PANCREATIC CANCER

This study is testing whether a combination of two drugs, atezolizumab and cabozantinib, can help control advanced pancreatic cancer that has spread and stopped responding to standard chemotherapy. It will involve about 30 patients to see if the treatment is safe and if it can sh…

This study is testing whether adding an experimental drug called futibatinib to standard immunotherapy and chemotherapy can better control advanced esophageal or pancreatic cancer. It is for adults who have not yet received treatment for their advanced cancer. The goal is to see …

This study is testing how well and safely the diabetes medication glipizide works to lower high blood sugar in people with pancreatic cancer. Researchers are enrolling about 29 participants with active pancreatic cancer and high blood sugar to measure their glucose levels before …

This trial is testing if adding a repurposed drug called ATRA to standard chemotherapy (gemcitabine and nab-paclitaxel) is more effective for controlling locally advanced pancreatic cancer. About 170 patients will be randomly assigned to receive either the standard two-drug combo…

This study is testing if a specific combination of chemotherapy drugs followed by a short, intense course of targeted radiation can help control pancreatic cancer that cannot be removed by surgery. The goal is to see if this approach can keep the cancer from growing or spreading …

This study is testing a new way to treat advanced pancreatic cancer by placing tiny radioactive seeds directly into the tumor. The seeds release a powerful form of radiation called alpha radiation, which is designed to destroy cancer cells from the inside. Researchers are checkin…

This early-stage trial is testing whether adding an experimental pill called TTI-101 to a targeted form of radiation is safe and can better control pancreatic cancer. The study is for people whose pancreatic cancer is difficult to remove with surgery, even after initial chemother…

This early-stage study is testing the safety of combining four drugs—two standard chemotherapy drugs and two newer immunotherapy drugs—to treat pancreatic cancer before surgery. The goal is to see if this combination is safe and can shrink tumors enough to allow for successful su…

This study is testing whether adding an experimental drug called ZN-c3 to an approved chemotherapy (gemcitabine) can help control advanced pancreatic cancer that has worsened after initial treatment. The main goal is to see if this combination can keep the cancer from growing for…

This study tested whether adding an experimental drug called ABTL0812 to standard chemotherapy could better control advanced pancreatic cancer that has spread. It involved 60 adults newly diagnosed with metastatic pancreatic cancer who had not yet received treatment for it. The t…

This early-stage study is testing a new oral medication called HBI-2376 in people with advanced solid tumors that have specific KRAS or EGFR mutations. The main goals are to find the highest safe dose of the drug and to understand how the body absorbs and processes it. The trial …

This study is testing whether a new oral drug called daraxonrasib works better than standard chemotherapy for people with advanced pancreatic cancer that has spread. The trial involves 501 patients whose cancer has continued to grow despite previous treatment. Researchers will co…

This study is testing a shorter, 3-week course of radiation combined with chemotherapy for people with pancreatic cancer that hasn't spread. Researchers will monitor side effects and collect blood samples before and after treatment to check for cancer DNA. The goal is to see if t…

This study is testing a new drug called NUV-1511 in adults with advanced solid tumors that have stopped responding to standard treatments. The first part checks the drug's safety and finds the right dose, while the second part looks at how well it shrinks tumors in specific cance…

This study is testing whether adding a drug called surufatinib to standard chemotherapy helps people with pancreatic cancer that is difficult to remove with surgery. The goal is to shrink the tumors first to make surgery more successful and improve long-term outcomes. It will inv…

This study is testing an experimental drug called DZ-002 as a maintenance therapy for adults with metastatic pancreatic cancer. The goal is to see if giving DZ-002 after successful initial chemotherapy can help control the cancer longer and prevent it from worsening. Researchers …

This study is testing a new combination of immune-based treatments for pancreatic cancer. It gives patients a cancer vaccine and a drug that helps the immune system fight cancer, both before and after surgery to remove the tumor. The main goal is to see if this approach is safe a…

This early-stage study is testing a four-part combination treatment for advanced pancreatic cancer that has stopped responding to standard chemotherapy. The treatment includes two immunotherapy drugs, a targeted vaccine, and a single dose of precise radiation. The main goal is to…

This study is testing whether using a Fitbit and a mobile app can help patients recover better after major surgery for gastrointestinal cancers. About 107 patients were randomly assigned to either use the app and tracker along with their usual care, or to receive usual care alone…

This early-stage study is testing whether adding three common cholesterol-lowering drugs to standard chemotherapy is safe and feasible for people with advanced pancreatic cancer. The idea is that by drastically lowering the body's cholesterol, the drugs might 'starve' the fast-gr…

