ADVANCED SOLID TUMOR

This is an early-stage study to check the safety and initial effectiveness of a new drug, CHS-114, when given with an existing immunotherapy (toripalimab) and possibly other standard treatments. It is for adults with advanced or metastatic solid tumors, including specific types o…

This is the first study in people to test a new drug called XB628 for advanced solid tumors that have returned or spread. The main goal is to find a safe and effective dose by giving the drug to about 75 participants. XB628 is designed to help the body's own immune cells find and…

This early-stage clinical trial is testing a new cancer drug called YL201, both by itself and in combination with other cancer treatments. The study aims to find the safest dose and see if it helps control advanced solid tumors in patients who have run out of standard treatment o…

This is the first study in humans testing a new drug called TORL-1-23 for people with advanced solid tumors, including ovarian, endometrial, and lung cancers. The main goals are to find a safe dose, see how the body processes the drug, and check for any early signs it might help …

This study is testing a new oral drug called JAB-23E73 for people with advanced solid tumors that have a specific genetic change in the KRAS gene. The main goals are to find a safe dose, see how the body processes the drug, and check if it can shrink tumors. It is for adults with…

This is an early-stage study testing a new experimental cancer drug called BG-C137 in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose, see how the body processes the drug, and check for any early signs …

This is the first study in people to test a new oral medication called NKT3964. The main goals are to find a safe dose and see if the drug shows early signs of shrinking tumors in adults with advanced cancers that have spread and no longer respond to standard treatments. The stud…

This is an early-stage study to find a safe dose and understand the side effects of a new drug called GS-5319. It is for adults with advanced solid tumors that have stopped responding to standard treatments and have a specific genetic alteration called MTAP-deletion. The main goa…

This early-stage study is testing a new drug called BGB-B455 in people with advanced solid tumors that have spread and express a specific protein called CLDN6. The main goals are to find a safe dose and understand what side effects participants experience. The study will enroll a…

This early-stage study is testing the safety and initial effectiveness of a new drug, WJB001, when combined with various other cancer therapies. It will involve about 86 adults with advanced solid tumors who have run out of standard treatment options. The main goals are to find s…

This is the first human study of an experimental oral medication called APR-1051 for people with advanced solid tumors that have spread. Researchers will test different doses in 90 patients to determine if the drug is safe, how it moves through the body, and whether it shows any …

This is a first-in-human study to test the safety and find the right dose of an experimental drug called SIBP-A13 for people with advanced solid tumors. It will enroll 144 adults whose cancer has progressed despite standard treatments. The main goals are to see how the body handl…

This early-stage trial is testing a new drug called OMTX705, both alone and combined with existing immunotherapy drugs, for people with advanced solid tumors that have stopped responding to standard treatments. The study aims to find the safest dose and see if the treatment shows…

This is the first human study testing a new cancer drug called TT125-802 in people with advanced solid tumors that have stopped responding to standard treatments. The main goal is to check if the drug is safe and well-tolerated, while also looking for early signs that it might he…

This is the first human study of an experimental drug called ABL103 for people with advanced solid tumors that have progressed despite standard treatments. The study aims to find the safest dose and see if the drug shows early signs of fighting cancer. It will enroll 96 adults wh…

This is a first-in-human study testing a new radioactive drug called [225Ac]-FPI-2068 in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose, see how the drug travels in the body, and check for early signs …

This is the first study in people testing a new antibody drug called NTX-1088. The main goal is to find a safe dose and see how the body handles the drug, both by itself and when given with another cancer immunotherapy (pembrolizumab). It is for adults with advanced solid tumors …

This study is testing a new oral drug called Alintegimod, given alongside standard immunotherapy drugs (ipilimumab and nivolumab), for people with advanced cancers that have spread. The main goals are to find a safe dose and see if the combination helps control the cancer. It is …

This early-stage study aims to find safe doses and gather initial evidence on whether a new drug called BGB-43395 can help control advanced cancers. The trial will enroll about 300 people with hormone-positive, HER2-negative breast cancer that has spread, as well as other solid t…

This early-stage study is testing a new type of cell therapy called FT825/ONO-8250 in adults with advanced solid tumors that have stopped responding to standard treatments. The therapy involves giving patients specially engineered immune cells designed to find and attack cancer c…

This is the first study in people testing a new oral drug called PLX-61639 for advanced solid tumors that have a specific genetic change (SMARCA4 mutation) and have stopped responding to standard treatments. The main goals are to find a safe dose and see if the drug shows early s…

