukemia (CLL). Participants included those newly diagnosed, those whose cancer returned or didn't respond to treatment, and those who had previously taken a similar drug. The main go…

This study tested a daily pill called roflumilast to see if it improves lung function in adults with asthma. About 450 participants took either the drug or a placebo for 24 weeks. Researchers measured breathing tests, asthma symptoms, and side effects to determine if the drug is …

This study tested a drug called cotadutide in 54 adults with a type of fatty liver disease (NASH) that includes liver scarring but not cirrhosis. The main goal was to see if the drug is safe and helps the liver. Participants received either the drug or a placebo, and researchers …

This study tested a new medicine called AZD5462 in 375 adults with stable chronic heart failure. The goal was to see if the drug could improve how well the heart pumps blood. Participants took either the study drug or a placebo, and doctors measured heart function using ultrasoun…

This study tested a new drug called AZD4604 in 36 adults with moderate-to-severe asthma. The goal was to see if it reduces airway inflammation better than a placebo over 4 weeks. Participants took the drug or a placebo and had their airway cells checked for signs of inflammation.…

This study tested a new inhaler that combines two medicines (budesonide and formoterol) for people whose asthma is not well controlled. Over 600 adults and teens took part for 24 weeks. The main goal was to see if the new inhaler improved lung function better than using one medic…

This study tested how well benralizumab, an asthma medication, works for people with severe uncontrolled asthma in everyday settings in Taiwan. 43 adults took the drug and reported their symptoms using questionnaires. The goal was to see if asthma control improved after starting …

This study tested an experimental inhaled drug called AZD8630 in 537 adults whose asthma is not well controlled despite using standard inhalers. Participants took the drug once daily for 12 weeks. The goal was to see if it could prevent asthma flare-ups and improve lung function …

This study followed 212 adults in Greece with moderate to severe COPD who were prescribed a new triple-combination inhaler (Trixeo Aerosphere). Researchers recorded why doctors switched from dual to triple therapy and measured changes in patients' breathing symptoms and quality o…

This early-stage study tested a single dose of a new drug called AZD6912 in 40 healthy adults to see if it is safe and how the body processes it. The drug is being developed to treat rheumatoid arthritis, an autoimmune disease that causes joint pain and swelling. Since this was a…

This study tested whether a combination of two drugs, zibotentan and dapagliflozin, is safe for people with liver cirrhosis. 73 adults with cirrhosis took either the combination, zibotentan alone, or a placebo. The main goal was to see if the drugs caused fluid retention, a commo…

This study tested two hormone-blocking drugs, fulvestrant and anastrozole, in 462 postmenopausal women with advanced breast cancer that is fueled by hormones. The goal was to see which drug better delays cancer growth. Participants had not received hormone therapy before. The res…

This study looked at 33 people with severe asthma who received tezepelumab before it was widely available in Spain. Researchers checked how well the drug controlled asthma symptoms and tracked side effects. The goal was to see how the drug works outside of a clinical trial settin…

This study tested two doses of a drug called tozorakimab in over 1,100 adults with COPD who had frequent flare-ups. Participants were former or current smokers already on standard inhalers. The goal was to see if the drug could safely reduce the number of moderate to severe COPD …

This study tested a new drug called AZD0780 to see if it can lower blood pressure in people with heart disease or related risks who also have high cholesterol. About 202 adults took part, and they received either the drug or a placebo for 4 weeks. The main goal was to measure cha…

This early-stage study tested a new daily pill, AZD4144, in 28 adults with obesity to see if it is safe and how it affects body inflammation. Participants took either the drug or a placebo for a short time. The main goals were to check for side effects and measure changes in bloo…

This study tested a new drug called baxdrostat in about 800 adults with high blood pressure that remains high despite taking two or more medications. Participants took either 1 mg, 2 mg, or a placebo pill daily for 12 weeks. The goal was to see if baxdrostat could safely lower bl…

This study tested a monthly injection called tezepelumab in 305 adults with severe asthma who needed daily steroid pills. The goal was to see if the drug could help them safely reduce or stop their steroid use. Results showed many participants could lower their steroid dose witho…

