PANCREATIC CANCER

This study tested a personalized vaccine made from each patient's unique cancer mutations (neoantigens) in people with pancreatic cancer. The vaccine was given after chemotherapy and before or after surgery to see if it is safe and boosts the immune system. 33 patients took part …

This early-phase study tested a new drug called CUE-102 in 42 adults with advanced colorectal, gastric, pancreatic, or ovarian cancers that had stopped responding to standard treatments. Participants had a specific genetic marker (HLA-A*0201) and their tumors produced a protein c…

This study tested whether giving higher doses of a precise type of radiation (SBRT) over five sessions is safe for people with pancreatic cancer that cannot be removed by surgery. Thirty participants received the treatment to find the highest dose that does not cause severe side …

This early-phase trial tested a new type of radiation called carbon ion therapy for people with advanced pancreatic cancer that cannot be removed by surgery. The main goal was to find the highest safe dose by monitoring side effects in 14 participants. The study has been complete…

This study tested a combination of three chemotherapy drugs (paclitaxel protein bound, gemcitabine, and cisplatin) in 34 people with metastatic pancreatic cancer that had not been treated before. If the cancer got worse, a fourth drug (paricalcitol) was added. The goal was to see…

This study tested a combination of two drugs, cabozantinib and pembrolizumab, in 21 people with metastatic pancreatic cancer that had worsened after standard treatments. The goal was to see if the combination could slow cancer growth or shrink tumors. The study measured how long …

This early study tested a new drug called Cabotamig (ARB202) in 33 adults with advanced gastrointestinal cancers (like stomach, liver, or bowel cancer) that had stopped responding to standard treatments. The drug works by targeting a marker called CDH17 on cancer cells and helpin…

This study tested a combination of a pancreatic cancer vaccine (GVAX), an immunotherapy drug (pembrolizumab), and focused radiation (SBRT) in 58 people with locally advanced pancreatic cancer. The goal was to see if this mix could delay the spread of cancer to other parts of the …

This early-phase study tested a combination of three drugs (gemcitabine, capecitabine, and erlotinib) in 30 people with advanced pancreatic cancer that had already been treated. The main goal was to find the safest dose and understand side effects. This is not a cure, but aims to…

This study tested a new type of radiation called carbon ion radiotherapy for people with pancreatic cancer that cannot be removed by surgery. The goal was to see if it works better than standard radiation to control the disease and help people live longer. The study included 25 a…

This study tested a combination of two drugs, lenvatinib and pembrolizumab, in 611 people with advanced solid tumors including breast, ovarian, stomach, colorectal, brain, bile duct, and pancreatic cancers that had stopped responding to standard treatments. The goal was to see if…

This study tested a combination of two drugs, NT-I7 and pembrolizumab, in 215 people with advanced solid tumors that had come back or stopped responding to treatment. The goal was to find a safe dose and see if the combo could shrink tumors. The study included people with several…

This study tested whether adding a drug called paricalcitol (similar to vitamin D) to standard chemotherapy could help people with advanced pancreatic cancer that had stopped responding to treatment. 27 adults with metastatic pancreatic cancer took part. The goal was to see if th…

This early-stage study tested a new drug (BI 765049) alone or with another drug (ezabenlimab) in 21 Asian adults with advanced cancers like stomach, lung, or liver cancer that had stopped responding to treatment. The goal was to find a safe dose and see if the drugs could shrink …

This early-phase study tested the safety of combining a tumor-destroying procedure (IRE) with an immunotherapy drug (pembrolizumab) in 2 people with locally advanced pancreatic cancer that could not be removed by surgery. The goal was to see if the combination was safe enough to …

This study tested a new experimental therapy using special immune cells designed to attack five proteins found on pancreatic cancer cells. It included 37 patients whose cancer had returned, not gone away, or who could not have standard chemotherapy. The main goals were to check i…

This study tested a drug called niraparib in 32 people with advanced pancreatic cancer that has specific DNA repair problems. The goal was to see if the drug could slow down cancer growth. Participants took niraparib pills, and researchers measured how long they lived without the…

This early-phase study tested a personalized vaccine made from yeast that is designed to teach the immune system to recognize and attack leftover cancer cells. It included 5 adults with different cancers who had already completed treatment aimed at curing their disease. The goal …

This study tested a combination of four drugs (CRS-207, pembrolizumab, ipilimumab, and tadalafil) in 17 adults with metastatic pancreatic cancer that had worsened after at least one prior chemotherapy. The goal was to see if the treatment could shrink tumors and to check its safe…

This study tested whether adding an immunotherapy drug (anti-PD-1 antibody) to standard chemotherapy could help people with pancreatic cancer that has not spread but is too advanced for immediate surgery. About 392 participants received either chemotherapy alone or chemotherapy p…

This study tested a new treatment for people with advanced gastrointestinal cancers that had spread and stopped responding to standard therapies. Doctors took immune cells from each patient's tumor, used CRISPR gene editing to remove a gene called CISH that slows down the immune …

This study tested whether a modified cold virus (LOAd703) is safe for people with pancreatic cancer. The virus is designed to infect and kill cancer cells while also boosting the immune system. 51 participants received the virus along with standard chemotherapy, with or without a…

This early-phase trial tested whether combining a special type of radiation (hypofractionated radiotherapy) with two immunotherapy drugs (MEDI4736 and tremelimumab) is safe and tolerable for people with advanced melanoma, lung, breast, or pancreatic cancer that has spread. The st…

