New diabetes drug aims to help those with kidney disease

NCT ID NCT07662135

Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Sep 03, 2026 · Updated 6 times

Summary

This study tests a new daily pill called elecoglipron in adults with type 2 diabetes and reduced kidney function. Participants also take dapagliflozin, a standard diabetes medicine. The goal is to see if elecoglipron improves blood sugar control, body weight, and blood pressure compared to a placebo. About 900 people will take part.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: elecoglipron
What this could lead to: If effective, elecoglipron could offer a new treatment option for people with type 2 diabetes and kidney problems, helping control blood sugar and possibly weight and blood pressure.
What could go wrong: This is an early-phase 3 trial, so results may not confirm benefit. Risks include side effects from the drug, and it may not work for everyone with kidney impairment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 900 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Jul 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosed with Type 2 Diabetes Mellitus for at least 90 days prior to screening * On SGTL2i or SGLT2i-naïve and other glucose lowering medication(s) * HbA1c value: 1. On stable dose of SGLT2i ≥ 7.0 % to ≤ 10.5% (53 to 91.3 mmol/mol) 2. SGLT2i-naive ≥ 7.5% to ≤ 10.5% (58 to 91.3 mmol/mol) * Impaired renal function * Body mass index (BMI) of ≥ 23 kg/m2 at screening * Stable body weight (self-reported or documented) for 90 days prior to screening Exclusion Criteria: * Type 1 Diabetes, secondary forms of diabetes (including congenital forms), or history of ketoacidosis or hyperosmolar coma * Currently receiving or anticipated to receive, therapeutic intervention for diabetic retinopathy and/or macular edema * Have had more than one episode of severe hypoglycemia within 180 days prior to screening or has a history of hypoglycemia unawareness or poor recognition of hypoglycemic symptoms * Clinically significant condition affecting the upper GI tract or chronic use of any medication that affects gastric motility or gastric emptying * History of acute or chronic pancreatitis * Severe congestive heart failure (New York Heart Association IV) * History/family history of medullary thyroid cancer or multiple endocrine neoplasia type 2

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Get notified about this study

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Conditions

The condition(s) this trial relates to.

chronic kidney disease type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Type 2 diabetes mellitus Type 2 diabetes with chronic kidney disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

184 sites in 16 countries. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

Open the record ↗
A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

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Sun City, Arizona, 85373, United States
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Surprise, Arizona, 85374, United States
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Concord, California, 94520, United States
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Sacramento, California, 95821, United States
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Victorville, California, 92392, United States
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Fleming Island, Florida, 32003, United States
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Lauderdale Lakes, Florida, 33313, United States
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Leesburg, Florida, 34748, United States
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Miami Lakes, Florida, 33016, United States
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Ocoee, Florida, 34761, United States
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Orlando, Florida, 32804, United States
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Chicago, Illinois, 60640, United States
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Braintree, Massachusetts, 02184, United States
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New Bedford, Massachusetts, 02740, United States
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Worcester, Massachusetts, 01604, United States
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Saint Joseph, Michigan, 49085, United States
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Saint Paul, Minnesota, 55117, United States
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Kansas City, Missouri, 64112, United States
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Omaha, Nebraska, 68144, United States
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Las Vegas, Nevada, 89119, United States
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Albuquerque, New Mexico, 87102, United States
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The Bronx, New York, 10451, United States
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Kinston, North Carolina, 28504, United States
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Raleigh, North Carolina, 27609, United States
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Winston-Salem, North Carolina, 27103, United States
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Cincinnati, Ohio, 45219, United States
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East Providence, Rhode Island, 02914, United States
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Gaffney, South Carolina, 29340, United States
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Greenville, South Carolina, 29605, United States
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San Antonio, Texas, 78212, United States
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San Antonio, Texas, 78257, United States
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Ogden, Utah, 84405, United States
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Arlington, Virginia, 22205, United States
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Dupnitsa, 2600, Bulgaria
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Haskovo, 6304, Bulgaria
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Kyustendil, 2500, Bulgaria
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Pleven, 5801, Bulgaria
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Plovdiv, 4002, Bulgaria
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Rousse, 7000, Bulgaria
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Stara Zagora, 6001, Bulgaria
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Varna, 9000, Bulgaria
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Varna, 9020, Bulgaria
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Binzhou, 256606, China
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Changsha, 430033, China
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Chengdu, 610081, China
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Hangzhou, 310006, China
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Jinan, 250013, China
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Liaocheng, 252000, China
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Liuzhou, 545006, China
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Luoyang, 471003, China
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Nanjing, 211100, China
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Nanyang, 473000, China
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Suining Shi, 629000, China
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Yibin, 610500, China
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Yichang, 443003, China
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Zhengzhou, 450002, China
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Zhengzhou, 450012, China
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Aarhus N, 8200, Denmark
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Gistrup, 9260, Denmark
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Herlev, 2730, Denmark
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Hillerød, 3400, Denmark
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Holbæk, 4300, Denmark
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Hvidovre, 2650, Denmark
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Bad Oeynhausen, 32545, Germany
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Berlin, 12047, Germany
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WITHDRAWN

