PANCREATIC CANCER

This early-stage study tests a vaccine designed to train the immune system to attack cells with a specific mutation (mutant KRAS) that can lead to pancreatic cancer. The study enrolls 37 people at high risk due to family history or pancreatic abnormalities. The main goals are to …

This study tests a personalized cancer vaccine (XH001) given after surgery for pancreatic cancer. The vaccine is designed to train the immune system to recognize and attack any remaining cancer cells. It is given along with standard immunotherapy and chemotherapy. The goal is to …

This study is testing a new approach for people with advanced pancreatic cancer that cannot be removed by surgery. A small device that gives off a special type of radiation is placed directly into the tumor, and patients also receive standard chemotherapy. The main goal is to see…

This study tests a drug called zanidatamab in about 200 adults with advanced HER2-positive cancers (like breast, stomach, lung, or ovarian cancer) that have worsened after at least one prior treatment. The goal is to see if the drug can shrink tumors and how long that effect last…

This study tests whether using a special surgical glue (Glubran 2) during pancreas surgery can reduce the risk of a dangerous leak from the pancreas. About 194 adults with a soft pancreas who need surgery for cancer will be randomly assigned to receive the glue or standard care. …

This study compares two radiation methods given before surgery for pancreatic cancer: a high-dose focused approach (SBRT) versus standard radiation with chemotherapy. About 102 people with resectable or locally advanced pancreatic cancer will take part. The goal is to see which m…

This early-phase study tests a new drug called AGX101 in people with advanced solid tumors that have not responded to standard treatments. AGX101 is designed to deliver a cancer-killing agent directly to tumor cells. The main goals are to find the safest dose and to check for sid…

This early-stage study tests a new treatment called IDOV-Immune, a virus designed to infect and kill cancer cells and boost the immune system. It is for adults with advanced solid tumors (like colorectal, pancreatic, or lung cancer) that have not responded to standard treatments.…

This study tests a new treatment for people with locally advanced pancreatic cancer that hasn't spread. Doctors will inject tiny radioactive particles directly into the tumor using a CT scan for guidance. The goal is to see if this approach is safe and feasible, and whether it ca…

This study tests whether adding the experimental drug QLS31905 to standard chemotherapy helps people with a specific type of advanced pancreatic cancer live longer. About 602 adults whose tumors have a protein called CLDN18.2 will receive either the drug combo or a placebo plus c…

This study tests an experimental drug called VMD-928, taken as a pill, either alone or with another drug (pembrolizumab), in people with advanced solid tumors or lymphoma that have stopped responding to standard treatments. The goal is to find a safe dose and see if it can shrink…

This early-phase trial tests a new drug called MDX2001 in about 285 adults with advanced solid tumors (cancers that have spread). The main goals are to check the drug's safety and find the right dose. Researchers will also see if it shrinks tumors. This is not a cure, but it may …

This early-phase trial tests an experimental drug called RSC-1255, given alone or with hydroxychloroquine, in adults with advanced solid tumors (such as lung, colon, pancreatic, or brain cancer) that have not responded to or cannot tolerate standard treatments. The study has two …

This early-phase study tests whether adding the cholesterol-lowering drug pitavastatin to standard chemotherapy (gemcitabine and nab-paclitaxel) can help control advanced pancreatic cancer that cannot be removed by surgery. About 18 adults whose cancer has not worsened on initial…

This study tests whether adding the experimental drug setidegrasib to standard chemotherapy helps people with a specific type of advanced pancreatic cancer (KRAS G12D mutation) live longer. About 614 adults whose cancer has spread and cannot be removed by surgery will receive eit…

This study tests a new drug called GI-108 in people with advanced or metastatic solid tumors (like lung, head and neck, pancreatic, or kidney cancer). The drug is designed to help the immune system fight cancer by targeting a protein called CD73 and delivering a modified immune s…

This study tests a combination of four drugs (liposomal irinotecan, 5-fluorouracil, oxaliplatin, and adebrelimab) plus short-course radiotherapy before surgery for people with pancreatic cancer that is either removable or borderline removable but has high-risk features. The goal …

This early-phase study tests a new investigational drug called azirkitug, alone or combined with other drugs, in adults with advanced solid tumors such as lung, head/neck, colorectal, and breast cancers. The main goals are to check safety, side effects, and how the drug moves thr…

This study tests a new treatment for several types of cancer that have a specific marker called CD70. Researchers take a patient's own white blood cells, modify their genes in the lab to help them recognize and attack CD70-positive cancer cells, and then return them to the patien…

This study tests whether adding low-dose radiation and an immunotherapy drug (pultelimab) to standard treatment can help shrink tumors in people with advanced pancreatic cancer. About 10 adults who have not had immunotherapy before will take part. The goal is to see if the combin…