This study tested a new inhaler medicine called AZD4604 in 339 adults with moderate-to-severe asthma that is not well controlled by their current treatments. Participants took the medicine or a placebo twice a day for 12 weeks. The goal was to see if the new medicine could reduce…

This study tested whether a medication called tezepelumab, given as an injection, could reduce nasal polyps and improve symptoms in people with severe chronic sinusitis. Over 400 participants with severe symptoms who needed surgery received either the drug or a placebo for 52 wee…

This study tested a short questionnaire called SCORED to see if it can accurately identify adults in Asia who are at risk for chronic kidney disease (CKD). Over 1,400 people took part. The goal was to see how well the questionnaire works as a simple, non-invasive screening tool t…

This study tested a medicine called nirsevimab in 33 Japanese infants under 1 year old who are at high risk for severe RSV infection due to heart or lung problems, weak immune systems, Down syndrome, or premature birth. The goal was to check safety and how the body responds to tw…

This study tested a single dose of nirsevimab, an antibody, to prevent severe RSV lung infections in healthy infants born at 29 weeks or later. About 800 babies in China received either the antibody or a placebo and were monitored for 150 days. The goal was to see if nirsevimab s…

This study tested a new inhaler (PT027) that combines a fast-acting bronchodilator with a steroid against a standard bronchodilator inhaler (PT007) in 190 adults with asthma. Researchers measured how well each drug improved lung function after triggering airway narrowing with a m…

This study tested a single dose of an inhaled drug called AZD8630 in 10 teenagers with asthma. The goal was to see how the drug moves through the body and whether it is safe. Participants used a dry powder inhaler and were monitored for side effects and immune responses.

This early-stage study tested a new daily inhaler called AZD8630 in 24 adults with asthma who already use medium-to-high dose steroid inhalers and long-acting bronchodilators. The main goals were to check safety and how the drug moves through the body. Participants took the inhal…

This study tested a new inhaler called PT007 in 118 adults with asthma. Participants received a single dose of PT007, a placebo, or the standard inhaler Ventolin on separate days. The main goal was to see how well PT007 improved lung function over 6 hours compared to the other tr…

This study followed 10 adults with moderate to severe COPD in Romania who were starting a new inhaler called TRIXEO AEROSPHERE. Researchers wanted to see how patients felt about their health and treatment over 3 to 6 months. The goal was to understand real-world benefits, not to …

This study tested whether a new propellant (HFO) in asthma inhalers causes breathing problems compared to the standard propellant (HFA). 52 adults with well-controlled asthma took part. The main goal was to measure lung function right after using each inhaler to see if the new on…

This study looked at how the antifungal drug itraconazole changes the amount of AZD9291 in the blood of people with a specific type of advanced lung cancer (EGFR mutation-positive NSCLC) that stopped responding to previous treatments. Thirty-nine adults took a single dose of AZD9…

This study looked at how the drug AZD2389 behaves in people with liver impairment compared to healthy adults. Thirty-five participants received a single dose to measure drug levels and check for side effects. The goal was to understand if liver problems change how the drug is pro…

This study looked at 11 Korean adults with a rare disease called NMOSD who were already taking or starting the drug Soliris. Researchers tracked side effects and whether the disease came back during normal medical care. The goal was to confirm the drug's safety and effectiveness …

This study tested a program to train doctors on the latest asthma guidelines and help them put that knowledge into practice. About 1500 people with asthma from 30 hospitals in China took part. The goal was to see if the program led to better use of inhaled steroids and improved a…

This study followed 245 people with type 2 diabetes at high heart risk for two years to see how many develop heart failure and what factors predict it. Researchers collected data from doctor visits and phone calls to track changes over time. The goal is to help doctors identify w…

This study looks at how well the drug T-DXd works compared to usual treatments for people with advanced HER2-positive solid tumors (like lung, colon, and ovarian cancers). Researchers will use data from past clinical trials and real-world patient records to compare survival rates…

This early-stage study tested the safety of a new drug called AZD2389 in 120 healthy adults. Researchers gave single or multiple doses to see how the body handles the drug and if it causes side effects. The goal was not to treat any disease, but to gather important safety informa…

