Lung cancer drug interaction study: what happens when you add a statin?

NCT ID NCT02197234

Completed Knowledge-focused Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Nov 20, 2025 · Last updated May 23, 2026 · Updated 20 times

Summary

This study looked at how the lung cancer drug AZD9291 (osimertinib) changes the way the body processes simvastatin, a common cholesterol medicine. It involved 52 adults with a specific type of advanced lung cancer (EGFR mutation-positive) whose disease had worsened after previous targeted therapy. The goal was to measure drug levels in the blood to understand potential interactions, not to test the cancer treatment itself.

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Contacts and locations

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Locations

Research Site

Atlanta, Georgia, 30322, United States
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Leuven, 3000, Belgium
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Angers, 49055, France
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Dijon, 21079, France
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Marseille, 13385, France
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Rennes, 35033, France
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Saint-Herblain, 44805, France
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Seongnam-si, 13620, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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Seoul, 06351, South Korea
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Badalona, 08916, Spain
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Barcelona, 08041, Spain
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Madrid, 28046, Spain
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Seville, 41013, Spain

Conditions

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NON-SMALL CELL LUNG CANCER NON-SMALL CELL LUNG CANCER