This study tests a new treatment for people with certain advanced cancers (like pancreatic, stomach, or colon cancer) that have a specific genetic change called KRAS G12V. The treatment involves taking a patient's own white blood cells, modifying them in a lab to better recognize…

This study tests a new drug combination (HRS-4642 plus chemotherapy and an immunotherapy) in 30 people with pancreatic cancer that can be surgically removed. The goal is to see if the treatment shrinks tumors before surgery and prevents return after surgery. Participants will rec…

This study tests a new drug called daraxonrasib to see if it can delay or prevent pancreatic cancer from returning after surgery and chemotherapy. About 500 adults who have had their pancreatic cancer removed will be randomly assigned to receive the drug or just be watched. The g…

This study tests a new drug called daraxonrasib, which targets a common cancer-driving protein (RAS). It is given alone or with standard chemotherapy to people with metastatic pancreatic cancer that has spread. The goal is to see if the new drug helps people live longer or slows …

This study tests a new drug called BOLD-100 combined with standard FOLFOX chemotherapy in people with advanced colorectal, pancreatic, stomach, or bile duct cancers. The goal is to see if the combination is safe and can shrink tumors or slow cancer growth. About 220 adults whose …

This early-phase study tests a new drug called PT0511 in adults with advanced solid tumors that have a KRAS mutation or amplification, including colorectal, pancreatic, and lung cancers. The main goals are to check safety, find the best dose, and see how the drug works alone or w…

This study tests a new vaccine made from engineered bacteria that targets KRAS mutations in colorectal and pancreatic cancer. It is given after surgery and chemotherapy to patients at high risk of recurrence. The goal is to see if the vaccine is safe and can help prevent the canc…

This study tests a new drug called ivonescimab, combined with targeted radiation and chemotherapy, for people with locally advanced pancreatic cancer that cannot be removed by surgery. The goal is to see if this combination is safe and can help control the disease longer. About 3…

This early-phase study tests an experimental drug called MRG007 in people with advanced solid tumors (like colorectal, gastric, or pancreatic cancer) that have not responded to standard treatments. The main goals are to find a safe dose and check for side effects, while also seei…

This program provides the experimental drug daraxonrasib to adults with advanced pancreatic cancer that has spread and worsened after prior treatments. It is for patients who have no good standard options and cannot join a daraxonrasib clinical trial. The goal is to offer a poten…

This study looks at whether removing the entire pancreas is better than removing just part of it for people with certain cancers in the head of the pancreas who are at high risk of complications. The main goal is to see if total removal helps patients live longer without making t…

This study tests an experimental drug called M9140 in people with advanced solid tumors (gastric, lung, or pancreatic cancer) that have a specific protein called CEACAM5. The drug is designed to deliver a chemotherapy-like payload directly to cancer cells. The trial aims to see i…

This study is for people with pancreatic cancer that cannot be surgically removed. It tests whether giving a higher dose of proton radiation along with the oral chemotherapy drug capecitabine can help more patients become eligible for surgery and improve survival. About 60 partic…

This study is for people with pancreatic cancer that can be removed by surgery. Researchers want to see if adjusting the treatment plan based on how the cancer responds can help more patients complete all their therapy and have surgery. About 125 adults will take part in this pha…

This study tests a new drug called RMC-5127 in people with advanced solid tumors that have a specific KRAS G12V gene change. The drug is given alone or with other medicines to see if it is safe and can shrink tumors. About 574 adults who have already tried other treatments will t…

This study tests whether a genetic test called PurIST can help doctors choose the best chemotherapy for people with pancreatic cancer that can be removed by surgery. About 84 participants will have their tumor's RNA analyzed to guide treatment. The goal is to see if this personal…

This early study tests a device called Suizenji that uses focused ultrasound waves to heat and destroy pancreatic cancer cells from outside the body. It is for 10 adults with advanced pancreatic cancer that cannot be removed by surgery. The goal is to see if the treatment is safe…

This study is testing whether adding an immune-boosting drug (BDB001) and targeted radiation to an existing immunotherapy (atezolizumab) can help control several advanced solid tumors, including pancreatic, lung, bladder, and triple-negative breast cancer. About 247 adults with t…

This study tests an experimental pill called JAB-21822 (Glecirasib) in people with advanced pancreatic cancer or other solid tumors that have a specific KRAS G12C mutation and have stopped responding to standard treatments. The goal is to see if the drug can shrink tumors and con…

This early-phase study tests whether adding a heat-based treatment (radiofrequency ablation) to standard chemotherapy is safe for people with advanced pancreatic cancer that hasn't spread to other organs. About 15 participants will receive the procedure via an endoscope guided by…

