BLADDER CANCER

This early-stage trial is testing a new type of immune cell therapy for adults with advanced bladder cancer that has stopped responding to standard treatments. Doctors will give patients specially engineered natural killer (NK) cells designed to recognize and attack cancer cells …

This study is testing whether combining three different treatments can better control advanced cancers that have spread. It is for adults with specific solid tumors, including pancreatic, lung, breast, and bladder cancers, who have run out of standard treatment options. The appro…

This study is observing how well the drug T-DXd works for people with advanced HER2-positive cancers who have already tried other treatments and have no good options left. It will follow about 100 patients in real-world US clinics to see how their tumors respond and how long the …

This early-stage trial is testing the safety of a new two-part treatment for people with advanced HER2-positive solid tumors that have stopped responding to standard therapies. First, a specially designed virus is injected directly into one tumor to help alert the immune system. …

This study aims to help patients and doctors choose between two main treatment paths for recurrent, high-grade bladder cancer that hasn't invaded the muscle wall. It will directly compare keeping the bladder with medication (bladder-sparing therapy) against surgically removing th…

This study is testing whether a urine test that detects cancer DNA can help doctors decide how long to continue immunotherapy in patients with a high-risk form of bladder cancer that cannot be fully removed by surgery. Participants will receive immunotherapy, and if their cancer …

This study is testing whether drinking special nutritional supplements before bladder removal surgery can help reduce infections and other complications after the operation. It will involve 232 patients across three Swiss hospitals who are scheduled for this major surgery. Patien…

This study is testing a new combination of targeted cancer drugs for people with advanced bladder cancer that has spread. The goal is to find the safest and most effective doses of these drugs, which work in different ways to attack cancer cells. The trial will include people who…

This study is testing a new method to personalize chemotherapy for muscle-invasive bladder cancer. Researchers will grow miniature 3D models of a patient's tumor in a lab to test which chemotherapy drugs work best before treatment begins. They will compare survival rates for pati…

This study is testing a new type of immune cell therapy called EBNK-001 for people with advanced solid tumors that have stopped responding to standard treatments. Participants receive 'off-the-shelf' natural killer (NK) cells from a donor after a short course of chemotherapy, wit…

This study aims to find the best way to help patients recover after surgery to remove the bladder for cancer. It is testing two common practices: using a small tube (stent) to drain urine and giving a drug (alvimopan) to help the bowels work again. Researchers want to see if thes…

This early-stage study is testing whether two new immunotherapy drugs, M7824 and PDS01ADC, can help the body's immune system fight advanced bladder, kidney, and related cancers that have spread. Researchers want to see if adding a precise, high-dose radiation treatment (SBRT) mak…

This study is testing a combination of two drugs, enfortumab vedotin and pembrolizumab, for patients with high-grade cancer in their kidney or ureter who are not candidates for or refuse the standard surgery to remove the organ. The goal is to see if this drug treatment can contr…

This study is testing whether adding a new immunotherapy drug (toripalimab) to a standard bladder cancer treatment (BCG) can better control high-risk bladder cancer. The goal is to help patients avoid having their bladder surgically removed. The study will enroll 31 patients to s…

This study is comparing two standard surgical methods for bladder cancer. It will see if patients do better with or without a temporary plastic tube (a ureteral stent) placed during surgery to remove the bladder. Researchers will track 70 patients for a year to measure complicati…

This study is testing whether washing the bladder with a combination of two chemotherapy drugs (gemcitabine and docetaxel) can help prevent low-grade bladder cancer from coming back. The treatment is given directly into the bladder through a catheter. Researchers will track how w…

This is the first study in people testing a new drug called EVOLVE104. It aims to find a safe dose and see if it can help control advanced bladder and several types of squamous cell cancers. The study is for patients whose cancer has continued to grow despite standard treatments.