This study looked at how a high-fat, high-calorie meal changes the amount of two drugs (zibotentan and dapagliflozin) in the blood of 26 healthy adults. Participants took the drug combination once with food and once without, and researchers measured drug levels and side effects. …

This study observed over 2,200 adults hospitalized for major bleeding while taking Factor Xa inhibitor blood thinners. Researchers collected data on patient traits, treatments received, and health outcomes to better understand how to manage these serious bleeding events. The goal…

This large study looked at over 2 million people with type 2 diabetes to see if those taking dapagliflozin had a different risk of breast or bladder cancer compared to those on other diabetes medications. Researchers tracked cancer cases for up to 12 years. The goal was to unders…

This study looked at medical records of 1,669 adults with HER2-low breast cancer that had spread or could not be removed by surgery. Researchers wanted to understand how common this type of cancer is and how doctors in Russia actually diagnose and treat it. The goal was to learn …

This study looked at whether baxdrostat, a new drug for high blood pressure, changes how the body makes cortisol (a stress hormone). 48 adults with uncontrolled high blood pressure took baxdrostat or a placebo for 8 weeks. Researchers measured cortisol levels before and after a s…

This early-stage study tested the safety and how the body processes an inhaled drug called AZD4604. It involved 56 healthy Japanese and Chinese adults who received either the drug or a placebo. The goal was to check for side effects and measure drug levels in the blood, not to tr…

This study followed 250 adults with COPD in Italy who started taking the triple-combination inhaler Trixeo (budesonide/glycopyrronium/formoterol). Researchers measured how patients felt about their health after 12 weeks and up to one year of treatment. The goal was to see real-wo…

This study reviewed medical records of 74 adults with severe asthma in Portugal who received benralizumab, a drug that helps control asthma by reducing certain white blood cells. Researchers looked at patient characteristics, how the drug was used, and what happened after treatme…

This study followed 31 adults with COPD for 12 weeks to see how their symptoms, lung function, and markers of inflammation change over time. Researchers measured things like breathing tests, daily symptoms, and blood or sputum markers. The goal was not to test a new treatment, bu…

This study tested whether giving the drug tozorakimab with two different injection devices (an autoinjector and a prefilled syringe) leads to similar drug levels in the body. It involved 254 healthy adults who received a single dose under the skin. The goal was to see if the devi…

This study looked back at the medical records of 718 adults with COPD in Spain who started taking the triple-combination inhaler Trixeo. Researchers wanted to see how many lung flare-ups (exacerbations) patients had in the year after starting the drug. The goal was to understand …

This study reviewed medical records of 350 Australian adults with advanced EGFR-mutant non-small cell lung cancer to see how they were treated with the drug osimertinib and what happened over time. Researchers looked at how long patients stayed on treatment, how long they lived, …

This study looked at the safety of the cancer drug olaparib in over 1,000 Chinese patients with ovarian or prostate cancer. Researchers tracked side effects and how doctors managed them in everyday medical practice. The goal was to better understand the drug's real-world safety p…

This study looked at how well researchers could collect, ship, and test stool and blood samples from 7 adults with an active C. diff infection. Participants also filled out questionnaires about their symptoms. The goal was to see if these methods are practical for future studies,…

This study created a registry of 227 adults with mantle cell lymphoma who had started a new type of drug therapy within the past 6 months. Researchers collected information on which treatments were used, how long patients stayed on them, and how patients felt about their quality …

This study looked at how the lung cancer drug AZD9291 (osimertinib) changes the way the body processes simvastatin, a common cholesterol medicine. It involved 52 adults with a specific type of advanced lung cancer (EGFR mutation-positive) whose disease had worsened after previous…

This study looked back at the medical records of 352 adults with severe asthma who received tezepelumab in UK clinics. Researchers tracked how many asthma attacks patients had in the year after starting the drug compared to the year before. The goal was to see how well the treatm…

This study looked at how a new drug called AZD5004 affects the way the body processes several common medicines, including cholesterol-lowering statins and a diabetes drug. Healthy adults aged 18 to 55 took part to see if combining these drugs changes their levels in the blood. Th…

