New hope for lung scarring: AZD8965 enters Mid-Stage trial

NCT ID NCT07652658

Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase IIb study tests three doses of AZD8965 against a placebo in 359 adults with idiopathic pulmonary fibrosis (IPF), a lung-scarring disease. The main goal is to see if AZD8965 can slow the decline in lung function over 24 weeks. Participants may also be taking standard IPF medications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: AZD8965
What this could lead to: If successful, AZD8965 could become a new treatment option to slow lung function decline in people with idiopathic pulmonary fibrosis.
What could go wrong: This is a mid-stage trial with 359 participants, so results may not confirm benefit. The drug may cause side effects or fail to improve lung function compared to placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 359 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Sep 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥ 40 years 2. IPF diagnosis 3. Participants with IPF receiving locally approved antifibrotic therapies at a stable dose, or participants with IPF not receiving local standard of care 4. FVC ≥ 45% predicted of normal 5. DLCO corrected for hemoglobin ≥ 25% predicted of normal Exclusion Criteria: 1. ILD other than IPF 2. The extent of emphysema is greater than the extent of fibrotic changes on chest HRCT scan 3. Acute exacerbation of IPF 4. Lower respiratory tract infection requiring treatment 5. Acute coronary syndrome/acute myocardial infarction, unstable angina ± coronary intervention with Percutaneous Coronary Intervention, or Coronary Artery Bypass Grafting 6. Heart failure 7. History of organ transplantation or is likely to receive lung transplantation

Get updates

Get notified about this study

Vår säkerhetsrekommendation!

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Conditions

The condition(s) this trial relates to.

idiopathic pulmonary fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Idiopathic pulmonary fibrosis (IPF)

