BLADDER CANCER

This early-phase study tests two experimental drugs, bintrafusp alfa and PDS01ADC, alone or with targeted radiation, in adults with metastatic bladder, kidney, or other non-prostate genitourinary cancers. The goal is to see if the combination is safe and helps the immune system f…

This early-phase study tests a new drug, BG-68501, in people with advanced solid tumors (like breast, ovarian, lung, or stomach cancer) that have not responded to standard treatments. The goal is to find a safe dose and see if the drug shrinks tumors when used alone or with other…

This study is for people with metastatic urothelial carcinoma, a type of advanced bladder cancer. It tests combinations of three drugs—sacituzumab govitecan, enfortumab vedotin, and pembrolizumab—to find safe doses and see if they shrink tumors. About 106 participants will join t…

This early-stage study tests whether giving immunotherapy at the same time as radiation is safe for people with bladder cancer who have already had surgery to remove their bladder. The trial will enroll 10 participants and closely monitor for serious side effects in the pelvic ar…

This study is testing a new type of radiation therapy that adapts to changes in the body during treatment. It aims to see if this approach can reduce side effects while still controlling the cancer. The trial is for people with prostate cancer that has returned after surgery, or …

This early-stage study tests a new treatment called IDOV-Immune, a virus designed to infect and kill cancer cells and boost the immune system. It is for adults with advanced solid tumors (like colorectal, pancreatic, or lung cancer) that have not responded to standard treatments.…

This early-stage trial tests a new drug called EVOLVE104 in 160 people with advanced bladder cancer or several types of squamous cell cancer that have not responded to standard treatments. The main goals are to check the drug's safety, find the best dose, and see if it can shrink…

This study tests whether combining an immunotherapy drug (toripalimab) with standard BCG therapy can stop high-risk bladder cancer from coming back after tumor removal surgery. About 31 adults with aggressive non-muscle-invasive bladder cancer will receive the combo treatment for…

This study tests adding new experimental drugs to the standard treatment (enfortumab vedotin plus pembrolizumab) for people with advanced bladder cancer that has spread. About 55 participants will receive the combination to see if it is safe and helps shrink tumors. The goal is t…

This early-stage trial tests a personalized cell therapy called 4SCAR-T for people with advanced bladder cancer that has spread and has no standard treatments left. About 20 participants will receive specially engineered immune cells designed to attack their cancer. The study aim…

This program provides access to an experimental treatment called cretostimogene grenadenorepvec for people with a type of bladder cancer that has not responded to standard therapy. It is for patients with non-muscle invasive bladder cancer that includes carcinoma in situ. The goa…

This study tests a new drug combination (datopotamab deruxtecan plus chemotherapy) against standard chemotherapy for people with advanced bladder cancer that has worsened after initial treatment. About 630 adults will participate to see if the new combo shrinks tumors or delays c…

This study tests a new drug called MK-3120 for people with high-risk bladder cancer that hasn't spread into the muscle. After standard surgery to remove the tumor, participants receive MK-3120 directly into the bladder. The main goals are to check safety and find the right dose. …

This study tests whether adding the drug tarlatamab to standard radiation is safe and effective for cancers that have a protein called DLL3. About 30 adults with cancers like melanoma, lung cancer, or glioblastoma will receive the combination. The goal is to find the best timing …

This study tests a new treatment for people with advanced bladder cancer that has not responded to standard therapies. The treatment uses specially engineered immune cells (CAR-NK cells) from a healthy donor to target and kill cancer cells. Up to 42 adults will receive the cells …

This study tests whether adding a precise, high-dose type of radiation (stereotactic body radiation therapy, or SBRT) to standard treatments like chemotherapy or immunotherapy can better control bladder cancer that has spread to a limited number of places (up to 3 spots). The tri…

This early-phase study tests a new drug, CLSP-1025, designed to direct immune cells to attack tumors that have a specific p53 R175H mutation. The trial enrolls adults with advanced solid tumors (like lung, colon, or pancreatic cancer) that have worsened after standard treatments.…

This study tests a comprehensive health program (prehabilitation) given before major cancer surgery, either alone or with standard pre-surgery chemotherapy. It includes 148 frail patients with pancreatic, liver, ovarian, kidney, or bladder cancers. The goal is to see if the progr…

