New drug targets 'Undruggable' cancer mutation in early trial
NCT ID NCT06778863
First seen Oct 31, 2025 · Last updated Apr 30, 2026 · Updated 29 times
Summary
This early-phase study tests a new drug, CLSP-1025, designed to attack cancer cells that have a specific change in the p53 gene (called R175H). The trial enrolls adults with advanced solid tumors (like lung, colon, or pancreatic cancer) that have this mutation and have not responded to standard treatments. The goal is to find the safest dose and see if the drug can shrink tumors.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Baylor University Medical Center
RECRUITINGDallas, Texas, 75246, United States
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Duke Cancer Institute
RECRUITINGDurham, North Carolina, 27701, United States
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Fox Chase Cancer Center
RECRUITINGPhiladelphia, Pennsylvania, 19111, United States
Contact Phone: •••-•••-••••
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Fred Hutchinson Cancer Center
RECRUITINGSeattle, Washington, 98109, United States
Contact Phone: •••-•••-••••
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Hackensack University Medical Center
RECRUITINGHackensack, New Jersey, 07601, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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HonorHealth Research Institute
RECRUITINGScottsdale, Arizona, 85258, United States
Contact Phone: •••-•••-••••
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Johns Hopkins - Sidney Kimmel Comprehensive Cancer Center
RECRUITINGBaltimore, Maryland, 21287, United States
Contact Phone: •••-•••-••••
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MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-••••
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Mary Crowley Cancer Research
RECRUITINGDallas, Texas, 75230, United States
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
Contact Phone: •••-•••-••••
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NYU Langone Health
RECRUITINGNew York, New York, 10016, United States
Contact Phone: •••-•••-••••
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Sarah Cannon Research Institute (SCRI) Oncology Partners
RECRUITINGNashville, Tennessee, 37203, United States
Contact Phone: •••-•••-••••
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The University of Arizona Cancer Center
RECRUITINGTucson, Arizona, 85719, United States
Contact Email: •••••@•••••
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The University of Chicago Comprehensive Cancer Center
RECRUITINGChicago, Illinois, 60637, United States
Contact Phone: •••-•••-••••
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Thomas Jefferson University, Sidney Kimmel Cancer Center
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
Contact Email: •••••@•••••
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USC - Norris Comprehensive Cancer Center
RECRUITINGLos Angeles, California, 90033, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California Davis Comprehensive Cancer Center
RECRUITINGSacramento, California, 95817, United States
Contact Phone: •••-•••-••••
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University of California San Francisco
RECRUITINGSan Francisco, California, 94143, United States
Contact Email: •••••@•••••
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University of Kentucky Markey Cancer Center
RECRUITINGLexington, Kentucky, 40536, United States
Contact Phone: •••-•••-••••
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University of Miami - Sylvester Comprehensive Cancer Center
RECRUITINGMiami, Florida, 33136, United States
Contact Phone: •••-•••-••••
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Vanderbilt University Medical Center
RECRUITINGNashville, Tennessee, 37232, United States
Contact Phone: •••-•••-••••
Conditions
Explore the condition pages connected to this study.