New daily pill aims to rival semaglutide for diabetes and weight loss

NCT ID NCT07662213

Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Sep 10, 2026 · Updated 4 times

Summary

This phase 3 study tests a new oral drug, elecoglipron, against the approved pill semaglutide in adults with type 2 diabetes who also have increased heart risk. The goal is to see which works better for lowering blood sugar and body weight over about a year. Participants take one of the two pills daily, and researchers track changes in HbA1c and weight.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: Elecoglipron (oral drug)
What this could lead to: If successful, elecoglipron could offer a new once-daily pill option for managing blood sugar and weight in people with type 2 diabetes.
What could go wrong: This is a phase 3 trial, so results are not yet known. Elecoglipron may not prove better or safer than existing treatments like semaglutide.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 1,200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

May 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosed with Type 2 Diabetes Mellitus (T2DM) for at least 90 days prior to screening * T2DM inadequately managed with lifestyle management alone or on stable treatment with other background glucose-lowering medication(s) * HbA1c value of ≥ 7% to ≤ 10.5% (53 to 91.3 mmol/mol) * Increased risk of cardiovascular (CV) events defined by ≥1 of: documented coronary heart disease, peripheral arterial disease, ischemic cerebrovascular disease, or heart failure (NYHA II-III); or ≥2 CV risk factors * Body mass index (BMI) of ≥ 23 kg/m2 at screening * Stable body weight (self-reported or documented) for 90 days prior to screening Exclusion Criteria: * Type 1 Diabetes Mellitus (T1DM), secondary forms of diabetes (including congenital forms), or history of ketoacidosis or hyperosmolar coma * Currently receiving or anticipated to receive, therapeutic intervention for diabetic retinopathy and/or macular edema * Have had more than one episode of severe hypoglycemia within 180 days prior to screening or has a history of hypoglycemia unawareness or poor recognition of hypoglycemic symptoms * Clinically significant condition affecting the upper Gastrointestinal (GI) tract or chronic use of any medication that affects gastric motility or gastric emptying * History of acute or chronic pancreatitis * Severe congestive heart failure (NYHA IV) * History/family history of medullary thyroid cancer or multiple endocrine neoplasia type 2

