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20,000 volunteers join quest to detect pancreatic cancer sooner

NCT ID NCT04970056

Knowledge-focused Sponsor: Arbor Research Collaborative for Health Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 3 times

Summary

This study is tracking 20,000 people who have a family history of pancreatic cancer or carry genes that raise their risk. Researchers hope to find better ways to detect the disease early, when it's more treatable. Participants will be followed over time to see who develops pancreatic cancer and what factors might predict it.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to better screening methods and earlier diagnosis of pancreatic cancer in high-risk individuals.
What could go wrong
This is an observational study, not a treatment trial. It may take years to yield actionable results, and early detection methods may not reduce mortality.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 20,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2020

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study will accrue subjects who present for risk assessment at one of the participating sites based on history of: * one or more family members with PDAC * a pathogenic or likely pathogenic germline variant in a gene linked to PDAC risk * personal history of PDAC with PGV in genes of research interest and/or part of a Familial Pancreatic Cancer kindred

Ages

18 to 90 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Individuals from the following groups who present for clinical evaluation and assessment of PDAC risk at any of the participating sites can be offered participation in the PRECEDE database: Cohort 1 Individuals without history of PDAC meeting any of the following criteria: 1. 2+ relatives with PDAC on same side of family where 2 affected are first degree related to each other and at least 1 affected is first degree related to subject; age 50+ or ≤10 years younger than earliest PDAC in family at time of diagnosis. 2. 2 affected first degree relatives with PDAC; age 50+ or 10 years younger than earliest PDAC in family 3. BRCA1, BRCA2, PALB2, ATM, MLH1, MSH2, MSH6, PMS2, EPCAM pathogenic or likely pathogenic variant AND 1 first or second degree relative with PDAC; age 50+ or 10 years younger than earliest PDAC in family 4. Familial Atypical Moles and Malignant Melanoma (FAMMM) with pathogenic or likely pathogenic CDKN2A variant; age 40+ 5. Peutz-Jegher syndrome with STK11 pathogenic or likely pathogenic variant; age 35+ 6. Hereditary pancreatitis with PRSS1 pathogenic or likely pathogenic variant and history of pancreatitis; age 40+ Cohort 2 Individuals without history of PDAC meeting any of the following criteria: 1. ATM, BRCA1, BRCA2, or PALB2 pathogenic or likely pathogenic variant regardless of family history, age 50+ 2. 2+ relatives with PDAC on the same side of family, any degree of relation, not meeting other criteria above; age 50+ or 10 years younger than earliest PDAC in family 3. 1 first degree relative with PDAC ≤ age 45; age up to 10 years younger than PDAC diagnosis in family member Cohort 3 Individual meeting criteria for Cohorts 1 or 2 EXCEPT age (i.e. too young to qualify for Cohorts 1 or 2) Cohort 4 Individuals without history of PDAC presenting for evaluation who do not meet any criteria for 1-3, 6, or the Cyst Cohort. Cohort 5 Individuals without history of PDAC who are not otherwise engaged in pancreas surveillance at a participating site may be invited to participate in the PRECEDE database and to donate a biosample (e.g. blood, saliva, and/or buccal swab) for discovery studies. This may include relatives of individuals in Cohorts 1-4,6, and the Cyst Cohort. Cohort 6a Individuals diagnosed with PDAC or pancreatic high-grade dysplasia after enrollment in PRECEDE meeting any of the following criteria: 1. Family history includes at least one first degree relative with PDAC, or 2 relatives with PDAC who are first degree related to each other 2. Personal or family history of a pathogenic or likely pathogenic germline variant in ATM, BRCA1, BRCA2, CDKN2A, EPCAM, MLH1, MSH2, MSH6, PALB2,PMS2, PRSS1, STK11 Cohort 6b Individuals with a personal history of PDAC or pancreatic high-grade dysplasia meeting any of the following criteria: 1. Family history includes at least one first degree relative with PDAC, or 2 relatives with PDAC who are first degree related to each other 2. Personal or family history of a pathogenic or likely pathogenic germline variant in ATM, BRCA1, BRCA2, CDKN2A, EPCAM, MLH1, MSH2, MSH6, PALB2,PMS2, PRSS1, STK11 3. Diagnosed ≤ age 45 Cohort 6c Individuals with newly diagnosed early stage (stage I or stage II) PDAC seen at a PRECEDE site that do not meet the criteria for 6a or 6b. Cohort 6d Individuals with PDAC seen at a PRECEDE site that do not meet the criteria for 6a, 6b, or 6c. Cyst Cohort Individuals with a personal history of a pancreatic cystic neoplasm not meeting any criteria for Cohorts 1-3 or 6 (no known family history of PDAC, no known pathogenic germline variants linked to PDAC risk) Exclusion Criteria: * Individuals not meeting the criteria above.

