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New antibody aims to cut lung attacks in bronchiectasis patients

NCT ID NCT07088926

Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 17, 2026 · Updated 6 times

Summary

This study tests an experimental drug called AZD0292 in 435 people aged 12 and older who have bronchiectasis and a long-term lung infection with Pseudomonas aeruginosa. The goal is to see if the drug can reduce the number of moderate-to-severe lung flare-ups compared to a placebo. Participants will receive the drug or placebo by IV and continue their usual care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 435 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

12 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Participant must be ≥ 12 years of age at the time of signing the informed consent/assent 2. Weight ≥ 35 kg 3. Bronchiectasis diagnosed by a physician and confirmed by CT demonstrating abnormal bronchial dilation in ≥ 1 lobe. Note: A historical CT scan within the past 5 years is acceptable. If not available, a CT scan should be conducted at screening to confirm eligibility. 4. Participants who are receiving appropriate standard of care therapy per local guidelines and have a documented history of ≥ 2 moderate exacerbations or ≥ 1 severe exacerbation in the preceding 12 months requiring antibiotics 5. Participants who are clinically stable and free from an exacerbation of bronchiectasis for 4 weeks prior to randomization 6. Participants with pre- or post-bronchodilator FEV1 ≥ 25% predicted value at screening. 7. Presence of positive (PCR or culture) PsA in an airway sample at least once in the last 24 months prior to screening 8. Presence of culture positive PsA in sputum at least within 5 weeks of randomization. Participants who have previously received PsA eradication therapy, as determined appropriate by their treating provider, but remain colonized with PsA are eligible for the study. 9. Capable of giving signed informed consent/assent which includes compliance with the requirements and restrictions listed in the ICF and in this protocol Exclusion Criteria: 1. Primary lung diagnosis other than bronchiectasis 2. Evidence of active tuberculosis or active nontuberculous mycobacteria being treated or requiring treatment. Participants currently receiving treatment for active TB or nontuberculous mycobacteria may be considered after completion of an appropriate course of therapy 3. Evidence of an active allergic bronchopulmonary aspergillosis being treated or requiring treatment 4. Need for long term supplemental oxygen. Oxygen use for ambulation and relief of breathlessness after exercise is allowed 5. Malignancy, current or within the previous 5 years, except for stable prostate cancer, adequately treated non-invasive basal cell and squamous cell carcinoma of the skin and cervical carcinoma in situ treated with apparent success more than one year prior to enrolment 6. AIDS or Advanced human immunodeficiency virus disease (CD4 count of \< 200 cells/mm3) 7. History of severe adverse reaction associated with a mAb, and/or history of severe allergic reaction (eg, anaphylaxis that required the use of epinephrine/adrenaline or hospitalization), and/or history of immune complex disease (Type III hypersensitivity reactions) to monoclonal antibody administration 8. Treatment with long term anti-PsA antibiotics, macrolides, or DPP-1 inhibitors, which are newly initiated within the 3 months prior to screening 9. Chronic immunosuppressive therapy (including prednisolone \> 5 mg or equivalent) newly initiated within the last 3 months 10. Receipt of investigational products indicated for the treatment or prevention of bronchiectasis exacerbations or expected receipt during the study 11. Participants with CF on CFTR modulator therapies which are newly initiated within the previous 3 months prior to screening 12. Female participants who are pregnant, lactating, or WOCBP and not using a highly effective method of contraception or abstinence from at least 4 weeks prior to study intervention administration and until at least 6 months after study intervention administration

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Conditions

The condition(s) this trial relates to.

bronchiectasis cystic fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bronchiectasis with pseudomonas aeruginosa colonization

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    170 sites in 25 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Research Site