This is the first study in people for a new oral drug called AVZO-021. It aims to find a safe dose and see if the drug can help control advanced solid tumors, including certain types of breast and ovarian cancer, that have stopped responding to standard treatments. The study will…

This is an early-stage study to test the safety and initial effectiveness of a new investigational drug called BGB-58067. The trial will enroll about 244 adults with advanced solid tumors that have a specific genetic feature called MTAP deficiency. Researchers will test the drug …

This trial is testing whether an experimental drug called raludotatug deruxtecan (R-DXd) can help control advanced or metastatic solid tumors. The study will enroll 200 adults with specific types of gynecological or genitourinary cancers that have progressed after previous treatm…

This is a first-in-human study to test the safety and find the right dose of a new immunotherapy drug called denikitug. It is being tested alone and in combination with another immunotherapy drug in adults with advanced solid tumors that have not responded to standard treatments.…

This early-stage study is testing a new drug called OBI-902 in people with advanced solid tumors that have not responded to standard treatments. Researchers aim to find the safest and most effective dose and see if the drug shows early signs of shrinking tumors. The study will en…

This early-stage trial is testing a new oral drug called MOMA-313, given alone or combined with an existing cancer drug (olaparib), in people with advanced solid tumors that have a specific genetic flaw. The main goals are to find safe doses and see how the body processes the dru…

This study is testing a new drug called GTAEXS617 in people with advanced solid tumors that have stopped responding to standard treatments. Researchers want to find the safest dose and see if the drug can shrink tumors in cancers like lung, pancreatic, ovarian, and breast cancer.…

This study is testing a new drug called QLC5508, given by IV along with other cancer medications, for people with advanced solid tumors. The main goals are to find the safest and most effective dose and to see if the treatment can shrink tumors. The trial will enroll about 444 ad…

This study is testing the safety and effectiveness of a new investigational drug called GI-101 for people with advanced or metastatic solid tumors. The drug is designed to work in two ways to help the immune system fight cancer. Researchers will test it alone and in combination w…

This is the first human study of an experimental cancer drug called M3554. It aims to find a safe dose and check for early signs that the drug might help control advanced soft tissue sarcomas and glioblastoma brain tumors. The study will enroll about 52 adults whose cancer has pr…

This study is testing whether two new drugs, QLP2117 and QL2107, are safe and effective when given together to patients with advanced solid tumors that have stopped responding to standard treatments. Researchers will enroll 90 patients to find the right dose and see if the combin…

This is the first study in humans testing a new drug called YL242, both alone and in combination with other treatments, for people with advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to check if the drug is safe, how the body processes …

This study is testing a new drug called STK-012 for people with advanced non-small cell lung cancer and other solid tumors. Researchers want to see if STK-012 works better when given alone or combined with standard cancer treatments. The trial will involve about 364 participants …

This is the first study in people for a new drug called KK2269. It aims to find a safe dose and see how well the body tolerates it. The study will test KK2269 alone in people with various advanced solid tumors, and also test it combined with a standard chemotherapy drug (docetaxe…

This is the first human trial testing a new cancer drug called DS5361b, both alone and combined with an existing immunotherapy drug (pembrolizumab). The study aims to find the safest dose and see if it helps control advanced solid tumors in people who have run out of standard tre…

This study is testing a multi-step treatment plan for people with locally advanced rectal cancer, aiming to shrink tumors before surgery. It combines a short course of radiation with two immunotherapy drugs (PD-1 antibody and IL-2) and a chemotherapy regimen (CAPOX). The main goa…

This is the first human study of an experimental drug called LM-24C5 for people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see how the body handles the drug. Researchers will also look for early signs…

This is the first study in people to test a new cancer drug called YL217. The main goals are to check its safety, find the right dose, and see if it can shrink tumors in adults with advanced solid tumors, particularly gastrointestinal cancers. YL217 is a type of targeted therapy …

This study is testing a new drug called BNT326, both by itself and in combination with other cancer immunotherapies, for people with advanced solid tumors that have spread or returned after prior treatment. The main goals are to find the safest and most effective dose and to see …

This is an early-stage study testing a new intravenous cancer drug called PM54 in patients with advanced solid tumors that have progressed after standard treatments. The main goals are to find the safest dose, understand how the body processes the drug, and look for early signs t…

This is the first study in people to test the safety of an experimental drug called AXT-1003. It is for adults with advanced solid tumors or non-Hodgkin lymphoma that have not responded to standard treatments. The main goal is to find a safe dose and see how the body processes th…

