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Cancer drug adagrasib offers continued hope in rollover trial

NCT ID NCT07415031

Disease control Sponsor: Mirati Therapeutics Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 19, 2026 · Updated 6 times

Summary

This study provides ongoing treatment with the cancer drug adagrasib (BMS-986503) to patients with advanced solid tumors who have already seen benefit in earlier studies. About 170 adults with non-small cell lung cancer, colorectal cancer, or other solid tumors can join if they are still benefiting from the drug. The main goal is to monitor side effects and safety over the long term.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 170 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2026

Expected to finish

Feb 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participant is eligible to receive continued study treatment as per the parent study, and/or investigator assessed clinical benefit. * Individuals with assigned female sex at birth (AFSB) must have documented proof that they are not of childbearing potential. IOCBP participants who are sexually active must agree to follow the instructions for method(s) of contraception and included in the ICF. Exclusion Criteria: * Participant is not eligible for study treatment per the parent study eligibility criteria. * Participants who have completed treatment with the study drugs, progressed on prior study treatment, or discontinued study treatment due to toxicity in the parent study are not eligible to receive study drug in this study. * Participants not receiving clinical benefit from parent study drug as assessed by the investigator. Other protocol defined inclusion/exclusion criteria applies.

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Conditions

The condition(s) this trial relates to.

colorectal cancer neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Solid tumors

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    97 sites in 20 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Florida Cancer Specialists - North

