New pill combo aims to tame type 2 diabetes
NCT ID NCT07662044
First seen Jun 27, 2026 · Last updated Sep 01, 2026 · Updated 6 times
Summary
This study tests an experimental drug called elecoglipron, taken alone or together with the existing medication dapagliflozin, in adults with type 2 diabetes whose blood sugar is not well controlled. About 800 participants will receive either the new drug, a placebo, or a combination, and researchers will track changes in blood sugar levels, weight, and safety over time. The goal is to see if elecoglipron offers a new way to manage diabetes effectively.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- elecoglipron and dapagliflozin
- What this could lead to
- If successful, this could provide a new oral medication option to help people with type 2 diabetes better control their blood sugar and possibly lose weight.
- What could go wrong
- This is a phase 3 trial, but results may not apply to all patients. Side effects are possible, and the drug may not prove superior to existing treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 800 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jul 2026
- Expected to finish
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Jul 2028
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Diagnosed with Type 2 Diabetes Mellitus (T2DM) for at least 90 days prior to screening * T2DM inadequately managed with lifestyle management alone or on stable treatment with other background glucose-lowering medication * HbA1c value of ≥ 7% to ≤ 10.5% (53 to 91.3 mmol/mol) * Body mass index (BMI) of ≥ 23 kg/m2 at screening * Stable body weight (self-reported or documented) for 90 days prior to screening Exclusion Criteria: * Type 1 diabetes, secondary forms of diabetes (including congenital forms), or history of ketoacidosis or hyperosmolar coma * Currently receiving or anticipated to receive, therapeutic intervention for diabetic retinopathy and/or macular edema * Have had more than one episode of severe hypoglycemia within 180 days prior to screening or has a history of hypoglycemia unawareness or poor recognition of hypoglycemic symptoms * Clinically significant condition affecting the upper GI tract or chronic use of any medication that affects gastric motility or gastric emptying * History of acute or chronic pancreatitis * Severe congestive heart failure (New York Heart Association IV) * History/family history of medullary thyroid cancer or multiple endocrine neoplasia type 2
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Type 2 diabetes mellitus are added.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
149 sites in 13 countries. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Research Site
NOT_YET_RECRUITINGBirmingham, Alabama, 35233, United States
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NOT_YET_RECRUITINGDaphne, Alabama, 36526, United States
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NOT_YET_RECRUITINGLomita, California, 90717, United States
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NOT_YET_RECRUITINGLos Alamitos, California, 90720, United States
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SUSPENDEDSan Diego, California, 92111, United States
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SUSPENDEDWalnut Creek, California, 94598, United States
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NOT_YET_RECRUITINGEnglewood, Colorado, 80110, United States
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NOT_YET_RECRUITINGBridgeport, Connecticut, 06606, United States
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NOT_YET_RECRUITINGJacksonville, Florida, 32256, United States
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NOT_YET_RECRUITINGOrlando, Florida, 32801, United States
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NOT_YET_RECRUITINGConyers, Georgia, 30094, United States
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NOT_YET_RECRUITINGDecatur, Georgia, 30030, United States
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NOT_YET_RECRUITINGHinesville, Georgia, 31313, United States
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NOT_YET_RECRUITINGEl Dorado, Kansas, 67042, United States
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NOT_YET_RECRUITINGNewton, Kansas, 67114, United States
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NOT_YET_RECRUITINGLexington, Kentucky, 40509, United States
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NOT_YET_RECRUITINGCovington, Louisiana, 70433, United States
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NOT_YET_RECRUITINGBowie, Maryland, 20715, United States
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NOT_YET_RECRUITINGSouthfield, Michigan, 48075, United States
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NOT_YET_RECRUITINGKansas City, Missouri, 64111, United States
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NOT_YET_RECRUITINGSt Louis, Missouri, 63141, United States
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NOT_YET_RECRUITINGLas Vegas, Nevada, 89119, United States
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NOT_YET_RECRUITINGAnderson, South Carolina, 29621, United States
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NOT_YET_RECRUITINGKnoxville, Tennessee, 37909, United States
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SUSPENDEDFort Worth, Texas, 76135, United States
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NOT_YET_RECRUITINGIrving, Texas, 75061, United States
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NOT_YET_RECRUITINGRenton, Washington, 98057, United States
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NOT_YET_RECRUITINGBuenos Aires, C1425AGC, Argentina
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NOT_YET_RECRUITINGCABA, C1120AAC, Argentina