This study tests a combination of three drugs (adebrelimab, etoposide, and cisplatin) given before surgery for a rare and aggressive type of bladder cancer. About 22 adults aged 18-75 with neuroendocrine bladder carcinoma will receive up to 4 cycles of treatment. The main goals a…

This study tests whether a urine DNA test can help doctors decide how long to give immunotherapy for a severe type of bladder cancer that can't be fully removed with surgery. About 53 adults with very-high-risk non-muscle-invasive bladder cancer will receive immunotherapy, and th…

This study tests a new drug, MGC026, in 250 adults with advanced solid tumors that have not responded to other treatments. The goal is to check the drug's safety, find the right dose, and see if it can shrink tumors. Participants receive the drug by IV and are closely monitored f…

This early-phase study tests a new drug, ONM-501, injected directly into tumors, either alone or with another drug (cemiplimab), in people with advanced solid tumors or lymphomas that have not responded to other treatments. The main goals are to find the safest dose and understan…

This study is testing whether adding an immune-boosting drug (BDB001) and targeted radiation to an existing immunotherapy (atezolizumab) can help control several advanced solid tumors, including pancreatic, lung, bladder, and triple-negative breast cancer. About 247 adults with t…

This study tests a combination of the drug enfortumab vedotin and radiation therapy given before surgery for muscle-invasive bladder cancer. It is for people who cannot take the standard chemotherapy drug cisplatin. The goal is to see if this approach is safe and can eliminate or…

This study tests a new approach to treat high-risk bladder cancer without removing the bladder. It combines a special freezing technique (cryoablation) with standard tumor removal, immunotherapy, and low-dose chemotherapy. The goal is to see if this combination can improve surviv…

This study looks at how well the drug T-DXd works in adults with advanced HER2-positive cancers that have spread and no longer respond to other treatments. About 100 people will take part, and researchers will track whether tumors shrink and how long the benefit lasts. The goal i…

This trial tests an experimental drug called CP-383 in people with advanced solid tumors that have not responded to standard treatments. The goal is to see if CP-383 can slow or stop cancer growth and to find the safest dose. About 150 participants will take the drug daily and ha…

This study tests whether adding a new drug (fianlimab) to standard chemotherapy and immunotherapy can help adults with muscle-invasive bladder cancer achieve a complete response, meaning no cancer is found after treatment. About 36 participants will receive either the standard co…

This early-phase study tests an experimental drug called PF-08046876 in adults with advanced solid tumors (bladder, lung, head/neck, esophagus, or pancreatic cancer) that have not responded to standard treatments. The drug is an antibody-drug conjugate designed to stick to cancer…

This study tests whether giving two chemotherapy drugs (mitomycin-C and gemcitabine) directly into the bladder can control high-risk bladder cancer that has not responded to the standard BCG therapy. About 82 adults with this type of cancer will receive the treatment and be monit…

This early-stage study tests a new drug called IDE892, alone or with other medicines, in people with advanced solid tumors that lack a gene called MTAP. The goal is to see if the drug is safe and can shrink tumors. About 260 adults with certain cancers (like lung, stomach, bladde…

This study tests a combination of two drugs (enfortumab vedotin and pembrolizumab) plus radiation therapy for people with muscle invasive bladder cancer. The goal is to kill the cancer while allowing patients to keep their bladder, avoiding the standard surgery to remove it. Abou…

This study tests if drinking a special nutritional supplement before bladder removal surgery can lower the risk of infections and other complications. About 232 adults having this surgery will be randomly assigned to receive the supplement or standard care. The main goal is to se…

This study tests whether putting two chemotherapy drugs (gemcitabine and docetaxel) directly into the bladder can keep low-grade bladder cancer from returning. About 34 adults with intermediate-risk, non-invasive bladder cancer will receive the treatment. The goal is to see if th…

This study tests a new treatment called EBNK-001, which uses donor immune cells (natural killer cells) to fight advanced solid tumors. About 83 adults with cancers like lung, breast, or colorectal cancer that have not responded to standard treatments will receive these cells alon…

