New targeted drug LNCB74 enters human trials for Hard-to-Treat cancers
NCT ID NCT06774963
First seen Jan 06, 2026 · Last updated Jun 16, 2026 · Updated 22 times
Summary
This early-phase study tests a new drug, LNCB74, in people with advanced solid tumors (ovarian, breast, endometrial, bile duct, or lung cancer) that have not responded to standard treatments. The drug is designed to deliver a cancer-killing agent directly to tumor cells. The main goals are to find the safest dose and to see if it can shrink tumors. About 145 adults will take part.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Cleveland Clinic Taussig Cancer Institute
RECRUITINGCleveland, Ohio, 44195, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Dana Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hoag Family Cancer Institute
RECRUITINGNewport Beach, California, 92663, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Inova Schar Cancer Institute
RECRUITINGFalls Church, Virginia, 22031, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Intermountain/LDS Hospital Ph 1 Research Program
RECRUITINGSalt Lake City, Utah, 84143, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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John Theurer Cancer Ctr at Hackensack Univ. Med Ctr.
NOT_YET_RECRUITINGHackensack, New Jersey, 07601, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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MD Anderson
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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NEXT Oncology
COMPLETEDSan Antonio, Texas, 78229, United States
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Roswell Park Comprehensive Cancer Center
RECRUITINGBuffalo, New York, 14203, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Sidney Kimmel Comprehensive Center at Jefferson
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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St. Elizabeth Healthcare
RECRUITINGEdgewood, Kentucky, 41017, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UPMC
RECRUITINGPittsburgh, Pennsylvania, 15213, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UT Health San Antonio - MD Anderson Cancer Center
RECRUITINGSan Antonio, Texas, 78229, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Washington University, Siteman Cancer Center
RECRUITINGSt Louis, Missouri, 63108, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.