Get updates

Get notified about this study

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Type 2 diabetes mellitus

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

203 sites in 15 countries. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

Open the record ↗
A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

Research Site
NOT_YET_RECRUITING

Birmingham, Alabama, 35205, United States
Research Site
NOT_YET_RECRUITING

Mesa, Arizona, 85213, United States
Research Site
NOT_YET_RECRUITING

Phoenix, Arizona, 85016, United States
Research Site
NOT_YET_RECRUITING

Tempe, Arizona, 85281, United States
Research Site
NOT_YET_RECRUITING

Covina, California, 91723, United States
Research Site
NOT_YET_RECRUITING

Encinitas, California, 92024, United States
Research Site
NOT_YET_RECRUITING

Garden Grove, California, 92844, United States
Research Site
NOT_YET_RECRUITING

Loma Linda, California, 92354, United States
Research Site
NOT_YET_RECRUITING

Long Beach, California, 90807, United States
Research Site
NOT_YET_RECRUITING

Pomona, California, 91768, United States
Research Site
NOT_YET_RECRUITING

Sacramento, California, 95821, United States
Research Site
NOT_YET_RECRUITING

Bridgeport, Connecticut, 06606, United States
Research Site
NOT_YET_RECRUITING

Crystal River, Florida, 34429, United States
Research Site
NOT_YET_RECRUITING

Hollywood, Florida, 33021, United States
Research Site
NOT_YET_RECRUITING

Jacksonville, Florida, 32209, United States
Research Site
NOT_YET_RECRUITING

Lake City, Florida, 32055, United States
Research Site
NOT_YET_RECRUITING

Leesburg, Florida, 34748, United States
Research Site
NOT_YET_RECRUITING

Orlando, Florida, 32806, United States
Research Site
NOT_YET_RECRUITING

Lilburn, Georgia, 30047, United States
Research Site
NOT_YET_RECRUITING

Idaho Falls, Idaho, 83404, United States
Research Site
NOT_YET_RECRUITING

Melrose Park, Illinois, 60160, United States
Research Site
NOT_YET_RECRUITING

Evansville, Indiana, 47710, United States
Research Site
NOT_YET_RECRUITING

Ames, Iowa, 50010, United States
Research Site
NOT_YET_RECRUITING

Wichita, Kansas, 67226, United States
Research Site
NOT_YET_RECRUITING

Bowling Green, Kentucky, 42101, United States
Research Site
NOT_YET_RECRUITING

Rockville, Maryland, 20852, United States
Research Site
NOT_YET_RECRUITING

Southfield, Michigan, 48076, United States
Research Site
NOT_YET_RECRUITING

Minneapolis, Minnesota, 55416, United States
Research Site
NOT_YET_RECRUITING

Jefferson City, Missouri, 65109, United States
Research Site
NOT_YET_RECRUITING

Kansas City, Missouri, 64114, United States
Research Site
NOT_YET_RECRUITING

Omaha, Nebraska, 68114, United States
Research Site
NOT_YET_RECRUITING

Henderson, Nevada, 89052, United States
Research Site
NOT_YET_RECRUITING

Las Vegas, Nevada, 89128, United States
Research Site
NOT_YET_RECRUITING

Albuquerque, New Mexico, 87112, United States
Research Site
NOT_YET_RECRUITING

Durham, North Carolina, 27701, United States
Research Site
NOT_YET_RECRUITING

Morehead City, North Carolina, 28557, United States
Research Site
NOT_YET_RECRUITING

Raleigh, North Carolina, 27612, United States
Research Site
NOT_YET_RECRUITING

Statesville, North Carolina, 28625, United States
Research Site
NOT_YET_RECRUITING

Wilmington, North Carolina, 28403, United States
Research Site
NOT_YET_RECRUITING

Columbus, Ohio, 43215, United States
Research Site
NOT_YET_RECRUITING

Oklahoma City, Oklahoma, 73134, United States
Research Site
NOT_YET_RECRUITING

Feasterville-Trevose, Pennsylvania, 19053, United States
Research Site
NOT_YET_RECRUITING

Philadelphia, Pennsylvania, 19114, United States
Research Site
NOT_YET_RECRUITING

Myrtle Beach, South Carolina, 29572, United States
Research Site
NOT_YET_RECRUITING

North Charleston, South Carolina, 29405, United States
Research Site
NOT_YET_RECRUITING