This program provides access to an experimental drug called AVM0703 for people with various solid tumors or blood cancers who have not responded to other treatments. It is available in the US upon a doctor's request. So far, 37 patients have received the drug, and side effects ha…

This early-phase study tests a new drug called BL-M17D1 in about 20 people with advanced HER2-positive or low-HER2 cancers of the digestive tract (esophagus, stomach, pancreas, colon) and other solid tumors. The main goals are to check safety, find the best dose, and see if the d…

This study tests whether adding two drugs (defactinib and avutometinib) to targeted radiation can help people with advanced pancreatic cancer live longer without their cancer growing. About 36 adults whose cancer is locally advanced or borderline resectable will receive the combi…

This study tests whether combining two drugs, pembrolizumab and olaparib, can shrink tumors in people with advanced pancreatic cancer that has a high number of genetic mutations. About 20 adults who have had no more than one prior treatment will receive the combination. The main …

This study tests a new way to treat advanced pancreatic cancer by placing tiny devices that release a special type of radiation directly into the tumor. The goal is to see if this is safe and possible for 15 people whose cancer has not responded to chemotherapy or who cannot have…

This program provides early access to two investigational immunotherapy drugs, botensilimab and balstilimab, for people with serious or life-threatening cancers such as colorectal, pancreatic, lung, liver, melanoma, sarcoma, ovarian, or prostate cancer. It is for patients who hav…

This study tests two different cancer vaccines (GVAX and a KRAS peptide vaccine) given with two immunotherapy drugs for people with pancreatic cancer that can be surgically removed. The goal is to find the safest dose and see if the treatment helps the immune system fight the can…

This study looks at how well the drug T-DXd works in adults with advanced HER2-positive cancers that have spread and no longer respond to other treatments. About 100 people will take part, and researchers will track whether tumors shrink and how long the benefit lasts. The goal i…

This early-phase trial tests whether adding an experimental MK2 inhibitor (zunsemetinib) to standard chemotherapy (mFOLFIRINOX) can work better for people with metastatic pancreatic cancer that hasn't been treated yet. About 51 adults will join to find the safest dose and watch f…

This early-phase study tests an experimental drug called PF-08046876 in adults with advanced solid tumors (bladder, lung, head/neck, esophagus, or pancreatic cancer) that have not responded to standard treatments. The drug is an antibody-drug conjugate designed to stick to cancer…

This study tests a new treatment for people with advanced pancreatic cancer whose tumors have a specific genetic change (KRAS G12V) and a certain immune type (HLA-A*11:01). The treatment uses the patient's own immune cells, modified in a lab to recognize and attack cancer cells. …

This early-stage trial is testing a new treatment for people with metastatic pancreatic or breast cancer that has spread. The treatment combines chemotherapy drugs with high-dose vitamin C and the patient's own stem cells to try to overcome drug resistance. The main goal is to ch…

This early-phase study tests a new treatment called PTC13, which uses a patient's own immune cells (T-cells) engineered to attack cancer cells that have a protein called CEA. The study includes adults with advanced colorectal, stomach, pancreatic, or other solid tumors that have …

This early-phase study tests a new treatment called CAR-NK cells (CL-NK-003) in 9 people with advanced pancreatic cancer that has not responded to standard therapies. The goal is to check safety and see if the cells can shrink tumors or slow the disease. Participants receive a si…

This early-phase study tests a new drug called PTM-101 given alongside standard chemotherapy for people with pancreatic cancer that is borderline resectable or locally advanced (not yet spread to distant organs). The goal is to see if adding PTM-101 is safe and can shrink tumors …

This early-phase study tests a new drug, KIVU-107, in about 76 adults with advanced solid tumors that have not responded to standard treatments. The drug is an antibody-drug conjugate designed to deliver a cancer-killing agent directly to tumor cells. The main goal is to find the…

This study tests a precise radiation technique for people with pancreatic cancer that cannot be removed by surgery. The goal is to see if this approach causes fewer stomach and bowel side effects while still controlling the cancer. About 134 participants will receive five high-do…

This study tests a new approach for people with borderline resectable pancreatic cancer—tumors that are hard to remove surgically. Participants first receive two chemotherapy drugs, then proton radiation combined with another chemo drug, followed by surgery if possible. The goal …

This early-stage study tests a new drug called PHN-012, which is designed to deliver a powerful cancer-killing agent directly to tumor cells. It is for people with advanced colon, pancreatic, or lung cancer who have tried other treatments without success. The main goals are to ch…

This study tests a new treatment for people with advanced pancreatic cancer that cannot be removed by surgery or has spread. The treatment uses the patient's own immune cells, which are mixed with a special antibody to help them attack cancer cells. Participants will receive up t…

