BLADDER CANCER

This early-phase study tested a new drug called UGN-301 (zalifrelimab) in 51 people with recurrent non-muscle invasive bladder cancer. The goal was to check the drug's safety and find the best dose when given directly into the bladder, alone or with other treatments. Results will…

This early study tested a drug called BGJ398 in 4 people with a specific type of bladder cancer that had returned after standard therapy. The goal was to see if the drug could make tumors disappear when viewed with a camera inside the bladder. The study was small and focused on p…

This study tested whether giving a short, intensive course of chemotherapy (Mitomycin C) directly into the bladder before surgery could reduce the chance of cancer coming back, compared to the usual approach of surgery followed by regular chemotherapy treatments. It involved 120 …

This study tested a two-step approach for people with advanced bladder cancer that has spread. First, doctors freeze some tumors (cryoablation), then give an immunotherapy drug (pembrolizumab or avelumab) to help the immune system attack remaining cancer. Only 9 people took part,…

This study tested whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard chemotherapy (gemcitabine and cisplatin) could shrink tumors more effectively before bladder cancer surgery. 39 adults with muscle-invasive bladder cancer received the combination before …

This early-phase study tested a combination of two drugs—CG0070 (given directly into the bladder) and nivolumab (given through a vein)—in 21 people with muscle-invasive bladder cancer who could not receive the standard chemotherapy drug cisplatin. The main goal was to check safet…

This study tested the drug pembrolizumab (Keytruda) alone or with other medicines in 296 people with high-risk bladder cancer that did not get better after standard BCG therapy. Participants were not able or willing to have their bladder removed. The goal was to see if the treatm…

This early-phase study tested the safety of combining different doses of external radiation therapy with the chemotherapy drug gemcitabine for people with bladder cancer. Nineteen participants with early-stage bladder cancer that had not spread were enrolled. The main goal was to…

This study tested a weekly, higher-dose radiation schedule (hypofractionated radiotherapy) for people with muscle-invasive bladder cancer who cannot have standard daily radiation or surgery. 65 participants received either standard or image-guided adaptive radiation to see if the…

This study compared two types of bladder removal surgery for people with bladder cancer: robot-assisted surgery and traditional open surgery. The main goal was to see which approach helped patients spend more days at home (alive and out of the hospital) in the first 90 days after…

This study compared two chemotherapy combinations (GC and HD-MVAC) given before or after bladder removal surgery in 500 patients with advanced bladder cancer. The goal was to see which regimen better delays cancer progression. Both treatments aim to control the disease, not cure …

This study tested a new combination of drugs (enfortumab vedotin plus pembrolizumab) given before and after bladder removal surgery for people with muscle-invasive bladder cancer. It compared this approach to the standard chemotherapy (gemcitabine plus cisplatin) given before sur…

This study tested several immunotherapy drug combinations in 272 people with advanced bladder cancer that had worsened after chemotherapy. The goal was to see if these combinations could shrink tumors or slow the cancer's growth. The flexible 'umbrella' design allowed researchers…

This study tested a drug called pemigatinib in 30 people with a type of bladder cancer that keeps coming back. Participants took the drug for 4-6 weeks before their scheduled surgery to remove the tumor. The goal was to see if the drug could completely eliminate the cancer before…

This study tested a combination of two drugs (toripalimab and gemcitabine) given before surgery to people with muscle-invasive bladder cancer who cannot take the standard chemotherapy drug cisplatin. The goal was to see how well the drugs shrink tumors before the bladder is remov…

This study tested whether a closed-system bladder irrigation device could lower the chance of urinary tract infections in 240 adults after prostate or bladder tumor surgery. Patients were randomly assigned to the new device or standard care. The closed system keeps the catheter s…

This study tested a new drug called enfortumab vedotin against standard chemotherapy in 608 adults with advanced bladder or urinary tract cancer that had worsened after prior treatment. The goal was to see if the new drug helped people live longer and slowed cancer growth. Result…

This early study tested a new imaging agent called 89Zr-girentuximab to see if it can help detect non-muscle-invasive bladder cancer using PET/CT scans. Six adults with confirmed bladder cancer took part. The goal was to check safety and how well the scan shows cancer spots.