This early-stage trial tests a new combination treatment for people with advanced HER2-positive solid tumors (like breast, lung, or stomach cancer). Participants receive an injection of a special virus directly into one tumor to activate the immune system, followed by an infusion…

This study tests whether growing a patient's tumor cells in the lab (organoids) can help doctors pick the most effective anti-HER-2 drug for advanced bladder cancer. About 224 adults who have failed standard chemotherapy will be enrolled. The goal is to see if this personalized a…

This study compares two types of light used during bladder cancer surgery: standard white light and blue light, which makes cancer cells glow. The goal is to see if blue light helps surgeons remove more cancer and lowers the chance of the cancer coming back. About 200 adults with…

This study tests whether rinsing the new bladder or urine pouch with a chlorhexidine antiseptic during and after surgery can reduce urinary tract infections. About 23 adults with bladder cancer having their bladder removed will receive this wash. The main goal is to see if urine …

This study tests an experimental drug called patritumab deruxtecan in people with advanced solid tumors that have spread or cannot be removed. The drug targets a protein called HER3 found on some cancer cells. About 740 adults with various cancers like lung, breast, or melanoma w…

This study tests a new version of BCG treatment (VERITY-BCG) for people with intermediate or high-risk non-muscle invasive bladder cancer who have not received BCG before. The goal is to see if the new treatment is as good as the standard BCG at preventing the cancer from returni…

This program provides ulixertinib, an experimental drug, to adults with advanced solid tumors that have specific genetic changes (MAPK pathway mutations) and who have run out of standard treatments. The goal is to control the cancer, not cure it. Participants may take ulixertinib…

This study tests a new drug called LY4052031 in people with advanced or spreading solid tumors, including bladder, breast, lung, and other cancers. The goal is to see if the drug is safe and works against these cancers. About 420 participants will take part, and the study will la…

This study tests a combination of two cancer drugs, enfortumab vedotin and pembrolizumab, in 20 people with high-grade upper tract urothelial cancer (a rare cancer of the kidney and ureter). Participants are those who cannot or choose not to have standard surgery to remove the ki…

This study is for people with a type of bladder cancer that hasn't spread into the muscle. It tests a drug called durvalumab, either alone or with other treatments like BCG, radiation, or chemotherapy. The goal is to find safe doses and see how well these combinations work at mak…

This study tests a new drug, sacituzumab tirumotecan, against standard chemotherapy for people with advanced bladder cancer that has gotten worse after prior treatments. About 590 participants will be randomly assigned to receive either the new drug or a chemotherapy chosen by th…

This study looks at whether placing a small tube (stent) in the ureter after bladder removal surgery reduces the risk of urinary tract infections. About 70 adults with bladder or pelvic cancer will be randomly assigned to receive a stent or not. Researchers will track infections …

This study compares two approaches for choosing chemotherapy drugs in people with muscle-invasive bladder cancer. One group receives drugs selected by testing on lab-grown tumor organoids, while the other gets standard treatment. The goal is to see if the organoid-guided approach…

This study tests whether a combination of two chemotherapy drugs, gemcitabine and docetaxel, can treat high-risk bladder cancer that did not respond to standard BCG therapy. About 174 adults will receive the drugs directly into the bladder weekly for 6 weeks, then monthly for up …

This study is testing a new, non-invasive urine test that looks for a marker called CREPT in cells shed from the bladder. The goal is to see if this test can accurately detect bladder cancer early and monitor for recurrence, potentially replacing more invasive procedures. The stu…

This study looks at whether buying over-the-counter pain relievers or digestive aids can be an early warning sign for 10 types of cancer, including pancreatic, colon, and ovarian cancer. Researchers will compare the shopping habits of 2,900 people—some recently diagnosed with can…

This study compares two types of scans—CT and MRI—to see which one is better at determining if bladder cancer has spread into the muscle layer. About 150 adults with newly diagnosed bladder cancer will receive both scans before surgery, and the results will be checked against tis…

This study looks at whether a urine test that detects tumor DNA and RNA can help doctors decide which high-risk bladder cancer patients truly need a second surgery. Currently, many patients undergo a repeat procedure, but it may not always be necessary. The goal is to see if the …