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NOT_YET_RECRUITINGCaba, C1128AAF, Argentina
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NOT_YET_RECRUITINGCiudad de Buenos Aires, C1094AAD, Argentina
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NOT_YET_RECRUITINGMar del Plata, B7600GNY, Argentina
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NOT_YET_RECRUITINGSan Nicolás, B2900DMH, Argentina
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NOT_YET_RECRUITINGSan Vicente, 5006, Argentina
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NOT_YET_RECRUITINGSanta Fe, S3000FWO, Argentina
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NOT_YET_RECRUITINGBaotou, 014030, China
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NOT_YET_RECRUITINGBinzhou, 256606, China
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NOT_YET_RECRUITINGCangzhou, 061002, China
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NOT_YET_RECRUITINGChangsha, 430033, China
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NOT_YET_RECRUITINGChengdu, 610081, China
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NOT_YET_RECRUITINGGanzhou, 341099, China
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NOT_YET_RECRUITINGHaikou, 570208, China
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NOT_YET_RECRUITINGHangzhou, 310006, China
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NOT_YET_RECRUITINGHuangshi, 435000, China
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NOT_YET_RECRUITINGHuzhou, 313003, China
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NOT_YET_RECRUITINGJinan, 250013, China
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NOT_YET_RECRUITINGJinzhou, 121002, China
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NOT_YET_RECRUITINGLanzhou, 730000, China
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NOT_YET_RECRUITINGLianyungang, 222023, China
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NOT_YET_RECRUITINGLiaocheng, 252000, China
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NOT_YET_RECRUITINGLiuzhou, 545006, China
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NOT_YET_RECRUITINGLoudi, 417099, China
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NOT_YET_RECRUITINGLuoyang, 471001, China
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NOT_YET_RECRUITINGLuoyang, 471003, China
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NOT_YET_RECRUITINGNanchang, 330006, China
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NOT_YET_RECRUITINGNanjing, 2100008, China
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NOT_YET_RECRUITINGNanjing, 211100, China
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NOT_YET_RECRUITINGNanyang, 473000, China
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NOT_YET_RECRUITINGNingbo, 315010, China
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NOT_YET_RECRUITINGPanjin, 124000, China
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NOT_YET_RECRUITINGQingdao, 266035, China
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NOT_YET_RECRUITINGSanmenxia, 472000, China
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NOT_YET_RECRUITINGShanghai, 200040, China
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NOT_YET_RECRUITINGSuining Shi, 629000, China
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NOT_YET_RECRUITINGTonghua, 134000, China
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NOT_YET_RECRUITINGXi'an, 710077, China
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NOT_YET_RECRUITINGXiangtan, 411100, China
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NOT_YET_RECRUITINGXuancheng, 242000, China
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NOT_YET_RECRUITINGYibin, 610500, China
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NOT_YET_RECRUITINGYichang, 443003, China
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NOT_YET_RECRUITINGYuncheng, 044099, China
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NOT_YET_RECRUITINGZhengzhou, 450002, China
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NOT_YET_RECRUITINGZhengzhou, 450012, China
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NOT_YET_RECRUITINGZhenjiang, 212002, China
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NOT_YET_RECRUITINGGandrup, 9362, Denmark
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NOT_YET_RECRUITINGHerlev, 2730, Denmark
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NOT_YET_RECRUITINGHillerød, 3400, Denmark
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NOT_YET_RECRUITINGHvidovre, 2650, Denmark
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NOT_YET_RECRUITINGAthens, 10676, Greece
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NOT_YET_RECRUITINGAthens, 11526, Greece
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NOT_YET_RECRUITINGAthens, 12131, Greece
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NOT_YET_RECRUITINGAthens, 15125, Greece
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NOT_YET_RECRUITINGHeraklion, 71500, Greece
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NOT_YET_RECRUITINGPiraeus, 18454, Greece
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NOT_YET_RECRUITINGThessaloniki, 54636, Greece
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NOT_YET_RECRUITINGThessaloniki, 57001, Greece
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NOT_YET_RECRUITINGThessaloniki, 57010, Greece
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NOT_YET_RECRUITINGBudapest, 1027, Hungary
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SUSPENDEDBudapest, 1036, Hungary
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NOT_YET_RECRUITINGBudapest, 1138, Hungary
