New asthma drug aims to cut severe attacks in patients not helped by inhalers

NCT ID NCT06932263

Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 21, 2026 · Updated 3 times

Summary

This study tests a new drug called tozorakimab in 540 adults with uncontrolled asthma despite using medium-to-high dose inhaled steroids. Participants will receive either the drug or a placebo as a shot under the skin. The main goal is to see if tozorakimab can reduce the number of severe asthma attacks over a year.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: tozorakimab
What this could lead to: If successful, tozorakimab could offer a new treatment option to reduce severe asthma attacks in people whose asthma is not well controlled with current inhalers.
What could go wrong: This is an early Phase IIb trial, so the drug may not prove effective or safe enough. Results may not apply to all asthma patients, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 540 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2025

Expected to finish

Feb 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Provision of signed and dated written informed consent prior to any study-specific procedures. 2. Adults aged 18-75, inclusive when signing the informed consent. 3. Documented physician-diagnosis of asthma for at least 12 months. 4. Treated with medium or high dose ICS in combination with LABA. 5. Demonstration of uncontrolled asthma through ACQ-6 score ≥ 1.5 . 6. Pre-bronchodilator FEV1 ≥ 40% to ≤ 90% of predicted normal. 7. Documented exacerbation history in the last 12 months and biomarker requirements of: 1. 2 severe exacerbations OR 2. 1 severe exacerbation and: (i) Eosinophils ≥ 150 cells/µl or (ii) FeNo ≥ 25 ppb 8. Participants need to demonstrate a ≥70% compliance for Asthma Daily Diary. 9. Women of Child Bearing Potential (WOCBP) must have a negative pregnancy test. 10. Contraceptive use by males and females should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies. Exclusion Criteria: 1. Completed treatment for respiratory infection with antibiotics in the 4 weeks prior to Visit 1. 2. Clinically significant pulmonary disease other than asthma . 3. Current smokers, former smokers with \>10 pack-years history. 4. Clinically significant aortic stenosis or pulmonary arterial hypertension. 5. Active tuberculosis, hepatitis, HIV, or current diagnosis of cancer or immune complex disease. 6. Unstable cardiovascular disorders.

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Get notified about this study

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Conditions

The condition(s) this trial relates to.

asthma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Asthma

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

168 sites in 19 countries. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

Open the record ↗
A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

Research Site
RECRUITING

Bakersfield, California, 93301, United States
Research Site
WITHDRAWN

Huntington Beach, California, 92647, United States
Research Site
TERMINATED

La Mesa, California, 91942, United States
Research Site
WITHDRAWN

Loma Linda, California, 92350, United States
Research Site
WITHDRAWN

Long Beach, California, 90815, United States
Research Site
RECRUITING

Newport Beach, California, 92663, United States
Research Site
RECRUITING

San Jose, California, 95117, United States
Research Site
TERMINATED

Wilmington, Delaware, 19805, United States
Research Site
SUSPENDED

Cutler Bay, Florida, 33189, United States
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SUSPENDED

Hialeah, Florida, 33015, United States
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WITHDRAWN

Leesburg, Florida, 34748, United States
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SUSPENDED

Miami, Florida, 33155, United States
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SUSPENDED

Miami, Florida, 33175, United States
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Miami Lakes, Florida, 33016, United States
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Orlando, Florida, 32819, United States
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Palmetto Bay, Florida, 33157, United States
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Tampa, Florida, 33607, United States
Research Site
SUSPENDED

Winter Park, Florida, 32789, United States
Research Site
WITHDRAWN

Boise, Idaho, 83706, United States
Research Site
RECRUITING

Noblesville, Indiana, 46060, United States
Research Site
TERMINATED

West Des Moines, Iowa, 50266, United States
Research Site
NOT_YET_RECRUITING

Hutchinson, Kansas, 67502, United States
Research Site
WITHDRAWN

Kansas City, Kansas, 66160, United States
Research Site
RECRUITING

Louisville, Kentucky, 40218, United States
Research Site
WITHDRAWN

White Marsh, Maryland, 21162, United States
Research Site
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Farmington Hills, Michigan, 48336, United States
Research Site
WITHDRAWN