This study gathers videos and data from 500 adults undergoing blue light cystoscopy for bladder cancer. The goal is to train an artificial intelligence (AI) system to help doctors find suspicious spots in real time. Participants receive standard care, and their anonymous recordin…

This study is testing a new type of PET scan that targets a protein called Trop2, found on many solid tumors. The goal is to see if this scan can find and stage cancers like bladder, lung, liver, and ovarian cancer better than current methods. About 400 adults with confirmed or s…

This study tests whether a special MRI scan, followed by a same-day biopsy, can diagnose muscle-invasive bladder cancer faster and more accurately than the usual surgery (TURBT). About 360 adults with suspected aggressive bladder cancer will be randomly assigned to one of the two…

This study is testing whether a simple rectal mucus sample can detect DNA changes linked to lung, pancreatic, bladder, and colorectal cancers. Researchers will collect samples from 450 adults using a special device and compare them to known tumor DNA. The goal is to see if this n…

This study is for people with high-risk bladder cancer who need regular check-ups with a camera in the bladder (cystoscopy). The camera test is uncomfortable and can cause side effects. Researchers want to see if a non-invasive urine test that looks for cancer DNA can help decide…

This study is testing a new urine test that looks for specific proteins to detect bladder cancer in people who have tiny amounts of blood in their urine (microscopic hematuria). The goal is to see if this simple, non-invasive test can accurately identify bladder cancer, potential…

This study involves 30 adults with bladder cancer who are scheduled to have their bladder removed. Right before surgery, while the patient is asleep, doctors will use a special ultrasound called Super-Resolution Ultrasound Localization Microscopy to look for any remaining cancer …

This study tests whether a type of MRI that does not require a contrast dye (called biparametric MRI) can accurately diagnose bladder cancer and tell if it has spread into the muscle. Researchers will compare this simpler scan to the standard contrast MRI in 58 adults suspected o…

This study is testing a new urine test that aims to predict whether bladder cancer patients will respond well to a standard treatment called BCG. About 400 adults with intermediate or high-risk non-muscle invasive bladder cancer will provide urine samples before starting BCG ther…

This study is testing a new platform that uses advanced genetic and functional tests to better understand tumors from 300 people with various high-risk cancers, including leukemia, myeloma, and pancreatic cancer. The goal is to see if this detailed analysis can change the recomme…

This study looks at whether a simple urine test that detects tumor DNA can identify bladder cancer patients who truly need a second surgery. About 196 adults with early-stage bladder cancer will be randomly assigned to have their repeat surgery decision guided by the urine test o…

This study is testing whether a new PET imaging tracer called [18F]FAPI-74 can find tumors as well as or better than the standard tracer in adults with certain cancers (like pancreatic, ovarian, or lung cancer). Participants will get both types of scans to compare how many tumors…

This study aims to see if a new urine test can accurately detect bladder cancer recurrence in 300 people with a history of the disease. Currently, patients need a camera inserted into the bladder (cystoscopy) to check for cancer return. If successful, this simple urine test could…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including lung, breast, and colon cancer. Researchers will see if the test can find cancer early and tell which type it is. In people with lung cancer, the test will also check for any cancer…

This study tests a new urine test called BCDx that aims to find bladder cancer early in people who have had it before. Researchers will check how accurate the test is compared to the standard scope exam. About 500 adults with a recent bladder cancer diagnosis will provide urine s…

This study is testing whether a special PET scan called 68Ga PSMA-PET/CT can find cancer spots in people with advanced bladder cancer or melanoma that has spread. About 20 participants will get both the new scan and the standard scan to compare. The goal is to see if the new scan…

This study looks at whether taking PET scans later (2.5 hours after injection) finds lymph node spread in muscle-invasive bladder cancer more accurately than standard scans (1 hour after). About 66 adults with this cancer will get both scans, and results will be compared to surgi…

This study tests whether dutasteride, a pill usually used for prostate issues, can stop low-grade bladder cancer from returning. About 95 adults with this type of bladder cancer will take the drug daily. The goal is to see if it reduces the need for repeated surgeries and improve…

This study tests whether using MRI to guide brachytherapy (internal radiation) for gynecologic cancers like cervical or uterine cancer can better target tumors and reduce radiation to nearby organs like the bladder and rectum. About 54 adults who are already eligible for standard…