    RECRUITING

    St. Petersburg, Florida, 33701, United States

  • Local Institution - 0003

    WITHDRAWN

    Newark, Delaware, 19713, United States

  • Local Institution - 0005

    WITHDRAWN

    Phoenix, Arizona, 85054, United States

  • Local Institution - 0006

    NOT_YET_RECRUITING

    Badalona, Barcelona, 08916, Spain

  • Local Institution - 0007

    NOT_YET_RECRUITING

    A Coruña, A Coruña [La Coruña], 15006, Spain

  • Local Institution - 0008

    NOT_YET_RECRUITING

    Seville, 41009, Spain

  • Local Institution - 0009

    NOT_YET_RECRUITING

    Pamplona, Navarre, 31008, Spain

  • Local Institution - 0010

    NOT_YET_RECRUITING

    Barcelona, Barcelona [Barcelona], 08028, Spain

  • Local Institution - 0011

    NOT_YET_RECRUITING

    Palma, Balears [Baleares], 07120, Spain

  • Local Institution - 0012

    NOT_YET_RECRUITING

    München, 81737, Germany

  • Local Institution - 0013

    NOT_YET_RECRUITING

    Bellingham, Washington, 98225, United States

  • Local Institution - 0014

    NOT_YET_RECRUITING

    Lisbon, Lisbon District, 1099-023, Portugal

  • Local Institution - 0015

    NOT_YET_RECRUITING

    Madrid, 28040, Spain

  • Local Institution - 0018

    NOT_YET_RECRUITING

    Málaga, 29011, Spain

  • Local Institution - 0019

    NOT_YET_RECRUITING

    Rome, Roma, 00144, Italy

  • Local Institution - 0020

    NOT_YET_RECRUITING

    Orbassano, 10043, Italy

  • Local Institution - 0021

    NOT_YET_RECRUITING

    Milan, 20141, Italy

  • Local Institution - 0022

    NOT_YET_RECRUITING

    Attiki, 18547, Greece

  • Local Institution - 0024

    NOT_YET_RECRUITING

    Madrid, Madrid, Comunidad de, 28034, Spain

  • Local Institution - 0026

    NOT_YET_RECRUITING

    Terni (Perugia), 6156, Italy

  • Local Institution - 0027

    NOT_YET_RECRUITING

    Córdoba, 14004, Spain

  • Local Institution - 0029

    NOT_YET_RECRUITING

    Barcelona, 08035, Spain

  • Local Institution - 0030

    NOT_YET_RECRUITING

    Santander, Cantabria, 39008, Spain

  • Local Institution - 0031

    NOT_YET_RECRUITING

    Roma, 00168, Italy

  • Local Institution - 0032

    NOT_YET_RECRUITING

    Angers, Maine-et-Loire, 49055, France

  • Local Institution - 0033

    NOT_YET_RECRUITING

    Ghent, 9000, Belgium

  • Local Institution - 0034

    NOT_YET_RECRUITING

    Amsterdam, 1006 BE, Netherlands

  • Local Institution - 0035

    NOT_YET_RECRUITING

    Harderwijk, 3844 DG, Netherlands

  • Local Institution - 0037

    NOT_YET_RECRUITING

    Beijing, Beijing Municipality, 100142, China

  • Local Institution - 0038

    NOT_YET_RECRUITING

    Changsha, Hunan, 410031, China

  • Local Institution - 0039

    NOT_YET_RECRUITING

    Jinan, Shandong, 250117, China

  • Local Institution - 0040

    NOT_YET_RECRUITING

    Chengdu, Sichuan, 610041, China

  • Local Institution - 0041

    NOT_YET_RECRUITING

    Xi'an, 710061, China

  • Local Institution - 0042

    NOT_YET_RECRUITING

    Zhengzhou, Henan, 450008, China

  • Local Institution - 0043

    NOT_YET_RECRUITING

    Shanghai, Shanghai Municipality, 200032, China

  • Local Institution - 0044

    NOT_YET_RECRUITING

    Hangzhou, Zhejiang, 310022, China

  • Local Institution - 0045

    NOT_YET_RECRUITING

    Xiamen, Fujian, 361003, China

  • Local Institution - 0046

    NOT_YET_RECRUITING

    Nanjing, Jiangsu, 210012, China

  • Local Institution - 0047

    NOT_YET_RECRUITING

    Linyi, Shandong, 276000, China

  • Local Institution - 0048

    NOT_YET_RECRUITING

    Nanchang, Jiangxi, 330006, China

  • Local Institution - 0049

    NOT_YET_RECRUITING

    Shenyang, Liaoning, 110001, China

  • Local Institution - 0050

    NOT_YET_RECRUITING

    Saint-Herblain, Loire-Atlantique, 44805, France

  • Local Institution - 0051

    NOT_YET_RECRUITING

    Poitiers, Vienne, 86021, France

  • Local Institution - 0052

    NOT_YET_RECRUITING

    Meldola, 47014, Italy

  • Local Institution - 0053

    NOT_YET_RECRUITING

    Bologna, 40138, Italy

  • Local Institution - 0054

    NOT_YET_RECRUITING

    Florence, 50139, Italy

  • Local Institution - 0055

    NOT_YET_RECRUITING

    Jerusalem, Jerusalem, 9103102, Israel

  • Local Institution - 0056

    NOT_YET_RECRUITING

    Breda, North Brabant, 4818 CK, Netherlands

  • Local Institution - 0058

    NOT_YET_RECRUITING

    Quimper, 29000, France

  • Local Institution - 0059

    NOT_YET_RECRUITING

    Marseille, 13915, France

  • Local Institution - 0060

    NOT_YET_RECRUITING

    Craiova, Dolj, 200746, Romania

  • Local Institution - 0061

