BLADDER CANCER

This study is testing whether adding a drug called durvalumab after standard bladder cancer treatment helps patients stay cancer-free longer. Durvalumab is an immunotherapy that helps the body's own immune system find and fight cancer cells. The trial will enroll 82 patients who …

This study tested a combination of four chemotherapy drugs (5-FU, leucovorin, gemcitabine, and cisplatin) in patients with advanced adenocarcinoma of the bladder, urethra, or a related structure called the urachal remnant. The goal was to see how well this drug combination could …

This early-stage study is testing a new two-part treatment for muscle-invasive bladder cancer in patients who cannot receive standard chemotherapy. Before surgery to remove the bladder, patients receive a liquid drug directly into the bladder (a 'bladder wash') combined with an i…

This study is testing if starting immunotherapy earlier can better control metastatic bladder cancer. It involves 154 adults who have had their bladder removed for cancer. Doctors use a sensitive blood test to detect tiny signs of cancer return and then immediately start the immu…

This study is testing whether a pill called erdafitinib can shrink recurrent bladder tumors in people with a specific genetic change (FGFR3 mutation). The drug is taken for a short period before a standard procedure to remove the tumor. Researchers want to see if this targeted ap…

This study is testing whether immunotherapy drugs given before bladder cancer surgery are safe and can shrink tumors to make surgery more successful. The trial includes 52 patients with muscle-invasive bladder cancer who cannot receive standard chemotherapy. Researchers are compa…

This study is for people with muscle-invasive bladder cancer who are scheduled for surgery but cannot take standard chemotherapy beforehand. Researchers want to see how two different drug combinations affect the immune system and the tumor. One group gets an immunotherapy drug (p…

This study is testing a new combination treatment for early-stage bladder cancer in patients who haven't received the standard BCG therapy. Participants receive the drugs directly into the bladder through a catheter, starting with weekly treatments for six weeks, then monthly if …

This study is testing if adding a drug called durvalumab (an immunotherapy) to standard chemotherapy works better than chemotherapy alone for bladder cancer that has spread to nearby lymph nodes. The goal is to shrink the cancer more effectively before surgery. Patients will be r…

This early-stage study is testing the safety of an experimental drug called UGN-201 in bladder cancer patients who are scheduled to have their bladder surgically removed. The research involves 10 participants and aims to understand if UGN-201 is safe to give before surgery and wh…

This study is testing whether a drug called ado-trastuzumab emtansine can help control advanced solid tumors that have specific abnormalities in the HER2 gene. The trial is enrolling adults with cancers like lung, bladder, and urinary tract cancers that have these genetic feature…

This study is testing a new combination treatment for people with high-grade bladder cancer that has not responded to the standard BCG therapy. The treatment involves placing a liquid containing BCG and/or a drug called N-803 directly into the bladder through a catheter. The goal…

This is the first human study testing the safety of an experimental drug called AB598 in people with advanced cancers. The trial will enroll 40 participants with various cancers including lung, stomach, bladder, and breast cancer to determine safe dosage levels and monitor side e…

This study tests whether adding the immunotherapy drug pembrolizumab to standard BCG treatment helps control high-risk bladder cancer in patients who want to avoid having their bladder removed. The trial involves 45 participants with early-stage but aggressive cancer that has a h…

This study is testing whether adding a new antibody drug called visugromab to standard immunotherapy helps shrink bladder tumors before surgery. It's for patients with muscle-invasive bladder cancer who cannot receive or refuse standard cisplatin chemotherapy. The goal is to see …

This study is testing whether adding a newer immunotherapy drug (atezolizumab) to standard chemotherapy (gemcitabine and cisplatin) is safe and effective for bladder cancer. It involves two groups of patients: those with cancer that has spread (metastatic) and those with cancer t…

This study is testing an investigational drug called TYRA300 for people with advanced bladder cancer and other solid tumors that have specific changes in a gene called FGFR3. The main goals are to find a safe and effective dose and to see if the drug can shrink or control the tum…

This study is testing whether adding a personalized cancer vaccine (V940) to standard immunotherapy (pembrolizumab) can better prevent cancer from returning in people with high-risk muscle-invasive bladder cancer after surgery. The vaccine is custom-made for each person based on …

This study is testing a new liquid treatment called UGN-103 for people with a specific type of early-stage bladder cancer that has a moderate risk of returning. The treatment is placed directly into the bladder once a week for six weeks. Researchers want to see if it can complete…

This study is testing whether a new drug delivery system called TAR-200, either alone or combined with an immunotherapy drug (cetrelimab), works better than the current standard BCG treatment for high-risk bladder cancer that hasn't spread into the muscle wall. The trial involves…

This study is testing a new oral drug called AZD5305 to see if it is safe and can help control advanced cancers. It is being tested alone and in combination with other cancer medicines in over 700 patients with various hard-to-treat solid tumors. The main goals are to find the ri…

This study is testing a new treatment approach for muscle-invasive bladder cancer. It combines a liquid treatment placed directly into the bladder (BCG) with standard chemotherapy and an immunotherapy drug given by IV. The main goal is to see if this combination can completely cl…

This study is testing a drug called atezolizumab to see if it can help control muscle-invasive bladder cancer and prevent it from coming back after standard chemotherapy and radiation. It is for patients who are not eligible for or refuse major surgery to remove their bladder. Th…