This study looks at whether giving patients IV fluids at home for four weeks after bladder cancer surgery can lower the chance of being readmitted to the hospital. About 130 adults having their bladder removed for cancer will be randomly assigned to either standard care or standa…

This study tests a new radiation technique called lattice radiation therapy (LRT) for people with solid tumors that have spread to soft tissues. The goal is to see if LRT shrinks tumors better than standard radiation and whether it helps the immune system attack cancer cells. Abo…

This study tests a telehealth program that teaches cancer survivors with an ostomy how to manage their care before and after surgery. The program includes seven group sessions online. Researchers want to see if it helps patients feel more confident and improves their quality of l…

This study tests whether a personalized home exercise program before bladder cancer surgery can improve physical function and recovery. About 128 adults scheduled for bladder or upper tract surgery will either receive the exercise program plus standard care, or standard care alon…

This study looks at how women with bladder cancer cope with emotional distress and sexual health issues. Researchers will compare standard care to an educational support program. Participants complete surveys about mood and sexual function. The goal is to see if extra education a…

This study looks at whether a comprehensive geriatric assessment (CGA) before and after bladder cancer surgery can help older, frail patients recover faster. About 140 patients aged 65 and older who are scheduled for cystectomy will receive either standard care or a CGA with a pe…

This study looks at two different treatment plans for people aged 65 and older with advanced bladder cancer who cannot take the standard chemotherapy drug cisplatin. The goal is to see which treatment better maintains quality of life and causes fewer side effects. Participants wi…

This study compares two types of bladder removal surgery in 70 men with bladder cancer. One method spares the prostate capsule, the other spares nerves. The goal is to see which approach better preserves erectile function and urinary control after surgery. Participants will compl…

This study tests whether watching educational videos can help older adults (65+) with bladder cancer avoid problems like trouble moving, medication issues, and low quality of life after bladder removal surgery. About 85 participants will watch the videos and answer surveys. The g…

This study looks at two common practices after bladder cancer surgery: using a ureteral stent (a tube to drain urine) and giving a drug called alvimopan to help the bowels work again. The goal is to see if avoiding stents reduces urinary tract infections and if alvimopan shortens…

This study looks at the best times to send messages encouraging physical activity to older cancer survivors (age 65+) who have chronic pain. Researchers will track activity levels and pain ratings to see how messages affect movement and pain episodes. The goal is to learn how to …

This study tests a redesigned surgical tool for removing bladder tumors. The goal is to see if it gives doctors better information about the tumor, such as whether all layers are removed and if cancer cells remain at the edges. About 25 adults who need their bladder removed will …

This study is observing 600 adults with bladder cancer in Russia to see what treatments they receive and how common certain markers (HER2 and PD-L1) are. It does not test a new drug but collects information to understand current care patterns. The goal is to improve future treatm…

This study is testing a program called CARES that provides advocacy, resources, education, and support to rural cancer patients. The goal is to see if it helps them start treatment sooner and finish it on time. About 320 adults with solid tumors like lung, breast, or colon cancer…

This study looks at why some people with non-invasive bladder cancer have trouble completing their treatment. It also tests a program where patients can receive BCG therapy at home, supported by a chatbot that tracks symptoms and quality of life. The goal is to see if this approa…

This study collects information from urologists' daily use of Blue Light Cystoscopy with Cysview (BLCC) to see how well it finds bladder cancer compared to standard white light cystoscopy. About 4,400 adults with suspected or known non-muscle invasive bladder cancer will take par…

This study is collecting information from 2000 bladder cancer patients who have had their bladder removed (radical cystectomy). Researchers will track symptoms and recovery using patient surveys. The goal is to understand recovery patterns so that future care can be improved.