This study is testing whether using MRI scans during radiation treatment can help doctors target cancer more precisely while patients receive chemotherapy. Researchers want to see if this approach is safe and practical for treating gastric and breast cancers. The study involves 7…

This early-stage study is testing the safety and effects of an experimental cancer drug called PF-08046876 in adults with advanced solid tumors. The drug is an antibody drug conjugate designed to target and kill cancer cells. Researchers will give the drug through an IV to about …

This study is testing a new combination treatment designed to control high-risk bladder cancer while allowing patients to keep their bladder. It combines a precise freezing technique performed during tumor removal with immunotherapy and low-dose chemotherapy. The goal is to see i…

This is the first study in people testing a new cancer drug called MGC026. It aims to find a safe dose and see if the drug can help shrink tumors in adults with advanced solid tumors that have not responded to other treatments. The study will also check how the drug moves through…

This is an early-stage study testing a new oral drug called BG-68501 in people with advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to find a safe dose and see how the body processes the drug, both when given alone and when combined with…

This program provides access to an investigational drug called ulixertinib for patients with advanced cancers that have specific genetic changes (MAPK pathway mutations). It is for people who have run out of other treatment options. The drug aims to control the cancer's growth, e…

This study is testing whether using MRI scans instead of CT scans to guide radiation therapy for gynecologic cancers can reduce side effects and improve treatment accuracy. Researchers at Johns Hopkins will compare how well MRI helps doctors target tumors while sparing healthy or…

This study is testing whether a new, precise radiation planning technique can protect the ovaries in young women (ages 18-50) receiving pelvic radiation for cancers like uterine or rectal cancer. The goal is to prevent radiation from causing early menopause, which can lead to ser…

This early-stage study is testing a new oral drug called CP-383 in people with advanced solid tumors that have spread or returned. The main goals are to find a safe dose and see if the drug can slow or stop cancer growth. It is for patients who have run out of standard treatment …

This study is testing a new medicine called MK-3120 for people with high-risk bladder cancer that is still in the lining of the bladder and hasn't spread to the muscle. The medicine is placed directly into the bladder. The main goals are to see if the treatment is safe and if peo…

This study is testing a special pre-surgery program designed to help frail patients get stronger before major cancer surgery. The program includes nutrition advice, breathing exercises, and physical training. Researchers want to see if this preparation helps patients have fewer c…

This study is testing whether giving patients IV fluids at home after major bladder cancer surgery helps them recover better and avoid being readmitted to the hospital. About 130 patients at Johns Hopkins will be randomly assigned to either receive the home IV fluid program along…

This study is testing whether it is safe to combine a new targeted drug called tarlatamab with standard radiation therapy. It is for adults with advanced cancers that have a specific protein called DLL3, including certain lung cancers, melanoma, and others. The main goal is to se…

This study is testing whether washing the bladder with two cancer drugs, one after the other, can help control high-risk bladder cancer in patients whose cancer did not respond to the standard BCG treatment. The trial aims to see if this approach can prevent the cancer from comin…

This study is testing whether a support program called CARES helps rural cancer patients start treatment sooner and complete it faster. The program provides navigation help and counseling sessions alongside usual cancer care. Researchers will compare outcomes for 320 patients who…

This trial tests a new type of immune cell therapy called 4SCAR-T for people with advanced bladder cancer that has spread and who have run out of standard treatment options. Doctors take a patient's own immune cells, modify them in a lab to better recognize and attack cancer cell…

This study is testing a more precise form of radiation therapy called an 'adaptive boost' for prostate and bladder cancer. It aims to see if this approach can control the cancer while causing fewer side effects like urinary or bowel problems. The study will enroll 60 adults who a…

This is a first-in-human study testing a new drug called CLSP-1025 for adults with advanced solid tumors that have a specific genetic change called the p53 R175H mutation. The main goals are to find a safe dose and see if the drug can help control the cancer. The drug works by en…

This study is testing a new type of radiation therapy called lattice radiation (LRT) for people with large cancer tumors that have spread to soft tissues. It compares LRT to standard radiation to see which is better at shrinking tumors and attracting immune cells to fight the can…

This is a first-in-human study to find a safe and effective dose of a new drug called ONM-501. The drug is injected directly into tumors and is being tested alone and in combination with an approved immunotherapy drug (cemiplimab) in adults with advanced cancers that have stopped…

This study is testing if rinsing the bowel segment used to create a new urine system with a common antiseptic (chlorhexidine) during and after bladder removal surgery can prevent infections. The goal is to see if this rinse helps keep the urine sterile and reduces the number of p…

This study is testing whether combining a targeted cancer drug (enfortumab vedotin) with precise radiation therapy can help shrink tumors before bladder removal surgery. It's for patients with muscle-invasive bladder cancer who cannot receive standard cisplatin chemotherapy. The …

