BLADDER CANCER

This study tests a new treatment for people with advanced solid tumors that have not responded to standard therapies. The treatment uses a patient's own immune cells, called T cells, which are genetically modified in a lab to better recognize and attack cancer cells. The main goa…

This study tests a new drug called TYRA300 in people with advanced bladder cancer or other solid tumors that have a specific gene change (FGFR3). The goal is to find a safe dose and see if the drug can shrink tumors. About 310 adults whose cancer has not responded to standard tre…

This early-stage study tests a combination of two drugs—romidepsin and durvalumab—given directly into the bladder for people with muscle-invasive bladder cancer who cannot receive standard chemotherapy. The goal is to see if this approach is safe and can shrink or eliminate tumor…

This early-phase study tests a new drug called AB598, alone or with other treatments, in about 40 people with advanced solid tumors like lung, bladder, or ovarian cancer. The main goal is to check if the drug is safe and tolerable. Participants must have measurable tumors and be …

This study tests whether combining two immune-boosting drugs, pembrolizumab and BCG, can keep high-risk bladder cancer from coming back. About 45 people with early-stage but aggressive bladder cancer will receive this combination as their first treatment. The goal is to see if th…

This study tests whether giving immunotherapy drugs (nivolumab alone or with ipilimumab) before bladder cancer surgery is safe and does not delay the operation. The goal is to shrink the tumor, making surgery more successful. It involves 52 adults with muscle-invasive bladder can…

This study tests a drug called ado-trastuzumab emtansine (T-DM1) in adults with advanced solid tumors that have a specific HER2 gene change. The goal is to see how well the drug shrinks or controls the cancer. About 131 people with lung, bladder, or other HER2-related cancers are…

This early-phase study tests a new drug called AI-061, which combines two immunotherapy agents (anti-PD-1 and anti-CTLA-4) into one treatment. The goal is to find the safest dose and see if it can shrink tumors in people with advanced cancers like melanoma, lung, and ovarian canc…

This study tests two immunotherapy drugs, nivolumab and urelumab, given before bladder removal surgery for patients with muscle-invasive bladder cancer who cannot or choose not to have chemotherapy. The goal is to see if adding urelumab boosts the immune response against the tumo…

This study tests whether adding the drug durvalumab to standard treatment (surgery, chemotherapy, and radiation) helps prevent bladder cancer from coming back. About 82 people with muscle-invasive bladder cancer that hasn't spread will take part. The main goal is to see if the co…

This study tests a new treatment called cretostimogene grenadenorepvec, a virus that targets cancer cells, to see if it can keep intermediate-risk bladder cancer from returning after surgery. About 367 people will be randomly assigned to receive the virus or just be watched. The …

This study tests whether adding a precise, high-dose radiation treatment (SBRT) can help restart the immune system's fight against cancer when immunotherapy drugs start to lose effect. About 69 adults with metastatic cancers (melanoma, lung, bladder, kidney, or head/neck) will re…

This study tests a drug called UGN-102 for people with a low-grade, intermediate-risk type of bladder cancer that hasn't spread into the muscle. The goal is to see if this drug can destroy the cancer without needing surgery. About 240 participants received the drug, and researche…

This study tests a new treatment (TAR-200, a drug-releasing device placed in the bladder) alone or with another drug (cetrelimab) against the standard BCG therapy for people with a high-risk type of bladder cancer that hasn't spread into the muscle. About 1,135 participants who h…

This study tests whether adding a personalized cancer vaccine (V940) to standard immunotherapy (pembrolizumab) can prevent muscle-invasive bladder cancer from coming back after surgery. About 230 adults with high-risk bladder cancer will receive either the vaccine plus immunother…

This study tests a new drug called UGN-103, which is placed directly into the bladder, to treat a type of low-grade bladder cancer that hasn't spread into the muscle. About 99 people with this cancer at intermediate risk of coming back will receive the treatment. The main goal is…

This study tests whether adding the immunotherapy drug durvalumab to standard chemotherapy helps shrink bladder cancer that has spread to nearby lymph nodes. About 60 adults with this type of cancer will be randomly assigned to receive either chemo alone or chemo plus durvalumab.…

This study tests whether adding the immunotherapy drug atezolizumab to standard chemotherapy (gemcitabine and cisplatin) is safe and effective for people with advanced or muscle-invasive bladder cancer. About 54 adults with good overall health are taking part. The goal is to see …

This early-stage trial tests a combination of two drugs, naptumomab estafenatox and durvalumab, in 120 adults with advanced or metastatic solid tumors that have not responded to standard treatments. The main goal is to find safe doses and check for side effects, while also measur…

