New diabetes pill elecoglipron faces final test in 600-Patient trial

NCT ID NCT07664553

Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 2 times

Summary

This phase 3 study tests whether a new oral drug called elecoglipron can help adults with type 2 diabetes better manage their blood sugar when added to their current insulin and other diabetes medications. About 600 participants will receive either elecoglipron or a placebo daily for 40 weeks. The main goal is to see if elecoglipron lowers HbA1c (a measure of average blood sugar) more than placebo.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: Elecoglipron (oral drug)
What this could lead to: If successful, elecoglipron could offer a new daily pill to help people with type 2 diabetes better control their blood sugar when insulin alone isn't enough.
What could go wrong: This is a phase 3 trial, but results are not yet available. The drug may not prove more effective than placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 600 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

May 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosed with T2DM for at least 90 days prior to screening * Stable treatment with background insulin and other background glucose-lowering medication(s) * HbA1c value of ≥ 7% to ≤ 10.5% * Body mass index (BMI) of ≥ 23 kg/m2 at screening * Stable body weight (self-reported or documented) for 90 days prior to screening Exclusion Criteria: * T1DM, secondary forms of diabetes (including congenital forms), or history of ketoacidosis or hyperosmolar coma * Currently receiving or anticipated to receive, therapeutic intervention for diabetic retinopathy and/or macular edema * Have had more than one episode of severe hypoglycemia within 180 days prior to screening or has a history of hypoglycemia unawareness or poor recognition of hypoglycemic symptoms * Clinically significant condition affecting the upper GI tract or chronic use of any medication that affects gastric motility or gastric emptying * History of acute or chronic pancreatitis. * Severe congestive heart failure (NYHA IV) * History/family history of medullary thyroid cancer or multiple endocrine neoplasia type 2

Get updates

Get notified about this study

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Type 2 diabetes mellitus

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

123 sites in 13 countries. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

Open the record ↗
A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

Research Site
NOT_YET_RECRUITING

Little Rock, Arkansas, 72205, United States
Research Site
NOT_YET_RECRUITING

Sacramento, California, 95821, United States
Research Site
NOT_YET_RECRUITING

Aurora, Colorado, 80045, United States
Research Site
SUSPENDED

DeLand, Florida, 32720, United States
Research Site
NOT_YET_RECRUITING

Doral, Florida, 33166, United States
Research Site
RECRUITING

Ocoee, Florida, 34761, United States
Research Site
NOT_YET_RECRUITING

Decatur, Georgia, 30030, United States
Research Site
NOT_YET_RECRUITING

Potomac, Maryland, 20854, United States
Research Site
SUSPENDED

Brooklyn, New York, 11220, United States
Research Site
NOT_YET_RECRUITING

Cary, North Carolina, 27518, United States
Research Site
NOT_YET_RECRUITING

Morehead City, North Carolina, 28557, United States
Research Site
NOT_YET_RECRUITING

Myrtle Beach, South Carolina, 29572, United States
Research Site
NOT_YET_RECRUITING

