New hope for COPD patients: drug aims to cut severe Flare-Ups

NCT ID NCT05742802

Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested a drug called tozorakimab in over 1,700 people with COPD who had a history of flare-ups. The goal was to see if it could safely reduce severe breathing attacks over the long term. Participants who completed earlier trials were given either tozorakimab or a placebo, and researchers tracked how many severe exacerbations occurred.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: Tozorakimab
What this could lead to: If successful, tozorakimab could become a new treatment option to reduce severe COPD flare-ups and improve breathing stability.
What could go wrong: This is an extension study, so results depend on earlier trials. COPD is complex, and not all patients may benefit; long-term safety is still being checked.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

1,713 people

The number who actually took part.

Started

Mar 2023

Finished

May 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 130 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Participants who have completed the treatment period and have not been prematurely discontinued from IP in the predecessor studies. 2. Participants who received their last dose of IP in the predecessor studies within the previous 12 weeks and were not withdrawn from the predecessor study. 3. FOCBP (female(s) of childbearing potential) must have a negative urine pregnancy test at Visit 1. 4. Participants who are willing to continue using contraceptive methods as agreed to for the predecessor OBERON or TITANIA studies. 5. Capable of giving signed informed consent. Exclusion Criteria: 1. Any clinically significant disorder or abnormal findings (clinical, laboratory, instrumental, etc) or major physical and/or cognitive impairment - which, in the opinion of the Investigator, may put the participant at risk because of his/her participation in the study or impact the interpretation of the study results, or otherwise make the participation of the participant inappropriate. 2. Participant meeting criteria for IP discontinuation as judged by the Investigator or the Sponsor. 3. Concurrent enrolment in other interventional clinical studies or treatment with another IP, with the exception of the OBERON and TITANIA predecessor studies. 4. Known history of: 1. Severe allergic reaction to any monoclonal and polyclonal antibody. 2. Allergy or reaction to any component of the IP formulation. 5. Chronic use (or expected need for chronic use during the study) of immunosuppressive medications (including, but not limited to, systemic corticosteroids), marketed or investigational biologic, or another prohibited medication. 6. Involvement in the planning and/or conduct of the study (applies to both staff employed by the Sponsor and/or staff at the study site). 7. Participants who are not able to comply with the study requirements, procedures, and restrictions.

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic obstructive pulmonary disease (COPD)