This study tests whether adding the experimental drug visugromab to standard immunotherapy can help shrink muscle-invasive bladder cancer before surgery. About 31 adults who cannot or choose not to receive cisplatin chemotherapy will receive the combination before having their bl…

This study aimed to test a virus-based treatment called CG0070 for people with a high-grade bladder cancer that hadn't spread into muscle. It was for patients whose cancer came back after standard therapy (BCG) and who chose not to have their bladder removed. The study was withdr…

This study tests a new robotic surgery system (Medtronic Hugo™) in 144 adults needing urologic procedures like prostate, bladder, or kidney surgery. The goal is to see if the robot helps surgeons complete the operation without switching to other methods, and to track any serious …

This study tests whether adding an experimental drug (N-803) to standard BCG therapy can help people with high-grade bladder cancer that has stopped responding to BCG alone. About 190 adults will receive the combination directly into the bladder through a catheter. The goal is to…

This study tested a combination of four chemotherapy drugs (5-FU, leucovorin, gemcitabine, and cisplatin) in 46 people with advanced bladder or urethral cancer that had spread or could not be removed by surgery. The goal was to see how many patients' tumors shrank or disappeared.…

This study is for people with muscle-invasive bladder cancer who cannot have their bladder removed due to age, health issues, or personal choice. After standard chemo-radiation, participants receive the drug atezolizumab to help keep the cancer from coming back. The goal is to co…

This study compares two drugs, mannitol and nitroglycerin, given during robotic surgery for prostate or bladder cancer to see if they can prevent acute kidney injury. The trial involves 90 adults with normal or mildly reduced kidney function. Researchers aim to find which drug be…

This study tests whether starting immunotherapy early, guided by a sensitive blood test that finds tumor DNA, can better treat bladder cancer that has spread after bladder removal surgery. About 154 adults with signs of cancer in their blood (but not always visible on scans) will…

This early-phase study tests a new drug called LY4101174 in people with advanced or metastatic solid tumors that have come back or spread. The drug is designed to target and attack cancer cells while sparing healthy ones. The study will check if the drug is safe and what dose wor…

This study tests whether adding the immune drug nivolumab after standard chemo-radiation can help keep bladder cancer from coming back. About 200 adults with muscle-invasive bladder cancer who cannot have bladder removal surgery are taking part. The main goal is to see how many a…

This study is testing an experimental drug called AZD5305, a PARP inhibitor, in people with advanced solid tumors like ovarian, breast, pancreatic, and prostate cancer. The goal is to see if the drug is safe and tolerable when given alone or with other cancer treatments. About 70…

This study tests a pill called erdafitinib in people whose bladder cancer has come back after standard treatments like BCG or chemotherapy. Only patients with a specific gene change (FGFR3 mutation) in their tumor can join. The goal is to see if the pill can shrink or eliminate t…

This trial tests whether giving a special BCG treatment directly into the bladder, followed by chemotherapy and immunotherapy, can make muscle-invasive bladder cancer disappear before surgery. The goal is to increase the chance of a complete response, so patients might avoid havi…

This study tests a combination of two chemotherapy drugs, gemcitabine and docetaxel, given directly into the bladder for people with early-stage bladder cancer who have not received standard BCG therapy. The goal is to see if this treatment can clear the cancer and keep it from c…

This study compares two imaging techniques—CT urography and intravenous urography—to see which works better for detecting urothelial tumors in the urinary tract. About 133 people at risk for bladder cancer will participate. The goal is to find out if CT scans alone can effectivel…

This early-phase study tests a special PET scan (using 18F-fluciclovine) to see if it can more accurately show how far muscle-invasive bladder cancer has spread, compared to standard CT or MRI scans. Sixteen adults with bladder cancer scheduled for bladder removal surgery will ge…

This study is testing a new urine test that looks for specific markers of bladder cancer. The goal is to catch the disease early in people at high risk, such as those over 50 with a heavy smoking history. Researchers will follow 173 participants for up to 4 years to see how accur…

This study is testing a new urine test that looks for specific proteins to detect bladder cancer in 450 people who have blood in their urine. The goal is to see if this simple, non-invasive test can accurately identify cancer, potentially reducing the need for a camera exam calle…

This study looks at a urine test called Bladder CARE Assay to see if it can accurately detect bladder cancer in people whose standard tests (cystoscopy or cytology) were not clear. About 80 adults with suspicious but inconclusive results will provide a urine sample before their n…

This study looks at whether giving radiation to the whole brain can lower the chance of brain tumors in people with a rare and aggressive type of bladder cancer (small cell carcinoma). About 31 patients who have already responded to chemotherapy will receive the radiation. Resear…

