CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

This study tests whether using air cleaners at home can lower the risk of COPD flare-ups and improve quality of life. About 770 adults with COPD will use either a real or sham air cleaner for several months. Researchers will track breathing problems, medication use, and daily fun…

This study tests whether adding umbilical cord stem cells to standard care can improve lung function and quality of life for people with severe COPD. Twenty adults aged 40-75 who are already on triple inhaler therapy will receive either stem cells or a placebo intravenously. Rese…

This study tests an experimental drug called tezepelumab in 990 adults with moderate to very severe COPD. The goal is to see if it can reduce the number of serious flare-ups (exacerbations) compared to a placebo over 76 weeks. Participants must be 40-80 years old, have had at lea…

This study tests an investigational drug called tezepelumab in adults with moderate to very severe COPD. The goal is to see if it can reduce the number of moderate or severe flare-ups (exacerbations) compared to a placebo. About 990 participants will receive either tezepelumab or…

This study tests three different doses of an experimental tablet called AZD6793 against a placebo in 1160 adults with moderate to very severe COPD. The main goal is to see if the drug can reduce the number of moderate or severe COPD flare-ups over 24 weeks. Participants must be a…

This study tests an experimental drug called 9MW1911 in 360 adults with moderate-to-severe COPD who have had at least two flare-ups in the past year. The goal is to see if the drug can reduce the number of serious breathing attacks over 52 weeks compared to a placebo. Participant…

This early-stage study tests a new cell therapy called REGEND007 for people with chronic obstructive pulmonary disease (COPD). The treatment uses special airway stem cells given through an IV to try to repair lung tissue. The study will include 12 adults aged 40-80 and will focus…

This study tracks 350 adults with uncontrolled COPD who are starting dupilumab, a medication that helps control inflammation. Over 24 months, researchers will measure changes in quality of life and monitor for side effects. The goal is to see how well dupilumab works in everyday …

This study tests if omalizumab, an allergy drug, can reduce serious breathing flare-ups in people with COPD who also have allergies. About 334 adults over 40 who smoke or used to smoke will receive the drug or a placebo for 12 months. The goal is to see if the drug helps control …

This study tests a new treatment using special stem cells from fetal tissue to help people with moderate to severe COPD. The goal is to see if it is safe and can improve lung function and control severe symptoms. About 30 adults aged 40-80 who have not responded well to standard …

This study compares two common steroids, hydrocortisone and prednisolone, to treat sudden worsening of COPD (a lung disease). About 2,000 adults over 40 will be randomly assigned one of the two drugs. The goal is to see which one better prevents hospital readmission or death with…

This study tests a new program called Mindful-Breath for people with COPD. It combines mindfulness, exercise training, and lifestyle advice, delivered in group sessions and via chat. The goal is to see if this approach is practical and helps reduce stress and increase physical ac…

This study looks at two ways to manage sedation in COPD patients who need a breathing machine (ventilator). One group gets no sedation at all, while the other has their sedation paused every day. The goal is to see which approach helps patients spend more days off the ventilator …

This study tests a special arm exercise using light weights and blood flow cuffs (low-load blood flow restriction training) in people with moderate COPD. The goal is to see if it improves arm strength, daily activities, and quality of life better than a fake version of the same e…

This study tests whether a lung rehab program can help people with COPD who live in rural areas. Researchers want to see if it improves quality of life and reduces shortness of breath. About 306 adults aged 40 and older with COPD will take part. The program is designed to bring a…

This early-stage study tests a new drug, BBT002, in healthy people and those with COPD to see if it is safe and how the body handles it. About 68 participants will receive either the drug or a placebo. The main goal is to check for side effects, not yet to prove it works.

This study looks at how common frailty is in older adults with COPD and tests whether the Vivifrail exercise program can improve their physical abilities, daily living skills, and quality of life. About 80 participants aged 60 and older with stable COPD will take part. The progra…

This study tests whether a device that uses gentle pressure changes to clear mucus and trapped air from the lungs can reduce shortness of breath after walking in people with COPD. About 33 adults with moderate to very severe COPD who have completed pulmonary rehab will use the ac…

This study looks at whether a structured walking and resistance band exercise program can help people with COPD feel less anxious and depressed, breathe easier, and sleep better. About 68 adults with COPD will either do the exercise program plus standard care or just standard car…

This study looks at whether treating a common stomach infection called H. pylori can improve symptoms and lung function in people with COPD. Researchers will give H. pylori treatment to 54 adults with both COPD and H. pylori infection, then measure changes in their breathing test…

This study tests whether breathing in nitric oxide for one week can help people with moderate-to-severe COPD exercise longer and with less effort. Sixteen adults aged 40-75 who have smoked heavily in the past will take part. The goal is to see if this treatment is safe and improv…

This study looks at how different frequencies of whole body vibration affect lung function, breathing, arm strength, flexibility, heart health, and quality of life. It includes both healthy adults and people with moderate to severe COPD. The goal is to find the best vibration dos…