This study tests a device that uses sound waves (histotripsy) to break apart pancreatic tumors without surgery. It includes 50 adults with advanced pancreatic cancer that cannot be removed. The main goal is to see if the procedure is safe and to track any complications within 30 …

This early-stage study tests a new treatment called GC203 TIL for people with pancreatic cancer that has not improved with standard therapies. The treatment uses a patient's own immune cells, which are collected from the tumor, modified in a lab to better fight cancer, and then g…

This study tests a type of internal radiation called high-dose-rate brachytherapy for people with liver tumors that cannot be surgically removed. The treatment uses a tiny radioactive source placed directly into the tumor to kill cancer cells while sparing nearby organs. Research…

This study looks at whether using a person's genetic information to decide the dose of chemotherapy can lower the risk of serious side effects. It involves 178 adults with colorectal or pancreatic cancer who have certain gene types. Participants are randomly assigned to receive e…

This early-phase study tests a combination of a vaccine targeting mutant KRAS proteins and two immunotherapy drugs (balstilimab and botensilimab) in adults with advanced colorectal or pancreatic cancer that has not responded to first-line chemotherapy. The goal is to see if the t…

This early-phase trial tests a new treatment using specially engineered natural killer (NK) cells that target a protein called TROP2 found on cancer cells. The cells are given directly into the abdomen to people with ovarian or pancreatic cancer that has stopped responding to sta…

This study tests a new drug (NC410) added to standard chemotherapy (FOLFIRINOX) and two immunotherapy drugs (nivolumab with or without ipilimumab) for people with metastatic pancreatic cancer who have not had prior treatment. The main goal is to check safety and find any unexpect…

This study tests a new drug called GAIA-102, given alone or with another drug (pembrolizumab), for people with advanced stomach or pancreatic cancer that has spread and causes fluid buildup in the belly (malignant ascites). The first part checks safety and the best dose, and the …

This study tests a new combination of drugs (QL1706, nab-paclitaxel, gemcitabine, with or without bevacizumab) as a first treatment for people with advanced pancreatic cancer that cannot be removed by surgery. About 58 adults aged 18-75 who have not had prior treatment for this s…

This study tests a new drug called ODM-212 combined with other anti-cancer treatments in people with advanced solid tumors, including mesothelioma, pancreatic cancer, and non-small cell lung cancer. The trial has two parts: first finding a safe dose, then checking how well it wor…

This study tests an experimental drug called FMC-376 in people with advanced solid tumors that have a specific genetic change (KRAS G12C). The goal is to find a safe dose and see if the drug can shrink tumors. About 400 adults whose cancer has worsened after standard treatments w…

This early-stage study tests two drugs, ulixertinib and palbociclib, together in people with advanced solid tumors, including pancreatic cancer and certain melanomas. The main goal is to find the safest dose and check for side effects. About 45 adults whose cancer has not respond…

This study tests new drug combinations (ADC drugs with or without other targeted therapy or immunotherapy) in 160 people with advanced pancreatic cancer that has spread or cannot be removed. The goal is to find the safest and most effective doses to shrink tumors and control the …

This study tests whether a combination of two drugs, AK130 and AK112, can help people with advanced pancreatic cancer that has not responded to up to two prior treatments. The trial will enroll 160 participants and measure how many patients see their tumors shrink or stop growing…

This study tests a new approach for advanced pancreatic cancer that cannot be removed by surgery. Doctors place tiny devices called Alpha DaRT seeds directly into the tumor to deliver a special type of radiation from the inside. The main goals are to see if the procedure is safe …

This early-phase study tests a new treatment called IX001 TCR-T for people with advanced pancreatic cancer that has a specific genetic change (KRAS G12V). The treatment uses the patient's own immune cells, which are modified in a lab to better recognize and attack the cancer. The…

This study is for people with solid tumors (like lung, ovarian, or pancreatic cancer) that have stopped responding to standard treatments. It tests a new drug called AOH1996, which works by blocking certain enzymes that cancer cells need to grow. The main goals are to find the be…

This study is for adults who have finished chemotherapy for gastrointestinal cancer and are in remission, but still have dangerously low platelet counts. Researchers want to see if adding a second drug (ATRA) to the standard platelet-boosting drug (romiplostim N01) works better t…

This study tests whether adding the experimental drug atebimetinib to standard chemotherapy helps people with metastatic pancreatic cancer live longer. About 510 adults who have not had prior treatment will be randomly assigned to receive either the new combination or standard ch…

This study offers expanded access to an experimental treatment called DNG64-CAR-V for people with advanced pancreatic cancer, sarcoma, or breast cancer. Up to 40 patients will receive the therapy intravenously or directly into tumors, alone or with other approved cancer drugs. Th…

