HEPATIC IMPAIRMENT

This study looked at how the experimental prostate cancer drug opevesostat stays in the body over time. Researchers compared 16 men with moderate liver impairment to healthy men. The goal was to see if liver problems affect drug levels, which helps doctors decide on safe dosing.

This study looked at how different levels of liver damage affect the way the body handles a single dose of the experimental drug KP-001. Twenty-four adults with either healthy livers or mild to moderate liver problems took part. Researchers measured drug levels in the blood to se…

This study looked at how the drug AZD5004 moves through the body in people with mild, moderate, or severe liver problems compared to those with healthy livers. Thirty-three adults received a single dose to measure drug levels and safety. The goal is to guide proper dosing for pat…

This study looked at how the body handles a single dose of the antifungal drug fosmanogepix in 28 adults with different levels of liver function. Researchers measured drug levels in the blood and checked for side effects. The goal is to understand if liver problems change how the…

This study looked at how the drug divarasib is processed in people with different levels of liver function. 31 healthy volunteers and people with mild to severe liver problems received a single dose. The goal was to measure drug levels in the blood and check for side effects, not…

This study looked at how the drug AZD2389 behaves in people with liver impairment compared to healthy adults. Thirty-five participants received a single dose to measure drug levels and check for side effects. The goal was to understand if liver problems change how the drug is pro…

This study looked at how the body handles a single injection of fazirsiran in people with different levels of liver damage (mild, moderate, or severe) compared to those with healthy livers. 34 participants received one shot and were followed for 6 months. The goal was to measure …

This study looked at how the drug bulevirtide (BLV) enters and leaves the bloodstream in people with normal and reduced liver function. Researchers measured drug levels and bile acids, and checked safety after multiple doses. The goal was to understand how liver impairment affect…

This study looked at how a single dose of repotrectinib stays in the blood of people with moderate or severe liver impairment compared to healthy volunteers. 18 adults took part to help understand if liver function changes drug levels. The results will guide dosing for patients w…

This study looked at how the body handles the drug seladelpar in 24 adults with primary biliary cholangitis (PBC) and varying degrees of liver impairment. Researchers measured drug levels in the blood and urine to see how liver function affects the drug's breakdown. The goal was …

This study looked at how a damaged liver affects the way the body handles a drug called MK-8189. Researchers compared 14 people with moderate liver problems to healthy volunteers after a single dose. The goal was to see differences in drug levels and safety, helping doctors decid…

This study looked at how the drug ESK001 is processed in people with different levels of liver function. Researchers gave a single dose to 32 volunteers, including healthy people and those with mild, moderate, or severe liver impairment. The goal was to measure drug levels in the…

This study looked at how the drug BPN14770 is handled by the body in people with different levels of liver impairment (mild, moderate, severe) compared to healthy volunteers. A total of 32 adults took a single dose of the drug. The main goal was to measure drug levels in the bloo…

This study looked at how a single injection of the experimental drug NNC0194-0499 behaves in the body of people with various degrees of liver impairment and in healthy volunteers. The drug is being developed for fatty liver disease (NAFLD/NASH). 33 adults received one shot, and r…

This study looked at how the drug cenerimod is handled by people with mild or moderate liver problems compared to healthy people. 24 adults received a single dose to measure drug levels and safety. The goal was to understand if liver impairment changes how the drug works, which h…

This study looked at how the drug golcadomide behaves in people with moderate or severe liver problems compared to healthy volunteers. 29 adults received a single dose to measure drug levels and check for side effects. The goal is to find safe dosing for patients with liver impai…

This study looked at how the body handles a single 50 mg dose of the drug ITF2357 in people with chronic liver disease compared to healthy volunteers. 24 adults took part to measure drug levels and safety. The goal was to understand if liver problems change how the drug works, no…

This study looked at how the body handles cagrilintide, a drug being developed for weight management, in people with different levels of liver function. It also measured how well the drug is absorbed when injected under the skin versus into a vein. The study involved 32 adults an…

This study looked at how the drug olpasiran is processed in people with different levels of liver impairment (mild, moderate, or severe) compared to people with healthy livers. A total of 25 adults took a single dose of the drug. The goal was to understand how liver function affe…

This study looked at how a single dose of the experimental drug AZD2693 is handled by the body in people with liver impairment compared to healthy volunteers. A total of 35 adults took part, receiving one injection under the skin. The main goal was to measure drug levels in the b…

This study looked at how the drug MK-8527 moves through the body in people with mild or moderate liver impairment compared to healthy people. 18 adults took a single dose, and researchers measured drug levels over time. The goal was to understand if liver problems change how the …

This study looked at how the drug evobrutinib is processed in people with different levels of liver impairment compared to those with healthy livers. Twenty-four participants received a single dose, and researchers measured drug levels in the blood and monitored safety. The goal …

This study looked at how the body handles a single dose of the drug MCI-186 in people with mild or moderate liver impairment compared to those with healthy livers. A total of 22 participants received one intravenous infusion. The goal was to measure drug levels in the blood to un…

This study looked at how the body processes a single dose of the drug AMG 133 in 36 adults with mild, moderate, or severe liver problems compared to those with healthy livers. The goal was to see if liver function changes drug levels and safety. Results will help doctors decide t…

This study looked at how the body processes efinopegdutide, a potential drug for fatty liver disease, in people with moderate to severe liver damage compared to healthy people. A total of 22 adults received a single dose, and researchers measured drug levels and safety. The goal …

This study looked at how moderate and severe liver impairment changes the way the body handles a single dose of the drug palovarotene. Researchers compared 31 participants with liver problems to healthy volunteers. The goal was to understand safety and drug levels in the blood, n…

This early-phase study looked at how the drug nalbuphine extended-release is processed in people with mild, moderate, or severe liver problems compared to those with healthy livers. It also explored whether the drug could help relieve itching in participants who reported it. The …