This was a special access program for a single patient with pancreatic cancer. It tested whether stem cells donated by a blood relative could help control the disease. The patient received 12 infusions of these cells over several months while doctors monitored their health and ca…

This study is testing whether adding a combination of three immunotherapy drugs to standard chemotherapy works better than chemotherapy alone for people with advanced pancreatic cancer that cannot be removed by surgery. It involves 328 adults whose cancer has progressed after pre…

This is an early-stage study testing the safety and optimal dose of a new treatment called LB1908, a type of CAR-T cell therapy, for adults with advanced cancers of the stomach, esophagus, or pancreas. The therapy involves collecting a patient's own immune cells, engineering them…

This early-stage study is testing the safety of combining two experimental drugs, palbociclib and gedatolisib, for people with advanced cancers that have stopped responding to standard treatments. The main goal is to find the highest dose of this drug combination that patients ca…

This large Phase 3 trial is comparing two different timing strategies for chemotherapy in people with pancreatic cancer that can be surgically removed. It tests whether giving strong chemotherapy both before and after surgery leads to better survival and cancer control than the s…

This study is testing a drug called entrectinib for people with advanced solid tumors that have specific genetic changes (NTRK, ROS1, or ALK gene rearrangements). It's a 'basket trial,' meaning it groups patients by their tumor's genetic type rather than where the cancer started …

This early-stage trial is testing the safety of a new, personalized treatment approach for pancreatic cancer. After surgery to remove the tumor, patients receive an immunotherapy drug followed by a vaccine designed specifically for their cancer, and then standard chemotherapy. Th…

This study is testing if adding a new drug called zolbetuximab to standard chemotherapy helps people with advanced pancreatic cancer that has spread. The drug works by targeting a specific protein found on many pancreatic cancer cells, aiming to help the immune system attack the …

This study aimed to test if a personalized immune cell therapy could prevent or delay the return of advanced gastrointestinal cancers (like pancreatic, liver, or colon cancer) after standard treatment like surgery. It was for patients whose cancer had specific genetic mutations a…

This early-stage study is testing a personalized vaccine designed to target specific mutations found in colorectal and pancreatic cancers. The vaccine is combined with two immunotherapy drugs (nivolumab and ipilimumab) to help the body's immune system recognize and attack cancer …

This study is testing if a supervised, at-home exercise program done during chemotherapy can help people with pancreatic cancer who are planning for surgery. It compares a structured video workout plan to general activity advice to see if it helps patients start follow-up chemo s…

This study is testing a new oral drug called AZD5305 to see if it is safe and can help control advanced cancers. It is being tested alone and in combination with other cancer medicines in over 700 patients with various hard-to-treat solid tumors. The main goals are to find the ri…

This study is testing a combination of four drugs (CRS-207, pembrolizumab, ipilimumab, and tadalafil) to see if it is safe and can help control advanced pancreatic cancer that has spread and has gotten worse after at least one round of prior chemotherapy. It is for adults whose c…

This study is testing whether the drug niraparib can help control advanced pancreatic cancer in patients whose tumors have specific genetic mutations affecting DNA repair. The trial is enrolling 32 adults whose cancer has progressed after at least one prior treatment and who have…

This early-stage trial is testing the safety and best dose of a new two-drug combination for people with advanced solid tumors that have stopped responding to standard treatments. The study is focusing on specific cancers, including certain types of lung, ovarian, and pancreatic …

This is a first-in-human study testing a new type of cancer treatment called P-MUC1C-ALLO1 in adults with advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to find a safe dose and see how well the body tolerates this 'off-the-shelf' CAR-T …

This study is testing whether adding two drugs, losartan and nivolumab, to standard chemotherapy and radiation can better shrink pancreatic tumors before surgery. The goal is to help surgeons completely remove the cancer and improve patient outcomes. It is for adults with localiz…

This study is testing whether a combination of three immunotherapy drugs can help control metastatic pancreatic cancer after initial chemotherapy. The trial compares two different treatment approaches to see which works better at keeping the cancer from growing. About 46 people w…

This study is testing if adding an investigational drug called Ampligen to standard cancer care helps people with locally advanced pancreatic cancer live longer without their cancer getting worse. It will compare the combination to standard care alone in about 90 people who have …

This study is testing an intensive treatment plan for people with pancreatic cancer that has grown into a major artery. The plan involves chemotherapy and radiation before surgery to remove the tumor and reconstruct the artery, followed by more chemotherapy after surgery. The mai…

This study is testing whether combining two immunotherapy drugs (nivolumab and ipilimumab) with targeted radiation can help control advanced colorectal or pancreatic cancer. The goal is to see if this three-part approach can help the body's own immune system better recognize and …