This study tested whether adding two experimental drugs (TTX-030 and budigalimab) to standard chemotherapy could help people with metastatic pancreatic cancer live longer without their disease getting worse. The trial involved 194 adults who had not yet received treatment for the…

This study tested an experimental drug called BMS-813160, given alone or with chemotherapy and/or the immunotherapy nivolumab, in 332 people with advanced colorectal or pancreatic cancer. The main goals were to check safety and side effects, and to see if the drug combination cou…

This study tested two common antibiotics, cefoxitin and piperacillin-tazobactam, to see which one better prevents surgical site infections after a complex pancreatic surgery called pancreatoduodenectomy. Nearly 1,000 adults having this surgery took part. The goal was to find the …

This study tested whether a more thorough endoscopic ultrasound could find cancer that has spread to lymph nodes in patients with pancreatic cancer who are scheduled for surgery. 33 adults with operable pancreatic tumors took part. The approach aimed to improve cancer staging by …

This study looked at 477 adults with pancreatic cysts to find better ways to tell which cysts are harmless and which might turn into cancer. Researchers combined medical images, patient history, and lab tests on cyst fluid and blood. The goal is to create a more accurate tool to …

This early-phase study tested a new imaging agent called NMK89 in 10 people with pancreatic cancer that produces a specific protein (MUC5AC). The agent was given as a single infusion and then tracked with PET/CT scans to see where it goes in the body and how safe it is. The goal …

This study tested a 12-week digital health coaching program for people with pancreatic cancer and their caregivers. The goal was to see if the program was easy to use and helpful. 20 participants from Moffitt Cancer Center took part in the pilot study.

This study tested a procedure called endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) to relieve severe pain in 19 people with advanced pancreatic cancer that cannot be removed by surgery. The treatment uses heat to target nerves that carry pain signals, aiming to r…

This study tested a program called STRONG that provides nutrition guidance and supportive care remotely to adults with pancreatic cancer who are receiving chemotherapy. The goal was to see if the program was easy to use and if patients were satisfied with it. Fifty participants w…

This study looked at over 2,000 older adults (80+) with pancreatic cancer that hadn't spread, who were still in good health. Researchers compared those who had surgery to remove the tumor with those who didn't, and also looked at the effect of additional treatments like chemother…

This study looks at how well the drug T-DXd works compared to usual treatments for people with advanced HER2-positive solid tumors (like lung, colon, and ovarian cancers). Researchers will use data from past clinical trials and real-world patient records to compare survival rates…

This study looked at whether the types of bacteria living in the gut are linked to whether pancreatic cancer has spread to nearby lymph nodes. Researchers compared stool samples from 55 patients with and without lymph node spread. They hope to find patterns that could help doctor…

This study looked at health data from over 723,000 older adults (70+) worldwide to understand how common pancreatic cancer and pancreatitis are, and how deadly they are. Researchers analyzed trends from 1990 to 2021 and made projections to 2040. The goal was to see how these dise…

This study looked at 236 adults with breast, pancreatic, or colorectal cancer who sought a second opinion at the University of Colorado. Researchers reviewed medical records to understand why some patients stayed for treatment while others did not. The goal is to learn more about…

This study looked at 44 adults who had surgery for pancreatic or related cancers. Researchers measured changes in the leftover pancreas, body composition, and energy use to better understand recovery. The goal was to gather information to improve future nutritional care, not to t…

This study looked at 159 people with advanced colorectal, pancreatic, biliary, or esophageal cancers to see if simple blood tests (tumor markers and liquid biopsies) and patient-reported symptoms could predict whether the cancer would get worse. Researchers compared changes in th…

This study tested whether an AI computer program could suggest treatments for stomach, colon, and pancreatic cancer that match what experts recommend. Researchers looked at past cases of 30 patients and compared the AI's suggestions to official guidelines and decisions made by a …

This study looked at whether a special website or two phone calls with a health coach could encourage more people with a personal or family history of certain cancers to get genetic testing. Over 800 adults who already completed a family health survey were randomly assigned to on…

This study tested whether it is safe and possible to collect a small blood sample from the portal vein (a major liver blood vessel) during a routine endoscopic ultrasound in 23 people with pancreatic cancer. The goal was to find and count circulating tumor cells (cancer cells tha…

This study compared two types of surgery for pancreatic, bile duct, and ampulla of Vater cancers: a less invasive (miniinvasive) approach and traditional open surgery. Researchers looked at 320 adults aged 21-75 to see which method caused fewer complications like infections or bl…

This study looked at whether a new biomarker called 'mass response' can help predict how well cancer treatments will work. Researchers collected tumor cells from 72 adults with various cancers using fluid samples or biopsies. The goal was to see if this biomarker could guide ther…

This study looked at 40 adults with operable pancreatic cancer to measure circulating tumor DNA (ctDNA) in blood from a vein and from the portal vein during surgery, as well as in fluid from the abdomen. The goal was to see if these DNA levels could help predict how the disease p…

This study looked at whether it is safe and possible to grow mini-tumors (organoids) from pancreatic cancer samples in the lab. 60 patients with pancreatic cancer provided tumor tissue during surgery or biopsy. Researchers then tested different chemotherapy drugs on these organoi…

This study tested whether giving vinegar through a tube during an endoscopic ultrasound can help collect pancreatic juice for cancer testing. 75 people with suspected pancreatic cancer took part. The goal was to see if this method works and find the best amount of vinegar and col…