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NOT_YET_RECRUITINGDebrecen, 4032, Hungary
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NOT_YET_RECRUITINGDunaújváros, 2400, Hungary
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SUSPENDEDSzeged, 6725, Hungary
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SUSPENDEDSzolnok, 5000, Hungary
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NOT_YET_RECRUITINGAmagasaki-shi, 660-8550, Japan
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NOT_YET_RECRUITINGChiba, 261-0004, Japan
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NOT_YET_RECRUITINGChitose-shi, 066-0032, Japan
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NOT_YET_RECRUITINGChūōku, 1040031, Japan
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NOT_YET_RECRUITINGKoga-shi, 306-0232, Japan
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NOT_YET_RECRUITINGMinatoku, 105-0004, Japan
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NOT_YET_RECRUITINGOkayama, 701-1192, Japan
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NOT_YET_RECRUITINGOyama-shi, 323-0022, Japan
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NOT_YET_RECRUITINGShinjuku-ku, 169-0072, Japan
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NOT_YET_RECRUITINGZentsuji-shi, 765-0071, Japan
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NOT_YET_RECRUITINGBratislava, 81108, Slovakia
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NOT_YET_RECRUITINGBratislava, 831 03, Slovakia
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NOT_YET_RECRUITINGKošice, 04001, Slovakia
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NOT_YET_RECRUITINGMartin, 036 01, Slovakia
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NOT_YET_RECRUITINGNámestovo, 02901, Slovakia
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NOT_YET_RECRUITINGPoprad, 05845, Slovakia
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NOT_YET_RECRUITINGRožňava, 048 01, Slovakia
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NOT_YET_RECRUITINGBrackenfell, 7560, South Africa
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NOT_YET_RECRUITINGCape Town, 7500, South Africa
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NOT_YET_RECRUITINGCape Town, 7570, South Africa
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NOT_YET_RECRUITINGClaremont, 7708, South Africa
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NOT_YET_RECRUITINGDurban, 4093, South Africa
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NOT_YET_RECRUITINGeMkhomazi, 4170, South Africa
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NOT_YET_RECRUITINGJohannesburg, 1827, South Africa
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NOT_YET_RECRUITINGKwaDukuza, 4449, South Africa
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NOT_YET_RECRUITINGPaarl, 7646, South Africa
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NOT_YET_RECRUITINGPretoria, 2, South Africa
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NOT_YET_RECRUITINGJongno-gu, 110-746, South Korea
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NOT_YET_RECRUITINGSeongnam-si, 463-712, South Korea
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NOT_YET_RECRUITINGSeoul, 03080, South Korea
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NOT_YET_RECRUITINGSeoul, 5505, South Korea
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NOT_YET_RECRUITINGBarcelona, 08016, Spain
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NOT_YET_RECRUITINGBarcelona, 08020, Spain
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NOT_YET_RECRUITINGBarcelona, 08035, Spain
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NOT_YET_RECRUITINGBarcelona, 08930, Spain
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NOT_YET_RECRUITINGFigueres, 17600, Spain
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NOT_YET_RECRUITINGSeville, 41003, Spain
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Research Site
NOT_YET_RECRUITINGSeville, 41950, Spain
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NOT_YET_RECRUITINGChanghua, 500, Taiwan
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RECRUITINGKaohsiung City, 80756, Taiwan
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NOT_YET_RECRUITINGKaohsiung City, 813, Taiwan
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NOT_YET_RECRUITINGNew Taipei City, 220, Taiwan
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NOT_YET_RECRUITINGTaichung, 40201, Taiwan
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Research Site
NOT_YET_RECRUITINGTaichung, 40705, Taiwan
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RECRUITINGTaichung, 433004, Taiwan
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NOT_YET_RECRUITINGTainan, 70403, Taiwan
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NOT_YET_RECRUITINGTainan County, 71044, Taiwan
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NOT_YET_RECRUITINGTaipei, 10002, Taiwan
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NOT_YET_RECRUITINGAdana, 01060, Turkey (Türkiye)
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NOT_YET_RECRUITINGAnkara, 06530, Turkey (Türkiye)
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NOT_YET_RECRUITINGAnkara, 06560, Turkey (Türkiye)
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NOT_YET_RECRUITINGBursa, 16310, Turkey (Türkiye)
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NOT_YET_RECRUITINGIzmir, 35340, Turkey (Türkiye)
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NOT_YET_RECRUITINGKayseri, 38039, Turkey (Türkiye)
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Research Site
NOT_YET_RECRUITINGSamsun, 55139, Turkey (Türkiye)
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