HEPATIC IMPAIRMENT

This study looks at how the body processes a drug called MK-1084 when the liver is not working normally. Researchers will give a single dose to people with liver impairment and to healthy volunteers, then measure drug levels in the blood over time. The goal is to understand if li…

This study looks at how a single dose of the experimental drug BI 1291583 enters the blood in people with and without liver problems. The drug is being developed for bronchiectasis, a chronic lung disease. About 32 adults aged 18–80 will take one tablet and be monitored for about…

This study looks at how mild or moderate liver problems change the way the body handles a single dose of the drug tasurgratinib. Researchers will compare 18 adults with stable liver impairment to healthy volunteers matched by age, weight, race, and gender. The goal is to understa…

This study looks at how a single dose of the experimental drug combination bemnifosbuvir/ruzasvir behaves in people with severe kidney or liver problems compared to healthy people. About 28 adults will take one dose and have their blood tested to measure drug levels and safety. T…

This early-stage study looks at how the body processes the drug Saroglitazar in people with mild, moderate, or severe liver cirrhosis caused by cholestatic liver disease. About 30 adults aged 18 to 80 will take the drug once daily for 28 days. The goal is to measure drug levels i…

This study looks at how the liver affects two experimental drugs, AZD9550 and AZD6234. Researchers will give a single dose to 28 adults with different levels of liver function (normal, moderate, or severe impairment) to see how the drugs move through the body and if they are safe…

This study looks at how a medicine called BI 3000202 behaves in the body of people with and without liver problems. About 44 adults aged 18 to 80 will take one tablet and have their blood tested over a month. The goal is to understand if liver impairment changes how the drug work…

This study looks at how the drug quizartinib moves through the body in people with severe liver impairment compared to healthy volunteers. About 12 adults aged 18 to 75 will receive a single dose, and researchers will measure drug levels and check for side effects. The goal is to…

This study looks at how the body handles a single dose of the drug inavolisib in people with moderate or severe liver problems compared to healthy people. About 32 adults will take part to measure drug levels and safety. The goal is to understand if liver impairment changes how t…

This study looks at how the liver processes a new medicine called PF-07328948. Researchers want to see if people with different levels of liver function handle the drug differently. About 26 adults, some with liver problems and some healthy, will take a single tablet and stay at …

This study looks at how the body processes a single dose of radiprodil in adults with mild, moderate, or severe liver problems compared to healthy adults. About 40 participants aged 18 to 75 will receive one 15 mg pill and be monitored for about 6 days. The goal is to see if live…

This study looks at how the drug mirdametinib is absorbed and removed from the body in people with moderate or severe liver problems compared to those with healthy livers. It involves 32 adults aged 18 to 80. The goal is to gather information, not to treat any condition.