This is the first time a new cancer drug called ifinatamab deruxtecan (I-DXd) is being tested in people. The study aims to find a safe and effective dose for patients with advanced solid tumors that have not responded to standard treatments. Researchers will monitor participants …

This is the first study in people to test a new cancer drug called PYX-201. Researchers want to find a safe and effective dose for adults with advanced solid tumors that have spread or returned after other treatments. The study will also look for early signs that the drug can shr…

This early-stage study is testing the safety and initial effectiveness of two new cancer drugs, BNT3212 alone and combined with BNT327. It is for adults with advanced solid tumors who have no other standard treatments left. The main goals are to find safe doses and see if the dru…

This study is testing a new drug called CLIO-8221 in people with advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to find the safest and most effective dose and to see if the drug can shrink tumors. It is for patients who have already tri…

This is the first human study of an experimental drug called INI-4001 for people with advanced solid tumors that have spread. The main goal is to find a safe dose and see how the body handles the drug, both by itself and when combined with other approved cancer immunotherapies. R…

This is the first time a new drug called IPN01195 is being tested in people. The study aims to find a safe and effective dose for adults with advanced solid tumors that have spread and have specific genetic changes. Researchers will test different doses to see how the body handle…

This early-stage study is testing the safety and initial effectiveness of combining two cancer drugs, valemetostat and a DXd antibody-drug conjugate, in people with advanced solid tumors. It will enroll about 210 adults with specific types of advanced breast, lung, or stomach can…

This is the first study in people testing a new cancer drug called MGC026. It aims to find a safe dose and see if the drug can help shrink tumors in adults with advanced solid tumors that have not responded to other treatments. The study will also check how the drug moves through…

This is an early-stage study testing a new oral drug called BG-68501 in people with advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to find a safe dose and see how the body processes the drug, both when given alone and when combined with…

This study is testing a new oral drug, PC14586 (rezatapopt), for people with advanced solid tumors that have a specific mutation in a gene called TP53 (Y220C). The main goals are to find a safe and effective dose and to see if the drug can shrink tumors. The trial is enrolling up…

This is the first study in people to test a new oral medication called CID-078 for advanced solid tumors. The main goals are to find a safe dose and see how well the body handles the drug. The study will enroll adults with cancers like triple-negative breast cancer, small cell lu…

This is an early-stage study to find a safe dose for a new experimental drug called BGB-26808. It will be tested alone and in combination with an existing immunotherapy drug, tislelizumab, in adults with advanced solid tumors that have spread or cannot be removed by surgery. The …

This is the first time a new drug called ISM6331 is being tested in people. The main goal is to find a safe dose and understand its side effects in 100 adults with advanced cancers like mesothelioma or other solid tumors that have not responded to standard treatments. Researchers…

This is the first study in people to test a new oral drug called AN4005 for patients with advanced solid tumors or lymphoma that have not responded to standard treatments. The main goal is to find a safe and tolerable dose by giving the drug to small groups of patients at increas…

This is a first-in-human study to find a safe dose of a new drug called MBS8 for people with advanced solid tumors that have stopped responding to standard treatments. The trial will test the drug alone and in combination with an existing immunotherapy in specific groups of melan…

This is an early-stage study to test the safety and initial effects of a new drug called BG-75098 for people with advanced solid tumors. The trial will first find a safe dose for the drug, given alone or with other cancer treatments. Researchers will also check if the drug shows …

This early-stage study is testing the safety and early effectiveness of an experimental drug called IL12-L19L19 in people with advanced solid tumors that have spread. The trial is for patients whose cancer has continued to grow despite receiving standard immunotherapy. Researcher…

This is the first study in people to test a new drug called NXP900 for advanced solid tumors. The main goals are to find a safe dose and see how the body processes the drug. The study will also look for early signs that the drug can shrink tumors, especially in cancers with speci…

This is the first study in humans to test an oral tablet called BB102 for patients with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see how the body processes the drug. Researchers will also check for early…

This is the first study in people testing PEP08, a new oral cancer drug, for patients with advanced solid tumors that have a specific genetic change called MTAP deletion. The main goals are to find safe doses, see how the body processes the drug, and look for early signs that it …

This early-stage study aims to find a safe dose of the drug nab-sirolimus for adults with advanced solid tumors who also have moderate liver problems. It will compare how the drug is processed in the body between these patients and those with normal liver function. The main goal …

