PANCREAS CANCER

This study tests whether adding a medical glue (Glubran 2) to the standard surgical connection after pancreas tumor removal can reduce the risk of a dangerous leak called pancreatic fistula. About 100 adults having this surgery will be randomly assigned to receive either the stan…

This study tests a new experimental drug, KESONOTIDE™, in people with advanced solid tumors like prostate, breast, lung, ovarian, pancreatic, skin cancer, or glioblastoma. The main goal is to check the drug's safety and find the right dose. About 80 adults will take part in two p…

This early-stage study tests a new treatment called CEA-targeted CAR-T cells for people with advanced solid tumors (such as lung, stomach, colon, rectal, esophageal, or pancreatic cancer) that have not responded to standard therapies. The treatment uses a patient's own immune cel…

This early-phase trial is testing whether adding Tumor Treatment Fields (TTF) – a device that sends low-intensity electric fields to the tumor – to a specific chemotherapy combination (protein-bound paclitaxel, cisplatin, and gemcitabine) can help control metastatic pancreatic ca…

This study tests a new drug, MGC026, in 250 adults with advanced solid tumors that have not responded to other treatments. The goal is to check the drug's safety, find the right dose, and see if it can shrink tumors. Participants receive the drug by IV and are closely monitored f…

This study tests whether adding two drugs (defactinib and avutometinib) to targeted radiation can help people with advanced pancreatic cancer live longer without their cancer growing. About 36 adults whose cancer is locally advanced or borderline resectable will receive the combi…

This study tests whether using multiple treatments together (like surgery, radiation, and chemotherapy) can help people with pancreatic cancer that has spread to only a few spots live longer and keep the cancer from growing. About 80 adults with this type of cancer will be random…

This study tests a new treatment for pancreatic cancer that has returned after standard therapy. The treatment uses a patient's own immune cells, modified to target a protein called B7-H3 on cancer cells, and includes a safety switch to control side effects. About 27 adults will …

This study tests a new type of CAR T cell therapy for adults with advanced solid tumors, including colorectal, pancreatic, lung, ovarian, and mesothelioma cancers. The therapy uses a patient's own immune cells, modified to recognize and attack cancer cells that have lost a specif…

This study tests if injecting a medical glue into the pancreas during surgery can prevent fluid leaks, a common complication. About 30 adults with pancreatic or nearby cancers will receive the glue injection. The goal is to see if the procedure is safe and reduces the need for fu…

This early-stage trial is testing a new treatment for people with metastatic pancreatic or breast cancer that has spread. The treatment combines chemotherapy drugs with high-dose vitamin C and the patient's own stem cells to try to overcome drug resistance. The main goal is to ch…

This early-stage study tests whether adding a procedure called irreversible electroporation (IRE) — which uses electric pulses to destroy cancer cells — to standard chemotherapy can help control locally advanced pancreatic cancer. About 20 adults with stage III pancreatic cancer …

This study is testing a new type of radiation therapy called SMART, which uses MRI scans to guide treatment in real time. It includes up to 397 adults with various cancers like pancreas, lung, or prostate cancer. The goal is to see if this approach is safe and improves tumor cont…

This study tests a new treatment for people with advanced pancreatic cancer that cannot be removed by surgery or has spread. The treatment uses the patient's own immune cells, which are mixed with a special antibody to help them attack cancer cells. Participants will receive up t…

This study tests a device that uses sound waves (histotripsy) to break apart pancreatic tumors without surgery. It includes 50 adults with advanced pancreatic cancer that cannot be removed. The main goal is to see if the procedure is safe and to track any complications within 30 …

This study tests if axelopran, a drug typically used for opioid-induced constipation, can help control tumor growth in people with advanced breast, lung, pancreas, or prostate cancer. About 34 adults whose cancer has worsened after standard treatment will take axelopran daily for…

This study tests whether adding Tumor Treating Fields (TTF) to targeted radiation therapy can slow tumor growth in people with locally advanced pancreas cancer. Participants receive radiation for five days and use a wearable TTF device for at least 18 hours daily. The goal is to …