    RECRUITING

    Orange, California, 92868, United States

  • Research Site

    RECRUITING

    San Francisco, California, 94143, United States

  • Research Site

    NOT_YET_RECRUITING

    Denver, Colorado, 80206, United States

  • Research Site

    RECRUITING

    Washington D.C., District of Columbia, 20007, United States

  • Research Site

    RECRUITING

    Jacksonville, Florida, 32209, United States

  • Research Site

    TERMINATED

    Miami Lakes, Florida, 33014, United States

  • Research Site

    RECRUITING

    Naples, Florida, 34102, United States

  • Research Site

    RECRUITING

    Ormond Beach, Florida, 32174, United States

  • Research Site

    RECRUITING

    Plantation, Florida, 33324, United States

  • Research Site

    RECRUITING

    Rincon, Georgia, 31326, United States

  • Research Site

    RECRUITING

    Kansas City, Kansas, 66160, United States

  • Research Site

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

  • Research Site

    WITHDRAWN

    Detroit, Michigan, 48202, United States

  • Research Site

    WITHDRAWN

    Rochester, Minnesota, 55905, United States

  • Research Site

    RECRUITING

    St Louis, Missouri, 63130, United States

  • Research Site

    RECRUITING

    New York, New York, 10016, United States

  • Research Site

    RECRUITING

    New Bern, North Carolina, 28562, United States

  • Research Site

    NOT_YET_RECRUITING

    Winston-Salem, North Carolina, 27104, United States

  • Research Site

    WITHDRAWN

    Tulsa, Oklahoma, 74133, United States

  • Research Site

    WITHDRAWN

    DuBois, Pennsylvania, 15801, United States

  • Research Site

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • Research Site

    RECRUITING

    Charleston, South Carolina, 29425, United States

  • Research Site

    WITHDRAWN

    Rock Hill, South Carolina, 29732, United States

  • Research Site

    WITHDRAWN

    Austin, Texas, 78705, United States

  • Research Site

    RECRUITING

    Mansfield, Texas, 76063, United States

  • Research Site

    RECRUITING

    Ciudad de Buenos Aires, C1180AAX, Argentina

  • Research Site

    RECRUITING

    Florida, B1602DQD, Argentina

  • Research Site

    RECRUITING

    Rosario, 2000, Argentina

  • Research Site

    RECRUITING

    San Miguel de Tucumán, 4000, Argentina

  • Research Site

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    Birtinya, 4575, Australia