Warren, Michigan, 48088, United States
Research Site
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St Louis, Missouri, 63141, United States
Research Site
WITHDRAWN

Bellevue, Nebraska, 68123, United States
Research Site
RECRUITING

Grand Island, Nebraska, 68803, United States
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Omaha, Nebraska, 68134, United States
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Toms River, New Jersey, 08755, United States
Research Site
NOT_YET_RECRUITING

Horseheads, New York, 14845, United States
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RECRUITING

Maspeth, New York, 11378, United States
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Asheville, North Carolina, 28803, United States
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Huntersville, North Carolina, 28078, United States
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Kings Mountain, North Carolina, 28086, United States
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Pinehurst, North Carolina, 28374, United States
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Toledo, Ohio, 43617, United States
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Edmond, Oklahoma, 73034, United States
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WITHDRAWN

Grants Pass, Oregon, 97527, United States
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Medford, Oregon, 97504, United States
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Portland, Oregon, 97202, United States
Research Site
TERMINATED

DuBois, Pennsylvania, 15801, United States
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RECRUITING

Philadelphia, Pennsylvania, 19140, United States
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Smithfield, Pennsylvania, 15478, United States
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Rock Hill, South Carolina, 29732, United States
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TERMINATED

Knoxville, Tennessee, 37919, United States
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RECRUITING

Austin, Texas, 78759, United States
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NOT_YET_RECRUITING

Boerne, Texas, 78006, United States
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NOT_YET_RECRUITING

Dallas, Texas, 75254, United States
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NOT_YET_RECRUITING

El Paso, Texas, 79912, United States
Research Site
TERMINATED

Forney, Texas, 75126, United States
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NOT_YET_RECRUITING

Greenville, Texas, 75401, United States
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RECRUITING

Kingwood, Texas, 77339, United States
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NOT_YET_RECRUITING

McKinney, Texas, 75069, United States
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NOT_YET_RECRUITING

Sugar Land, Texas, 77478, United States
Research Site
WITHDRAWN

Tyler, Texas, 75708, United States
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RECRUITING

Victoria, Texas, 77901, United States
Research Site
TERMINATED

Roy, Utah, 84067, United States
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TERMINATED

Bellingham, Washington, 98225, United States
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RECRUITING

Kingwood, West Virginia, 26537, United States
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RECRUITING

Milwaukee, Wisconsin, 53228, United States
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CABA, C1425BEN, Argentina
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WITHDRAWN

Ciudad de Buenos Aires, 1128, Argentina
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Ciudad de Buenos Aires, 1425, Argentina
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La Plata, B1900, Argentina
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Mendoza, 5500, Argentina
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Rosario, 2000, Argentina
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San Miguel de Tucumán, 4000, Argentina
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WITHDRAWN

Caxias do Sul, 95070-560, Brazil
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Criciúma, 88811-000, Brazil
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RECRUITING

Porto Alegre, 9061-000, Brazil
Research Site
RECRUITING

Porto Alegre, 91350-200, Brazil
Research Site
WITHDRAWN

Salvador, 40050 410, Brazil
Research Site
WITHDRAWN

Santo André, 09080-110, Brazil
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RECRUITING

São José do Rio Preto, 15090-000, Brazil
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RECRUITING

São Paulo, 04014-002, Brazil
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São Paulo, 05403-000, Brazil
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RECRUITING

Sorocaba, 18040-425, Brazil
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ACTIVE_NOT_RECRUITING

Curicó, 3341643, Chile
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ACTIVE_NOT_RECRUITING

Quillota, 2260000, Chile
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ACTIVE_NOT_RECRUITING

Santiago, 7500657, Chile
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ACTIVE_NOT_RECRUITING

Santiago, 7501126, Chile
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ACTIVE_NOT_RECRUITING

Santiago, 7750495, Chile
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ACTIVE_NOT_RECRUITING

Temuco, 4810345, Chile
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ACTIVE_NOT_RECRUITING

Viña del Mar, 2540488, Chile
Research Site
RECRUITING

Baotou, 014010, China
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RECRUITING

