CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

This study tested two doses of a drug called tozorakimab in over 1,100 adults with COPD who had frequent or severe flare-ups. Participants continued their usual inhaled treatments. The goal was to see if the drug could safely reduce the number of moderate to severe COPD attacks o…

This study compared two different triple-combination inhalers (BGF and FUV) in 22 adults with stable COPD. The goal was to see if one works better for small airway disease. Participants used each inhaler for a period and had their lung function tested. The study is complete and p…

This study tested a new inhaled medicine called HL231 in 487 Chinese adults with moderate to very severe COPD. The goal was to see if HL231 works better than an existing treatment (Ultibro) at improving lung function and reducing flare-ups over 26 to 52 weeks. Participants inhale…

This study tested a new version of a triple-combination inhaler (budesonide, glycopyrronium, and formoterol) for people with moderate to very severe COPD. The goal was to see if the new inhaler design is as safe as the current one. 559 adults aged 40 to 80 took part, using the in…

This study tested a bacterial vaccine spray (MV130) taken daily under the tongue for 12 months in 198 adults with moderate to severe COPD. The goal was to see if it could reduce the number and severity of lung flare-ups compared to a placebo. Researchers also monitored safety and…

This study tested two ways to help COPD patients who have trouble breathing due to high carbon dioxide levels. One method uses a high-speed nasal device, and the other uses a mask with a machine. The goal was to see if the nasal device works as well as the mask. The study include…

This study tested two doses of a drug called tozorakimab in over 1,100 adults with COPD who had frequent flare-ups. Participants were former or current smokers already on standard inhalers. The goal was to see if the drug could safely reduce the number of moderate to severe COPD …

This study followed 10 adults with moderate to severe COPD in Romania who were starting a new inhaler called TRIXEO AEROSPHERE. Researchers wanted to see how patients felt about their health and treatment over 3 to 6 months. The goal was to understand real-world benefits, not to …

This study looked at whether a four-week program of breathing exercises, aerobic exercise, or both could improve lung strength, walking ability, and well-being in women with stable COPD. 68 women took part and were split into five groups, including a placebo and a usual-care grou…

This study looked at two different breathing exercises for people with COPD, a long-term lung disease that makes it hard to breathe and causes a lot of mucus. The goal was to see which method—oscillating positive expiratory pressure (OPEP) therapy or autogenic drainage—works bett…

This study tested a new automatic feature on a breathing machine (ventilator) to see if it could better manage airway blockages during sleep. 23 adults with conditions like sleep apnea, COPD, or obesity-related breathing problems took part. The goal was to see if the automatic se…

This study looked at whether adding the 4-7-8 breathing technique to usual care can help people with mild-to-moderate COPD feel less short of breath, improve lung function, and boost quality of life. Forty adults aged 40-64 took part. The approach is simple and drug-free, aiming …

This study tested whether L-menthol, a mint-flavored compound, can reduce shortness of breath and improve exercise ability in people with COPD. Twenty adults with COPD cycled under different conditions to measure their breathing and performance. The goal was to see if L-menthol c…

This study looked at how doing a mental task (like counting backwards) affects balance in people with chronic lung disease (COPD). 36 adults (COPD patients and healthy volunteers) had their balance measured while standing still and while thinking. The goal was to see if the extra…

This study looked at how two different breathing exercises affect muscle oxygen levels in 24 people with COPD. Participants did both a traditional and a functional breathing exercise on separate days, then walked for 2 minutes. Researchers measured muscle oxygen, shortness of bre…

This study looked at 123 adults with COPD or asthma to see if doctors can estimate breathing muscle strength using easy-to-get measurements like peak airflow and body composition. Participants did breathing tests and a fixed-pressure exercise until they got tired. The goal was to…

This study looked at how breathing and swallowing interact in 16 people with severe COPD who were in the hospital for a sudden worsening of their condition. Researchers wanted to see if using a non-invasive breathing mask (NIV) changes this interaction. The goal was to better und…

This study looked at how COPD affects blood vessels in the lungs using MRI scans. Researchers measured blood flow in the lungs of 30 COPD patients at rest and after exercise. The goal was to better understand how the disease progresses and how it might be treated in the future.

This study looked back at the medical records of 718 adults with COPD in Spain who started taking the triple-combination inhaler Trixeo. Researchers wanted to see how many lung flare-ups (exacerbations) patients had in the year after starting the drug. The goal was to understand …

This completed study tested a new device that collects fluid from the nose to find biological markers for respiratory diseases like COPD, asthma, hayfever, and sinusitis. Researchers compared 111 adults—both healthy volunteers and those with these conditions—to see if nasal bioma…

This study in 30 healthy adults aims to see if cyclosporine changes how the body absorbs CHF6001, a potential COPD treatment. Participants take CHF6001 alone first, then with cyclosporine, and blood samples are compared. The goal is to understand drug interactions, not to treat a…

This study looked at how well people with COPD can control the force of their knee muscles. Researchers compared 36 participants (COPD patients and healthy volunteers) while they performed precise muscle tasks. The goal was to understand if COPD causes problems with fine muscle c…

This study looked at how over 1600 people's bodies reacted to different types of breakfasts, like whole grain vs. refined grain and high-fat vs. high-carb. The goal was to understand why people respond differently to the same foods, based on factors like their gut bacteria and he…

This completed study looked at how low fat-free mass (muscle) affects the outlook for people with COPD. Researchers evaluated 90 adults using breathing tests, a 6-minute walk test, and chest CT scans. The goal was to understand if muscle loss is linked to worse disease progressio…

This study looked at how well people with COPD can learn to use different inhaler devices. Researchers checked for mistakes in using the inhalers and measured how long it took to take the medicine. The goal was to understand common errors, not to test a new drug or cure.