  • Research Site

    RECRUITING

    Macquarie University, 2109, Australia

  • Research Site

    RECRUITING

    South Brisbane, 4101, Australia

  • Research Site

    RECRUITING

    Ghent, 9000, Belgium

  • Research Site

    RECRUITING

    Leuven, 3000, Belgium

  • Research Site

    RECRUITING

    Liège, 4000, Belgium

  • Research Site

    RECRUITING

    Sint-Niklaas, 9100, Belgium

  • Research Site

    RECRUITING

    Blumenau, 89030-101, Brazil

  • Research Site

    RECRUITING

    Campinas, 13060-080, Brazil

  • Research Site

    RECRUITING

    Curitiba, 80030-110, Brazil

  • Research Site

    RECRUITING

    Curitiba, 80230-130, Brazil

  • Research Site

    RECRUITING

    Porto Alegre, 9061-000, Brazil

  • Research Site

    RECRUITING

    Porto Alegre, 90630-165, Brazil

  • Research Site

    WITHDRAWN

    Porto Alegre, 91350-200, Brazil

  • Research Site

    WITHDRAWN

    Salvador, 40050-410, Brazil

  • Research Site

    RECRUITING

    São José dos Campos, 12230-001, Brazil

  • Research Site

    RECRUITING

    São Paulo, 05.403-010, Brazil

  • Research Site

    RECRUITING

    São Paulo, 05403-000, Brazil

  • Research Site

    RECRUITING

    Calgary, Alberta, T2N4Z6, Canada

  • Research Site

    RECRUITING

    Vancouver, British Columbia, V5Z 1M9, Canada

  • Research Site

    RECRUITING

    Ajax, Ontario, L1S 2J5, Canada

  • Research Site

    RECRUITING

    Stoney Creek, Ontario, L8G 2V6, Canada

  • Research Site

    RECRUITING

    Québec, Quebec, G1V 4G5, Canada

  • Research Site

    RECRUITING

    Saint-Charles-Borromée, Quebec, J6E 2B4, Canada

  • Research Site

    WITHDRAWN

    Trois-Rivières, Quebec, G8T 7A1, Canada

  • Research Site

    RECRUITING

    Concepción, 4070196, Chile

  • Research Site

    RECRUITING

    Santiago, 8150000, Chile

  • Research Site

    RECRUITING

    Santiago, 8380453, Chile

  • Research Site

    RECRUITING

    Talca, 3481349, Chile

  • Research Site

    RECRUITING

    Viña del Mar, 2540364, Chile

  • Research Site

    RECRUITING

    Aalborg, 9000, Denmark

  • Research Site

    WITHDRAWN

    Aarhus N, 8200, Denmark

  • Research Site

    RECRUITING

    Hvidovre, 2650, Denmark

  • Research Site

    RECRUITING

    Odense C, 5000, Denmark

  • Research Site

    RECRUITING

    Roskilde, 4000, Denmark

  • Research Site

    RECRUITING

    Brest, 29200, France

  • Research Site

    RECRUITING

    Créteil, 94010, France

  • Research Site

    RECRUITING

    Marseille, 13915, France

  • Research Site

    RECRUITING

    Montpellier, 34295, France

  • Research Site

    RECRUITING

    Paris, 75014, France

  • Research Site

    RECRUITING

    Pessac, 33604, France

  • Research Site

    RECRUITING

    Strasbourg, 67091, France

  • Research Site

    RECRUITING

    Toulouse, 31100, France

  • Research Site

    RECRUITING

    Berlin, 10117, Germany

  • Research Site

    WITHDRAWN

    Darmstadt, 64283, Germany

  • Research Site

    RECRUITING

    Essen, 45239, Germany

  • Research Site

    RECRUITING

    Frankfurt, 60596, Germany

  • Research Site

    RECRUITING

    Halle, 06108, Germany

  • Research Site

    RECRUITING

    Hanover, 30625, Germany

  • Research Site

    RECRUITING

    Konstanz, 78464, Germany

  • Research Site

    RECRUITING

    München, 80336, Germany

  • Research Site

    RECRUITING

    München-Pasing, 81241, Germany

  • Research Site

    RECRUITING

    Athens, 11527, Greece

  • Research Site

    RECRUITING

    Athens, 12462, Greece

  • Research Site

    RECRUITING

    Athens, 15126, Greece

  • Research Site

    RECRUITING

    Athens, 17562, Greece

  • Research Site

    RECRUITING

    Ioannina, 45500, Greece

  • Research Site

    RECRUITING

    Larissa, 41110, Greece

  • Research Site

    RECRUITING

    Pátrai, 26500, Greece

  • Research Site

    RECRUITING

    Thessaloniki, 57010, Greece

  • Research Site

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    Ashkelon, 7830604, Israel