This study looked at medical records of 833 people with advanced non-small cell lung cancer to understand what treatments they received and how they fared. Researchers gathered data from doctors' surveys across multiple countries. The goal was to learn about real-world care patte…

This study reviewed medical records of 405 adults in Egypt with advanced breast cancer to find out how many had a subtype called HER2-low. Researchers looked at past test results to count cases and describe patient characteristics. The goal was to better understand this group, no…

This early-stage study tested the safety and how the body handles a new drug called AZD6793 in 39 healthy Japanese and Chinese adults. Participants received either the drug or a placebo, and researchers monitored for side effects and drug levels in the blood. The goal was to gath…

This study looked at information from over 361,000 people hospitalized with COVID-19 in Brazil. Researchers used a large public health database to describe patient details and outcomes, such as death rates. The goal was to understand the impact of COVID-19 on the healthcare syste…

This study reviewed medical records of 217 Dutch adults hospitalized with serious bleeding while taking a factor Xa inhibitor blood thinner. All patients received andexanet alfa to reverse the blood thinner's effects. Researchers aimed to describe patient characteristics and outc…

This study tracked the safety of the diabetes drug Forxiga (dapagliflozin) in over 1,000 adults with type 2 diabetes across eight hospitals in Vietnam. Researchers monitored side effects for 24 weeks to meet local regulatory requirements. The goal was to gather real-world safety …

This early-stage study tested a single dose of a new drug, AZD5148, in 84 healthy adults to see if it is safe and how the body processes it. Participants received the drug either as a shot into a vein or muscle. The study did not aim to treat any disease, but to gather important …

This study reviewed medical records of 729 people in Japan with biliary tract cancer that could not be removed by surgery. Researchers wanted to see if bile duct problems (like blockages or infections) that required hospital care affected how long patients could stay on their fir…

This study tracked 366 people in Japan who received Evusheld to treat or prevent COVID-19. The goal was to see what side effects occurred in real-world use. The study focused on serious allergic reactions and heart problems. Results help doctors understand the drug's safety profi…

This study looked at 125 adults in Greece with high potassium levels who also had chronic kidney disease (some on dialysis) or heart failure. Researchers observed how doctors used the drug sodium zirconium cyclosilicate in everyday practice over six months. The goal was to unders…

This study looked at whether capivasertib changes how the body handles rosuvastatin, a cholesterol-lowering drug. Twenty healthy adults took rosuvastatin alone and then with capivasertib. Researchers measured drug levels in the blood to see if there is an interaction. The results…

This early-stage study tested a new drug called AZD7798 in 112 healthy volunteers and people with Crohn's disease. The main goal was to check if the drug is safe and how the body processes it. No treatment benefits were expected at this phase.

This study reviewed medical records of 204 adults in Brazil with a common type of advanced breast cancer (HR+/HER2-). Researchers wanted to see which treatments doctors used and how patients fared. No new drugs were tested; the goal was to learn from real-world practice.

This study looked at how doctors in seven Central Eastern European countries prescribe dapagliflozin for chronic kidney disease in routine care. Researchers reviewed medical records of about 1,090 adults to see who gets the drug and what happens over the next year. The goal was t…

This study tested a wearable heart monitoring patch in 54 people recovering from severe heart failure. The goal was to see if the patch could collect useful heart measurements to help design better future drug studies. Participants wore the patch at home for a few days after leav…

This study looked at how the drug AZD5004 moves through the body in people with mild, moderate, or severe liver problems compared to those with healthy livers. Thirty-three adults received a single dose to measure drug levels and safety. The goal is to guide proper dosing for pat…

This study observed 724 people with PNH, a rare blood disorder, in China to learn more about how the disease progresses and how patients respond to treatments like eculizumab. Researchers tracked symptoms, lab results, and complications such as blood clots or kidney problems. The…

This study looked at 1000 adults with a long-lasting dry cough that might be cough-variant asthma. Researchers measured a breath marker called FeNO to see if it could predict who would feel better after 8 weeks of using an asthma inhaler (budesonide-formoterol). The goal was to f…