Memphis, Tennessee, 38119, United States
Research Site
NOT_YET_RECRUITING

Morristown, Tennessee, 37813, United States
Research Site
NOT_YET_RECRUITING

Dallas, Texas, 75390, United States
Research Site
NOT_YET_RECRUITING

Houston, Texas, 77004, United States
Research Site
NOT_YET_RECRUITING

Houston, Texas, 77040, United States
Research Site
NOT_YET_RECRUITING

Houston, Texas, 77079, United States
Research Site
NOT_YET_RECRUITING

Katy, Texas, 77450, United States
Research Site
NOT_YET_RECRUITING

San Antonio, Texas, 78229, United States
Research Site
NOT_YET_RECRUITING

San Antonio, Texas, 78231, United States
Research Site
NOT_YET_RECRUITING

Sugar Land, Texas, 77478, United States
Research Site
NOT_YET_RECRUITING

Weslaco, Texas, 78596, United States
Research Site
NOT_YET_RECRUITING

Bountiful, Utah, 84010, United States
Research Site
NOT_YET_RECRUITING

Salt Lake City, Utah, 84124, United States
Research Site
NOT_YET_RECRUITING

Leesburg, Virginia, 20176, United States
Research Site
NOT_YET_RECRUITING

Norfolk, Virginia, 23502, United States
Research Site
NOT_YET_RECRUITING

Renton, Washington, 98057, United States
Research Site
NOT_YET_RECRUITING

Seattle, Washington, 98104, United States
Research Site
NOT_YET_RECRUITING

Seattle, Washington, 98105, United States
Research Site
NOT_YET_RECRUITING

Morgantown, West Virginia, 26505, United States
Research Site
NOT_YET_RECRUITING

Buenos Aires, C1120AAC, Argentina
Research Site
RECRUITING

Buenos Aires, C1425AGC, Argentina
Research Site
NOT_YET_RECRUITING

Caba, C1128AAF, Argentina
Research Site
RECRUITING

Ciudad de Buenos Aires, C1094AAD, Argentina
Research Site
NOT_YET_RECRUITING

Rosario, S2000CVD, Argentina
Research Site
NOT_YET_RECRUITING

San Nicolás, B2900DMH, Argentina
Research Site
RECRUITING

San Vicente, 5006, Argentina
Research Site
RECRUITING

Botany, 2019, Australia
Research Site
RECRUITING

East Toowoomba, 4350, Australia
Research Site
NOT_YET_RECRUITING

Fitzroy, 3065, Australia
Research Site
NOT_YET_RECRUITING

Heidelberg Heights, 3081, Australia
Research Site
NOT_YET_RECRUITING

Kingswood, 2747, Australia
Research Site
RECRUITING

Melbourne, 3004, Australia
Research Site
RECRUITING

Parkville, 3050, Australia
Research Site
NOT_YET_RECRUITING

Penrith, 2750, Australia
Research Site
RECRUITING

St Leonards, 2065, Australia
Research Site
NOT_YET_RECRUITING

Brasília, 71625-009, Brazil
Research Site
NOT_YET_RECRUITING

Campinas, 13060-803, Brazil
Research Site
NOT_YET_RECRUITING

Curitiba, 80030-480, Brazil
Research Site
NOT_YET_RECRUITING

Natal, 59020-500, Brazil
Research Site
NOT_YET_RECRUITING

Porto Alegre, 90630-165, Brazil
Research Site
NOT_YET_RECRUITING

São José dos Campos, 12243-280, Brazil
Research Site
NOT_YET_RECRUITING

São Paulo, 04012-180, Brazil
Research Site
RECRUITING

Plovdiv, 4001, Bulgaria
Research Site
NOT_YET_RECRUITING

Sofia, 1407, Bulgaria
Research Site
RECRUITING

Sofia, 1618, Bulgaria
Research Site
NOT_YET_RECRUITING

Sofia, 1700, Bulgaria
Research Site
NOT_YET_RECRUITING

Yambol, 8600, Bulgaria
Research Site
RECRUITING

Vancouver, British Columbia, V5Y 3W2, Canada
Research Site
NOT_YET_RECRUITING

Guelph, Ontario, N1H 1B1, Canada
Research Site
RECRUITING

Sarnia, Ontario, N7T 4X3, Canada
Research Site