Memphis, Tennessee, 38119, United States
Research Site
NOT_YET_RECRUITING

Houston, Texas, 77040, United States
Research Site
NOT_YET_RECRUITING

Round Rock, Texas, 78681, United States
Research Site
NOT_YET_RECRUITING

San Antonio, Texas, 78231, United States
Research Site
NOT_YET_RECRUITING

Renton, Washington, 98057, United States
Research Site
NOT_YET_RECRUITING

Campbelltown, 2560, Australia
Research Site
RECRUITING

East Toowoomba, 4350, Australia
Research Site
NOT_YET_RECRUITING

Heidelberg Heights, 3081, Australia
Research Site
NOT_YET_RECRUITING

Parkville, 3050, Australia
Research Site
NOT_YET_RECRUITING

St Leonards, 2065, Australia
Research Site
NOT_YET_RECRUITING

Dupnitsa, 2600, Bulgaria
Research Site
NOT_YET_RECRUITING

Kozloduy, 3320, Bulgaria
Research Site
NOT_YET_RECRUITING

Plovdiv, 4001, Bulgaria
Research Site
NOT_YET_RECRUITING

Sofia, 1618, Bulgaria
Research Site
NOT_YET_RECRUITING

Stara Zagora, 6000, Bulgaria
Research Site
NOT_YET_RECRUITING

Veliko Tarnovo, 5000, Bulgaria
Research Site
NOT_YET_RECRUITING

Yambol, 8600, Bulgaria
Research Site
NOT_YET_RECRUITING

Surrey, British Columbia, V3T 4G8, Canada
Research Site
RECRUITING

Vancouver, British Columbia, V5Y 3W2, Canada
Research Site
NOT_YET_RECRUITING

Brampton, Ontario, L6S 0C6, Canada
Research Site
NOT_YET_RECRUITING

North York, Ontario, M6B 3H7, Canada
Research Site
NOT_YET_RECRUITING

Sarnia, Ontario, N7T 4X3, Canada
Research Site
NOT_YET_RECRUITING

Scarborough Village, Ontario, M1R 0B1, Canada
Research Site
RECRUITING

Toronto, Ontario, M4G3E8, Canada
Research Site
NOT_YET_RECRUITING

Saint-Charles-Borromée, Quebec, J6E 2B4, Canada
Research Site
NOT_YET_RECRUITING

Changsha, 410013, China
Research Site
NOT_YET_RECRUITING

Changsha, 410015, China
Research Site
NOT_YET_RECRUITING

Hefei, 230000, China
Research Site
NOT_YET_RECRUITING

Hefei, 230601, China
Research Site
NOT_YET_RECRUITING

Huai'an, 223005, China
Research Site
NOT_YET_RECRUITING

Langfang, 065000, China
Research Site
NOT_YET_RECRUITING

Liangyugang, 222002, China
Research Site
NOT_YET_RECRUITING

Luoyang, 471009, China
Research Site
NOT_YET_RECRUITING

Nanjing, 2100008, China
Research Site
NOT_YET_RECRUITING

Nanyang, 473009, China
Research Site
NOT_YET_RECRUITING

Pinggu, 101200, China
Research Site
NOT_YET_RECRUITING

Pingxiang, 337055, China
Research Site
NOT_YET_RECRUITING

Shijiazhuang, 050000, China
Research Site
NOT_YET_RECRUITING

Tianjin, 300134, China
Research Site
NOT_YET_RECRUITING

Yueyang, 414000, China
Research Site
NOT_YET_RECRUITING

Broumov, 55001, Czechia
Research Site
NOT_YET_RECRUITING

České Budějovice, 370 01, Czechia
Research Site
NOT_YET_RECRUITING

Ostrava, 710 00, Czechia
Research Site
NOT_YET_RECRUITING

Pilsen, 301 00, Czechia
Research Site
NOT_YET_RECRUITING

Prague, 140 00, Czechia
Research Site
NOT_YET_RECRUITING

Prague, 170 00, Czechia
Research Site
NOT_YET_RECRUITING

Prague, 181 00, Czechia
Research Site
NOT_YET_RECRUITING

Amberg, 92224, Germany
Research Site
NOT_YET_RECRUITING

Bad Oeynhausen, 32545, Germany
Research Site
WITHDRAWN

Berlin, 13597, Germany
Research Site
WITHDRAWN

Bochum, 44869, Germany
Research Site
WITHDRAWN

Brandenburg an der Havel, 14776, Germany
Research Site
WITHDRAWN

Daaden, 57567, Germany
Research Site
NOT_YET_RECRUITING

Duisburg, 47051, Germany
Research Site
NOT_YET_RECRUITING

Eisenach, 99817, Germany
Research Site
NOT_YET_RECRUITING

Elsterwerda, 04910, Germany
Research Site
NOT_YET_RECRUITING

Falkensee, 14612, Germany
Research Site
NOT_YET_RECRUITING

Frankfurt, 60596, Germany
Research Site
WITHDRAWN

Fulda, 36037, Germany
Research Site
NOT_YET_RECRUITING