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

185 sites in 22 countries. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

Open the record ↗
A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

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Birmingham, Alabama, 35205, United States
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Phoenix, Arizona, 85006, United States
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Phoenix, Arizona, 85032, United States
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Loma Linda, California, 92350, United States
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Los Angeles, California, 90033, United States
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Newport Beach, California, 92663, United States
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Sacramento, California, 95817, United States
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Stanford, California, 94305, United States
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Aurora, Colorado, 80045, United States
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Denver, Colorado, 80206, United States
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Ocala, Florida, 34470, United States
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Weston, Florida, 33331, United States
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Atlanta, Georgia, 30322, United States
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Boise, Idaho, 83712, United States
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Champaign, Illinois, 61820, United States
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Chicago, Illinois, 60611, United States
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Kansas City, Kansas, 66160, United States
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Lexington, Kentucky, 40536, United States
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Baltimore, Maryland, 21201, United States
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Boston, Massachusetts, 02114, United States
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Ann Arbor, Michigan, 48109, United States
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Detroit, Michigan, 48202, United States
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New York, New York, 10017, United States
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New York, New York, 10029, United States
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Greensboro, North Carolina, 27403, United States
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Cincinnati, Ohio, 45267, United States
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Oklahoma City, Oklahoma, 73117, United States
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Bethlehem, Pennsylvania, 18015, United States
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Philadelphia, Pennsylvania, 19104, United States
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Philadelphia, Pennsylvania, 19140, United States
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Charleston, South Carolina, 29425, United States
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Dallas, Texas, 75254, United States
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El Paso, Texas, 79902, United States
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Houston, Texas, 77030, United States
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Burlington, Vermont, 05401, United States
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Richmond, Virginia, 23298, United States
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Alberdi, X5033DCE, Argentina
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Buenos Aires, 1425, Argentina
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Ciudad de Buenos Aires, C1414AIF, Argentina
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Florida, B1602DQD, Argentina
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Rosario, 2000, Argentina
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San Fernando, B1646EBJ, Argentina
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Port Macquarie, 2444, Australia
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Wollongong, 2500, Australia
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Haskovo, 6300, Bulgaria
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Plovdiv, 4001, Bulgaria
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Rousse, 7000, Bulgaria
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Sofia, 1618, Bulgaria
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Sofia, 1680, Bulgaria
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Sofia, 1756, Bulgaria
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Sherwood Park, Alberta, T8H 2M7, Canada
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Vancouver, British Columbia, V5Z 1M9, Canada
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Ajax, Ontario, L1S 2J5, Canada
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Burlington, Ontario, L7N 3V2, Canada
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Kingston, Ontario, K7M 4E7, Canada
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North York, Ontario, M2K 1E1, Canada
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Saint-Charles-Borromée, Quebec, J6E 2B4, Canada
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Sherbrooke, Quebec, J1H 5N4, Canada
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Providencia, 7500504, Chile
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Santiago, 7750495, Chile
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Talca, 3481349, Chile
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Viña del Mar, 2531172, Chile
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Viña del Mar, 2540488, Chile
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Beijing, 100000, China
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Beijing, 100029, China
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Beijing, 100730, China
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Changchun, 130041, China
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Changsha, 430033, China
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Chengdu, 610041, China
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Chengdu, 610078, China
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Guangzhou, 510735, China
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Lanzhou, 730030, China
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Nanchang, 330000, China
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Nanjing, 2100008, China
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Shanghai, 200433, China
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Shenyang, 110015, China
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Wuhan, 430048, China
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Xuzhou, 221000, China
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Zhengzhou, 450000, China
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Aarhus, 8200, Denmark
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Copenhagen, 2100, Denmark
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Hellerup, 2900, Denmark
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Odense C, 5000, Denmark
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Angers, 49933, France
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Brest, 29609, France
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Bron, 69677, France
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Montpellier, 34295, France
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Nice, 6000, France
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Paris, 75877, France
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Rennes, 35033, France
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Tours, 37000, France
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Bonn, 53127, Germany
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Essen, 45239, Germany
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Freiburg im Breisgau, 79106, Germany
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Fulda, 36043, Germany
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Giessen, 35392, Germany
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Hamburg, 20251, Germany
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Hanover, 30459, Germany
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Heidelberg, 69126, Germany
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Hemer, 58675, Germany
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Konstanz, 78464, Germany
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Leipzig, 04103, Germany
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Lübeck, 23538, Germany
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Marburg, 35037, Germany
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Munich, 81377, Germany
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Stuttgart, 70376, Germany
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Witten, 58452, Germany
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Wuppertal-Barmen, 42283, Germany
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Athens, 11527, Greece
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Athens, 12462, Greece
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Heraklion, 71110, Greece
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Ioannina, 45500, Greece
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Pátrai, 26500, Greece
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Thessaloniki, 57010, Greece
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Budapest, 1083, Hungary
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Budapest, 1121, Hungary
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Debrecen, 4032, Hungary
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Törökbálint, 2045, Hungary
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Ashkelon, 78278, Israel
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Jerusalem, 9103102, Israel
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Kfar Saba, 4428164, Israel
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Petah Tikva, 4941492, Israel
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Rehovot, 76100, Israel
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Foggia, 71100, Italy
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Forlì, 47121, Italy
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Modena, 41124, Italy
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Monza, 20900, Italy
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Pavia, 27100, Italy
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Rozzano, 20089, Italy
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Siena, 53100, Italy
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Torino, 10126, Italy
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Fukuoka, 810-8563, Japan
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Hachioji-shi, 193-0998, Japan
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Hamamatsu, 431-3192, Japan
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Hiroshima, 734-8530, Japan
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Kakogawa-shi, 675-8611, Japan
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Kumagaya-shi, 360-0197, Japan
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Kumamoto, 861-4193, Japan
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Matsusaka-shi, 515-8544, Japan
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Sakaishi, 591-8555, Japan
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Sendai, 980-8574, Japan
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Seto-shi, 489-8642, Japan
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Shimotsuke-shi, 329-0498, Japan
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Shinjuku-ku, 162-8655, Japan
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Yokohama, 236-0037, Japan
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Yokohama, 236-0051, Japan
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Benito Juárez, 03330, Mexico
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Chihuahua City, 31203, Mexico
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Coyocan, 04330, Mexico
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León, 37160, Mexico
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Mérida, 97130, Mexico
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Monterrey, 64460, Mexico
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Monterrey, 64465, Mexico
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Oaxaca City, 68000, Mexico
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Pachuca, 42070, Mexico
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Bialystok, 15-044, Poland
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Krakow, 31-202, Poland
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Lodz, 90-153, Poland
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Poznan, 60-569, Poland
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Rzeszów, 35-205, Poland
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Warsaw, 02-507, Poland
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Cape Town, 7700, South Africa
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Durban, 4001, South Africa
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Parktown West, 2193, South Africa
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Somerset West, 7130, South Africa
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Seongnam-si, 13620, South Korea
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Seoul, 02841, South Korea
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Seoul, 04401, South Korea
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Seoul, 06351, South Korea
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Seoul, 5505, South Korea
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Barcelona, 08036, Spain
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Barcelona, 8025, Spain
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L'Hospitalet de Llobregat, 08907, Spain
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Madrid, 28006, Spain
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Málaga, 29010, Spain
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Valencia, 46010, Spain
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Kaohsiung City, 80756, Taiwan
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Kaohsiung City, 824, Taiwan
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Taichung, 40705, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 11220, Taiwan
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Taipei, 11696, Taiwan
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Taoyuan, 333, Taiwan
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Yunlin, 640, Taiwan
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Bristol, BS105NB, United Kingdom
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Cottingham, HU16 5JQ, United Kingdom
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Edinburgh, EH16 4SA, United Kingdom
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Exeter, EX2 5DW, United Kingdom
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Liverpool, L9 7AL, United Kingdom
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London, SW3 6NP, United Kingdom

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