Contacts and locations

Locations

Research Site

Sheffield, Alabama, 35660, United States
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Tempe, Arizona, 85283, United States
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Lincoln, California, 95648, United States
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Newport Beach, California, 92663, United States
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Northridge, California, 91324, United States
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Boynton Beach, Florida, 33435, United States
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Cape Coral, Florida, 33990, United States
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Ormond Beach, Florida, 32174, United States
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Pensacola, Florida, 32503, United States
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Plantation, Florida, 33324, United States
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Tampa, Florida, 33607, United States
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Winter Park, Florida, 32789, United States
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Evergreen Park, Illinois, 60805, United States
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Normal, Illinois, 61761, United States
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Greenwood, Indiana, 46143, United States
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Kansas City, Kansas, 66160, United States
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Bowling Green, Kentucky, 42101, United States
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Baton Rouge, Louisiana, 70836, United States
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Zachary, Louisiana, 70791, United States
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Baltimore, Maryland, 21224, United States
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White Marsh, Maryland, 21162, United States
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North Dartmouth, Massachusetts, 02747, United States
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Farmington Hills, Michigan, 48336, United States
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Grand Rapids, Michigan, 49546, United States
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Rochester, Minnesota, 55905, United States
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St Louis, Missouri, 63110, United States
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Buffalo, New York, 14203, United States
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Durham, North Carolina, 27705, United States
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Gastonia, North Carolina, 28054, United States
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Fargo, North Dakota, 58104, United States
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Toledo, Ohio, 43617, United States
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Tulsa, Oklahoma, 74133, United States
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DuBois, Pennsylvania, 15801, United States
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Philadelphia, Pennsylvania, 19140, United States
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Pittsburgh, Pennsylvania, 15213, United States
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Sayre, Pennsylvania, 18840, United States
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Rock Hill, South Carolina, 29732, United States
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Franklin, Tennessee, 37067, United States
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Amarillo, Texas, 79106, United States
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Boerne, Texas, 78006, United States
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Kingwood, Texas, 77339, United States
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McKinney, Texas, 75069, United States
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Tomball, Texas, 77375, United States
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Colchester, Vermont, 05446, United States
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Williamsburg, Virginia, 23188, United States
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Cudahy, Wisconsin, 53110, United States
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Buenos Aires, C1121 ABE, Argentina
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CABA, C1425BEN, Argentina
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Ciudad de Buenos Aires, C1414AIF, Argentina
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Córdoba, X5003DCE, Argentina
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Mar del Plata, 7600, Argentina
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Mar del Plata, B7600GWV, Argentina
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Mendoza, M5500CCG, Argentina
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Quilmes, B1878FNR, Argentina
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San Fernando, B1646EBJ, Argentina
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San Juan Bautista, 1888, Argentina
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San Miguel de Tucumán, T4000IAR, Argentina
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Campbelltown, 2560, Australia
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Frankstown, 3199, Australia
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Macquarie University, 2109, Australia
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Melbourne, 3000, Australia
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Nedlands, 6009, Australia
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Southport, 4215, Australia
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Spearwood, 6163, Australia
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Wollongong, 2500, Australia
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Woodville South, 5011, Australia
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Brussels, 1000, Belgium
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Ghent, 9000, Belgium
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Leuven, 3000, Belgium
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Liège, 4000, Belgium
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Namur, 5101, Belgium
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Blumenau, 89030-101, Brazil
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Botucatu, 18618-686, Brazil
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Brasília, 71681-603, Brazil
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Curitiba, 80440-220, Brazil
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Porto Alegre, 90035074, Brazil
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Porto Alegre, 9061-000, Brazil
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Porto Alegre, 91010-006, Brazil
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Rio de Janeiro, 22061-080, Brazil
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São Bernardo do Campo, 09750-420, Brazil
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São Paulo, 01409-001, Brazil
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São Paulo, 05403-000, Brazil
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Dupnitsa, 2600, Bulgaria
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Kozloduy, 3320, Bulgaria
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Lovech, 5500, Bulgaria
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Petrich, 2850, Bulgaria
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Pleven, 5800, Bulgaria
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Rousse, 7002, Bulgaria
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Sliven, 8800, Bulgaria
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Sofia, 1000, Bulgaria
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Sofia, 1606, Bulgaria
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Vratsa, 3000, Bulgaria
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Edmonton, Alberta, T5A 4L8, Canada
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Sherwood Park, Alberta, T8L 0N2, Canada
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Ajax, Ontario, L1S 2J5, Canada
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Guelph, Ontario, N1H 6J2, Canada
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Winchester, Ontario, K0C 2K0, Canada
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Montreal, Quebec, H3T 1E2, Canada
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Québec, Quebec, G1G 5X1, Canada
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Québec, Quebec, G1V 4G5, Canada
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Chile, 7770484, Chile
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Curicó, 3341643, Chile
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Santiago, 7500010, Chile
