New drug targets Hard-to-Treat cancers in early trial
NCT ID NCT06465069
First seen Nov 01, 2025 · Last updated May 01, 2026 · Updated 26 times
Summary
This study tests a new drug, LY4052031, in people with advanced or spreading solid tumors, including bladder, breast, and lung cancers. The drug is designed to attach to a protein on cancer cells and deliver a toxic payload to kill them. The trial has two parts: first to find the safest dose, then to see how well it shrinks tumors. About 420 participants will be enrolled, and the study lasts up to 4 years.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Aichi Cancer Center Hospital
RECRUITINGNagoya, 464-8681, Japan
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Asan Medical Center
RECRUITINGSeoul, 05505, South Korea
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Beijing Cancer hospital
RECRUITINGBeijing, 100142, China
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Catalan Institute of Oncology Duran i Reynals Hospital
RECRUITINGBarcelona, 8908, Spain
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City of Hope National Medical Center
RECRUITINGDuarte, California, 91010-0269, United States
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Columbia University Irving Medical Center
RECRUITINGNew York, New York, 10032-3729, United States
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Florida Cancer Specialists and Research Institute
RECRUITINGSt. Petersburg, Florida, 33705, United States
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Hospital Madrid Norte Sanchinarro
RECRUITINGMadrid, 28050, Spain
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Hospital Universitario 12 de Octubre
RECRUITINGMadrid, 28041, Spain
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Hospital Universitario Virgen Del Rocio
RECRUITINGSeville, 41013, Spain
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Icahn School of Medicine at Mount Sinai
RECRUITINGNew York, New York, 10029-6574, United States
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Institut Gustave Roussy (Igr)
RECRUITINGVillejuif, 94805, France
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Linear Clinical Research
RECRUITINGNedlands, 6009, Australia
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02215, United States
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
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National Cancer Center Hospital East
RECRUITINGKashiwa, Chiba, 277-8577, Japan
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Renji Hospital, Shanghai Jiaotong University School of Medicine
NOT_YET_RECRUITINGShanghai, 200000, China
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START Midwest Cancer and Hematology Centers of W Michigan
RECRUITINGGrand Rapids, Michigan, 49546, United States
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START Mountain Region
RECRUITINGWest Valley City, Utah, 84119, United States
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Sarah Cannon Research Institute
RECRUITINGNashville, Tennessee, 37203, United States
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Sarah Cannon Research Institute at HealthOne
RECRUITINGDenver, Colorado, 80218, United States
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South Texas Accelerated Research Therapeutics (START)
RECRUITINGSan Antonio, Texas, 78229, United States
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St Bartholomew's Hospital
RECRUITINGLondon, EC1A 7BE, United Kingdom
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St Vincent's Hospital
RECRUITINGDarlinghurst, 2010, Australia
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Sun Yat-sen University Cancer Center
RECRUITINGGuangzhou, 510060, China
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The Cancer Institute Hospital of JFCR
RECRUITINGKōtō City, 135-8550, Japan
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The Christie NHS Foundation Trust
RECRUITINGManchester, M20 4BX, United Kingdom
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University of Chicago Hospital
RECRUITINGChicago, Illinois, 60637, United States
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University of Texas MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030-4000, United States
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University of Utah - Huntsman Cancer Institute
RECRUITINGSalt Lake City, Utah, 84112, United States
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Washington University School of Medicine in St. Louis
RECRUITINGSt Louis, Missouri, 63110, United States
Conditions
Explore the condition pages connected to this study.