RECRUITING

Scarborough Village, Ontario, M1R 0B1, Canada
Research Site
RECRUITING

Stouffville, Ontario, L4A1H2, Canada
Research Site
RECRUITING

Toronto, Ontario, M4G3E8, Canada
Research Site
NOT_YET_RECRUITING

Toronto, Ontario, M6G 1M2, Canada
Research Site
RECRUITING

Toronto, Ontario, M9V 4B4, Canada
Research Site
RECRUITING

Montreal, Quebec, H4N 2W2, Canada
Research Site
RECRUITING

Saint-Charles-Borromée, Quebec, J6E 2B4, Canada
Research Site
NOT_YET_RECRUITING

Changsha, 410013, China
Research Site
NOT_YET_RECRUITING

Changsha, 410015, China
Research Site
NOT_YET_RECRUITING

Hefei, 230000, China
Research Site
NOT_YET_RECRUITING

Hefei, 230601, China
Research Site
NOT_YET_RECRUITING

Huai'an, 223005, China
Research Site
NOT_YET_RECRUITING

Langfang, 065000, China
Research Site
NOT_YET_RECRUITING

Liangyugang, 222002, China
Research Site
NOT_YET_RECRUITING

Luoyang, 471009, China
Research Site
NOT_YET_RECRUITING

Nanjing, 2100008, China
Research Site
NOT_YET_RECRUITING

Nanyang, 473009, China
Research Site
NOT_YET_RECRUITING

Pinggu, 101200, China
Research Site
NOT_YET_RECRUITING

Pingxiang, 337055, China
Research Site
NOT_YET_RECRUITING

Shijiazhuang, 050000, China
Research Site
NOT_YET_RECRUITING

Tianjin, 300134, China
Research Site
NOT_YET_RECRUITING

Yueyang, 414000, China
Research Site
NOT_YET_RECRUITING

Bad Oeynhausen, 32545, Germany
Research Site
NOT_YET_RECRUITING

Berlin, 13597, Germany
Research Site
NOT_YET_RECRUITING

Chemnitz, 09116, Germany
Research Site
NOT_YET_RECRUITING

Damme, 49401, Germany
Research Site
NOT_YET_RECRUITING

Duisburg, 47051, Germany
Research Site
NOT_YET_RECRUITING

Elsterwerda, 04910, Germany
Research Site
NOT_YET_RECRUITING

Erlangen, 91054, Germany
Research Site
WITHDRAWN

Essen, 45359, Germany
Research Site
RECRUITING

Falkensee, 14612, Germany
Research Site
NOT_YET_RECRUITING

Gladbeck, 45968, Germany
Research Site
NOT_YET_RECRUITING

Hamburg, 21109, Germany
Research Site
RECRUITING

Hamburg, 22607, Germany
Research Site
NOT_YET_RECRUITING

Leipzig, 04249, Germany
Research Site
WITHDRAWN

Mannheim, 68167, Germany
Research Site
RECRUITING

Münster, 48145, Germany
Research Site
RECRUITING

Oldenburg, 23758, Germany
Research Site
NOT_YET_RECRUITING

Pirna, 01796, Germany
Research Site
NOT_YET_RECRUITING

Sankt Ingbert, 66386, Germany
Research Site
NOT_YET_RECRUITING

Wangen, 88239, Germany
Research Site
NOT_YET_RECRUITING

Budapest, 1036, Hungary
Research Site
NOT_YET_RECRUITING

Budapest, 1089, Hungary
Research Site
RECRUITING

Budapest, 1132, Hungary
Research Site
NOT_YET_RECRUITING

Debrecen, 4032, Hungary
Research Site
WITHDRAWN

Salgótarján, 3100, Hungary
Research Site
NOT_YET_RECRUITING

Szeged, 6725, Hungary
Research Site
WITHDRAWN

Szolnok, 5000, Hungary
Research Site
WITHDRAWN

Zalaegerszeg, 8900, Hungary
Research Site
NOT_YET_RECRUITING

Bari, 70124, Italy
Research Site
NOT_YET_RECRUITING

Bologna, 40138, Italy
Research Site
NOT_YET_RECRUITING

Chieti, 66100, Italy
Research Site
NOT_YET_RECRUITING

Milan, 20132, Italy
Research Site
NOT_YET_RECRUITING

Milan, 20138, Italy
Research Site
NOT_YET_RECRUITING

Modena, 41100, Italy
Research Site
NOT_YET_RECRUITING

Naples, 80138, Italy
Research Site
NOT_YET_RECRUITING

Roma, 00161, Italy
Research Site