This program provides ulixertinib, an experimental drug, to adults with advanced solid tumors that have specific genetic changes (MAPK pathway mutations) and who have run out of standard treatments. The goal is to control the cancer, not cure it. Participants may take ulixertinib…

This study looks at whether closely monitoring and controlling blood sugar levels can help people with pancreatic cancer who are receiving chemotherapy. About 50 participants will wear a continuous glucose monitor and be randomly assigned to either tight blood sugar control or st…

This study tests a new drug called LY4052031 in people with advanced or spreading solid tumors, including bladder, breast, lung, and other cancers. The goal is to see if the drug is safe and works against these cancers. About 420 participants will take part, and the study will la…

This study tests whether adding the drugs ivonescimab and AK117 to standard chemotherapy helps people with metastatic pancreatic cancer live longer. About 999 adults aged 18-75 who have not had prior treatment for their advanced cancer will be randomly assigned to receive either …

This early-stage study tests a personalized cell therapy for 18 adults with advanced pancreatic cancer that has not responded to standard treatments. The therapy uses a patient's own immune cells, modified to recognize and attack cancer cells with a specific KRAS mutation. The ma…

This early-stage study is testing a new radioactive drug injection called 177Lu-CTR-FAPI in patients with advanced, metastatic cancers like pancreatic cancer. The main goals are to see if the treatment is safe, to measure how much radiation reaches the tumors, and to check if it …

This study tests an artificial intelligence model called PANDAPro that helps doctors find pancreatic cancer on regular CT scans. Researchers will compare how well doctors detect cancer with and without AI assistance, using scans from 100,000 people. The goal is to catch cancers t…

This study tests a special dye and imaging system that makes cancer cells glow, helping surgeons see and remove tumors more completely during surgery for colorectal, pancreatic, esophageal, and gastric cancers. About 66 adults scheduled for surgery will receive the dye beforehand…

This study is testing a new blood test that looks for tiny particles called exosomes to find pancreatic cancer early. The goal is to see if this test can accurately detect the disease in 2000 adults, including those with and without cancer. If successful, it could lead to a simpl…

This study looks at whether buying over-the-counter pain relievers or digestive aids can be an early warning sign for 10 types of cancer, including pancreatic, colon, and ovarian cancer. Researchers will compare the shopping habits of 2,900 people—some recently diagnosed with can…

This study aims to develop a non-invasive breath test to detect pancreatic cancer earlier. Researchers will measure tiny molecules in the breath of 1,005 participants, including those with pancreatic cancer, diabetes, or non-specific symptoms. The goal is to help doctors identify…

This study is testing a new type of PET scan that uses a special tracer to find cancers like pancreatic, breast, lung, and others. The goal is to see if this scan can better detect and stage tumors compared to standard scans. About 26 adults with suspected or confirmed cancer, pl…

This study aims to improve how doctors see digestive system cancers (like liver, stomach, and pancreatic cancer) using special PET/CT imaging probes. Researchers will test these probes in 400 adults to measure how they spread in the body and how well they find tumors. The goal is…

This study tests a new type of PET scan that uses a special tracer (FAPi) to find pancreatic cancer that standard CT scans might miss. About 60 adults with pancreatic cancer will get both a CT scan and this new scan. The goal is to see if the new method is better at detecting whe…

This early-phase study tests a new contrast agent (68Ga-labelled claudin 18.2) used with PET/CT scans to better see pancreatic cancer. About 12 adults with pancreatic cancer will receive the agent to check its safety and how well it targets tumors. The goal is to improve cancer i…

This study tests a new type of PET scan that looks for a protein called CLDN18.2 on cancer cells. It includes 56 adults with stomach, pancreatic, bile duct, or esophageal cancer, plus healthy volunteers. The goal is to see if this scan can accurately find tumors and help doctors …

This study is testing whether a simple rectal mucus sample can detect DNA changes linked to lung, pancreatic, bladder, and colorectal cancers. Researchers will collect samples from 450 adults using a special device and compare them to known tumor DNA. The goal is to see if this n…

This study tests an artificial intelligence system that analyzes contrast-enhanced CT scans to help doctors decide the best course of action for people with suspected pancreatic diseases. The AI will classify patients into three groups: needing immediate treatment, close monitori…

This study is testing a new breath test to find pancreatic cancer earlier. The test looks for tiny molecules made by cancer cells that are released in a person's breath. Researchers will collect breath samples from about 6,000 people who have been referred for possible pancreatic…

This study is testing a new platform that uses advanced genetic and functional tests to better understand tumors from 300 people with various high-risk cancers, including leukemia, myeloma, and pancreatic cancer. The goal is to see if this detailed analysis can change the recomme…