Changchun, 130021, China
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Chengdu, 610000, China
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Chongqing, 400010, China
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Guangzhou, 510163, China
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Haikou, 570311, China
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Hefei, 230061, China
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Hohhot, 10050, China
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Huizhou, 516001, China
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Qingdao, 266011, China
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Shanghai, 200025, China
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Shanghai, 200065, China
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Shanghai, 201114, China
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Shenzhen, 518020, China
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Wenzhou, 325027, China
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Xuzhou, 221000, China
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Brest, 29200, France
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Créteil, 94010, France
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Lyon, 69317, France
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Marseille, 13015, France
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Pessac, 33604, France
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Strasbourg, 67091, France
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RECRUITING

Suresnes, 92150, France
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RECRUITING

Athens, 11521, Greece
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RECRUITING

Athens, 17562, Greece
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WITHDRAWN

Ioannina, 45500, Greece
Research Site
ACTIVE_NOT_RECRUITING

Pátrai, 26500, Greece
Research Site
RECRUITING

Thessaloniki, 57001, Greece
Research Site
ACTIVE_NOT_RECRUITING

Thessaloniki, 57010, Greece
Research Site
ACTIVE_NOT_RECRUITING

Balassagyarmat, 2660, Hungary
Research Site
WITHDRAWN

Budapest, 1036, Hungary
Research Site
WITHDRAWN

Budapest, 1121, Hungary
Research Site
ACTIVE_NOT_RECRUITING

Debrecen, 4032, Hungary
Research Site
ACTIVE_NOT_RECRUITING

Gödöllő, 2100, Hungary
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ACTIVE_NOT_RECRUITING

Pécs, 7635, Hungary
Research Site
ACTIVE_NOT_RECRUITING

Törökbálint, 2045, Hungary
Research Site
RECRUITING

Belagavi, 590010, India
Research Site
RECRUITING

Coimbatore, 641028, India
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RECRUITING

Dehradun, 248001, India
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RECRUITING

Delhi, 110029, India
Research Site
WITHDRAWN

Faridabad, 121012, India
Research Site
RECRUITING

Gurgaon, 122001, India
Research Site
RECRUITING

Kochi, 682027, India
Research Site
SUSPENDED

Lucknow, 226003, India
Research Site
RECRUITING

New Delhi, 110005, India
Research Site
RECRUITING

Vadodara, 391760, India
Research Site
RECRUITING

Haifa, 3109601, Israel
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Jerusalem, 91120, Israel
Research Site
RECRUITING

Kfar Saba, 44281, Israel
Research Site
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Ramat Gan, 52621, Israel
Research Site
RECRUITING

Rehovot, 76100, Israel
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RECRUITING

Catania, 95123, Italy
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RECRUITING

Foggia, 71100, Italy
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RECRUITING

Genoa, 16132, Italy
Research Site
RECRUITING

Roma, 00168, Italy
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RECRUITING

Fukuoka, 811-1394, Japan
Research Site
RECRUITING

Ginowan-shi, 901-2214, Japan
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RECRUITING

Hiroshima, 730-0013, Japan
Research Site
RECRUITING

Ishinomaki, 986-8522, Japan
Research Site
RECRUITING

Kawaguchi-shi, 332-8558, Japan
Research Site
RECRUITING

Kiyose-shi, 204-8585, Japan
Research Site
RECRUITING

Kobe, 650-0017, Japan
Research Site
RECRUITING

Meguro-ku, 152-8902, Japan
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RECRUITING

Miura, 238-0111, Japan
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RECRUITING

Neyagawa, 572-8551, Japan
Research Site
RECRUITING

Sapporo, 060-0033, Japan
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RECRUITING