This study is testing if using a special blue light during bladder cancer surgery helps doctors see and remove more of the cancer compared to the standard white light. Researchers want to see if this leads to less cancer left behind and a lower chance of the cancer coming back. A…

This study is testing a new way to choose chemotherapy drugs for patients after surgery for muscle-invasive bladder cancer. Researchers will grow tiny 3D models of a patient's own tumor in the lab and test different chemotherapy drugs on them to see which ones work best. The goal…

This study is testing whether adding a new experimental drug to the current standard treatment is safe and more effective for people with advanced bladder cancer. It will involve about 55 participants who have not yet received treatment for their advanced cancer. The main goals a…

This is a first-in-human study to test the safety and find the right dose of a new investigational drug called LY4052031 for people with advanced or metastatic solid tumors. The drug is designed to target a specific protein found on many cancer cells, delivering its medicine dire…

This early-stage study is testing a new drug, IDE892, both alone and in combination with another drug called IDE397. It is for adults with advanced solid tumors that have a specific genetic change called MTAP deletion and have stopped responding to standard treatments. The main g…

This study compares two surgical approaches for bladder cancer removal in men. Researchers want to see if leaving more prostate tissue intact during surgery helps preserve sexual function without compromising cancer treatment. The study will follow 70 men for two years, tracking …

This study is testing whether a combination of chemotherapy and immunotherapy can effectively treat muscle-invasive bladder cancer, with the goal of allowing patients to keep their bladder instead of needing surgery to remove it. About 36 adults with localized bladder cancer will…

This first-in-human study is testing an experimental cancer treatment called IDOV-Immune, which uses a modified virus designed to infect and destroy cancer cells while boosting the immune system. The trial aims to find the safest dose and check for early signs that the treatment …

This is the first human study of an experimental cancer drug called LY4101174. Researchers want to find a safe dose and see if it can help control advanced cancers that have spread or returned after other treatments. The study will enroll about 490 people with various solid tumor…

This program provides access to an investigational treatment called cretostimogene for people with a specific type of bladder cancer that has not responded to the standard BCG therapy. It is for patients who are not eligible for or refuse surgery to remove their bladder. The trea…

This study is testing an experimental drug called patritumab deruxtecan (HER3-DXd) in people with advanced solid tumors that have spread or cannot be removed by surgery. The goal is to see if the drug can shrink tumors and control the disease in people who have already tried at l…

This study is for people with advanced bladder cancer that has continued to grow despite receiving a specific prior combination treatment. It will compare a new drug combination (datopotamab deruxtecan plus a platinum chemotherapy) against a standard chemotherapy combination. The…

This study aims to find the best treatment approach for older adults with advanced bladder cancer who cannot tolerate standard chemotherapy. Researchers will compare two different treatment combinations to see which provides better quality of life with fewer side effects. The stu…

This study is testing if a non-invasive urine test can help doctors decide which patients with early-stage bladder cancer need a second surgery. Currently, many patients get a second surgery to check for leftover cancer, but it might not be needed for everyone. The goal is to use…

This study is testing a new combination of two cancer drugs (enfortumab vedotin and pembrolizumab) given alongside targeted radiation therapy. The goal is to see if this approach can effectively control muscle-invasive bladder cancer for patients who are not candidates for, or wh…

This study is testing a new, personalized method to choose the best drug for patients with advanced bladder cancer that has spread or cannot be removed by surgery. Researchers will grow tiny 3D models of a patient's own tumor in the lab to test which drug it responds to best, and…

This study is testing whether a combination of three drugs (adebrelimab, etoposide, and cisplatin) given before bladder removal surgery can help shrink or eliminate a rare and aggressive form of bladder cancer called neuroendocrine carcinoma. About 22 patients with this specific …

This study is testing a new urine test to detect bladder cancer in people who have small amounts of blood in their urine that can't be seen with the naked eye. The goal is to create a better non-invasive test that could reduce the need for uncomfortable camera examinations of the…

This study is testing a new type of MRI scan to see if it can accurately detect muscle-invasive bladder cancer. Researchers want to know if this shorter scan, which doesn't use a contrast dye, works as well as the standard, longer MRI. They will enroll 58 patients suspected of ha…