This study aims to see if a mixed meal test can better diagnose type 3c diabetes, which is caused by pancreatic cancer or chronic pancreatitis. Researchers will enroll 775 adults aged 30 to 84 who have new-onset diabetes and either pancreatic cancer or chronic pancreatitis. The g…

This study is testing a new blood test that uses laser light and artificial intelligence to find signs of five different cancers (breast, colon, pancreatic, ovarian, and lung) at an early stage. Researchers will collect blood samples from 1,400 people aged 45 and older who are su…

This study tests whether a special imaging scan called PYLARIFY PET-CT can accurately detect cancer that has spread in people with pancreatic cancer, liver cancer, or breast cancer. About 36 adults will receive the scan to see if it matches standard methods. The goal is to improv…

This study looks at whether adding an MRI scan to the usual CT scan helps doctors choose the best treatment for people with pancreatic cancer. About 200 patients who are initially thought to be candidates for surgery will be randomly assigned to get either a CT scan alone or a CT…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including lung, breast, and colon cancer. Researchers will see if the test can find cancer early and tell which type it is. In people with lung cancer, the test will also check for any cancer…

This study is testing a new type of PET/CT scan that uses a special tracer called 18F-T2 to find cancers that have high levels of a protein called CAIX. About 200 adults with cancers like kidney, bladder, lung, or breast cancer will get this scan to see if it works better than th…

This early-phase study aims to develop a new blood test that detects cancer by measuring specific enzyme activity in plasma. Researchers will compare enzyme levels in 120 patients with localized breast, lung, or pancreatic cancer against 100 healthy volunteers. The goal is to see…

This pilot study tests if brodalumab, a drug approved for autoimmune diseases, can safely reduce severe side effects caused by cancer immunotherapy. About 11 adults with various solid tumors who have immune-related side effects will receive brodalumab. The goal is to see if it lo…

This study tests a new radiation technique called lattice radiation therapy (LRT) for people with solid tumors that have spread to soft tissues. The goal is to see if LRT shrinks tumors better than standard radiation and whether it helps the immune system attack cancer cells. Abo…

This study looks at whether a home-based resistance exercise program combined with protein supplements can help people with pancreatic cancer maintain muscle mass while undergoing chemotherapy. About 45 participants will be assigned to one of three groups: exercise plus protein, …

This study tests whether a remote exercise and nutrition program can help people with pancreatic cancer get stronger before surgery. Researchers want to see if the program is practical and acceptable for patients. The study involves 26 adults with borderline resectable pancreatic…

This study tests a new, faster method to deliver radiation therapy for severe abdominal pain caused by pancreatic cancer. Normally, planning this treatment takes over a week because a special CT scan is needed. Here, doctors will use the patient's existing diagnostic CT scan to p…

This study looks at whether a low dose of oral ketamine can help reduce anxiety in people with pancreatic cancer. About 20 participants will receive either ketamine or a placebo in a crossover design, meaning everyone gets both treatments at different times. The main goal is to s…

This study tests a program that gives extra nutrition help to people with pancreatic cancer after they have surgery. Participants use a mobile app to log their meals and get support from a dietitian remotely. The goal is to see if the program is easy to use and helps patients fee…

This study tests a new drug called JMT203 in people with lung or pancreatic cancer who are losing weight and muscle (cancer cachexia). The goal is to see if the drug is safe and can help patients gain or maintain weight. About 307 adults will take part across two phases, starting…

This study looks at a procedure called celiac plexus neurolysis, which uses alcohol to block pain nerves in people with pancreatic cancer. Doctors usually inject another numbing drug (bupivacaine) first, but it's not clear if that helps or might even reduce the alcohol's effect. …

This study looks at whether artificial intelligence can help detect cachexia—a severe loss of weight and muscle—early in people with pancreatic cancer. Researchers will also see if diet and exercise programs are practical and helpful for these patients. About 120 adults with panc…

This study is checking if people with type 2 diabetes who take the drug exenatide have a higher chance of getting pancreatic cancer compared to those taking other diabetes medicines. Researchers will look at health records from over 24,000 adults in seven European countries. The …

This study is working on a new, less invasive test to find pancreatic cancer at an early stage and to see how well treatment is working. Researchers will study 700 people with pancreatic cancer or related conditions to find biological markers in the blood or tissue. The goal is t…

This study is collecting tissue and fluid samples from 160 people with suspected bile duct, liver, or pancreatic cancers. Researchers want to learn more about these cancers to develop better ways to diagnose and treat them. Participants will give extra samples during their regula…