Sapporo, 064-0804, Japan
Research Site
RECRUITING

Takamatsu, 761-8073, Japan
Research Site
RECRUITING

Ube, 755-8505, Japan
Research Site
RECRUITING

Yokohama, 232-0024, Japan
Research Site
RECRUITING

Yokohama, 232-0066, Japan
Research Site
RECRUITING

Yokohama, 245-8575, Japan
Research Site
RECRUITING

Lima, 15046, Peru
Research Site
RECRUITING

Lima, 15082, Peru
Research Site
RECRUITING

Lima, 15088, Peru
Research Site
RECRUITING

Lima, LIMA 1, Peru
Research Site
WITHDRAWN

Lima, LIMA 21, Peru
Research Site
WITHDRAWN

Lima, LIMA 33, Peru
Research Site
RECRUITING

Iloilo City, 5000, Philippines
Research Site
WITHDRAWN

Las Piñas, 1742, Philippines
Research Site
RECRUITING

Lipa, 4217, Philippines
Research Site
RECRUITING

Manadaluyong City, 1552, Philippines
Research Site
RECRUITING

Quezon City, 1100, Philippines
Research Site
WITHDRAWN

Roxas City, 5800, Philippines
Research Site
RECRUITING

Bellville, 7530, South Africa
Research Site
RECRUITING

Benoni, 1501, South Africa
Research Site
RECRUITING

Brackenfell, 7560, South Africa
Research Site
RECRUITING

Cape Town, 7700, South Africa
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RECRUITING

Durban, 4093, South Africa
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RECRUITING

eMkhomazi, 4170, South Africa
Research Site
RECRUITING

Somerset West, 7130, South Africa
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RECRUITING

Cheongju-si, 28644, South Korea
Research Site
RECRUITING

Daegu, 42415, South Korea
Research Site
RECRUITING

Seoul, 03080, South Korea
Research Site
RECRUITING

Seoul, 03312, South Korea
Research Site
RECRUITING

Seoul, 03722, South Korea
Research Site
RECRUITING

Seoul, 05505, South Korea
Research Site
RECRUITING

Seoul, 06591, South Korea
Research Site
RECRUITING

Seoul, 08308, South Korea
Research Site
RECRUITING

Barcelona, 08003, Spain
Research Site
RECRUITING

Barcelona, 8025, Spain
Research Site
RECRUITING

Madrid, 28041, Spain
Research Site
RECRUITING

Málaga, 29010, Spain
Research Site
WITHDRAWN

Mérida, 06800, Spain
Research Site
RECRUITING

Patraix, 46017, Spain
Research Site
RECRUITING

Santander, 39008, Spain
Research Site
RECRUITING

Kaohsiung City, 80756, Taiwan
Research Site
WITHDRAWN

New Taipei City, 231, Taiwan
Research Site
RECRUITING

Taichung, 40705, Taiwan
Research Site
RECRUITING

Taichung, 433004, Taiwan
Research Site
RECRUITING

Taipei, 10002, Taiwan
Research Site
RECRUITING

Taipei, 110, Taiwan
Research Site
RECRUITING

Taipei, 11220, Taiwan
Research Site
RECRUITING

Taipei, 11696, Taiwan
Research Site
RECRUITING

Bangkok, 10700, Thailand
Research Site
RECRUITING

Chanthaburi, 22000, Thailand
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RECRUITING

Chiang Rai, 57000, Thailand
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RECRUITING

Chon Buri, 20000, Thailand
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RECRUITING

Khon Kaen, 40002, Thailand
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RECRUITING

Nakhon Sri Thammarat, 80000, Thailand
Research Site
RECRUITING

Adana, 01330, Turkey (Türkiye)
Research Site
RECRUITING

Ankara, 06280, Turkey (Türkiye)
Research Site
RECRUITING

Bursa, 16059, Turkey (Türkiye)
Research Site
RECRUITING

Gaziantep, 27470, Turkey (Türkiye)
Research Site
RECRUITING

Istanbul, 34890, Turkey (Türkiye)
Research Site
RECRUITING

Kayseri, 38039, Turkey (Türkiye)
Research Site
RECRUITING

Mersin, 33079, Turkey (Türkiye)
Research Site
RECRUITING

Da Nang, 550000, Vietnam
Research Site
RECRUITING

Haiphong, 180000, Vietnam
Research Site
RECRUITING

Hanoi, 100000, Vietnam
Research Site
RECRUITING

Ho Chi Minh City, 10000, Vietnam
Research Site
RECRUITING

Ho Chi Minh City, 700000, Vietnam
Research Site
WITHDRAWN

Ho Chi Minh City, 700000, Vietnam
Research Site
RECRUITING

Huế, 530000, Vietnam

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