This study is testing a new urine test that might detect returning bladder cancer without needing invasive camera exams. Researchers will enroll 300 people with a history of bladder cancer to see if this test is as accurate as the current standard procedure. The goal is to create…

This study is testing whether a new type of imaging scan, called a 68Gallium PSMA-PET/CT scan, can effectively find where cancer has spread in people with advanced bladder cancer or melanoma. Researchers want to see if this new scan works better, the same, or not as well as the s…

This study is testing a new blood test to see if it can detect many different types of cancer early, before symptoms appear. It will involve 7,000 people, both with and without cancer, to see if the test can spot cancer signals and identify where in the body the cancer started. T…

This study is testing a new diagnostic platform called the Italian Tumor Chemogenomic Profiler (IT-TCP). Researchers will analyze tumor samples from 300 patients with various high-risk cancers to see if this detailed analysis can help guide treatment choices. The goal is to see i…

This study aims to develop and test a new diagnostic tool that uses artificial intelligence (AI) to analyze small pieces of a patient's tumor. The goal is to predict whether a patient will respond to certain immunotherapy cancer drugs before they start treatment. Researchers will…

This study is collecting real-world information on a special blue light scope used during bladder exams. It aims to see if this blue light technology helps doctors find more bladder cancers and remove them more completely than the standard white light scope alone. The study will …

This study is testing whether taking PET scan images 2.5 hours after injection, instead of the standard 1 hour, improves the detection of cancer spread to lymph nodes in patients with muscle-invasive bladder cancer. Researchers will compare the accuracy of the delayed images agai…

This study is testing whether a simple rectal mucus sample can detect lung, pancreatic, bladder, and colorectal cancers by looking for DNA changes. Researchers will collect samples from 450 people using a special swab device to see if cancer-related genetic markers appear in the …

This study is developing and testing a new type of genetic test for bladder cancer. The goal is to create a more affordable and sensitive test that can check for many cancer-related genetic changes at once. Researchers will use it on tissue samples from 400 patients to see if it …

This study aims to find out if women aged 50 and older who have blood in their urine from a sudden bladder infection need to go through the full set of tests to check for cancer. Researchers will follow 300 women for a year after they get standard tests like a bladder scope and a…

This study is testing a new urine test that aims to predict whether bladder cancer patients will respond to standard BCG immunotherapy. Currently, about half of patients don't benefit from BCG treatment, leading to additional therapies or bladder removal surgery. The test measure…

This study is testing a new type of imaging scan to see if it can better detect and monitor many different solid tumors. The scan uses a special tracer that attaches to a protein called Trop2, which is often found on cancer cells. Researchers will compare this new scan to standar…

This study is testing whether a non-invasive urine test that looks for cancer DNA can help doctors decide when patients with high-risk bladder cancer need a follow-up cystoscopy. Cystoscopy is an effective but uncomfortable camera exam of the bladder. Researchers want to see if u…

This study is testing whether a non-invasive urine test can help doctors decide which patients with high-risk bladder cancer truly need a second surgery. Currently, many patients get this second procedure as a precaution, but it carries risks and costs. Researchers will compare t…

This study is testing a new approach to diagnosing invasive bladder cancer. It compares the standard surgical biopsy method against a new method that uses a detailed MRI scan first, followed by a smaller biopsy on the same day. The goal is to see if the MRI method helps patients …

This study is testing a new imaging substance called [18F]FAPI-74 to see if it can detect certain cancers better than current standard scans. It will involve 320 adults with one of 10 specific cancer types who are scheduled for treatment. Participants will receive both the new tr…

This study is testing whether a personalized home exercise program, delivered through a smartphone app, can help patients get stronger before bladder cancer surgery. Researchers want to see if being more physically fit before the operation leads to better recovery, fewer complica…

This study aims to create and test a counseling program to help people manage sexual health problems after bladder cancer treatment. First, researchers will interview patients to understand their specific challenges and what kind of support they want. Then, they will test if the …

This study is testing whether an educational video program can help older adults with bladder cancer prepare for and recover from major surgery (cystectomy). Participants are randomly assigned to watch videos before surgery, with some also receiving extra geriatric support after …

This study is testing whether a special health checkup and follow-up plan helps older, frail adults recover better from bladder cancer surgery. Researchers will compare patients who receive this extra care to those who get standard care. The main goal is to see if the plan helps …

