Triple threat: vaccine, immunotherapy, and radiation take on pancreatic cancer

This early-phase study tests a new combination of treatments for people with pancreatic cancer that has not responded to standard therapies. The approach combines two immunotherapy drugs (nivolumab and ipilimumab) with a vaccine targeting a protein called TGFβ-15 and precise radiation therapy. The goal is to see if this mix is safe and can help control the cancer by boosting the immune system's ability to attack tumors. About 20 participants will be enrolled.