This study looks at 250 people with pancreatic cancer whose stomach is blocked by the tumor. It compares three standard procedures to see which one helps patients eat better, tolerate chemotherapy, and maintain nutrition. Participants fill out quality-of-life questionnaires but r…

This observational study looks at whether combining information from CT scans, blood tests, and pathology reports can more accurately predict how pancreatic cancer will progress. Researchers will collect data from medical records of about 1,030 people who had surgery for pancreat…

This study is testing whether a wearable activity tracker can be used by people with pancreatic or breast cancer to track fatigue during treatment. About 46 participants will wear the device for 14 days and share heart rate data. The goal is to see if patients find the tracker ea…

This study collects blood, tissue, and health information from up to 20,000 people with pancreas diseases like pancreatic cancer or pancreatitis. Researchers will use these samples and data to better understand these conditions and develop better screening methods in the future. …

This study looks at whether CT scans can help doctors predict how well pancreatic cancer patients will respond to chemotherapy. About 259 adults with pancreatic or liver cancer will get CT scans before and during treatment. The goal is to find imaging markers that show if the tum…

This study looks at how obesity might cause pancreatic cancer to grow differently in African American and White people. Researchers will compare genes, body fat, and tumor behavior in 125 adults. The goal is to find new ways to prevent or treat this cancer in high-risk groups.

This study looks at tiny particles called exosomes in the blood and tissue of people with pancreatic cancer and those with noncancerous pancreatic disease. The goal is to understand how these messengers might be linked to cancer coming back and patient outcomes. About 181 adults …

This study will observe 3,000 Chinese patients with pancreatic cancer who are already receiving a drug called irinotecan liposome. Researchers will collect data on side effects, survival, and tumor response to see how well the treatment works in everyday medical practice. No new …

This study looks at whether adding a geriatrician to the care team can improve outcomes for people aged 70 and older with gastrointestinal cancers like stomach, colon, or pancreatic cancer. Researchers will test if an online fitness questionnaire is easy to use and if geriatric c…

This study looks at whether a digital app can help cancer patients get genetic testing directly from their oncologist, instead of visiting a separate genetics clinic. The goal is to see if this approach reduces patient distress and improves care. About 180 adults with breast, pro…

This study collects tissue, blood, urine, and stool samples from 5,000 people undergoing colonoscopy or endoscopy, including those with cancer, polyps, or inflammatory bowel disease, as well as healthy volunteers. The goal is to find new biomarkers that could lead to better scree…

This study aims to understand why some cancers come back after surgery by detecting tumor cells and DNA in blood, urine, and bone marrow. Researchers will collect samples from 620 adults with various solid cancers (like lung, colon, or pancreatic cancer) and track their health ov…

This study collects samples (mouth swabs, stool, and small pancreas tissue samples) from 300 adults who may have pancreatic cancer. Researchers want to see if certain bacteria or fungi are linked to the disease, its severity, and patient outcomes. The goal is to find new ways to …

This study collects blood and leftover tissue samples from 9,600 adults with different types of cancer. Researchers will use these samples to develop and improve tests that detect cancer DNA in the blood, which may help monitor for cancer return or how well treatment is working. …

This study looks at how pancreatic cancer changes over time in patients receiving chemotherapy. Researchers will take small tissue samples from the tumor before and after treatment to see if the cancer's molecular subtype shifts. The goal is to better understand how the cancer ad…

This study aims to understand how gene changes in metastatic pancreatic cancer relate to treatment response. Researchers will analyze tumor samples from 190 adults starting chemotherapy. The goal is to see if returning genetic results within 8 weeks is feasible, which could help …

This study looks at whether taking a blood sample from the vein that drains directly from a liver or pancreas tumor gives more useful genetic information than a standard arm vein sample. About 15 adults scheduled for a biopsy will provide both samples, and researchers will compar…

This study looks at whether a custom diet plan can help people recover better after Whipple surgery for pancreatic or bile duct cancer. Twenty adults will receive tailored nutrition before and after surgery, and their recovery, weight, and lab results will be tracked for six mont…

This study is testing a small, portable device called the P4 that sits inside an MRI scanner to make the images more consistent and accurate. The goal is to better measure how well pancreatic cancer treatments are working by tracking blood flow changes in the tumor. The study inc…

This study aims to learn more about what causes pancreatic cancer by collecting medical and family history, blood, and urine samples from up to 10,000 people. Participants include those with pancreatic disease, those at high risk, and healthy controls. The information and samples…

This study is testing a new type of ultrasound called multiparametric ultrasound (mpUS) to see if it can give doctors more detailed information about tissue in the pancreas and thyroid. Researchers will compare mpUS images to standard ultrasound and other tests. The goal is to le…