This study tested a single dose of a new drug called AZD4076 in 40 healthy men to see if it is safe and how the body processes it. The drug is being developed for non-alcoholic steatohepatitis (NASH), a serious liver condition. Since this was a very early (Phase 1) trial in healt…

This study looked at how the drug zibotentan is processed in the bodies of 30 healthy adults, including both non-Asian and Japanese participants. Each person received a single dose of the drug, and researchers measured its levels in the blood over time. The goal was to gather inf…

This study looked at medical records and visited about 600 adults with moderate to severe systemic lupus erythematosus (SLE) to track how active their disease was over time. Researchers measured disease activity using a standard score called SLEDAI-2K. The goal was to better unde…

This study checked how many Brazilian adults with risk factors like diabetes or high blood pressure have undiagnosed chronic kidney disease (CKD). Over 8,000 people were tested with a simple finger-stick device that measures creatinine. Those with abnormal results were referred f…

This study looked at how an experimental drug called AZD0780 changes the way the body processes metformin, a standard diabetes medication. Fourteen healthy adults took both drugs in a fixed order, and researchers measured drug levels and side effects. The goal was purely to gathe…

This study looked at gene changes in 182 people with advanced lung cancer whose disease got worse after first treatment with osimertinib. Researchers collected tissue and blood samples to find out why the drug stopped working. The goal is to help doctors choose better treatments …

This study looked at how many people with severe asthma in Egypt use oral corticosteroids (OCS), a common but strong medication. Researchers collected data from 201 patients across multiple clinics to understand steroid use and asthma types. The goal was to gather information to …

This study looked at how the drug camizestrant affects another drug (midazolam) and how a common seizure drug (carbamazepine) affects camizestrant. It involved 40 healthy postmenopausal women and did not aim to treat any disease. The goal was to gather safety and interaction info…

This study looked at how two different types of inhaler propellants affect the lungs' natural ability to clear mucus and particles. It involved 35 healthy, non-smoking adults who inhaled a harmless radioactive tracer and had their lung clearance measured with a special camera. Th…

This study looked back at health records of over 91,000 adults in Spain with chronic kidney disease (CKD) to understand how the condition is managed in routine practice. Researchers tracked which treatments patients received, how often they had lab tests, and how many developed h…

This study looked at how a new drug called AZD5004 interacts with two other medications in healthy people. In one part, researchers checked if taking itraconazole (an antifungal) changes how the body processes AZD5004. In another part, they tested if AZD5004 affects the levels of…

This study reviewed medical records of over 1,100 people with a type of breast cancer called HER2-negative that had spread and stopped responding to treatment. Researchers re-tested old tumor samples to find out how many actually had a newer subtype called HER2-low. The goal was …

This study looked back at medical records of over 500 women in Gulf countries whose breast cancer had spread and was previously labeled as HER2-negative. Researchers re-checked the original tumor samples to find out how many actually had a newer subtype called HER2-low. The goal …

This early-stage study tested a new drug called AZD6793 in 93 people, mostly healthy volunteers and a few with COPD. The main goal was to check if the drug is safe and how the body processes it. Researchers gave different doses as a liquid or tablet, with and without food. This i…

This study followed 18 adults with severe asthma for at least 3 years to understand their symptoms, treatments, and daily life. Researchers collected data from medical records and monthly patient surveys. No new treatments were tested; the goal was to learn more about how severe …

This study analyzed health records from over 3,500 people with COPD who had a severe flare-up and were then treated with a medication called BGF. Researchers tracked how often patients had another flare-up or heart-related event over time. The goal was to learn more about real-wo…

This study reviewed medical records of 123 adults hospitalized with a brain bleed while taking a common type of blood thinner (factor Xa inhibitor). Researchers collected data on patient characteristics, treatments, and outcomes to better understand the problem and improve future…

This study looked back at medical records of 420 people with severe asthma in Spain who were given the drug tezepelumab after it was approved. The goal was to describe their characteristics, like age and smoking history, and track how well their asthma was controlled over time. I…

This study looked at how a single dose of the experimental drug AZD2693 is handled by the body in people with liver impairment compared to healthy volunteers. A total of 35 adults took part, receiving one injection under the skin. The main goal was to measure drug levels in the b…