Brandenburg an der Havel, 14776, Germany
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Chemnitz, 09116, Germany
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Duisburg, 47051, Germany
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Duisburg, 47269, Germany
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Erlangen, 91054, Germany
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Frankfurt, 60596, Germany
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Hamburg, 22607, Germany
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Heilbronn, 74076, Germany
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Hohenmölsen, 06679, Germany
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Ludwigshafen, 67059, Germany
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SUSPENDED

Münster, 48153, Germany
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Nittendorf, 93152, Germany
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Obertshausen, 63179, Germany
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Pirna, 01796, Germany
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Sankt Ingbert, 66386, Germany
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Stuttgart, 70174, Germany
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Aligarh, 202002, India
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Belagavi, 590006, India
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Belgavi, 590010, India
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Calicut, 673 008, India
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Chennai, 600037, India
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Chennai, 600086, India
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Coimbatore, 641018, India
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Delhi, 110029, India
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Guntur, 522001, India
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Kolkata, 700020, India
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Lucknow, 226030, India
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Nagpur, 440010, India
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Pune, 411021, India
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Chigasaki-shi, 253-0044, Japan
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Chikushino-shi, 8188502, Japan
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Gifu, 501-1194, Japan
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Kagoshima, 892-0853, Japan
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Kitakyushu, 805-8508, Japan
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Kumamoto, 862-0965, Japan
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Kyoto, 605-0981, Japan
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Kyoto, 606-8507, Japan
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Maebashi, 371-8511, Japan
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Nagoya, 451-8511, Japan
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Nagoya, 468-0009, Japan
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Osaka, 559-0012, Japan
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Sapporo, 060-0062, Japan
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Suita-shi, 564-8565, Japan
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Tachikawa-shi, 190-8531, Japan
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Toyota-Shi, 471-8513, Japan
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Batu Caves, 68100, Malaysia
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Kuala Lumpur, 59100, Malaysia
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Miri, 98000, Malaysia
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Seremban, 70300, Malaysia
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Seri Manjung, 32040, Malaysia
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Chihuahua City, 31238, Mexico
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Cuernavaca, 62250, Mexico
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Cuernavaca, 62448, Mexico
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Guadalajara, 44150, Mexico
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Guadalajara, 44600, Mexico
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Guadalajara, 44670, Mexico
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Mexico City, 0 3100, Mexico
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Monterrey, 64030, Mexico
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Monterrey, 64460, Mexico
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Zapopan, 45116, Mexico
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Barcelona, 08035, Spain
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Ferrol, 15405, Spain
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Lleida, 25198, Spain
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Madrid, 28040, Spain
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Majadahonda, 28222, Spain
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Málaga, 29010, Spain
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Santander, 39008, Spain
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Seville, 41010, Spain
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Seville, 41013, Spain
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Seville, 41950, Spain
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Valencia, 46010, Spain
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Zaragoza, 50009, Spain
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Kaohsiung City, 833401, Taiwan
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New Taipei City, 23561, Taiwan
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New Taipei City, Taiwan
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Taichung, 40447, Taiwan
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Taichung, 40705, Taiwan
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Taichung, 433004, Taiwan
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Tainan, 710, Taiwan
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Taipei, 100, Taiwan
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Taipei, 110, Taiwan
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Taoyuan, 333, Taiwan
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Zhubei, 302, Taiwan
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Bangkok, 10210, Thailand
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Bangkok, 10700, Thailand
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Chiang Mai, 50200, Thailand
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Hat Yai, 90110, Thailand
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Muang, 70000, Thailand
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Ratchathewi, 10400, Thailand
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Adana, 01060, Turkey (Türkiye)
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Ankara, 06530, Turkey (Türkiye)
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Antalya, 07070, Turkey (Türkiye)
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Bakırköy, 34147, Turkey (Türkiye)
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Gaziantep, 27470, Turkey (Türkiye)
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Kayseri, 38039, Turkey (Türkiye)
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Kayseri, 38080, Turkey (Türkiye)
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Yüreğir, 1240, Turkey (Türkiye)
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Kyiv, 01601, Ukraine
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Kyiv, 02002, Ukraine
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Kyiv, 03037, Ukraine
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Kyiv, 03049, Ukraine
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Kyiv, 03057, Ukraine
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Kyiv, 04050, Ukraine
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Kyiv, 04210, Ukraine
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Lviv, 79010, Ukraine
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Lviv, 79016, Ukraine
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Vinnytsia, 21029, Ukraine
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RECRUITING

Blackpool, FY3 7EN, United Kingdom
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Glasgow, G4 0SF, United Kingdom
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Hull, HU3 2JZ, United Kingdom
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Penzance, TR18 3DX, United Kingdom
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Sandbach, CW11 1EQ, United Kingdom
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Thetford, IP24 1JD, United Kingdom
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NOT_YET_RECRUITING

Whitney, OX29 4QB, United Kingdom
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Haiphong, 180000, Vietnam
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NOT_YET_RECRUITING

Hanoi, 100000, Vietnam
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Hanoi, 10000, Vietnam
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NOT_YET_RECRUITING

Hà Nội, 100000, Vietnam
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NOT_YET_RECRUITING

Ho Chi Minh City, 700000, Vietnam
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NOT_YET_RECRUITING

Hochiminh City, 700000, Vietnam
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WITHDRAWN

Viet Tri, 35000, Vietnam

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