This is the first human study testing a new cancer drug called DS-3939a in people with advanced solid tumors that have spread or cannot be removed by surgery. The trial will enroll 540 participants to determine safe dosage levels and see if the drug helps control cancer growth. R…

This study is testing a new drug called HY05350 for people with advanced solid tumors that have a specific protein called MSLN. The first part checks the drug's safety and finds the right dose, while the second part looks at how well it shrinks tumors. It's for adults whose cance…

This study is testing a new drug called LM-2417 in people with advanced solid tumors that have not responded to standard treatments. The main goals are to find a safe dose and see how well the body handles the drug, both alone and when combined with other cancer therapies. Resear…

This is a first-in-human study to find a safe dose of a new drug called BAL0891. It will test the drug alone and in combination with other cancer therapies in 260 adults with advanced solid tumors or a type of leukemia that has returned or not responded to treatment. The main goa…

This early-stage study is testing a new oral medication called HH2853 in adults with advanced cancers that have come back or stopped responding to standard treatments. The main goals are to find a safe and tolerable dose and to see if the drug shows any early signs of helping to …

This early-stage study is testing a new combination of two drugs, ZGGS18 and ZG005, for people with advanced solid tumors that have not responded to standard treatments. The main goals are to find the safest and most effective dose and to see if the treatment can shrink tumors. T…

This is the first study in people to test a new oral drug called SW-682. It aims to find a safe and effective dose for adults with advanced solid tumors that have stopped responding to other treatments. The study will focus on patients whose tumors have specific genetic changes i…

This early-phase trial is testing the safety and best dose of a combination of two targeted drugs, adagrasib and olaparib, for people with advanced solid tumors that have a specific genetic change called a KRAS G12C mutation. It will enroll about 52 adults with cancers like pancr…

This is a first-in-human study to test the safety and dosing of an experimental drug called BMS-986500. It will be given alone to people with various advanced solid tumors and in combination with other drugs to people with advanced breast cancer that has stopped responding to pri…

This early-stage study is testing a new targeted cancer drug called BG-C9074, both alone and in combination with other cancer therapies. The trial aims to find safe doses and see if the drug helps control advanced solid tumors in people who have run out of standard treatment opti…

This study is testing a new treatment called VSV-02 for people with advanced solid tumors who have few or no other treatment options left. VSV-02 is a specially engineered virus designed to both kill cancer cells directly and boost the body's immune system to fight the cancer. Th…

This early-stage trial is testing a new oral drug called ALTA2618 for people with advanced cancers that have a specific genetic mutation called AKT1 E17K. The study aims to find the safest and most effective dose and see how well the drug works against cancers like breast and end…

This early-stage study is testing whether adding targeted, high-dose radiation to standard immunotherapy can better control advanced solid tumors that have spread to multiple sites. It will enroll about 28 patients whose cancer has spread to 3-10 locations and who are already on …

This is the first human study testing a new drug called IPH5301 for people with advanced cancers that have spread. The trial has two parts: first finding the safest dose of IPH5301 alone, then testing it combined with standard chemotherapy in breast cancer patients. It's for adul…

This is the first study in people testing an experimental drug called STX-001, which is injected directly into tumors. Researchers want to see if it is safe and if it can help shrink tumors in adults with advanced cancers that have stopped responding to standard treatments. The s…

This is the first study in people to test a new drug called CHS-114, which is designed to help the immune system fight cancer. It will be given alone and in combination with another immunotherapy drug to adults with advanced solid tumors, including head and neck cancer, that have…

This early-stage trial is testing a new oral drug called PTT-4256 in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see how the body processes the drug. Researchers will also look for early signs t…

This is a first-in-human study testing a new drug called CLSP-1025 for adults with advanced solid tumors that have a specific genetic change called the p53 R175H mutation. The main goals are to find a safe dose and see if the drug can help control the cancer. The drug works by en…

This is the first human study of a new cancer drug called BNT317, developed by BioNTech. It will test the safety and find the right dose for patients with advanced solid tumors who have run out of standard treatment options. The study will enroll 39 participants and follow them f…

This is the first study to test a new oral gel called TRX-920 in people with advanced solid tumors that have not responded to standard treatments. The main goals are to find the highest safe dose, understand the drug's side effects, and see if it helps control the cancer. The gel…

This is the first study in people testing a new oral drug called IMP1734 for advanced solid tumors that have spread or returned. The main goals are to find a safe dose and see how the body processes the drug. Researchers will also check if the drug helps shrink tumors in patients…

