CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

This study tests whether adding the drug dupilumab to standard COPD treatment can prevent another serious flare-up after a hospital stay. About 754 adults with COPD who have high levels of certain white blood cells will receive either dupilumab or a placebo for around 90 days. Th…

This study looks at whether adding Guben Kechuan Granules to standard care helps people with COPD recover faster after a serious flare-up. The trial will involve 126 adults aged 40-75 who are about to leave the hospital. Researchers will measure lung function, breathing difficult…

This study looks at how a once-daily triple inhaler (fluticasone furoate, umeclidinium, and vilanterol) affects lung function in adults with COPD. About 60 participants aged 50-85 will take the inhaler daily for 12 weeks (with an optional extension to 48 weeks) and undergo specia…

This study tests an experimental injection called JKN2401 in 888 adults with moderate-to-severe COPD. The goal is to see if it can safely reduce the number of serious breathing flare-ups compared to a placebo. Participants will continue their usual COPD medications during the tri…

This study will track 600 Korean adults with COPD who are starting the medication Breztri. Researchers want to see how safe the drug is in everyday use and whether it helps improve breathing. Participants will be followed for up to 24 weeks to record any side effects and measure …

This study explores whether a single-lead electrocardiogram (ECG) combined with machine learning can help screen for pulmonary embolism (a blood clot in the lungs). Researchers will enroll 500 adults who need testing for this condition. They will record a 1-minute ECG and analyze…

This study looks at whether metformin, a drug used for diabetes, is safe and tolerable for older adults (65+) with COPD who do not have diabetes. Researchers will also check if metformin changes blood markers linked to aging. The goal is to see if this approach could help manage …

This study looks at whether different ways of doing pursed-lip breathing can help people with COPD breathe easier. About 122 adults aged 40 and older with stable COPD will try one of three breathing ratios (1:3, 1:4, or 1:5) for 10 minutes, or receive standard care. Researchers w…

This pilot study tests whether a pharmacist-led program can help adults aged 45 and older who have COPD and at least one other chronic condition. Participants will receive inhaler training and medication advice to improve safety and reduce shortness of breath. The study focuses o…

This study tests whether special 'active' sports shoes can help people with severe COPD walk farther during a six-minute walk test. Researchers will compare walking distance in the special shoes versus regular shoes in 75 hospitalized patients. If the shoes improve performance, t…

This study looks at whether a structured program led by physiotherapists can help people with COPD use their inhalers correctly. Many patients make mistakes that prevent the medicine from reaching their lungs, leading to worse symptoms and more flare-ups. Over 12 months, 116 part…

This study tests whether a structured training program on energy conservation techniques can help people with COPD manage fatigue and breathlessness during daily activities like bathing and dressing. Researchers will compare the training group to a control group, measuring change…

This study looks at whether a special breathing exercise (threshold inspiratory muscle training) can make the diaphragm thicker and move better in people with stable COPD. Fifteen adults aged 40-59 with moderate COPD will do the training, and doctors will use ultrasound to measur…

This study tests whether teaching people with COPD using a fast-paced presentation style (Pecha Kucha) can help them feel more confident managing their condition, reduce symptoms like breathlessness, and improve their ability to do daily activities. Sixty adults with COPD who use…

This study looks at how breathing in wildfire smoke can harm your lungs and brain over time. Researchers will expose 24 healthy adults to different amounts of smoke in a safe setting to measure changes in breathing and thinking. The goal is to find out who is most at risk and how…

This study is testing a wearable patch called WearME-Pro that aims to monitor lung function in adults with COPD while they go about their daily lives at home. About 82 participants will use the patch and a mobile app for up to 10 months, and their results will be compared to a st…

This study will test a small, handheld ultrasonic spirometer against the standard hospital spirometer in 100 adults with chronic lung diseases like COPD or asthma. Participants will take lung function tests with both devices to see if the portable one gives accurate and reliable …

This study looks at whether a simple breath test, called FeNO, can help predict when people with COPD will have a flare-up. Researchers will follow 120 adults with COPD who are already using a triple inhaler. The goal is to see if FeNO levels can forecast future lung problems and…