This study aims to find the best time to send encouraging messages to help older cancer survivors be more physically active. Researchers will test if receiving a message makes participants more likely to be active in the next hour and if it affects their pain levels over the next…

This study is testing whether providing extra educational support can help women with bladder cancer feel less demoralized and improve their sexual function. Researchers will enroll 80 women and randomly assign them to receive either standard care or standard care plus a special …

This study aims to understand how major surgeries for bladder, prostate, and kidney cancers, as well as procedures for kidney stones, affect patients' ability to return to their jobs. Researchers will survey 2,000 patients in Poland about their work status and follow employed pat…

This study aims to understand how bladder cancer is currently treated in Russia and how often certain tumor markers appear. Researchers will collect medical records and tumor samples from about 600 patients across 30 centers. The study does not test new treatments; it only observ…

This study aims to collect blood, urine, saliva, and tissue samples from people with bladder/urinary tract cancer and healthy volunteers. Researchers will compare these samples to understand what genetic and cellular changes cause this cancer to develop. The goal is to identify n…

This study compares how well the cancer drug T-DXd works compared to standard treatments for patients with advanced HER2-positive solid tumors. Researchers will analyze existing medical records from about 105 patients who received either T-DXd in previous trials or standard care …

This study is creating a collection of blood, urine, and tissue samples from people with bladder cancer. Researchers will use this 'biorepository' to study how bladder cancer develops, returns after treatment, and affects survival over time. The study involves 1,000 participants …

This large international study is collecting information on a new, more precise type of radiation therapy that uses real-time MRI scans to guide treatment. It aims to see if this advanced technology helps people with many types of cancer live longer, better control their tumors, …

This study collects tumor tissue samples from cancer patients to research whether laboratory tests can predict which patients will respond to immunotherapy drugs. Researchers will analyze how live tumor samples react to immunotherapy treatments in the lab, then compare those resu…

This study is testing a modified surgical tool to see if it can provide better information about bladder cancer tumors. Researchers will use the tool on bladders that have already been surgically removed from patients for medical reasons. The goal is to see if this new method of …

This study is testing a new artificial intelligence (AI) tool designed to help match people with advanced cancer to suitable clinical trials. It will enroll up to 50,000 patients to see if using this AI system makes it easier for patients to find and join trials. The researchers …

This study aims to understand and improve how hospitals around the world treat patients who are urgently admitted with blood in their urine (hematuria). Researchers will observe the care of about 1,050 adult patients to see how different treatment approaches affect hospital stay …

This study aims to understand how bladder cancer treatment affects the body's energy use and muscle function. Researchers will measure these changes in 30 patients undergoing chemotherapy and surgery. The goal is to gather information that could help design better supportive care…

This study aims to understand the course of rare cancers in the urinary system (like bladder, kidney, and prostate cancers) by tracking patients over time. Researchers will collect medical information, blood, urine, and sometimes tumor samples from about 1,100 adults with these c…

This study aims to collect and store blood, urine, stool, saliva, and tumor samples from 500 bladder cancer patients at Toulouse University Hospital. Researchers want to understand how bacteria in the bladder and gut might affect how patients respond to cancer treatments like BCG…

This study is building a large, long-term database of health information and biological samples from people with cancer, people at risk for cancer, and healthy volunteers. The goal is to collect this data to help researchers better understand what causes cancer and how to prevent…

This study collects blood, urine, and tissue samples from people with or suspected of having cancers of the kidney, bladder, prostate, and other urinary system cancers. The samples are stored in a tissue bank and used for research to understand the genetic causes of these cancers…

This study is creating a detailed registry to track how patients recover after surgery to remove the bladder for cancer treatment. Researchers will collect information from 2,000 patients about their symptoms and recovery experiences. The goal is to establish a baseline so future…

This study screens adults with various cancers to see if they qualify for experimental treatments being tested by the National Cancer Institute's Surgery Branch. Participants undergo tests and evaluations to determine their eligibility for specific treatment trials. The study als…

This study aims to see if changes in what people buy—like pain relief or digestive aids—can serve as an early warning sign for certain cancers. Researchers will compare the shopping history of 1,450 recently diagnosed cancer patients with 1,450 people without cancer, using up to …