PANCREAS CANCER

This early-phase study tests whether adding a new drug called IM156 to standard chemotherapy (gemcitabine and nab-paclitaxel) is safe for people with advanced pancreatic cancer. About 19 adults with confirmed metastatic pancreatic cancer are taking part. The main goal is to check…

This early-phase study tests an experimental drug called MOMA-313, given alone or with another drug (olaparib), in people with advanced solid tumors that have a specific DNA repair problem (HR deficiency). The main goals are to check safety, find the best dose, and see if the dru…

This study tests a new drug called 9-ING-41, given alone or with chemotherapy, in adults with advanced cancers that have stopped responding to standard treatments. The goal is to see if the drug is safe and can help control the cancer. About 350 people with various cancer types, …

This early-stage study tests a new drug called TORL-2-307-ADC in people with advanced solid tumors, including stomach, pancreas, and esophageal cancers. The main goals are to find a safe dose and check for side effects. About 163 participants will receive the drug to see if it ca…

This study tests whether giving a precise dose of radiation directly to the tumor during surgery can help people with pancreatic cancer that has grown into nearby blood vessels. Participants had already received chemotherapy and standard radiation before the procedure. The main g…

This study tests a combination of four drugs—two standard chemotherapy drugs plus two experimental ones—in people with advanced pancreatic cancer that has spread. The goal is to see if this mix is safe and can shrink tumors. About 40 adults who haven't had treatment yet will take…

This study tests whether adding three cholesterol-lowering drugs (atorvastatin, ezetimibe, and evolocumab) to standard chemotherapy can slow or stop pancreatic cancer growth. It involves 3 adults with newly diagnosed advanced or metastatic pancreatic cancer. The goal is to see if…

This study tests whether adding a drug called defactinib to targeted radiation therapy can help control advanced pancreatic cancer better than radiation alone. About 42 people with locally advanced pancreatic cancer that cannot be removed by surgery will take part. The main goal …

This early-phase study tests whether using electric pulses to deliver chemotherapy (bleomycin) directly to the surgical site can lower the chance of pancreatic cancer returning after surgery. About 10 to 20 adults with removable pancreatic tumors will receive this treatment. The …

This early-stage study tests whether a single dose of psilocybin, the active ingredient in magic mushrooms, can reduce depression and anxiety in people with advanced pancreatic, biliary, or other gastrointestinal cancers. 24 participants and their family members are involved. The…

This study looks at whether a supervised exercise program is safe and practical for people with pancreatic cancer. Sixteen participants will attend exercise sessions before their main treatment. The goal is to see if at least half of them can stick with the program, and to check …

This early-phase study tests whether ketorolac, a nonsteroidal anti-inflammatory drug (NSAID) similar to ibuprofen, is safe and can help stabilize or increase weight in people with advanced pancreatic cancer who are experiencing cachexia (unintended weight loss). About 28 partici…

This study is looking at 200 people with pancreatic cancer to see if analyzing their tumor's genes and growing mini-tumors in a lab can help doctors choose more personalized treatments. Participants provide tissue, blood, and stool samples, and their medical records are reviewed.…

This study looks at a new approach to genetic testing for people with ovarian, prostate, or pancreas cancer. Instead of always sending patients to a genetic counselor, doctors offer the test and counselors share results by phone. The goal is to see how this affects patient distre…