This is an early-stage study to test a new oral medication called VLS-1488 in adults with advanced solid tumors. The main goals are to find a safe dose and see if the drug shows any early signs of helping to control the cancer. The study is for people with specific advanced cance…

This is the first human study of an experimental cancer drug called XL309. Researchers are testing it alone and combined with another cancer drug (olaparib) in 429 patients with advanced solid tumors that have stopped responding to standard treatments. The main goals are to deter…

This is the first time a new cancer drug called ASKC202 is being tested in people. The study aims to find a safe dose and see how the body processes the drug, both alone and when combined with another drug called ASK120067. It will enroll about 150 adults with advanced solid tumo…

This study is testing a new drug called EP0031 for people with advanced cancers that have specific RET gene changes, including lung cancer. The goal is to find the right dose and see if the drug is safe and effective, especially for patients whose cancer has stopped responding to…

This is an early-stage safety study for a new drug called ANK-101, which is injected directly into tumors. It aims to find a safe dose for people with advanced solid cancers that have stopped responding to standard treatments. The study will test the drug alone in different types…

This is the first study in humans to test a new drug called ARC101 for people with advanced solid tumors. The main goals are to find a safe dose and see how the body processes the drug. Researchers will also look for early signs that the drug might help shrink tumors.

This early-stage study is testing a new drug called GI-108 in people with advanced or spreading solid tumors, including lung, head and neck, pancreatic, and kidney cancers. The main goals are to find a safe dose and see if the drug shows any signs of helping to shrink tumors. The…

This early-stage study is testing the safety of a new drug called VAX014, which is injected directly into tumors. Researchers want to see if VAX014, alone or combined with standard immunotherapy drugs, can help the body's immune system fight advanced cancers. The study will enrol…

This study is testing whether the experimental drug ZG005 can help control advanced solid tumors in people who haven't responded to standard treatments. The trial will enroll 100 adults with various advanced cancers to see how well the drug works and how safe it is. Researchers w…

This study is testing a new cancer drug called IPN01203 in adults with advanced solid tumors that have spread and stopped responding to standard immunotherapies. Researchers will first find the safest and most effective dose, then test how well the drug controls tumor growth. The…

This study is testing a new drug called LY4050784 for people with advanced solid tumors that have a specific genetic change called a SMARCA4/BRG1 alteration. The main goals are to find a safe dose of the drug, given alone or with other cancer treatments, and to see if it helps sh…

This is the first human study of an experimental drug called PLB-002 for adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and understand how the drug behaves in the body. The study will enroll about 100 …

This study is testing a new drug called LM-108, given alongside an immunotherapy drug (penpulimab) and standard chemotherapy, for people with advanced solid tumors that cannot be removed by surgery. The main goals are to find a safe dose and see if this combination can help contr…

This is a first-in-human study to test the safety and find the right dose of a new experimental drug called BG-C0902 for people with advanced solid tumors. The drug is designed to target two specific proteins found on some cancer cells. Researchers will enroll about 63 participan…

This is the first study in people to test a new drug called XTX301 for advanced solid tumors. The main goals are to find a safe dose and see if the drug can shrink tumors. It is for patients with cancers like lung, melanoma, or ovarian cancer that have spread or gotten worse desp…

This is the first human study of an experimental cancer drug called ADCE-T02 for people with advanced solid tumors that have stopped responding to standard treatments. Researchers will test different doses in 210 participants to find the safest amount and see how the body process…

This is the first study in people testing a new experimental drug called BG-T187 for advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to find a safe dose, see how the body processes the drug, and check for early signs that it might help s…

This is a first-in-human study to test the safety and find the right dose of a new investigational drug called LY4052031 for people with advanced or metastatic solid tumors. The drug is designed to target a specific protein found on many cancer cells, delivering its medicine dire…

This early-stage trial is testing a new drug called SIBP-A17 in people with advanced solid tumors that have stopped responding to standard treatments. Researchers will give increasing doses to 196 participants to find the safest amount and learn how the body processes the drug. T…

This is the first study in people to test a new drug called JZP898. Researchers want to see if it is safe and tolerable when given alone and when combined with an existing immunotherapy drug (pembrolizumab) for adults with advanced or metastatic solid tumors. The main goals are t…

This is the first study in people to test a new drug called HCB101 for advanced cancers that have stopped responding to standard treatments. The main goals are to find a safe dose and check for side effects in up to 80 adults with advanced solid tumors or non-Hodgkin lymphoma. Re…