Gladbeck, 45968, Germany
Research Site
NOT_YET_RECRUITING

Hamburg, 22607, Germany
Research Site
WITHDRAWN

Hannoversch Münden, 34346, Germany
Research Site
NOT_YET_RECRUITING

Magdeburg, 39120, Germany
Research Site
NOT_YET_RECRUITING

Mannheim, 68167, Germany
Research Site
NOT_YET_RECRUITING

Münster, 48153, Germany
Research Site
NOT_YET_RECRUITING

Nittendorf, 93152, Germany
Research Site
NOT_YET_RECRUITING

Obertshausen, 63179, Germany
Research Site
WITHDRAWN

Oldenburg, 23758, Germany
Research Site
WITHDRAWN

Pirna, 01796, Germany
Research Site
NOT_YET_RECRUITING

Bangalore, 560 092, India
Research Site
NOT_YET_RECRUITING

Belagavi, 590006, India
Research Site
NOT_YET_RECRUITING

Chennai, 600086, India
Research Site
NOT_YET_RECRUITING

Coimbatore, 641018, India
Research Site
NOT_YET_RECRUITING

Guntur, 522001, India
Research Site
NOT_YET_RECRUITING

Hyderabad, 500034, India
Research Site
NOT_YET_RECRUITING

Indore, 452008, India
Research Site
NOT_YET_RECRUITING

Kochi, 682041, India
Research Site
NOT_YET_RECRUITING

Madurai, 625020, India
Research Site
NOT_YET_RECRUITING

Mumbai, 400012, India
Research Site
NOT_YET_RECRUITING

New Delhi, 110029, India
Research Site
NOT_YET_RECRUITING

Pune, 411021, India
Research Site
NOT_YET_RECRUITING

Asahikawa-shi, 070-8530, Japan
Research Site
NOT_YET_RECRUITING

Kamakura-shi, 247-0056, Japan
Research Site
NOT_YET_RECRUITING

Kashiwa-shi, 277-0825, Japan
Research Site
NOT_YET_RECRUITING

Kobe, 650-0047, Japan
Research Site
NOT_YET_RECRUITING

Komoro, 384-8588, Japan
Research Site
NOT_YET_RECRUITING

Kumamoto, 862-0976, Japan
Research Site
NOT_YET_RECRUITING

Kyoto, 606-8507, Japan
Research Site
RECRUITING

Miyazaki, 880-0034, Japan
Research Site
RECRUITING

Naka, 311-0113, Japan
Research Site
NOT_YET_RECRUITING

Sapporo, 060-0062, Japan
Research Site
NOT_YET_RECRUITING

Yokohama, 230-8765, Japan
Research Site
NOT_YET_RECRUITING

Batu Caves, 68100, Malaysia
Research Site
NOT_YET_RECRUITING

Kuala Lumpur, 59100, Malaysia
Research Site
NOT_YET_RECRUITING

Miri, 98000, Malaysia
Research Site
NOT_YET_RECRUITING

Putrajaya, 62250, Malaysia
Research Site
NOT_YET_RECRUITING

Seremban, 70300, Malaysia
Research Site
NOT_YET_RECRUITING

Bialystok, 15-897, Poland
Research Site
NOT_YET_RECRUITING

Częstochowa, 42-217, Poland
Research Site
NOT_YET_RECRUITING

Kielce, 25-355, Poland
Research Site
WITHDRAWN

Krakow, 31-261, Poland
Research Site
NOT_YET_RECRUITING

Lodz, 90-338, Poland
Research Site
NOT_YET_RECRUITING

Poznan, 60-354, Poland
Research Site
NOT_YET_RECRUITING

Radom, 26-600, Poland
Research Site
NOT_YET_RECRUITING

Warsaw, 00-124, Poland
Research Site
NOT_YET_RECRUITING

Warsaw, 02-507, Poland
Research Site
NOT_YET_RECRUITING

Bucheon-si, 14647, South Korea
Research Site
NOT_YET_RECRUITING

Gyeonggi-do, 13620, South Korea
Research Site
NOT_YET_RECRUITING

Jongno-gu, 110-746, South Korea
Research Site
NOT_YET_RECRUITING

Junggu, 22332, South Korea
Research Site
NOT_YET_RECRUITING

Seoul, 03080, South Korea
Research Site
NOT_YET_RECRUITING

Seoul, 03722, South Korea
Research Site
NOT_YET_RECRUITING

Seoul, 06591, South Korea
Research Site
NOT_YET_RECRUITING

Seoul, 5505, South Korea
Research Site
NOT_YET_RECRUITING

Bangkok, 10330, Thailand
Research Site
NOT_YET_RECRUITING

Bangkok, 10400, Thailand
Research Site
NOT_YET_RECRUITING

Bangkok, 10700, Thailand
Research Site
NOT_YET_RECRUITING

Hat Yai, 90110, Thailand
Research Site
NOT_YET_RECRUITING

Muang, 50200, Thailand
Research Site
NOT_YET_RECRUITING

Mueang, 20000, Thailand

More trials for these conditions

Other studies related to the condition(s) this trial covers.