AstraZeneca

This phase 3 trial tests whether a single infusion of AZD0120, a CAR-T cell therapy that targets two proteins on myeloma cells, can outperform the standard approach of high-dose chemotherapy followed by a stem cell transplant. The study enrolls adults newly diagnosed with multipl…

Researchers are testing whether torvutatug samrotecan, alone or with bevacizumab, works better than standard care as maintenance therapy for people with platinum-sensitive relapsed ovarian, fallopian tube, or primary peritoneal cancer. The trial enrolls about 600 participants who…

This study will follow 600 adults in Korea who have been prescribed Breztri for COPD, a long-term lung disease. Researchers want to see how safe the drug is in everyday use and whether it works as expected. Participants will take Breztri as their doctor prescribes, and the study …

This study follows about 100 adults in Japan who have severe chronic sinusitis with nasal polyps and are starting treatment with tezepelumab, a biologic given as a shot. Researchers will track how symptoms and quality of life change over time using a standard questionnaire called…

This trial is testing whether an investigational drug called AZD6234, given as a weekly injection, can help adults with type 2 diabetes and excess weight lose more weight than a placebo. Participants will receive either AZD6234 or a placebo for 68 weeks, and researchers will meas…

This trial is testing whether anifrolumab, an experimental antibody, can help Chinese adults with moderate-to-severe systemic lupus erythematosus (SLE) achieve remission. Participants receive anifrolumab infusions over 52 weeks alongside standard care, with a focus on safely redu…

This trial tests whether a structured care pathway — based on standard asthma guidelines — can improve disease management for adults with uncontrolled asthma who already use high-dose inhalers. Doctors and nurses at some clinics will receive extra training and tools to follow the…

This study tests whether adding the experimental drug saruparib to standard hormone therapy can slow the growth of metastatic hormone-sensitive prostate cancer. It includes men whose cancer has not progressed after prior chemotherapy or a specific type of radiation therapy. Parti…

This study offers continued access to anifrolumab (Saphnelo) for people with systemic lupus erythematosus, systemic sclerosis, or myopathies who completed a prior anifrolumab trial and are still benefiting from the drug. Participants receive the same treatment as before, while re…

This study tests anifrolumab, a drug for systemic lupus erythematosus (SLE), given either as a shot under the skin or through an IV. The goal is to see how the body processes the drug and check its safety. About 92 adults with lupus will take part.

This study tests whether a new drug called baxdrostat can lower blood pressure in Chinese adults whose hypertension remains uncontrolled despite taking two or more blood pressure medications. Participants receive either baxdrostat or a placebo daily for 12 weeks, while continuing…

This study tests anifrolumab, a drug already used in adults with lupus, in children aged 5 to 17. The goal is to see how the drug moves through the body and if it is safe. Twenty-four children with moderate to severe lupus will receive the drug as a shot under the skin, while con…

This study observes 210 patients in South Korea who are prescribed Tezepelumab for severe asthma or chronic sinusitis with nasal polyps. Researchers will track side effects and how well the drug controls symptoms in everyday use. The goal is to confirm the drug's safety and effec…

This Phase 3 trial tests whether a new combination pill containing laroprovstat and rosuvastatin lowers LDL cholesterol better than rosuvastatin alone. About 200 adults with high cholesterol and a history of heart disease or high risk will take either the combo or a placebo plus …

This phase 3 trial tests whether a combination of two drugs (balcinrenone and dapagliflozin) works better than dapagliflozin alone for people with advanced chronic kidney disease (stages 3b and 4). About 2,800 participants will take the combination or a placebo daily, alongside s…

This study will screen 477 current or former smokers in Brazil for lung cancer using CT scans. It aims to see how often the scans give false alarms (false positives) in a region where lung infections are common. The goal is to improve screening accuracy and reduce unnecessary fol…

Researchers at one site in the United Kingdom are studying how the experimental drug AZD4954 is absorbed, broken down, and removed from the body. The trial enrolls 16 healthy men aged 30 to 65, split into two groups of eight. In one part, participants take a single oral liquid do…

This study will enroll 1,500 current or former smokers aged 50-80 to see if an artificial intelligence (AI) model can help doctors better detect lung nodules and predict cancer spread. Participants will undergo CT scans, and the AI's results will be compared to standard radiologi…

This observational study tracks how patients with stage II to IVB gastric or gastroesophageal junction cancer are actually treated in routine clinical practice across Greece. Researchers will collect data on patient characteristics, treatment choices, timing of therapies, and bio…

This study follows 300 adults in China who have had a kidney transplant due to glomerulonephritis (GN), a type of kidney disease. The goal is to see how often GN comes back after the transplant and what factors might influence that. Participants will be monitored for three years …

This early-stage trial is investigating how a single oral dose of the experimental drug AZD4144 is processed by the body in people with mild, moderate, or severe liver impairment compared to healthy volunteers. The goal is to measure how liver function affects drug levels in the …

This observational study follows Indian adults with resectable non-small cell lung cancer who are prescribed durvalumab as part of their routine care. The goal is to monitor how often patients experience serious side effects, including severe adverse events and other complication…

This study observes people with a common type of advanced breast cancer (HR+/HER2-) who are already on standard hormone therapy. Researchers use simple blood tests to look for changes in the ESR1 gene, which can make the cancer stop responding to treatment. By tracking these muta…

This study observes how well a combination of two drugs, olaparib and abiraterone, works as a first treatment for men with metastatic castration-resistant prostate cancer who have already tried other hormone therapies. Researchers will track how long patients stay on the treatmen…

This study tracks how the experimental drug AZD1390 moves through and leaves the body after a single dose. It involves about 8 adults with advanced solid tumors who are not currently on active cancer treatment. By using a tiny radioactive label, researchers can measure the drug i…

This study looks at medical records of 3,000 adults with lung cancer to see if the stage at diagnosis is shifting to earlier, more curable stages. Researchers will track how often cancer is found through screening programs, chest X-rays, or heart scans. No new treatments or tests…

This study will review medical records of about 240 adults in Kazakhstan with HER2-positive metastatic breast cancer to see how they were treated and how well they did. Researchers will look at treatments given in routine care (except one specific drug) and track outcomes like ho…

This study aims to learn about genetic changes in metastatic prostate cancer and how they affect patient outcomes. Researchers will collect and analyze tissue and blood samples from 100 adults in Brazil who are receiving standard palliative therapy. The goal is to better understa…

This study will look at how the lupus medication Saphnelo (anifrolumab) is being used in women aged 15 to 50 who could become pregnant. Researchers will track how many women use the drug each year and describe their health characteristics. The goal is to gather real-world informa…