    NOT_YET_RECRUITING

    Paris, Île-de-France Region, 75014, France

  • Local Institution - 0062

    NOT_YET_RECRUITING

    Madrid, 28041, Spain

  • Local Institution - 0063

    NOT_YET_RECRUITING

    Saint-Herblain, Loire-Atlantique, 44800, France

  • Local Institution - 0065

    NOT_YET_RECRUITING

    La Tronche, Isère, 38700, France

  • Local Institution - 0067

    NOT_YET_RECRUITING

    Budapest, 1122, Hungary

  • Local Institution - 0068

    NOT_YET_RECRUITING

    Seoul, 120-752, South Korea

  • Local Institution - 0069

    NOT_YET_RECRUITING

    Gyeonggi-do, 410-769, South Korea

  • Local Institution - 0070

    NOT_YET_RECRUITING

    Seoul, 06351, South Korea

  • Local Institution - 0071

    NOT_YET_RECRUITING

    Utrecht, 3543 AZ, Netherlands

  • Local Institution - 0072

    NOT_YET_RECRUITING

    Vancouver, British Columbia, V5Z 4E6, Canada

  • Local Institution - 0074

    NOT_YET_RECRUITING

    Strasbourg, Alsace, 67091, France

  • Local Institution - 0075

    NOT_YET_RECRUITING

    Gleizé, Rhône, 69400, France

  • Local Institution - 0076

    NOT_YET_RECRUITING

    Nice, Alpes-Maritimes, 06000, France

  • Local Institution - 0077

    NOT_YET_RECRUITING

    Tours, 37032, France

  • Local Institution - 0078

    NOT_YET_RECRUITING

    Saint-Mandé, 94163, France

  • Local Institution - 0079

    NOT_YET_RECRUITING

    Pesaro, 61122, Italy

  • Local Institution - 0080

    NOT_YET_RECRUITING

    Boston, Massachusetts, 02215, United States

  • Local Institution - 0081

    NOT_YET_RECRUITING

    Athens, Attikí, 115 28, Greece

  • Local Institution - 0082

    NOT_YET_RECRUITING

    Long Beach, California, 90806, United States

  • Local Institution - 0083

    NOT_YET_RECRUITING

    Madrid, 28007, Spain

  • Local Institution - 0084

    NOT_YET_RECRUITING

    Valencia, Valenciana, Comunitat, 46010, Spain

  • Local Institution - 0085

    NOT_YET_RECRUITING

    Créteil, 94010, France

  • Local Institution - 0086

    NOT_YET_RECRUITING

    Nice, Alpes-Maritimes, 06189, France

  • Local Institution - 0087

    NOT_YET_RECRUITING

    Thessaloniki, 54639, Greece

  • Local Institution - 0088

    NOT_YET_RECRUITING

    Singapore, Central Singapore, 168583, Singapore

  • Local Institution - 0089

    NOT_YET_RECRUITING

    Budapest, 1121, Hungary

  • Local Institution - 0090

    NOT_YET_RECRUITING

    Bron, Rhône, 69677, France

  • Local Institution - 0091

    NOT_YET_RECRUITING

    Besançon, Doubs, 25000, France

  • Local Institution - 0092

    WITHDRAWN

    Boston, Massachusetts, 00215, United States

  • Local Institution - 0093

    NOT_YET_RECRUITING

    St Leonards, New South Wales, 2065, Australia

  • Local Institution - 0102

    NOT_YET_RECRUITING

    Gdansk, 80-214, Poland

  • Local Institution - 0103

    NOT_YET_RECRUITING

    Pessac, Aquitaine, 33600, France

  • Local Institution - 0106

    NOT_YET_RECRUITING

    Tel Aviv, 6423906, Israel

  • Local Institution - 0107

    NOT_YET_RECRUITING

    Milan, 20141, Italy

  • Local Institution - 0110

    NOT_YET_RECRUITING

    Tōon, Ehime, 791-0295, Japan

  • Local Institution - 0112

    NOT_YET_RECRUITING

    Wichita, Kansas, 67208, United States

  • Local Institution - 0113

    NOT_YET_RECRUITING

    Birmingham, B9 5SS, United Kingdom

  • Local Institution - 0114

    NOT_YET_RECRUITING

    Leicester, LE1 5WW, United Kingdom

  • Local Institution - 0115

    NOT_YET_RECRUITING

    London, London, City of, SE1 9RT, United Kingdom

  • Local Institution - 0119

    NOT_YET_RECRUITING

    Haifa, 31048, Israel

  • Mayo Clinic in Rochester, Minnesota

    RECRUITING

    Rochester, Minnesota, 55905, United States

  • Metro-Minnesota Community Oncology Research Consortium (MMCORC)

    RECRUITING

    Saint Paul, Minnesota, 55101, United States

  • Nebraska Cancer Specialists

    RECRUITING

    Omaha, Nebraska, 68114, United States

  • Oncology Associates Of Oregon, Pc

    RECRUITING

    Eugene, Oregon, 97401, United States

  • Southern California Permanente Medical Group

    RECRUITING

    Bellflower, California, 90706, United States

  • Texas Oncology - Baylor Charles A. Sammons Cancer Center

    RECRUITING

    Dallas, Texas, 75246, United States

  • Texas Oncology - DFW

    RECRUITING

    Grapevine, Texas, 76051, United States

  • Texas Oncology-Bedford

    RECRUITING

    Bedford, Texas, 76022, United States

  • The West Clinic, PLLC dba West Cancer Center

    RECRUITING

    Germantown, Tennessee, 38138, United States

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