This study is testing a new drug called AI-081 in people with advanced solid tumors that have spread or cannot be removed by surgery. The drug is designed to work in two ways at once by targeting two different pathways that help tumors grow. Researchers will first find the safest…

This early-stage study is testing the safety and initial effectiveness of combining two targeted cancer drugs, pemigatinib and afatinib, in people with advanced solid tumors that have specific genetic changes and have stopped responding to standard treatments. The main goals are …

This is the first human study of an experimental cancer drug called LY4101174. Researchers want to find a safe dose and see if it can help control advanced cancers that have spread or returned after other treatments. The study will enroll about 490 people with various solid tumor…

This is the first human study of an experimental drug called ERX-315 for people with advanced solid tumors that have stopped responding to standard treatments. The main goal is to find a safe dose and understand how the body processes the drug. Researchers will also look for earl…

This is the first human study testing a new oral drug called MOMA-341 for people with advanced solid tumors that have specific genetic features (MSI-H or dMMR). The main goal is to find safe doses and see how the body handles the drug when taken alone or combined with other cance…

This early-stage study is testing a new oral drug called lunresertib, both alone and in combination with two other experimental drugs, for people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find safe dose levels, understan…

This study is testing an experimental drug called patritumab deruxtecan (HER3-DXd) in people with advanced solid tumors that have spread or cannot be removed by surgery. The goal is to see if the drug can shrink tumors and control the disease in people who have already tried at l…

This is the first study in people of an experimental pill called MRTX1719. It is for adults with advanced solid tumors that have a specific missing gene called MTAP, which is found in some lung cancers, mesothelioma, and other cancers. The main goals are to find a safe dose, see …

This is an early-stage study to find a safe dose and see how the body handles a new drug called ZGGS18. It is for people with advanced solid tumors who have no other standard treatments left. The main goals are to check for side effects and see how the drug moves through the body…

This is the first study in people to test a new drug called AU-007 for advanced cancers that have spread or cannot be removed by surgery. The main goals are to find a safe dose and see if the drug shows early signs of helping. It will be tested alone and in combination with other…

This early study tests a new immune cell therapy for people with advanced solid tumors who haven't responded to standard treatments. Doctors collect and grow tumor-fighting immune cells from each patient's own tumor, modify them, and infuse them back into the patient. The study a…

This is the first study in people to test a new drug called M0324 for advanced solid tumors. The main goal is to find a safe dose and see how the body handles the drug. Researchers will test M0324 alone, with an immunotherapy drug, and with chemotherapy in about 77 participants.

This early-stage study is testing whether adding the common diabetes medication metformin to standard cancer treatments is safe for people with advanced solid tumors. Researchers want to find the highest dose of metformin that can be safely combined with chemotherapy or immunothe…

This is a first-in-human study to test the safety and find the right dose of a new drug called HCB301. It is for adults with advanced solid tumors or Hodgkin lymphoma that have not responded to standard treatments. The main goals are to see what side effects occur and how the bod…

This is the first human study of an experimental drug called JMT106 for people with advanced solid tumors, including certain lung and liver cancers. The main goal is to find a safe dose and see how the body handles the drug in about 200 participants who have run out of standard t…

This is an early-stage study to test the safety and initial effectiveness of a new oral drug called BG-75202. It will be given to people with advanced breast cancer and other solid tumors who have run out of standard treatment options. The study will first test the drug alone to …

This is the first human study testing a new oral medication called AVZO-023 for patients with advanced solid tumors, focusing on a common type of breast cancer. The trial aims to find the safest and most effective dose, first by giving AVZO-023 alone, and then in combination with…

This study is testing a new type of PET scan that uses a special tracer called 64Cu-GRIP B. The goal is to see if this scan can safely detect a marker of immune system activity (granzyme B) in tumors of patients with advanced cancers, including prostate, kidney, and bladder cance…

This early-stage study is testing a new imaging agent, 89Zr-DFO-REGN5054, in patients with advanced solid tumors who are receiving the immunotherapy drug cemiplimab. The main goal is to see if the imaging agent is safe and to understand how it moves through the body. Researchers …

This study is monitoring patients for five years after they received an experimental cancer immunotherapy from Replimune. The goal is to check for any delayed side effects or safety issues that might appear long after treatment. About 50 patients with cancers like melanoma or liv…

This study aims to understand the genetic makeup of advanced cancers to help match patients with the most suitable early-stage drug trials. It involves analyzing tumor tissue and blood samples from about 40 adults with advanced solid tumors or lymphoma. The goal is to learn if de…