Greek sinusitis study aims to personalize treatment by analyzing inflammation

NCT ID NCT07663409

Knowledge-focused Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 23, 2026 · Updated 3 times

Summary

This study will collect and analyze nasal tissue from 230 Greek patients with chronic sinusitis (with or without nasal polyps) to identify different inflammation patterns, called endotypes. By understanding these patterns, researchers hope to better match patients with the most effective biologic treatments. The study is observational and does not test any new drug or intervention.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to: If successful, this study could help doctors choose more personalized treatments for chronic sinusitis patients based on their specific inflammation type.
What could go wrong: This is an observational study, not a treatment trial, so it won't directly test any new therapy. Results may not apply to non-Greek populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 230 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

CRSwNP patients who are scheduled to undergo first ESS (prospective patients) will be recruited from approximately 6 Ear-Nose-Throat (ENT) and 1 pulmonology clinics. Moreover, CRSwNP and CRSsNP patients who have already performed their first ESS in the period between 2012 and enrolment and have stored nasal tissue samples (retrospective patients) will be recruited from 1 ENT clinic.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years * If CRSwNP group: Physician-diagnosed severe, uncontrolled CRSwNP according to the EUFOREA/EPOS 2020 and ICAR-RS 2021 guidelines with: * CRSwNP severity consistent with the need for surgery as defined by a total nasal polyp score (NPS) of ≥5 (≥2 for each nostril) * Nasal Congestion Score (NCS) of ≥2 * Ongoing documented symptoms of CRSwNP for \> 8 weeks before surgery If CRSsNP group: Diagnosis of CRSsNP according to the EUFOREA/EPOS 2020 and ICAR-RS 2021 guidelines * Have performed in the period between 2012 and enrolment or are scheduled to perform endoscopic sinus surgery (ESS) for the first time at enrolment * Have available nasal polyp tissue sample from the first endoscopic sinus surgery (ESS) * Have provided signed and dated written informed consent * If CRSwNP group: Patients receiving any standard of care treatment for CRSwNP, provided the participant is stable on that treatment for ≥30 days Exclusion Criteria: * Patients with cystic fibrosis or immunodeficiency * Presence of acute exacerbation of CRS symptoms within 2 weeks prior to surgery * Use of systemic corticosteroids within 30 days prior to surgery, or antileukotrienes within 15 days prior to surgery, or biologic therapy prior to surgery * Not adequate amount (\<0.15g) or quality (e.g. storage temperature, contamination) of tissue sample for analyses * Not available blood (serum) sample, only for patients scheduled to perform endoscopic sinus surgery (ESS) for the first time at the date of enrolment, for analyses.

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Conditions

The condition(s) this trial relates to.

chronic rhinosinusitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CRSWNP or CRSSNP patients

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

4 sites. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

Open the record ↗
A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Greek sinusitis study aims to personalize treatment by analyzing inflammation

What the study statuses mean