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Santiago, 7500698, Chile
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Santiago, 8150000, Chile
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Talca, 3465584, Chile
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Baotou, 14010, China
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Beijing, 100057, China
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Beijing, 100144, China
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Changchun, 130021, China
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Changsha, 410015, China
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Chengdu, 610000, China
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Chengdu, 610014, China
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Chongqing, 400013, China
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Chongqing, 400037, China
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Guangzhou, 510120, China
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Guangzhou, 510180, China
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Haikou, 570311, China
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Hangzhou, 310006, China
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Hohhot, 010010, China
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Kunming, 650032, China
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Linhai, 317000, China
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Nanchang, 330006, China
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Nanjing, 210006, China
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Ningbo, 315010, China
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Shanghai, 200002, China
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Shanghai, 201199, China
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Shenyang, 110000, China
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Shenyang, 110004, China
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Shenzhen, 518020, China
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Shenzhen, 518053, China
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Shijiazhuang, 50051, China
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Suzhou, 215002, China
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Taiyuan, 030001, China
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Wuhan, 430022, China
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Wuxi, 214023, China
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Xiamen, 361004, China
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Xuzhou, 221000, China
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Xuzhou, 221009, China
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Yangzhou, 225001, China
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Yinchuan, 750004, China
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Zhanjiang, 524004, China
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Zunyi, 563100, China
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Barranquilla, 80007, Colombia
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Ibague, 730006, Colombia
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Rionegro, 054047, Colombia
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Zipaquirá, 200251, Colombia
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Brno, 625 00, Czechia
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Jindřichův Hradec, 377 01, Czechia
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Liberec, 460 63, Czechia
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Olomouc, 779 00, Czechia
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Rokycany, 337 01, Czechia
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Aalborg, 9000, Denmark
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Copenhagen, 2400, Denmark
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Hvidovre, 2650, Denmark
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Næstved, 4700, Denmark
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Roskilde, 4000, Denmark
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Vejle, 7100, Denmark
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Hämeenlinna, 13530, Finland
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Helsinki, 00290, Finland
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Kuopio, 70210, Finland
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Turku, 20520, Finland
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Bordeaux, 33076, France
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Brest, 29609, France
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La Tronche, 38700, France
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Lyon, 69317, France
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Marseille, 13326, France
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Montpellier, 34295, France
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Nantes, 44093, France
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Toulouse, 31300, France
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Ahrensburg, 22926, Germany
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Bamberg, 96049, Germany
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Berlin, 10717, Germany
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Berlin, 12157, Germany
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Cologne, 51069, Germany
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Darmstadt, 64283, Germany
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Halle, 06108, Germany
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Marburg, 35037, Germany
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Peine, 31224, Germany
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Alexandroupoli, 68100, Greece
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Athens, 11527, Greece
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Exohi Thessaloniki, 57010, Greece
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Ioannina, 45500, Greece
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Pátrai, 26500, Greece
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Thessaloniki, 57010, Greece
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Budapest, 1036, Hungary
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Debrecen, 4032, Hungary
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Edelény, 3780, Hungary
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Encs, 3860, Hungary
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Mosonmagyaróvár, 9200, Hungary
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Nyíregyháza-Sóstóhegy, 4481, Hungary
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Százhalombatta, 2440, Hungary
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Belagavi, 590010, India
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Coimbatore, 641028, India
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Dehradun, 248001, India
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Jaipur, 302039, India
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Nagpur, 440012, India
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Nashik, 422007, India
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New Delhi, 110029, India
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Thane, 401107, India
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Ashkelon, 78278, Israel
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Beersheba, 8410101, Israel
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Jerusalem, 9103102, Israel
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Kfar Saba, 4428164, Israel
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Rehovot, 76100, Israel
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Tel Aviv, 6423906, Israel
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Bari, 70124, Italy
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Carrara, 54033, Italy
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Milan, 20142, Italy
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Milan, 20154, Italy
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Naples, 80131, Italy
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Roma, 00168, Italy
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Salerno, 84131, Italy
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Sassari, 07100, Italy
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Statte, 74010, Italy
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Telese Terme, 82037, Italy
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Tradate, 21049, Italy
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Vercelli, 13100, Italy
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Verona, 37134, Italy
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Asahikawa-shi, 078-8510, Japan
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Fujieda-shi, 426-8677, Japan