This study looks at whether JING SI HERBAL TEA can help reduce urinary symptoms like pain or urgency that often occur after intravesical therapy for bladder cancer. About 100 adults with bladder cancer who are receiving this therapy will drink the tea and report changes in their …

This study looks at what information and support people need after having their bladder removed due to bladder cancer. Researchers will follow 200 patients over time to understand their changing needs and how to improve rehabilitation. The goal is to help patients better manage t…

This study gives a targeted drug called abemaciclib to 20 people with bladder cancer who cannot have standard chemotherapy. The drug is taken for a short time before surgery to remove the bladder. Researchers compare tumor samples taken before and after treatment to see how the d…

This study looks at tumor samples from 15 people with kidney or bladder cancer whose cancer came back after immunotherapy. Researchers compare the genes and structure of the original tumor with the new growth to find clues about why the cancer became resistant. The goal is to bet…

This study follows 600 people with non-muscle invasive bladder cancer to see how lifestyle factors like smoking and body weight influence whether the cancer comes back. Researchers will track recurrences over time. The goal is to understand which habits matter most, not to test a…

This study creates a registry of over 3,500 people, including those with and without urothelial cancer, to better understand the disease. Researchers will look at genetic markers in saliva and risk factors to find links to cancer risk and outcomes. The goal is to improve how we p…

This study collects fresh tumor samples from 416 adults with various cancers (bladder, kidney, colorectal, head and neck, liver, lung, skin, endometrial) to develop and train a live tumor diagnostic platform. The goal is to see how accurately the platform can predict whether a pa…

This study looks at how bladder cancer treatments affect patients' quality of life years later. Researchers will track 2,000 people in Denmark to find out which late side effects are most common and who is at higher risk. The goal is to better understand the long-term impact of t…

This study looks at two blood thinners (apixaban and enoxaparin) given to bladder cancer patients after surgery to remove their bladder. The goal is to see which one patients are more likely to take as prescribed, which they prefer, and how much each costs them. About 90 adults w…

This study looks at whether a new screening method using PHI and mp-MRI can find prostate cancer earlier in men with certain gene mutations (DRG). The goal is to see if this approach works better than the current standard of DRE and PSA tests. About 320 men with prostate or bladd…

This study looks at the chromosomes of people with bladder cancer to find patterns that may help explain how the disease starts and grows. No treatments or medications are given. The goal is simply to learn more about the biology of bladder cancer by analyzing tissue samples from…

This study explores whether a special type of radiation therapy can protect the ovaries of young women (ages 18-50) undergoing pelvic radiation for cancers like uterine, rectal, or cervical cancer. The goal is to see if doctors can consistently see the ovaries on daily scans and …

This study compares two treatments for a type of bladder cancer that keeps coming back: medication placed directly into the bladder versus surgery to remove the bladder. Researchers want to see which option gives patients a better quality of life and fewer side effects. About 570…

This early-phase study tested the safety of a drug called UGN-201 in 10 people with bladder cancer who were scheduled to have their bladder removed (cystectomy). The main goal was to see if the drug caused any serious side effects before or after surgery. Researchers also looked …

This study looks at whether wearable fitness trackers like Fitbit can help doctors spot early signs of complications in people recovering from bladder removal surgery (cystectomy). About 50 participants will wear a Fitbit before and after surgery and answer daily questions on the…

This study looks at four different tools to help people who have had cancer improve their diet and physical activity. About 353 cancer survivors will try these tools to see which ones work best. The goal is to find simple ways to help survivors follow healthy lifestyle guidelines…

This study is testing a new system that combines aging, mental health, and social needs checks for cancer patients aged 65 and older. The goal is to help doctors provide care that fits each patient's life. About 35 people with different cancers will try it during their first visi…

This study looks at how two drugs, pembrolizumab and entinostat, change the immune system in people with muscle-invasive bladder cancer who cannot have standard chemotherapy. About 20 participants receive the drugs before their scheduled bladder removal surgery. The goal is to me…

This study collects DNA from over 21,000 New York cancer patients to look for inherited gene changes linked to several cancer types. It is an exploratory project that does not offer treatment but aims to find clues for future research. Participants include people with breast, col…

This study looks at how robotic surgery for prostate, bladder, or kidney cancer affects patients' finances. About 120 adults who had surgery in the last year will fill out questionnaires about money worries, medical costs, and travel expenses. The goal is to understand which pati…

This study aims to find out why some people are more likely to get bladder cancer by looking at their genes and lifestyle habits, like smoking. Researchers will compare about 6,000 people with and without bladder cancer to see how their bodies process cancer-causing chemicals. Th…