This study tracks 1,100 adults with common and rare urinary tract cancers (like bladder, kidney, or testicular cancer) over their lifetime. Researchers collect medical records, blood, urine, and tumor samples to understand how these cancers behave and respond to treatment. The go…

This study compares two common treatments for a type of bladder cancer that keeps coming back: treatments that keep the bladder (like medicine placed directly into the bladder) versus surgery to remove the bladder. Researchers want to see which approach causes less financial stre…

This study is creating a registry—a bank of information and samples—from up to 1,000 people with bladder cancer. Researchers will use the collected blood, urine, and tissue to learn how tumors develop, come back, and affect long-term survival. Participants can join other studies …

This study is testing whether tumor DNA found in blood or urine (ctDNA) can help doctors better predict how T1G3 bladder cancer will behave. Researchers will collect samples from 35 adults before and after standard treatments to see if ctDNA levels change and if they relate to ca…

This study collects blood, urine, saliva, and tumor tissue from 500 adults with or at risk for urothelial cancer (bladder, ureter, urethra). Researchers will analyze the DNA and other molecular features of these samples to understand what causes the cancer and how it responds to …

This study collects tumor samples from 2,000 people with various cancers to learn how to predict who will respond to immunotherapy. Participants donate tissue during a routine biopsy. The goal is to understand tumor biology and improve future treatment decisions, not to test a ne…

This study is testing whether a simple urine test every 6 months for 2 years can help find bladder cancer at an earlier stage in people at high risk. Participants must be 50 or older with a heavy smoking history or long-term exposure to certain workplace chemicals. The goal is to…

This study looks at how certain drugs that affect the body's natural endocannabinoid system change the way bladder muscle contracts. Researchers will collect a small piece of healthy-looking bladder tissue from 65 adults having bladder cancer surgery. In the lab, they will test h…

This study is testing whether an artificial intelligence tool can help match cancer patients to clinical trials they might be eligible for. Researchers will enroll up to 50,000 people with various types of cancer and use the AI to suggest trials. The goal is to see if this approa…

This study looks at how hospitals handle patients who are admitted with blood in their urine (hematuria). Researchers will track about 1,050 adults to see differences in care, how long they stay, and what happens after. The goal is to create better guidelines and improve the pati…

This study aims to create a simple, affordable test that detects important gene mutations in bladder cancer. Researchers will analyze tumor tissue from 400 patients to see if these mutations affect survival and treatment response. The goal is to help doctors personalize care and …

This study is creating a huge collection of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand cancer causes, improve early detection, and develop person…

This study looks at how urological diseases and treatments impact patients' jobs and daily lives. Researchers will survey 2,000 adults admitted to a hospital in Poland, focusing on those having major cancer surgeries or stone procedures. Participants will report their work status…

This study aims to see if growing a patient's bladder cancer cells in the lab (called organoids) can help doctors choose the most effective chemotherapy after surgery. About 266 adults with muscle-invasive bladder cancer will have their tumor cells tested against different drugs.…

This study is collecting tumor, blood, urine, and stool samples from 1000 adults with suspected or diagnosed bladder cancer. The samples will be stored for future research to better understand the disease. No treatment or direct benefit is offered to participants.

This study screens up to 7,000 adults with cancers like melanoma, lung, or colorectal cancer to see if they qualify for experimental treatments developed by the National Cancer Institute's Surgery Branch. These treatments involve taking a patient's own immune cells, growing them …

This study is a large registry that will follow 8,000 cancer patients who receive radiation therapy guided by an MR-Linac, a machine that combines an MRI scanner with a radiation beam. The goal is to see if this technology helps people live longer, controls tumors better, and imp…

This study looks at how bladder cancer treatment changes your body's energy use and muscle function. Researchers will measure resting energy in 30 patients before and after chemotherapy and bladder removal surgery. The goal is to learn more so doctors can design better care plans…

This study aims to understand the sexual health challenges and needs of bladder cancer patients, and to develop a support program. Researchers will interview 30 patients to learn about their experiences and preferences. The goal is to create a program that helps patients and thei…

This study is testing whether a new machine that combines radiation therapy with real-time MRI imaging is safe and practical for treating several types of cancer, including stomach and breast cancer. About 70 adults will receive this treatment along with chemotherapy. The goal is…

This study looks at 300 women aged 50 and older who have blood in their urine along with a bladder infection. Researchers want to see if these women need the full set of cancer tests (like a camera in the bladder and CT scans) or if they can safely skip them. The goal is to find …

This study collects blood, urine, saliva, and tissue samples from people who have or may have cancer, as well as their blood relatives. The goal is to help researchers learn more about the genetic and molecular causes of cancer. No direct treatment is given, but the samples may l…