This study is developing an AI method to track the movement of tumors and nearby organs during radiation therapy without using physical markers. Researchers will use data from 300 patients receiving radiation for various cancers or heart arrhythmias to train and test the system. …

This study is testing a new test called NEO-Match® that uses nanomechanical profiling to see if it can predict how well pancreatic cancer patients respond to treatment. About 200 adults with suspected pancreatic cancer will provide an extra biopsy sample during their standard car…

This study looks at muscle wasting, weight loss, and tiredness in people with stomach, pancreas, or bowel cancer who are having surgery. Researchers will track changes in body composition, physical activity, and quality of life over a year. The goal is to better understand cachex…

This study is a registry that collects information from 1,500 people with advanced pancreatic cancer in Austria. Researchers want to see which treatments are used and how well they work in real life. The goal is to find patterns that could help improve care for future patients.

This study is creating a huge collection of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand cancer causes, improve early detection, and develop person…

This study is gathering tumor tissue and blood cells from 200 adults with advanced solid tumors like colorectal, lung, or pancreatic cancer. The goal is to learn how often certain genetic changes occur and to store participants' own immune cells for possible future use in making …

This study tests whether an app that tracks symptoms like pain, appetite, and weight, combined with artificial intelligence, can help doctors better assess and support nutrition in 200 patients who have had surgery for pancreatic cancer. The goal is to see if this approach improv…

This study explores whether a special MRI technique called 3D-MRE can measure the stiffness of pancreatic tumors to help predict how the disease will progress. Researchers will enroll 200 adults with pancreatic cancer and compare imaging results with treatment responses and survi…

This study is creating a registry and collecting blood, tissue, and other samples from people with or at high risk for pancreatic disease. The goal is to gather information that will help researchers better understand pancreatic cancer and improve future diagnosis and treatment. …

This study looks at whether people aged 50+ who recently developed diabetes or whose diabetes got worse might have early signs of pancreatic cancer. Participants will get an MRI scan and give blood samples over time to help create a future blood test. The goal is to catch pancrea…

This study is for people with pancreatic cysts or lesions. Researchers will collect blood, tissue, and scan data from over 1,100 participants to develop noninvasive tools that predict which cysts may turn cancerous. The goal is to improve decision-making and personalize care with…

This study is a large registry that will follow 8,000 cancer patients who receive radiation therapy guided by an MR-Linac, a machine that combines an MRI scanner with a radiation beam. The goal is to see if this technology helps people live longer, controls tumors better, and imp…

This study aims to see if watching a video before genetic testing helps people with certain cancers better understand their hereditary cancer risk. About 1020 adults with breast, ovarian, pancreatic, prostate, colorectal, renal, melanoma, or sarcoma cancers will take part. Resear…

This study aims to create and improve educational materials about genetic testing for people with breast, ovarian, prostate, pancreatic, or colorectal cancer. Researchers will interview 445 participants from diverse cultural and language backgrounds to get their feedback on the m…

This study collects blood, urine, and bone marrow samples from 320 people with solid cancers (like lung, colon, or pancreatic cancer) and from those undergoing lung cancer screening. The goal is to detect tiny bits of tumor cells and DNA in these fluids to learn how cancer spread…

This study aims to understand how the tumor's surroundings change during chemoradiotherapy for locally advanced cervical and pancreatic cancers. Researchers will collect tissue and blood samples before, during, and after treatment from about 60 participants. The goal is to learn …

This study aims to find out how often three specific BRCA gene mutations occur in Ashkenazi Jewish patients with pancreatic cancer. Researchers will test 100 participants to better understand the genetic links. The goal is to help relatives of patients get earlier screening and t…

This study follows 4,000 adults with pancreatic cysts to learn which ones turn into cancer and which stay harmless. Participants provide health updates over time, but no treatment is given. The goal is to help doctors decide when surgery is needed and when it can be safely avoide…

This research study aims to discover new genes that may increase the risk of childhood cancer. Researchers will collect blood samples and health information from 1,500 people in families where cancer clusters. The goal is to build a registry and sample bank to help future diagnos…

This early-phase study tests a small device placed into pancreatic tumors during surgery to check how different drugs affect the cancer. Ten adults having their pancreas removed will receive the device, which is taken out with the tumor after about 4 hours. The main goal is to en…

This study enrolls 5,000 people at high risk for pancreatic cancer to collect blood, pancreatic juice, and medical images over 10 years. Researchers will use these samples to develop and validate tests for early detection, including AI-assisted analysis. Participants must be 18 o…

This study looks at whether regular screening with endoscopic ultrasound or MRI can find early signs of pancreatic cancer in people who have a high inherited risk due to BRCA1/2, ATM, or PALB2 gene mutations. About 200 adults with these mutations will be monitored over time. The …