This study observed 257 adults with heart failure who were prescribed dapagliflozin as part of their routine care. Researchers tracked how long patients stayed on the medication, any changes in treatment, and how their quality of life changed over time. The goal was to gather rea…

This study reviewed medical records of 342 women with advanced ovarian cancer and a BRCA gene mutation who took the drug olaparib after their first round of chemotherapy. Researchers measured how long the cancer stayed under control and how long the women lived over three years. …

This study reviewed medical records of 300 liver cancer patients in Brazil to understand their health, treatments, and survival. It did not test any new drugs or treatments. The goal was to learn more about how liver cancer is managed in real-world settings.

This study looked at how the drug AZD5462 moves through the body in people with kidney problems compared to healthy volunteers. Sixteen adults took a single dose, and researchers measured drug levels and checked for side effects. The goal was to understand how kidney function aff…

This early-stage study tested a single dose of AZD5148 in 16 healthy Japanese adults to see if it is safe and how the body processes it. Participants received the drug either as an injection into a vein or muscle, or a placebo. The goal was only to gather safety and drug-level in…

This study tested whether a new propellant (HFO) in a budesonide/albuterol inhaler delivers the same amount of medicine into the body as the current propellant (HFA). 66 healthy adults received single doses of both versions to compare drug levels and safety. The goal is to ensure…

This study tested a single dose of the drug AZD4144 in 41 adults with severe kidney disease, end-stage kidney disease, and healthy volunteers. Researchers measured how the drug moves through the body and checked for side effects. The goal was to understand how kidney problems aff…

This study tested how the drug AZD6234 moves through the body in people with different levels of kidney function, from mild to end-stage disease, compared to healthy volunteers. A total of 24 adults received a single injection of the drug. The goal was to see if kidney problems c…

This study interviewed 48 adults with HR+/HER2- metastatic breast cancer who had taken capivasertib plus fulvestrant for at least one week. Researchers wanted to learn about patients' attitudes toward the dosing schedule and any side effects that affected their ability to stay on…

This study monitored over 1,000 people with chronic kidney disease (but not on dialysis) who were taking the drug Forxiga. Researchers tracked side effects and factors that might affect safety. The goal was to gather real-world safety information, not to test if the drug works.

This early-stage study tested a new drug called AZD1163 in 108 healthy volunteers to see if it is safe and how the body processes it. Participants received either the drug or a placebo by injection or IV. The goal was to check for side effects and measure drug levels in the blood…

This study looked at 22 adults with advanced HER2-positive or HER2-low breast cancer who were taking the drug trastuzumab deruxtecan (T-DXd). Researchers wanted to see how often patients stopped treatment early or needed dose changes in everyday medical practice. The goal was to …

This study looked at how doctors in Latin America find and follow up on lung nodules (small spots in the lungs) to catch lung cancer early. Researchers tracked 562 adults with lung nodules to see how long it took to get a diagnosis and start treatment. The goal was to find gaps i…

This early-stage study tested the safety of a new drug, AZD8965, in 147 healthy adults, including Japanese and Chinese participants. Researchers gave single or multiple doses to see how the body processes the drug and whether food affects it. The goal was to gather safety informa…

This study looked at medical records of 721 Russian patients who had surgery for carpal tunnel syndrome to see how many also have a rare inherited nerve disease called hereditary transthyretin amyloidosis. The goal was to measure how common this disease is in that group. No treat…

This study tested a new drug (AZD7798) in 9 adults with Crohn's disease to see how it changes inflammation in the small intestine. Researchers used special PET scans to measure these changes. The goal was to understand how the drug works in the body, not to treat the disease dire…

This completed study looked at information from 1,000 people with lupus to understand the challenges they face. Researchers reviewed existing data, talked with doctors, and built agreement among experts on how to improve patient care. The goal was to identify gaps in diagnosis an…

This study reviewed medical records of 197 adults in Israel with severe asthma who started taking benralizumab between 2019 and 2024. Researchers looked at how many asthma attacks patients had before and during treatment. The goal was to understand real-world benefits and patient…