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New Dual-Action antibody targets tumors in early trial

NCT ID NCT07266428

First seen Dec 11, 2025 · Last updated May 25, 2026 · Updated 17 times

Summary

This study tests an experimental drug called OTP-01 in about 170 adults with advanced solid tumors that have not responded to standard treatments. The drug is designed to attack cancer in two ways—by blocking PD-1 and VEGFR2—to shrink tumors and slow disease. The main goals are to find the safest dose, check for side effects, and see if tumors shrink.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Auckland City Hospital

    RECRUITING

    Auckland, 1023, New Zealand

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Cancer Research SA

    RECRUITING

    Adelaide, Australia

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Chris O'Brien Lifehouse

    RECRUITING

    Camperdown, 2050, Australia

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Dana-Farber Cancer Institute

    RECRUITING

    Boston, Massachusetts, 02215, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Linear Clinical Research

    RECRUITING

    Nedlands, 6009, Australia

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • START Dublin Early Phase Clinical Trials Unit

    RECRUITING

    Dublin, D07 R2WY, Ireland

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • START Mountain Region

    RECRUITING

    West Valley City, Utah, 84119, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • South Texas Accelerated Research Therapeutics (START)

    RECRUITING

    San Antonio, Texas, 78229, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • South Texas Accelerated Research Therapeutics (START) Midwest

    RECRUITING

    Grand Rapids, Michigan, 49546, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

Explore the condition pages connected to this study.