This study tests a new drug called CNSI-Fe(II), which is injected directly into tumors. It uses iron to trigger a type of cell death called ferroptosis, aiming to shrink or control advanced solid tumors like lung, pancreas, and colorectal cancer. About 54 adults whose cancers hav…

This study tests a high-dose, short-course radiation treatment for people with locally advanced pancreatic cancer that cannot be removed by surgery. The goal is to see if this approach can control tumor growth in the treated area for at least two years. About 30 participants will…

This study tests if injecting a medical glue into the pancreas during surgery can prevent fluid leaks, a common and serious complication. About 90 adults with pancreatic or nearby cancers who are having a Whipple procedure will be randomly assigned to receive the glue injection o…

This study is looking for 20,000 people who have a family history of pancreatic cancer or carry certain gene changes that raise their risk. The goal is to find better ways to detect pancreatic cancer early, when it's easier to treat. Participants will be followed over time to see…

This study tests a special PET probe called [68Ga]CBP8 to see if it can detect tissue damage caused by radiation therapy in people with lung or pancreatic cancer. About 72 participants will get a PET scan before and 3-6 months after radiation. The goal is to find early signs of r…

This study tests whether a digital app (Open Food Facts) plus nutrition education can help 170 people at high risk for breast, pancreas, colon cancer, or with Lynch syndrome or BRCA mutations improve their diet quality. Participants will use the app to reduce ultra-processed food…

This study tests whether using virtual reality (VR) can reduce severe belly pain and improve daily life in people with digestive tract cancers. 360 participants will be randomly assigned to one of three groups: skills-based VR, distraction VR, or a sham VR. The goal is to see if …

This study looks at whether a blood test that detects tiny bits of tumor DNA (called ctDNA) can help doctors better manage gastrointestinal cancers like pancreas, colon, and bile duct cancer. About 100 adults with these cancers will provide blood and stool samples to see if certa…

This study follows 5,000 adults with pancreatic cysts to understand how these cysts grow and change over time. Researchers aim to create a better way to tell which cysts are harmless and which may turn into cancer. Participants provide medical records and test results over up to …

This study is looking at certain proteins, called convertases, in pancreatic tumor samples from 50 adults. Researchers want to see if the levels of these proteins are linked to how the immune system reacts to the cancer. The goal is to find new ways to predict how the disease wil…

This study is for people with pancreatic cancer that can be surgically removed. Researchers want to see if tiny pieces of tumor DNA found in the blood (ctDNA) can help predict how well patients do. The goal is to learn more about this biomarker to improve future diagnosis and tre…

This study collects tumor and normal tissue samples from people already scheduled for surgery or biopsy at the NIH Clinical Center. The goal is to provide researchers with biological material to discover new molecular targets for cancer therapies. Up to 1800 adults and children (…

This study collects blood samples from 30 adults with pancreatic cancer to build a research database. The goal is to store these samples and link them with health records for future studies on biomarkers. Participants must be patients at the University of Pennsylvania and able to…

This study is gathering tumor tissue and blood cells from 200 adults with advanced solid tumors like colorectal, lung, or pancreatic cancer. The goal is to learn how often certain genetic changes occur and to store participants' own immune cells for possible future use in making …

This study is screening 9,000 people at high risk for pancreas cancer to find early warning signs. Participants include those with strong family history or certain genetic mutations. Researchers will analyze pancreatic juice and cyst fluid to detect cancer markers before the dise…

This study creates a registry for people with pancreatic diseases or a high risk of pancreatic cancer, including those with family history or certain genetic mutations. Researchers collect health data and blood samples to study causes and find early detection markers. The goal is…

This study aims to understand how the tumor's surroundings change during chemoradiotherapy for locally advanced cervical and pancreatic cancers. Researchers will collect tissue and blood samples before, during, and after treatment from about 60 participants. The goal is to learn …