This study looks back at medical records of 1000 people with COPD who had a special heart test. The goal is to learn more about a condition called pulmonary hypertension, where blood vessels in the lungs are under high pressure. By studying these records, researchers hope to bett…

This study looks at how people with chronic lung diseases like COPD and asthma experience shortness of breath. Some feel severe distress with mild breathing problems, while others notice little even when lung function is poor. Researchers will group participants based on this per…

This study explores how the brain processes chronic breathlessness in people with advanced cancer, COPD, or heart failure. Researchers will use brain scans (fMRI) and virtual reality to see if different diseases cause different breathlessness patterns. The goal is to learn if cur…

This study collects blood, airway, and urine samples from up to 2,000 healthy volunteers and people with lung diseases like COPD and pulmonary fibrosis. The goal is to establish normal ranges and learn how gene changes in airway cells may lead to disease. Participants must be 18 …

This study compares a new type of hospital care, called an Acute Medical Unit, to standard hospital care for older adults with sudden medical illnesses like infections or falls. Researchers want to see if this model reduces time spent in the hospital, improves quality of life, an…

This study tests whether a wrist-worn device that counts coughs can help predict serious COPD flare-ups before they happen. Fifty adults with COPD will wear the device and answer weekly symptom questions. The study is observational, meaning it does not change the care participant…

This study is testing a digital lifestyle platform designed to help patients with COPD, heart disease, fractures, or minor stroke maintain healthy habits after leaving inpatient rehabilitation. About 240 adults will use the platform, which offers personalized tips, educational co…

This study looks at how mucus buildup in the airways affects people with asthma, COPD, and chronic cough. Researchers will use CT scans and breathing tests to compare 240 adults and 50 children with these conditions to healthy volunteers. The goal is to find patterns and markers …

This study looks at how well people with COPD, a less-known lung condition called PRISM, and healthy adults can exercise, how strong their muscles are, and how their blood vessels work. Researchers will also measure daily activity and quality of life. The goal is to better unders…

This study looks at how different kinds of social support—like emotional help, practical assistance, and companionship—affect the ability of people with COPD to manage their own health. Researchers will survey about 111 adults with COPD and interview 20 of them to understand what…

This study follows about 500 adults with uncontrolled COPD who are taking dupilumab as part of their regular care. Researchers will collect information on their health, symptoms, and any side effects over 36 months. The goal is to better understand the types of patients using thi…

This study tracks 50 COPD patients who have been hospitalized for a sudden worsening of their condition (called an acute exacerbation). Participants wear a device that monitors oxygen levels, breathing rate, pulse, activity, sleep, and skin temperature for three months after leav…

This study is observing 10,000 adults aged 40-80 with COPD to learn how combining Western and traditional Chinese medicine can help manage the disease and its related health problems. Researchers will track symptoms, use digital monitors, and analyze risk factors to improve long-…

People with serious mental illness often have undiagnosed physical problems like heart disease, diabetes, or cancer. This study adds routine health checkups to psychiatric clinics to see if they catch these hidden conditions better than usual care. About 2,800 adults with psychot…

This study looks at 100 COPD patients on breathing machines to see if a new ultrasound-based breathing test (D-RSBI) is better than the standard test (RSBI) at predicting when they can safely breathe on their own. Researchers will measure the diaphragm during a breathing trial an…

This study looks at why many people with COPD and asthma do not use their inhalers correctly, and tests new ways to help them stick to their treatment. Researchers will work with 1,000 patients and their healthcare providers to measure adherence and improve inhalation techniques …

This study looks at how the immune system influences disease control in people with inflammatory airway diseases like asthma, COPD, and bronchiectasis. Researchers will analyze blood and sputum samples from 200 participants and compare them with healthy volunteers. The goal is to…

This study looks at whether giving extra oxygen during a 6-minute walk test helps people with chronic lung disease walk farther and feel better. About 114 adults with conditions like COPD or interstitial lung disease will do two walking tests—one with their usual oxygen and one w…

This study will collect information from about 500 adults in Moscow who have moderate to very severe COPD and have had frequent flare-ups. Researchers will look at their medical records and ask them questions to understand their age, lifestyle, treatments, and other health proble…

This study is observing 900 adults in Greece who have both chronic lung disease (COPD) and heart problems. Researchers will track their health, including lung flare-ups and heart complications, over two years. The goal is to better understand these patients and how they use healt…

This study is testing a wearable system called WearME to see if it can accurately measure breathing and activity in people with COPD. Researchers will compare the device's readings to standard lung function tests. The goal is to find a simpler way to monitor COPD at home. The stu…

This study looks at how taking multiple medications affects the health of elderly people with chronic diseases like heart disease, diabetes, and high blood pressure. Researchers will survey 2000 patients aged 65 and older in Shaanxi Province, China, over two years. The goal is to…