Liver impairment study tests drug processing in 33 volunteers

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: For ALL participants: * Adults 18-80 years of age * Weight ≥50kg and BMI between ≥18 to ≤40 kg/m2 For participants with normal hepatic function: * Participant must be stable on a concomitant medication and/or treatment regimen for at least 2 weeks prior to screening For Healthy Controls: -Participant must be medically healthy with no significant findings on medical evaluation at screening to include but not limited to an eGFR \>90 ml/min/1.73 m2 For participants with hepatic impairment: * Group 1 (mild) must have an Child-Pugh score of 5 or 6, Group 2 (moderate) must have a Child-Pugh score of 7 to 9, Group 3 (severe) must have a Child-Pugh score of 10 to 15. * Participant must have a diagnosis of chronic (≥ 6 months) and stable hepatic impairment (eg, no clinically significant change in signs, symptoms, or laboratory parameters of hepatic disease status within 30 days prior to study screening Exclusion Criteria: For ALL participants: * Poorly controlled diabetes mellitus (A1C \>10% at screening). * Unwillingness to use adequate contraception * Uncontrolled hypertension or hypotension * Presence of unstable systemic disease or psychologic conditions. * Any clinically significant abnormalities in rhythm, conduction, or morphology of the resting ECG and any clinically important abnormalities in the 12-lead ECG. Specific For Healthy Controls: -Positive screening for HIV, Hepatitis B, or Hepatitis C - -Any clinically significant disease or disorder to include but not limited to acute or chronic liver disease Specific For Hepatically Impaired Participants: * eGFR \<60 ml/min/1.73 m2 * Fluctuating or rapidly deteriorating hepatic function, as indicated by strongly varying or worsening of clinical and/or laboratory signs of hepatic impairment to include rising LFTs, paracentesis at less than 4 week intervals, oesophageal banding within the last 3 months, or treatment for GI bleeding within the last 6 months * Presence of a hepatocellular carcinoma or acute liver disease caused by an infection or drug toxicity.