  • Research Site

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    Haifa, 34362, Israel

  • Research Site

    RECRUITING

    Jerusalem, 00000, Israel

  • Research Site

    RECRUITING

    Jerusalem, 91031, Israel

  • Research Site

    RECRUITING

    Ramat Gan, 52621, Israel

  • Research Site

    RECRUITING

    Tel Aviv, 6423906, Israel

  • Research Site

    RECRUITING

    Milan, 20122, Italy

  • Research Site

    RECRUITING

    Palermo, 90127, Italy

  • Research Site

    RECRUITING

    Pavia, 27100, Italy

  • Research Site

    RECRUITING

    Perugia, 06129, Italy

  • Research Site

    RECRUITING

    Roma, 00163, Italy

  • Research Site

    RECRUITING

    Rozzano, 20089, Italy

  • Research Site

    RECRUITING

    Torrette, 60126, Italy

  • Research Site

    NOT_YET_RECRUITING

    Bunkyō City, 113-8655, Japan

  • Research Site

    RECRUITING

    Gifu, 500-8717, Japan

  • Research Site

    RECRUITING

    Hiratsuka-shi, 254-8502, Japan

  • Research Site

    RECRUITING

    Kamogawa-shi, 296-0041, Japan

  • Research Site

    RECRUITING

    Kiyose-shi, 204-8522, Japan

  • Research Site

    RECRUITING

    Kiyose-shi, 204-8585, Japan

  • Research Site

    NOT_YET_RECRUITING

    Kurashiki-shi, 710-8602, Japan

  • Research Site

    NOT_YET_RECRUITING

    Meguro-ku, 153-0061, Japan

  • Research Site

    RECRUITING

    Miyazaki, 889-1692, Japan

  • Research Site

    RECRUITING

    Nagasaki, 852-8501, Japan

  • Research Site

    RECRUITING

    Ogi, 845-0032, Japan

  • Research Site

    RECRUITING

    Shinjuku-ku, 160-8582, Japan

  • Research Site

    RECRUITING

    Shinjuku-ku, 162-8655, Japan

  • Research Site

    RECRUITING

    Urayasu-shi, 279-0021, Japan

  • Research Site

    RECRUITING

    Bandar Puncak Alam, 42300, Malaysia

  • Research Site

    RECRUITING

    Kuala Lumpur, 59100, Malaysia

  • Research Site

    RECRUITING

    Sibu, 96000, Malaysia

  • Research Site

    RECRUITING

    Amsterdam, 1081 HV, Netherlands

  • Research Site

    RECRUITING

    Rotterdam, 3015 GD, Netherlands

  • Research Site

    WITHDRAWN

    Zutphens, 7207 AE, Netherlands

  • Research Site

    WITHDRAWN

    Bellavista, CALLAO 2, Peru

  • Research Site

    NOT_YET_RECRUITING

    Callao, Bellavista, Peru

  • Research Site

    RECRUITING

    Lima, 15023, Peru

  • Research Site

    RECRUITING

    Lima, 15036, Peru

  • Research Site

    RECRUITING

    Lima, 15038, Peru

  • Research Site

    NOT_YET_RECRUITING

    Lima, 15082, Peru

  • Research Site

    WITHDRAWN

    Lima, 15088, Peru

  • Research Site

    RECRUITING

    Lima, LIMA 1, Peru

  • Research Site

    WITHDRAWN

    Lima, LIMA 29, Peru

  • Research Site

    RECRUITING

    Iloilo City, 5000, Philippines

  • Research Site

    NOT_YET_RECRUITING

    Manila, 1000, Philippines

  • Research Site

    RECRUITING

    Quezon City, 1100, Philippines

  • Research Site

    RECRUITING

    Tondo, 1012, Philippines

  • Research Site

    RECRUITING

    Anyang-si, 14068, South Korea

  • Research Site

    RECRUITING

    Cheongju-si, 28644, South Korea

  • Research Site

    RECRUITING

    Daegu, 42415, South Korea

  • Research Site

    RECRUITING

    Seongnam-si, 13620, South Korea

  • Research Site

    RECRUITING

    Seoul, 04763, South Korea

  • Research Site

    RECRUITING

    Seoul, 05030, South Korea

  • Research Site

    RECRUITING

    Seoul, 05505, South Korea

  • Research Site

    RECRUITING

    Seoul, 07441, South Korea

  • Research Site

    RECRUITING

    Ulsan, 44033, South Korea

  • Research Site

    RECRUITING

    Barcelona, 08003, Spain

  • Research Site

    RECRUITING

    Barcelona, 08036, Spain

  • Research Site

    RECRUITING

    Benalmádena, 29631, Spain

  • Research Site

    RECRUITING

    Madrid, 28040, Spain

  • Research Site

    RECRUITING

    Madrid, 28046, Spain

  • Research Site

    RECRUITING

    Mérida, 06800, Spain

  • Research Site

    RECRUITING

    Patraix, 46017, Spain

  • Research Site

    RECRUITING

    Valencia, 46009, Spain

  • Research Site

    RECRUITING

    Kaohsiung City, 80756, Taiwan

  • Research Site

    RECRUITING

    Taichung, 40447, Taiwan

  • Research Site

    RECRUITING

    Taichung, 40705, Taiwan

  • Research Site

    RECRUITING

    Taipei, 0116, Taiwan

  • Research Site

    RECRUITING

    Taipei, 10002, Taiwan

  • Research Site

    RECRUITING

    Taipei, 110, Taiwan

  • Research Site

    RECRUITING

    Taoyuan, 333, Taiwan

  • Research Site

    RECRUITING

    Bangkok, 10400, Thailand

  • Research Site

    RECRUITING

    Muang, 40002, Thailand

  • Research Site

    RECRUITING

    Muang, 50200, Thailand

  • Research Site

    RECRUITING

    Nonthaburi, 11000, Thailand

  • Research Site

    RECRUITING

    Pathum Thani, 12120, Thailand

  • Research Site

    RECRUITING

    Adana, 1330, Turkey (Türkiye)

  • Research Site

    RECRUITING

    Ankara, 6340, Turkey (Türkiye)

  • Research Site

    RECRUITING

    Diyarbakır, 21280, Turkey (Türkiye)

  • Research Site

    RECRUITING

    Istanbul, 34098, Turkey (Türkiye)

  • Research Site

    RECRUITING

    Istanbul, 34890, Turkey (Türkiye)

  • Research Site

    RECRUITING

    Mersin, 33343, Turkey (Türkiye)

  • Research Site

    RECRUITING

    Zeytinburnu, 34020, Turkey (Türkiye)

  • Research Site

    RECRUITING

    Belfast, BT9 7AB, United Kingdom

  • Research Site

    RECRUITING

    Birmingham, B9 5SS, United Kingdom

  • Research Site

    RECRUITING

    Brighton, BN2 1ES, United Kingdom

  • Research Site

    RECRUITING

    Cambridge, CB2 0AY, United Kingdom

  • Research Site

    RECRUITING

    Dundee, DD1 9SY, United Kingdom

  • Research Site

    RECRUITING

    Edinburgh, EH16 4SA, United Kingdom

  • Research Site

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    Exeter, EX2 5DW, United Kingdom

  • Research Site

    RECRUITING

    Liverpool, L14 3PE, United Kingdom

  • Research Site

    RECRUITING

    Manchester, M23 9LT, United Kingdom

  • Research Site

    NOT_YET_RECRUITING

    Can Tho, 900000, Vietnam

  • Research Site

    RECRUITING

    Haiphong, 180000, Vietnam

  • Research Site

    RECRUITING

    Hanoi, 100000, Vietnam

  • Research Site

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    Hà Nội, 100000, Vietnam

  • Research Site

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    Ho Chi Minh City, 700000, Vietnam

  • Research Site

    RECRUITING

    Huế, 530000, Vietnam

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