NOT_YET_RECRUITING

Roma, 00168, Italy
Research Site
RECRUITING

Asahikawa-shi, 070-8530, Japan
Research Site
RECRUITING

Chūōku, 103-0002, Japan
Research Site
RECRUITING

Kamakura-shi, 247-0056, Japan
Research Site
RECRUITING

Koga-shi, 306-0232, Japan
Research Site
NOT_YET_RECRUITING

Kumamoto, 862-0976, Japan
Research Site
RECRUITING

Mitaka-shi, 181-0013, Japan
Research Site
RECRUITING

Mito, 310-0826, Japan
Research Site
RECRUITING

Miyazaki, 880-0034, Japan
Research Site
NOT_YET_RECRUITING

Nagoya, 467-8602, Japan
Research Site
RECRUITING

Nagoya, 468-0009, Japan
Research Site
RECRUITING

Naka, 311-0113, Japan
Research Site
RECRUITING

Naka, 311-0133, Japan
Research Site
RECRUITING

Nishinomiya-shi, 663-8113, Japan
Research Site
NOT_YET_RECRUITING

Osaka, 558-8558, Japan
Research Site
NOT_YET_RECRUITING

Sapporo, 062-0007, Japan
Research Site
RECRUITING

Takamatsu, 760-0018, Japan
Research Site
RECRUITING

Bialystok, 15-897, Poland
Research Site
NOT_YET_RECRUITING

Krakow, 31-261, Poland
Research Site
RECRUITING

Lodz, 90-338, Poland
Research Site
NOT_YET_RECRUITING

Lublin, 20-718, Poland
Research Site
NOT_YET_RECRUITING

Poznan, 60-354, Poland
Research Site
NOT_YET_RECRUITING

Radom, 26-600, Poland
Research Site
NOT_YET_RECRUITING

Warsaw, 00-124, Poland
Research Site
RECRUITING

Warsaw, 02-507, Poland
Research Site
NOT_YET_RECRUITING

Busan, 48108, South Korea
Research Site
NOT_YET_RECRUITING

Changwon-si, 51353, South Korea
Research Site
NOT_YET_RECRUITING

Daegu, 41404, South Korea
Research Site
NOT_YET_RECRUITING

Daejeon, 35015, South Korea
Research Site
NOT_YET_RECRUITING

Daejeon, 35233, South Korea
Research Site
NOT_YET_RECRUITING

Guri-si, 11923, South Korea
Research Site
NOT_YET_RECRUITING

Incheon, 21565, South Korea
Research Site
NOT_YET_RECRUITING

Seoul, 05278, South Korea
Research Site
NOT_YET_RECRUITING

Seoul, 06351, South Korea
Research Site
NOT_YET_RECRUITING

Seoul, 3722, South Korea
Research Site
RECRUITING

Changhua, 50006, Taiwan
Research Site
NOT_YET_RECRUITING

Kaohsiung City, 81362, Taiwan
Research Site
NOT_YET_RECRUITING

New Taipei City, 220, Taiwan
Research Site
RECRUITING

Taichung, 40201, Taiwan
Research Site
RECRUITING

Taichung, 40705, Taiwan
Research Site
RECRUITING

Taichung, 433004, Taiwan
Research Site
RECRUITING

Tainan, 704, Taiwan
Research Site
RECRUITING

Taipei, 10002, Taiwan
Research Site
NOT_YET_RECRUITING

Taoyuan, 333, Taiwan
Research Site
NOT_YET_RECRUITING

Yung Kang City, 71044, Taiwan
Research Site
RECRUITING

Aberdeen, AB25 2ZN, United Kingdom
Research Site
NOT_YET_RECRUITING

Addlestone, KT15 2BH, United Kingdom
Research Site
NOT_YET_RECRUITING

Banbury, OX16 9AD, United Kingdom
Research Site
NOT_YET_RECRUITING

Bristol, BS34 5TF, United Kingdom
Research Site
NOT_YET_RECRUITING

Bristol, BS34 6BQ, United Kingdom
Research Site
RECRUITING

Edinburgh, EH4 2XU, United Kingdom
Research Site
RECRUITING

Hounslow, TW3 3LN, United Kingdom
Research Site
RECRUITING

Penzance, TR18 3DX, United Kingdom
Research Site
RECRUITING

Poole, BH16 5PW, United Kingdom
Research Site
RECRUITING

Soham, CB7 5JD, United Kingdom
Research Site
WITHDRAWN

Wansford, PE8 6PL, United Kingdom
Research Site
RECRUITING

Yate, BS37 4AX, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.