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New hope for advanced cancers? EVOLVE104 enters human testing

NCT ID NCT07217171

First seen Nov 01, 2025 · Last updated May 25, 2026 · Updated 38 times

Summary

This early-stage trial tests a new drug called EVOLVE104 in 160 people with advanced bladder cancer or several types of squamous cell cancer that have not responded to standard treatments. The main goals are to check the drug's safety, find the best dose, and see if it can shrink tumors. This is a first step to see if the drug is promising enough for larger studies.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

    Contact Email: •••••@•••••

  • Memorial Sloan Kettering Cancer Center

    RECRUITING

    New York, New York, 10065, United States

    Contact Email: •••••@•••••

  • SCRI

    RECRUITING

    Nashville, Tennessee, 37203, United States

    Contact Email: •••••@•••••

  • START Midwest

    RECRUITING

    Grand Rapids, Michigan, 49546, United States

    Contact Email: •••••@•••••

  • The Winship Cancer Institute Emory University

    RECRUITING

    Atlanta, Georgia, 30322, United States

    Contact Email: •••••@•••••

  • Thomas Jefferson University, Sidney Kimmel Cancer Center

    RECRUITING

    Philadelphia, Pennsylvania, 19107, United States

    Contact Email: •••••@•••••

  • USC/Norris Comprehensive Cancer Center

    RECRUITING

    Los Angeles, California, 90033, United States

    Contact Email: •••••@•••••

  • Virginia Cancer Specialists

    RECRUITING

    Fairfax, Virginia, 22031, United States

    Contact Email: •••••@•••••

  • Yale University Cancer Center

    RECRUITING

    New Haven, Connecticut, 06511, United States

    Contact Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.