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New pill aims to keep pancreatic cancer away after surgery

NCT ID NCT07252232

Disease control Sponsor: Revolution Medicines, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 16, 2026 · Updated 7 times

Summary

This study tests a new drug called daraxonrasib in people with pancreatic cancer who have already had surgery and chemotherapy. The goal is to see if taking the drug can delay or prevent the cancer from returning compared to just watching and waiting. About 500 adults will be randomly assigned to receive the drug or no additional treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 500 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Jul 2030

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * At least 18 years old and has provided informed consent. * Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. * Histologically confirmed PDAC with successful (R0/R1) curative intent surgical resection and no evidence of recurrent or metastatic disease. * Must have received perioperative (neoadjuvant, adjuvant, or a combination of both) multi-agent chemotherapy. * Must have completed most recent treatment within the past 12 weeks. * Adequate organ function (bone marrow, liver, kidney, coagulation). * Documented RAS mutation status. * Able to take oral medications. Exclusion Criteria: * Prior therapy with direct RAS-targeted therapy (eg. degraders and/or inhibitors). * Any conditions that may affect the ability to take or absorb study drug. * Major surgery within 28 days prior to randomization. * Patient is unable or unwilling to comply with protocol-required study visits or procedures.

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Conditions

The condition(s) this trial relates to.

malignant pancreatic neoplasm pancreatic adenocarcinoma pancreatic ductal adenocarcinoma pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pancreatic cancer PDAC Pdac - pancreatic ductal adenocarcinoma Resectable pancreatic ductal adenocarcinoma (PDAC) Resected pancreatic adenocarcinoma

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    74 sites in 9 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Asan Medical Center

    RECRUITING

    Seoul, 05505, South Korea

  • Avera Cancer Institute

    RECRUITING

    Sioux Falls, South Dakota, 57105, United States

  • Azienda Ospedaliero Universitaria Pisana

    RECRUITING

    Pisa, 56126, Italy

  • Beatson West of Scotland Cancer Centre

    RECRUITING

    Glasgow, G22 0YN, United Kingdom

  • CRLCC Eugene Marquis

    RECRUITING

    Rennes, Cedex, 35042, France

  • Cancer Institute Hospital of JFCR

    RECRUITING

    Tokyo, 135-8550, Japan

  • Cedars-Sinai Cancer at Cedars-Sinai Medical Center

    RECRUITING

    Los Angeles, California, 90048, United States

  • Centro Ricerche Cliniche di Verona s.r.l.

    RECRUITING

    Verona, 37134, Italy

  • Clinica Universidad de Navarra

    RECRUITING

    Pamplona, Navarre, 31008, Spain

  • Columbia University Medical Center

    RECRUITING

    New York, New York, 10032, United States

    Contact Email: •••••@•••••

  • Community Health Network

    RECRUITING

    Indianapolis, Indiana, 46250, United States

  • Comprehensive Cancer Centers of Nevada

    RECRUITING

    Las Vegas, Nevada, 89169, United States

  • Dana Farber Cancer Institute (DFCI)

