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Can a personalised tool sharpen ovarian cancer risk prediction?

NCT ID NCT07809659

Diagnosis Sponsor: Instituto Portugues Oncologia de Lisboa Francisco Gentil Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 09, 2026 · Last updated Sep 10, 2026 · Updated 1 time

Summary

Researchers are comparing two ways to assess ovarian cancer risk in people who are cancer-free but may be at higher risk because of family history or genetics. One approach follows standard national guidelines, using family history and sometimes genetic testing. The other uses the CanRisk tool, which combines family history, genetic test results, and other health and lifestyle factors to estimate risk more personally. The study measures whether CanRisk is practical, acceptable to doctors and participants, and cost-effective in everyday care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
the CanRisk risk assessment tool
What this could lead to
If it works, this could give doctors a more personalised way to estimate ovarian cancer risk and guide who needs closer monitoring or preventive options.
What could go wrong
This trial measures whether the tool is practical and acceptable, not whether it saves lives. A tool that works in research may still be too slow, costly, or hard to fit into busy clinics.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 2,130 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2026

Expected to finish

Sep 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Women, trans men, non-binary people with female reproductive organs 2. Aged 18 to 75 years 3. Referred or self-referred because of a family history suggestive of increased risk for ovarian, fallopian tube or peritoneum cancer, or because a family member has been found to have a PV associated with OC risk 4. Able to give informed consent 5. Expected to remain in the study catchment area for the duration of follow-up. Exclusion Criteria: 1. Personal history of cancer 2. Previously undergone Risk-Reducing Salpingo-Oophorectomy (RRSO) 3. Previously undergone multifactorial risk assessment (using CanRisk or another tool) incorporating risk factors, family history and genetic testing (panel +/- PGS) 4. Any condition or circumstance that, in the opinion of the investigator, could interfere with the participant's ability to participate or comply with study requirements

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Conditions

The condition(s) this trial relates to.

ovarian cancer prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ovarian cancer

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Dept of Clinical Therapeutics, Alexandra Hospital

    RECRUITING

    Athens, Greece

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