New Dual-Action antibody OTP-01 enters human trials for advanced cancers
NCT ID NCT07266428
First seen Dec 11, 2025 · Last updated May 06, 2026 · Updated 16 times
Summary
This study tests an experimental drug called OTP-01 in people with advanced solid tumors that have not responded to other treatments. The drug targets two proteins (PD-1 and VEGFR2) to help the immune system fight cancer and block tumor blood supply. The main goals are to find the safest and most effective dose, check for side effects, and see if tumors shrink. About 170 adults will receive OTP-01 by IV infusion, with regular blood tests and scans to monitor results.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Auckland City Hospital
RECRUITINGAuckland, 1023, New Zealand
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cancer Research SA
RECRUITINGAdelaide, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Chris O'Brien Lifehouse
RECRUITINGCamperdown, 2050, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Linear Clinical Research
RECRUITINGNedlands, 6009, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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START Mountain Region
RECRUITINGWest Valley City, Utah, 84119, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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South Texas Accelerated Research Therapeutics (START)
RECRUITINGSan Antonio, Texas, 78229, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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South Texas Accelerated Research Therapeutics (START) Midwest
RECRUITINGGrand Rapids, Michigan, 49546, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Conditions
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