    RECRUITING

    Boston, Massachusetts, 02215, United States

  • Dong-A University Hospital

    RECRUITING

    Busan, 49201, South Korea

  • Duke Cancer Center

    RECRUITING

    Durham, North Carolina, 27710, United States

  • Florida Cancer Specialists

    RECRUITING

    St. Petersburg, Florida, 33701, United States

  • Fondazione IRCCS Istituto Nazionale dei Tumori

    RECRUITING

    Milan, 20133, Italy

  • Fred Hutchison Cancer Center

    RECRUITING

    Seattle, Washington, 98109, United States

  • Froedtert Hospital and the Medical College of Wisconsin

    RECRUITING

    Milwaukee, Wisconsin, 53226, United States

  • Hartford Healthcare

    RECRUITING

    Hartford, Connecticut, 06103, United States

  • HonorHealth Research Institute

    RECRUITING

    Scottsdale, Arizona, 85258, United States

  • Hopital Claude Huriez - CHU Lille

    RECRUITING

    Lille, Cedex, 59037, France

  • Hospital Clinic de Barcelona

    RECRUITING

    Barcelona, 08036, Spain

  • Hospital Clinico Universitario de Valencia

    RECRUITING

    Valencia, 46010, Spain

  • Hospital Universitari Vall d'Hebron - VHIO

    RECRUITING

    Barcelona, 08035, Spain

  • Hospital Universitario 12 de Octubre

    RECRUITING

    Madrid, 28041, Spain

  • Hospital Universitario Virgen del Rocio

    RECRUITING

    Seville, 41013, Spain

  • Hôpital Paul Brousse

    RECRUITING

    Villejuif, Val-De- Marne, 94804, France

  • IEO - Instituto Europeo di Oncologia

    RECRUITING

    Milan, 20141, Italy

  • IOV - Istituto Oncologico Veneto IRCCS

    RECRUITING

    Padova, 35128, Italy

  • Icahn School of Medicine at Mount Sinai

    RECRUITING

    New York, New York, 10029, United States

  • Imperial College Healthcare NHS Foundation Trust, Hammersmith Hospital

    RECRUITING

    London, W12 0HS, United Kingdom

  • Institut Gustave Roussy

    RECRUITING

    Villejuif, Val-de-Marne, 94805, France

  • Institut Paoli Calmettes

    RECRUITING

    Marseille, 13009, France

  • Kanagawa Cancer Center

    RECRUITING

    Yokohama, Kanagawa, 241-8515, Japan

  • Krankenhaus Nordwest GmbH

    RECRUITING

    Frankfurt, 60488, Germany

  • Kyoto University Hospital

    RECRUITING

    Kyoto, 606-8507, Japan

  • Kyushu University Hospital

    RECRUITING

    Fukuoka, 812-8582, Japan

  • Laura and Issac Perlmutter Cancer Center at NYU Langone-Ambulatory Care Center

    RECRUITING

    New York, New York, 10016, United States

  • Massachusetts General Hospital

    RECRUITING

    Boston, Massachusetts, 02114, United States

  • Mayo Clinic

    RECRUITING

    Phoenix, Arizona, 85054, United States

  • Mayo Clinic

    RECRUITING

    Jacksonville, Florida, 32224, United States

  • Mayo Clinic Cancer Center

    RECRUITING

    Rochester, Minnesota, 55905, United States

  • Memorial Sloan Kettering Cancer Center

    RECRUITING

    New York, New York, 10065, United States

  • National Cancer Center Hospital

    RECRUITING

    Tokyo, 104-0045, Japan

  • National Cancer Center Hospital East

    RECRUITING

    Chiba, 277-8577, Japan

  • Pan American Oncology Trials, LLC

    RECRUITING

    San Juan, 00909, Puerto Rico

    Contact Email: •••••@•••••

  • Rocky Mountain Cancer Centers, LLP

    RECRUITING

    Lakewood, Colorado, 80228, United States

  • SCRI Oncology Partners

    RECRUITING

    Nashville, Tennessee, 37203, United States

  • Saint Luke's Cancer Institute

    RECRUITING

    Kansas City, Missouri, 64111, United States

  • Samsung Medical Center

    RECRUITING

    Seoul, 06351, South Korea

  • Seoul National University Hospital

    RECRUITING

    Seoul, 03080, South Korea

  • Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins & Sibley Memorial Hospital

    RECRUITING

    Baltimore, Maryland, 21287, United States

  • Stanford Cancer Institute

    RECRUITING

    Palo Alto, California, 94304, United States

  • Taylor Cancer Research Center

    RECRUITING

    Maumee, Ohio, 43537, United States

  • Texas Oncology - DFW

    RECRUITING

    Dallas, Texas, 75246, United States

  • Texas Oncology - Northeast Texas

    RECRUITING

    Longview, Texas, 75601, United States

  • The Christie NHS Foundation Trust

    RECRUITING

    Manchester, M20 4BX, United Kingdom

  • The Royal Marsden NHS Foundation Trust, Royal Marsden Hospital-London

    RECRUITING

    London, SW3 6JJ, United Kingdom

    Contact Email: •••••@•••••

  • UC San Diego Moores Cancer Center

    RECRUITING

    La Jolla, California, 92037, United States

  • UPMC Hillman Cancer Center

    RECRUITING

    Pittsburgh, Pennsylvania, 15232, United States

  • Universitaetsklinikum Heidelberg

    RECRUITING

    Heidelberg, 69120, Germany

  • University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Medical Centre

    RECRUITING

    Birmingham, B15 2TH, United Kingdom

  • University of California, Los Angeles

    RECRUITING

    Los Angeles, California, 90404, United States

  • University of California, San Francisco

    RECRUITING

    San Francisco, California, 94143, United States

  • University of Kansas Medical Center Research Institute, Inc.

    RECRUITING

    Lawrence, Kansas, 66045, United States

  • University of Miami Hospital and Clinics, Sylvester Comprehensive Cancer Center

    RECRUITING

    Miami, Florida, 33136, United States

  • University of Nebraska Medical Center

    RECRUITING

    Omaha, Nebraska, 68198, United States

  • University of Pennsylvania, Abramson Cancer Center

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • University of Rochester Medical Center

    RECRUITING

    Rochester, New York, 14642, United States

    Contact Email: •••••@•••••

  • University of Texas MD Anderson Cancer Center

    NOT_YET_RECRUITING

    Houston, Texas, 77030, United States

    Contact Email: •••••@•••••

  • University of Utah, Huntsman Cancer Institute

    RECRUITING

    Salt Lake City, Utah, 94112, United States

  • Virginia Cancer Specialists

    RECRUITING

    Fairfax, Virginia, 22031, United States

  • Winship Cancer Institute, Emory University

    RECRUITING

    Atlanta, Georgia, 30322, United States

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