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Which antibiotic wins? study tests infection prevention in pancreatic surgery

NCT ID NCT03269994

Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at nearly 1,000 adults having pancreatic surgery to see which antibiotic, cefoxitin or piperacillin-tazobactam, works better at preventing wound infections within 30 days after the operation. Participants received one of the two antibiotics before surgery. The goal is to help doctors choose the best option to reduce infections and improve recovery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

967 people

The number who actually took part.

Started

Nov 2017

Finished

Jan 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \>/= 18 years * Patients undergoing elective pancreatoduodenectomy (PD) for any diagnosis/indication Exclusion Criteria: * Patients undergoing a minimally invasive PD, such as laparoscopic or robotic PD * Patients with known and documented allergies to any of the penicillins, cephalosporins, or β-lactamase inhibitors * Patients who are otherwise ineligible to receive the antibiotics in this study * Patients highly unlikely to undergo PD according to the surgeon's judgment, such as conditions amenable to pancreas enucleation, ampullectomy, etc. * Patients with long-term glucocorticosteroid use. The following uses of corticosteroids are permitted: single doses, topical applications (e.g., for rash), inhaled sprays (e.g., for obstructive airways diseases), eye drops or local injections (e.g., intra-articular) * Patients unable to provide informed consent * Creatinine clearance (CrCl) \</= 40 mL/min * Patients receiving hemodialysis or peritoneal dialysis * Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive hCG laboratory test * Patients with a known bacterial infection present at the time of surgery or who received antimicrobial therapy within 7 days prior to surgery

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Conditions

The condition(s) this trial relates to.

malignant pancreatic neoplasm pancreas disorder pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pancreas cancer Pancreatic cancer Pancreatic diseases

Contacts and locations

Locations

  • Baptist Memorial Healthcare

    Memphis, Tennessee, 38120, United States

  • Baylor Scott & White Health

    Dallas, Texas, 75246, United States

  • Brody School of Medicine at East Carolina University

    Greenville, North Carolina, 27834, United States

  • Duke University

    Durham, North Carolina, 27713, United States

  • Emory University School of Medicine

    Atlanta, Georgia, 30322, United States

  • Gundersen Lutheran Medical Foundation

    La Crosse, Wisconsin, 54601, United States

  • Hackensack Meridian Health / Hackensack University Medical Center Cancer Center

    Hackensack, New Jersey, 07601, United States

  • Hamilton Health Sciences Center (Juravinski Hospital)

    Hamilton, Ontario, Canada

  • Indiana University

    Indianapolis, Indiana, 46202, United States

  • Intermountain Healthcare

    Murray, Utah, 84107, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Memoral Sloan Kettering Westchester (Consent only)

    Harrison, New York, 10604, United States

  • Memorial Sloan Kettering Basking Ridge (Consent only)

    Basking Ridge, New Jersey, 07920, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Memorial Sloan Kettering Commack (Consent only)

    Commack, New York, 11725, United States

  • Montefiore Health Systems (Montefiore Medical Center)

    The Bronx, New York, 10467, United States

  • Mount Sinai Hospital

    New York, New York, 10029, United States

  • Mount Sinai West

    New York, New York, 10029, United States

  • NorthShore University Health System

    Evanston, Illinois, 60201, United States

  • Northwestern Medicine (Data Collection)

    Chicago, Illinois, 60611, United States

  • Ohio State University

    Columbus, Ohio, 43210, United States

  • Ottawa Hospital

    Ottawa, Ontario, K1H 8L6, Canada

  • Pennsylvania State Hershey

    Hershey, Pennsylvania, 17033, United States

  • Providence Health & Services (Portland Med Ctr)

    Portland, Oregon, 97213, United States

  • Sunnybrook Health Sciences Centre

    Toronto, Ontario, M4N 3M5, Canada

  • Thomas Jefferson University Hospital

    Philadelphia, Pennsylvania, 19107, United States

  • UC Davis Comprehensive Cancer Center

    Sacramento, California, 95817, United States

  • University of Iowa

    Iowa City, Iowa, 52242, United States

  • University of Nebraska Medical Center

    Omaha, Nebraska, 68198-7680, United States

  • University of Utah

    Salt Lake City, Utah, 84112, United States

  • University of Washington School of Medicine

    St Louis, Missouri, 63110, United States

  • University of Wisconsin

    Madison, Wisconsin, 53792, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.