This study looked at how well a new urine test called VISIOCYT finds bladder tumors compared to the usual method. About 700 people who were either being checked for a possible bladder tumor or were already being monitored for one took part. The test was done alongside standard cy…

This study tested a program to help bladder cancer patients and their caregivers before and after bladder removal surgery. A nurse or health professional prepared them for surgery and taught stoma care, and they got access to a recovery website with videos and tips. The goal was …

This early-phase study tested whether a nutritional drink called Impact Advanced Recovery, given before and after bladder removal surgery, could reduce complications and help men recover better. Thirty men with bladder cancer took part. The goal was to see if the drink could lowe…

This study compared two ultrasound-guided nerve block techniques to prevent involuntary leg muscle spasms during bladder tumor surgery. Sixty patients aged 50-80 were randomly assigned to receive either a single-injection or a two-injection nerve block. The goal was to see which …

This study tested whether using FitBit activity trackers and daily smartphone surveys after bladder cancer surgery could help patients recover better and avoid going back to the hospital. 38 adults who had bladder removal surgery were randomly assigned to either standard care or …

This study looks at how well the drug T-DXd works compared to usual treatments for people with advanced HER2-positive solid tumors (like lung, colon, and ovarian cancers). Researchers will use data from past clinical trials and real-world patient records to compare survival rates…

This study tested a web-based app called STOMA Care for bladder and colorectal cancer patients who had ostomy surgery and their caregivers. The goal was to see if the app was easy to use and helpful for learning stoma care skills, improving knowledge, and boosting quality of life…

This study tested whether an AI tool can help health providers write medical summaries that are easier for patients to understand. 120 providers were split into two groups: one used AI, the other did not. The goal was to see if AI could make the text clearer, more accurate, and f…

This study tested a new online tool called the Personal Patient Profile for Bladder Cancer (P3-BC) to help patients facing bladder removal surgery communicate better with their doctors and make informed decisions. Twenty-four adults with bladder cancer participated to see if the …

This large study looked at over 2 million people with type 2 diabetes to see if those taking dapagliflozin had a different risk of breast or bladder cancer compared to those on other diabetes medications. Researchers tracked cancer cases for up to 12 years. The goal was to unders…

This study looked at CT scans from 316 bladder cancer patients to see if a computer model could predict whether the cancer would come back after surgery. The goal was to help doctors identify high-risk patients who might need closer monitoring. The research was completed and focu…

This study looked at whether advanced MRI scans can more accurately determine how far bladder cancer has spread, which helps doctors choose the right treatment. Researchers enrolled 186 people with suspected or confirmed bladder cancer. The goal was to see if combining these scan…

This study looked at whether a care plan led by a geriatrician and a trained nurse could improve survival and quality of life for older adults (70+) with advanced cancer. 792 patients with breast, colorectal, lung, prostate, bladder, ovarian cancer, or lymphoma took part. The app…

This study tested whether a special type of PET/MR scan can accurately detect if bladder cancer has been completely eliminated by chemotherapy. 13 adults with muscle-invasive bladder cancer were scanned after chemotherapy, and the results were compared to tissue removed during su…

This small pilot study looked at whether DNA from cancer cells (called ctDNA) can be detected in the blood or urine of people with muscle-invasive bladder cancer who are receiving a combination of surgery, radiation, and chemotherapy. The goal was to see if collecting and measuri…

This study looked at people with advanced solid tumors (like lung, bladder, or skin cancer) who had been on immunotherapy (PD-1/PD-L1 inhibitors) for one year and whose disease was stable. It randomly assigned them to either stop treatment or continue until their cancer got worse…

This study looked at how immune checkpoint inhibitors, a type of cancer drug, might cause artery disease in 39 people with cancer. Researchers used ultrasound and blood tests to find early signs of blood vessel damage. The goal was to better understand these side effects, not to …