BLADDER CANCER

This study tests a treatment called HIVEC, which delivers heated chemotherapy directly into the bladder. It is for people with high-grade bladder cancer that did not respond to standard BCG therapy and who cannot or choose not to have their bladder removed. The goal is to see if …

This study tests a drug called entinostat combined with chemotherapy for people with advanced bladder cancer that has not responded to initial treatment. The goal is to see if this combination can shrink tumors or slow the disease. About 29 participants will receive the treatment…

This early-phase trial is testing a new drug called ATO-101 for people with a type of bladder cancer (non-muscle-invasive) that has come back after standard treatments like BCG therapy. The drug delivers a short-range radioactive particle directly to cancer cells in the bladder, …

This study tests a program called Primary Care Connect (PC2) for cancer survivors who also have heart-related conditions like high blood pressure, diabetes, or high cholesterol. The goal is to see if the program helps them stay connected to their primary care doctor and better ma…

This study tests a new cell therapy called SL-28 for people with advanced solid tumors that have not responded to standard treatments. The therapy uses donor immune cells to attack the cancer. The goal is to see if it is safe and can shrink tumors in up to 60 participants with va…

This study will see if combining a special PET scan (FAPI PET/CT) with urine tests can more accurately detect and stage bladder cancer. About 262 adults with bladder cancer will receive the scan and provide urine samples before standard treatment. The goal is to improve how docto…

This study looks at whether skipping a routine urine culture before bladder tumor surgery is just as safe as doing one. The goal is to see if it leads to more post-surgery fevers or infections. About 2,600 adults scheduled for bladder tumor surgery will take part, and researchers…

This study tests a new type of radiation therapy that adapts to the bladder's changing shape during treatment. The goal is to reduce bowel side effects like diarrhea in people with muscle-invasive bladder cancer who cannot have surgery. About 120 participants will be randomly ass…

This study tests whether simple comfort measures—like playing calming music, using visual distractions, or timing numbing gel—can reduce pain and anxiety during bladder cancer exams. About 378 adults with bladder cancer will be randomly assigned to receive these extra comforts or…

This study explores whether analyzing tumor DNA in urine can be a simple, non-invasive way to monitor prostate and bladder cancer. Researchers will collect urine samples from 25 patients at different treatment stages to find the best methods for collecting and analyzing the DNA. …

This study looks at stored tumor samples from 100 people who had their bladder removed for muscle-invasive bladder cancer. Researchers want to see if the mix of cancer cells, supportive tissue, and immune cells can help predict who will do better or worse after surgery. The goal …