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Conditions

The condition(s) this trial relates to.

cystic tumor of the pancreas inherited disease susceptibility malignant pancreatic neoplasm Pancreatic Cyst pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with high grade dysplasia pancreatic mucinous-cystic neoplasm pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Genetic predisposition Pancreas cancer Pancreas cyst Pancreatic ductal adenocarcinoma

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    57 sites in 11 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Azienda Ospedaliera Universitaria Integrata Verona

    RECRUITING

    Verona, Italy

  • Beaumont/Corewell Health

    RECRUITING

    Royal Oak, Michigan, 48073, United States

  • British Columbia Cancer Agency

    RECRUITING

    Vancouver, British Columbia, Canada

  • Cedars-Sinai Medical Center

    RECRUITING

    Los Angeles, California, 90048, United States

  • City of Hope

    RECRUITING

    Duarte, California, 91010, United States

  • Columbia University Irving Medical Center

    RECRUITING

    New York, New York, 10032, United States

  • Emory University Hospital

    RECRUITING

    Atlanta, Georgia, 30322, United States

  • Epworth HealthCare

    RECRUITING

    Richmond, Victoria, 3121, Australia

  • Fox Chase Cancer Center

    RECRUITING

    Philadelphia, Pennsylvania, 19111, United States

  • Hackensack Meridian Health

    RECRUITING

    Hackensack, New Jersey, 07601, United States

  • Hoag

    RECRUITING

    Newport Beach, California, 92663, United States

  • Honor Health Research Institute

    RECRUITING

    Scottsdale, Arizona, 85258, United States

  • Hospital Clínic de Barcelona

    RECRUITING

    Barcelona, Spain

  • Hospital Universitari Arnau De Vilanova

    RECRUITING

    Lleida, 25198, Spain

  • Huntsman Cancer Institute

    RECRUITING

    Salt Lake City, Utah, 84112, United States

  • Icahn School of Medicine At Mount Sinai

    RECRUITING

    New York, New York, 10029, United States

  • Illinois CancerCare

    RECRUITING

    Bloomington, Illinois, 61704, United States

  • Inova Schar Cancer Institute

    RECRUITING

    Fairfax, Virginia, 22031, United States

  • Intermountain Health

    WITHDRAWN

    St. George, Utah, 84790, United States

  • Landspitali University Hospital

    RECRUITING

    Reykjavik, Iceland

  • MD Anderson Center

    WITHDRAWN

    Houston, Texas, 77030, United States

  • Massachusetts General Hospital

    RECRUITING

    Boston, Massachusetts, 02114, United States

  • Mayo Clinic Arizona

    NOT_YET_RECRUITING

    Phoenix, Arizona, 85054, United States

  • Mayo Clinic Jacksonville

    RECRUITING

    Jacksonville, Florida, 32224, United States

  • McGill University Health Centre

    RECRUITING

    Montreal, Quebec, Canada

  • Memorial Sloan Kettering Cancer Center

    NOT_YET_RECRUITING

    New York, New York, 10022, United States

  • Moffitt Cancer Center

    RECRUITING

    Tampa, Florida, 33612, United States

  • National Cancer Centre Singapore

    RECRUITING

    Singapore, 168583, Singapore

  • National Cheng Kung University Hospital (NCKUH)

    RECRUITING

    Tainan, Taiwan T.o.c., 704, Taiwan

  • National Taiwan University Hospital

    RECRUITING

    Taipei, Taiwan

  • NorthShore University HealthSystem

    RECRUITING

    Evanston, Illinois, 60201, United States

  • Oregon Health & Science University

    RECRUITING

    Portland, Oregon, 97239, United States

  • Providence Health and Services

    RECRUITING

    Burbank, California, 91505, United States

  • Ramón y Cajal University Hospital

    RECRUITING

    Madrid, Spain

  • Semmelweis University, Institute of Pancreatic Diseases

    RECRUITING

    Budapest, Hungary

  • Sheba Medical Center

    RECRUITING

    Ramat Gan, Israel

  • The Ohio State University

    RECRUITING

    Columbus, Ohio, 43210, United States

  • The University of Texas Southwestern Medical Center

    TERMINATED

    Dallas, Texas, 75390, United States

  • UC Davis

    RECRUITING

    Sacramento, California, 95817, United States

  • UC Irvine Health

    RECRUITING

    Orange, California, 92868, United States

  • UC San Diego Moores Cancer Center

    RECRUITING

    La Jolla, California, 92093, United States

  • UCLA Health

    RECRUITING

    Los Angeles, California, 90095, United States

  • Umass Memorial Medical Center

    RECRUITING

    Worcester, Massachusetts, 01655, United States

  • University Health Network

    RECRUITING

    Toronto, Ontario, Canada

  • University of California, San Francisco (UCSF)

    RECRUITING

    San Francisco, California, 94143, United States

  • University of Chicago Medicine

    RECRUITING

    Chicago, Illinois, 60637, United States

  • University of Kansas Medical Center

    RECRUITING

    Kansas City, Kansas, 66160, United States

  • University of Liverpool

    RECRUITING

    Liverpool, United Kingdom

  • University of Miami

    RECRUITING

    Miami, Florida, 33136, United States

  • University of Michigan

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

  • University of Nebraska Medical Center

    RECRUITING

    Omaha, Nebraska, 68198, United States

  • University of Pennsylvania

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • University of Pittsburgh Medical Center (Upmc)

    RECRUITING

    Pittsburgh, Pennsylvania, 15232, United States

  • University of Rochester Medical Center

    RECRUITING

    Rochester, New York, 14642, United States

  • University of Tennessee Graduate School of Medicine

    RECRUITING

    Knoxville, Tennessee, 37930, United States

  • University of Virginia

    RECRUITING

    Charlottesville, Virginia, 22903, United States

  • University of Washington

    RECRUITING

    Seattle, Washington, 98195, United States

  • VCU Massey Comprehensive Cancer Center

    RECRUITING

    Richmond, Virginia, 23298, United States

  • White Plains Hospital

    RECRUITING

    White Plains, New York, 10601, United States

  • Yale University

    RECRUITING

    New Haven, Connecticut, 06510, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.