This study allows patients who were already taking the drug ruxolitinib in a previous cancer trial to continue receiving it, along with their other cancer treatments, if they are benefiting. It's for people with pancreatic, colorectal, breast, or lung cancer who are doing well on…

This study tests whether adding an experimental drug called PEGPH20 to standard chemotherapy helps control advanced pancreatic cancer. PEGPH20 works by breaking down a substance called hyaluronan that pancreatic tumors produce, which may help shrink tumors. The research involves …

This early-stage trial is testing a new drug called TST001 for people with advanced stomach, gastroesophageal junction, or pancreatic cancer. The main goals are to find a safe dose and see how well the body handles the drug, both alone and when combined with other standard cancer…

This study is testing a new radioactive imaging agent to see if it can help find cancers that produce a specific protein called CEA. Twenty patients with various CEA-positive cancers will receive the agent and undergo PET scans to see if it highlights their tumors. The goal is to…

This study is testing new software that uses standard CT scans to predict how blood flow will change during complex pancreatic cancer surgery. The goal is to help surgeons plan operations better by avoiding damage to vital blood vessels. If successful, this tool could replace a m…

This study aimed to test a new blood test designed to find hidden pancreatic cancer in people recently diagnosed with type 2 diabetes. The plan was to enroll 10,000 adults aged 50+ with new diabetes. If the blood test suggested cancer, participants would get an MRI scan to check.…

This study aimed to test a new two-step PET scan method to better find cancer cells that produce a specific marker called CA19-9. It was designed for adults with certain cancers like pancreatic, bladder, or gastrointestinal tumors. The main goals were to find the safest dose and …

This study is testing whether a structured exercise and coaching program can help pancreatic cancer patients feel stronger and improve their quality of life while they receive chemotherapy or radiation before surgery. Researchers will compare patients who follow the exercise prog…

This study is testing whether connecting patients with advanced pancreatic cancer to specialized comfort care (palliative care) teams early in their treatment improves their quality of life and may help them live longer. It involves 250 adults who are about to start first-line ca…

This study is testing whether a remote nutrition coaching program is practical and helpful for people with pancreatic cancer during their first 12 weeks of chemotherapy. It involves 40 participants who will receive coaching and monitoring over the phone or online. The main goal i…

This study is testing whether pancreatic enzyme replacement therapy (PERT) can help people with advanced pancreatic cancer maintain their body weight while on chemotherapy. Researchers are comparing two different dosing schedules of the enzyme supplement pancrelipase. The main go…

This study is testing a remote nutrition support program for people with pancreatic cancer who are receiving chemotherapy. The program provides regular video visits with a dietitian and asks participants to track their food intake. Researchers want to see if this approach helps p…

This early study is testing whether ketorolac, a common anti-inflammatory pain medication, can help stabilize or increase weight in people with advanced pancreatic cancer who are experiencing significant weight loss (cachexia). Researchers will give 28 participants ketorolac for …

This study collects tumor tissue and blood samples from people with cancer to help researchers find new targets for future treatments. Participants are adults who are already having surgery or biopsy for their cancer care. No experimental treatments are given—researchers only col…

This study aims to see if a new way of analyzing medical scans, called radiomics, can help doctors predict early on which patients with advanced pancreatic cancer will not respond well to standard first-line chemotherapy. It involves looking back at the scans and records of 400 a…

This study is testing a new type of PET scan to see if it can show how much of a standard chemotherapy drug actually gets into pancreatic tumors. Researchers will scan about 30 patients with pancreatic cancer before they start treatment. The goal is to gather information that cou…

This study is testing a new program to help family members of people with hereditary cancer get genetic testing. The program includes a website and a personal guide. Researchers want to see if this approach makes it easier for families to understand and act on their genetic cance…

This study collects leftover tissue and blood samples from patients with various cancers to help researchers understand these diseases better. The samples come from patients already having medical procedures, using only material that would otherwise be discarded. Researchers will…

This study is creating a large national registry of pancreatic cancer patients to collect real-world information on how the disease is treated and how patients fare over time. It will analyze past medical records from 2010 onward and follow over 800 new patients through 2029. The…

This study aims to understand if a narrowed artery (celiac axis stenosis) leads to more complications after surgery to remove pancreatic cancer. It will observe 99 adult patients who are having this specific surgery. The goal is to gather knowledge to help surgeons better plan an…

This study aims to create a large collection of blood and tissue samples from people with pancreatic cancer. Researchers will analyze these samples alongside medical records to understand why the disease affects different racial and ethnic groups differently. The goal is to find …