This study is testing if a short, high-precision form of radiation (SBRT) can help restart the effectiveness of immunotherapy drugs in patients whose cancer has started to grow again. It involves adults with certain advanced cancers (like melanoma, lung, or bladder cancer) who ar…

This study is testing the safety and performance of Medtronic's new Hugo robotic surgery system for urologic procedures, primarily for cancers of the bladder, prostate, and kidney. It will enroll 144 adult patients needing specific cancer surgeries to see if the robot can complet…

This study is testing a new treatment called cretostimogene to see if it can prevent intermediate-risk bladder cancer from returning after tumor removal surgery. About 367 participants will be randomly assigned to receive either the new treatment or standard observation with regu…

This early-stage trial is testing the safety and finding the right dose of a two-drug combination (naptumomab estafenatox and durvalumab) for people with advanced or metastatic solid tumors. It will enroll about 120 adults with one of many eligible cancer types, including breast,…

This early-stage study tests a personalized cell therapy for people with advanced solid tumors. Doctors collect a patient's own immune cells, genetically modify them in a lab to better recognize and attack cancer, then infuse them back into the patient. The main goals are to chec…

This study is testing if adding a drug called nivolumab (an immunotherapy) after standard chemotherapy and radiation treatment helps keep bladder cancer from returning. It is for 200 adults with muscle-invasive bladder cancer who are not candidates for or refuse major surgery to …

This study is testing a new type of PET scan to see if it can more accurately show how far muscle-invasive bladder cancer has spread, compared to the standard CT or MRI scans used today. The scan uses a special imaging agent called 18F-fluciclovine, which may help doctors see can…

This study is testing a more personalized screening method for men at high genetic risk of prostate cancer. Researchers want to see if using a specific blood test (PHI) and an advanced MRI scan can find aggressive cancers earlier than the current standard tests. The goal is to he…

This study is testing a new urine test designed to detect bladder cancer early, before symptoms appear. It focuses on adults over 50 with a significant history of smoking, who are at higher risk. The goal is to see if this non-invasive test can accurately find cancer sooner, whic…

This study is testing a new urine test to better detect bladder cancer in people who see blood in their urine. The goal is to see if this test can be as accurate as the current standard, which involves inserting a camera into the bladder. If successful, it could help many patient…

This study is testing a new urine test called Bladder CARE™ to see if it can accurately detect bladder cancer in patients whose standard test results are unclear or uncertain. Researchers will collect a urine sample from 80 participants before their scheduled bladder exam and the…

This study aims to see if a single type of CT scan (CTU) can effectively monitor bladder cancer recurrence, potentially replacing the current standard practice of using two different scans (IVU and CT). Researchers are comparing the image quality and information provided by both …

This study is comparing two different blood-thinning medications that patients take at home after surgery to remove their bladder for cancer. The goal is to see which drug patients are better at taking consistently, which one they prefer, and what the typical out-of-pocket cost i…

This study is testing whether giving radiation to the whole brain can prevent brain tumors from developing in patients with an aggressive type of bladder cancer that has spread. The treatment is for patients whose cancer has responded well to chemotherapy but remains at high risk…

This study is testing whether giving one of two drugs, mannitol or nitroglycerin, during robotic surgery for prostate or bladder cancer can help prevent a sudden drop in kidney function afterward. It will involve 90 patients with generally healthy or mildly reduced kidney functio…

This study is testing whether a specific herbal tea can help reduce uncomfortable urinary symptoms that often occur after bladder cancer treatments. Researchers will enroll 100 bladder cancer patients who are receiving standard post-surgery bladder treatments. Half will receive t…

This study is creating a large registry to learn more about bladder and other urinary tract cancers. Researchers are collecting health information and saliva samples from over 3,500 people, including those with cancer and those without, to look for genetic markers and other facto…

This study aims to identify why some people develop bladder cancer while others don't, focusing on how genetics and lifestyle factors like smoking interact. Researchers are comparing over 6,000 people with and without bladder cancer to measure genetic differences and tobacco-rela…

This is a laboratory research study aiming to understand the genetic changes that occur in bladder cancer. Researchers will analyze tissue samples from 5,000 participants who have been diagnosed with bladder cancer. The goal is to gather knowledge about the disease's biology, not…

This study aims to help patients and doctors make better decisions when bladder cancer returns after initial treatment. Researchers are following 570 patients who choose either bladder removal surgery or additional drug therapy to see which approach leads to better quality of lif…

This study is testing a new system designed to give doctors a more complete picture of an older patient's overall health and life circumstances when planning cancer treatment. It combines questions about aging, daily function, mental health, and social needs like housing and food…

This study is testing whether fitness trackers and daily smartphone surveys can help spot early warning signs in patients recovering from major bladder surgery. The goal is to see if this remote monitoring can help healthcare providers respond quickly to potential problems, aimin…

This study aims to understand how long-term side effects from bladder cancer treatment affect patients' quality of life. Researchers will survey 2,000 patients in Denmark who were treated for bladder cancer to measure these impacts. The goal is to identify which patients are most…

This study is testing a cancer drug called abemaciclib in bladder cancer patients who cannot receive standard chemotherapy. Twenty participants will take the drug for about a month before having their bladder surgically removed. Researchers will compare tumor samples taken before…

This study aims to understand what information and support bladder cancer patients need before and after bladder removal surgery. Researchers will follow 200 Swedish-speaking adults who have undergone this major operation to identify gaps in care and education. The goal is to imp…