New cancer Drug's hidden impact on cough medicine revealed

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Main Inclusion Criteria: * Have a Body Mass Index (BMI) between 18 and 30 kg/m2 inclusive and weigh at least 50 kg. * All females must have a negative pregnancy test at the Screening Visit and on admission to the Clinical Unit. * Females of non-childbearing potential must be confirmed at the screening visit (postmenopausal or documentation of irreversible surgical sterilisation). * Male participants must have documentation of vasectomy done 6 months prior to screening visit. Participants must be willing to use one barrier method of contraception (condom) during sexual intercourse with a female partner of childbearing potential from the time of first study intervention administration until 16 weeks after the last dose of capivasertib. Main Exclusion Criteria: * History of any clinically important disease or disorder * History or presence of gastrointestinal, hepatic or renal disease. * Any clinically important illness, medical/surgical procedure (excluding placement of vascular access), or significant traumatic injury within 4 weeks of the first administration of study intervention or an anticipated need for major surgery during the study. * Any clinically significant skin abnormalities that are chronic or currently active. * Abnormal hepato-renal and bone marrow organ function laboratory values. * Any clinically important abnormalities in clinical chemistry, haematology, or urinalysis. * Any clinically significant abnormalities in glucose metabolism. * Any positive result on screening for serum HBsAg OR anti-HBc antibody, indicative of active hepatitis B, hepatitis C, or human immunodeficiency virus (HIV) * Current smokers or those who have smoked or used other nicotine/nicotine-containing products within the previous 3 months prior to Screening Visit. * Known or suspected history of alcohol or drug abuse or excessive intake of alcohol. * Use of drugs with enzyme inducing properties 3 weeks prior to the first administration of study intervention. * Use of strong inhibitors of Cytochrome P450 3A4 (CYP3A4) or strong/moderate inducers of CYP3A4 within 2 weeks prior to first dose of capivasertib. * Concurrent use of herbal or natural products intended as treatment or prophylaxis that may interact with capivasertib. * Participants who have previously received capivasertib. * Any clinically significant abnormal findings in vital signs and 12-lead electrocardiogram (ECG). * History of severe allergy/hypersensitivity