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Fukuoka, 819-8555, Japan
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Hamamatsu, 430-8525, Japan
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Hiroshima, 734-8530, Japan
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Iizuka-shi, 820-8505, Japan
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Itabashi-ku, 173-8610, Japan
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Iwata-shi, 438-8550, Japan
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Kanazawa, 920-8650, Japan
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Kawachinagano-shi, 586-8521, Japan
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Kobe, 651-0072, Japan
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Matsusaka-shi, 515-8544, Japan
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Mizunami-shi, 509-6134, Japan
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Nagoya, 460-0001, Japan
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Obihiro, 080-0017, Japan
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Okayama, 700-8558, Japan
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Osaka, 531-0073, Japan
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Osaka, 543-8555, Japan
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Osaka, 545-8586, Japan
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Shinjuku-ku, 162-8655, Japan
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Shizuoka, 420-8630, Japan
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Toshima-ku, 170-0003, Japan
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Toyonaka-shi, 560-8552, Japan
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Yokohama, 221-0855, Japan
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Yokohama, 223-0059, Japan
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Yokohama, 232-0024, Japan
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Benito Juárez, 03650, Mexico
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Chihuahua City, 31000, Mexico
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Guadalajara, 44100, Mexico
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Guadalajara, 44200, Mexico
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México, 01710, Mexico
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Monterrey, 64460, Mexico
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Morelia, 58000, Mexico
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Oaxaca City, 68020, Mexico
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Veracruz, 91910, Mexico
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Eindhoven, 5623EJ, Netherlands
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Groningen, 9713 GZ, Netherlands
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Harderwijk, 3844 DG, Netherlands
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Heerlen, 6419 PC, Netherlands
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Zutphen, 7207 AE, Netherlands
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Lørenskog, 1478, Norway
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Oslo, 450, Norway
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Tønsberg, 3103, Norway
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Lima, 15036, Peru
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Lima, 15046, Peru
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Lima, 15088, Peru
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Lima, LIMA 21, Peru
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Baguio City, 2600, Philippines
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Cebu City, 6000, Philippines
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Iloilo City, 5000, Philippines
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Bialystok, 15-044, Poland
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Bydgoszcz, 85-796, Poland
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Katowice, 40-648, Poland
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Krakow, 30-033, Poland
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Lublin, 20-412, Poland
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Ostrowiec Świętokrzyski, 27-400, Poland
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Ostróda, 14-100, Poland
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Poznan, 60-693, Poland
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Rzeszów, 35-205, Poland
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Sosnowiec, 41-208, Poland
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Wroclaw, 53-301, Poland
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Guimarães, 4835-235, Portugal
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Lisbon, 1649-035, Portugal
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Lisbon, 1998-018, Portugal
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Matosinhos Municipality, 4454-509, Portugal
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Vila Franca de Xira, 2600-009, Portugal
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Brasov, 500283, Romania
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Bucharest, 050159, Romania
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Cluj-Napoca, 400371, Romania
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Timișoara, 300002, Romania
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Daegu, 42415, South Korea
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Incheon, 21431, South Korea
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Jeonju, 54907, South Korea
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Seoul, 05030, South Korea
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Seoul, 06591, South Korea
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Seoul, 07061, South Korea
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Galdakao, 48960, Spain
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Madrid, 28040, Spain
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Málaga, 29010, Spain
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Mérida, 06800, Spain
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Pozuelo de Alarcón, 28223, Spain
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Santander, 39008, Spain
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Valencia, 46010, Spain
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Zaragoza, 50009, Spain
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Gothenburg, 413 46, Sweden
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Gothenburg, 41345, Sweden
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Lund, 222 22, Sweden
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Stockholm, 11239, Sweden
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Hsinchu, 300, Taiwan
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Kaohsiung City, 80756, Taiwan
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Taichung, 40447, Taiwan
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Taichung, 40705, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 110, Taiwan
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Taoyuan, 333, Taiwan
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Yunlin, 640, Taiwan
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Bang Kra So, 11000, Thailand
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Hat Yai, 90110, Thailand
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Khon Kaen, 40002, Thailand
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Muang,, 55000, Thailand
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Muang, 22000, Thailand
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Mueang, 20000, Thailand
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Nakhon Ratchasima, 30000, Thailand
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Ankara, 06620, Turkey (Türkiye)
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Istanbul, 34854, Turkey (Türkiye)
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Mersin, 33343, Turkey (Türkiye)
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Bradford, BD9 6RJ, United Kingdom
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Corby, NN17 2UR, United Kingdom
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Corby, NN18 9EZ, United Kingdom
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High Wycombe, HP11 2QW, United Kingdom
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Northwood, HA6 2RN, United Kingdom
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Preston, PR2 9QB, United Kingdom
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Shipley, BD18 3SA, United Kingdom
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Hanoi, 100000, Vietnam
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Hanoi, 10000, Vietnam
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Ho Chi Minh City, 700000, Vietnam

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