GENETIC PREDISPOSITION

This study tests whether using a person's genetic risk for mold infections can help doctors choose the right antifungal medicine for patients with acute myeloid leukemia (AML) receiving chemotherapy. About 410 adults with AML will be randomly assigned to get either standard or ge…

This study is looking for 20,000 people who have a family history of pancreatic cancer or carry certain gene changes that raise their risk. The goal is to find better ways to detect pancreatic cancer early, when it's easier to treat. Participants will be followed over time to see…

This study looks at how a person's genes and their environment (like alcohol use) together increase the risk of developing liver cancer from alcohol-related liver disease. Researchers will study 1000 people to find new genetic variants linked to this cancer. The goal is to better…

This study looks at how certain genes increase the risk of liver cancer (hepatocellular carcinoma) in people with nonalcoholic fatty liver disease (NAFLD). Researchers will follow 500 adults aged 45-75 with NAFLD to understand how genetic factors and lifestyle interact. The goal …

This study is creating a registry of 100 women who have had a heart attack (acute coronary syndrome). Researchers will collect genetic, biochemical, and molecular information to better understand how heart attacks differ among women. The goal is to identify subtypes that could le…

This study looks at how a person's genetic makeup influences their body's response to oral semaglutide, a medication used for type 2 diabetes. Researchers will give 125 people with normal to prediabetic blood sugar levels the drug for two weeks and measure changes in blood sugar …

This study tests whether applying minoxidil (a hair growth cream) to the breasts for two weeks before surgery can improve blood flow and tissue survival during breast reconstruction. Twenty-five women at high genetic risk for breast cancer who are having both breasts removed and …

This study compares two ways of providing pre-test genetic education to people at high risk for certain cancers: a chatbot (GIA) versus a genetic counselor. About 96 participants will receive education from either the chatbot or a counselor, then decide whether to get genetic tes…

This study is for people with genetic conditions affecting the heart or blood vessels, their family members, and healthy volunteers. Researchers will collect medical data, blood, urine, and tissue samples to learn more about these diseases. The goal is to improve diagnosis and un…

This study looks at whether a genetic test can help assess prostate cancer risk in men who either have the disease or are at high risk. Researchers will analyze DNA from 3,000 men to find rare and common genetic changes linked to prostate cancer. The goal is to see if this inform…

This study looks at how parents and children (ages 10-24) communicate after learning the child has a genetic risk for cancer. Researchers want to find out what helps or hinders these conversations, and how they affect the child's emotions and health choices. The goal is to improv…

This study is building a collection of prostate tissue samples from people with inherited gene mutations that raise their risk for aggressive prostate cancer. Researchers will compare these samples to those from people without such mutations to learn how the disease develops and …

This study looks for new genetic causes of cancer in people diagnosed at a young age (under 40, or under 30 for breast cancer). Standard genetic tests often miss the cause, so researchers will use a more detailed method called exome sequencing to search for hidden risk factors. T…

This study follows 56 adolescents and young adults with a genetic predisposition to cancer as they leave pediatric care and enter the adult health system. Researchers want to see if these individuals find adult doctors and continue recommended cancer screenings over the next 8 ye…

This study is testing a new online platform called Nest for young adults aged 18-39 who have had genetic testing for cancer risk. The platform gives patients and their doctors up-to-date information about genetic findings. The goal is to see if the tool is easy to use and helps p…